H. Motamedi

<I>Ziziphus spina-christi</I>, a Native Plant from Khuzestan, Iran, as a Potential Source for Discovery New Antimicrobial Agents (2009)

H. Motamedi, A. Safary, S. Maleki, S.M. Seyyednejad

The antibacterial activity of <I>Ziziphus spina-christi</I> leaves ethanolic and methanolic extracts were examined using agar disc diffusion method against eight bacteria...

A Preliminary Study on the Antibacterial Activity of Quercus brantii Against Bacterial Pathogens, Particularly Enteric Pathogens (2009)

A. Safary, H. Motamedi, S. Maleki, S.M. Seyyednejad

The antibacterial activity of Q. brantii fruits ethanolic and methanolic extracts were examined using agar disc diffusion method against eight bacteria (Salmonella typhi, Proteus mirabilis, Shigella...

Antibacterial Activity of the Fruits of Iranian Torilis leptophylla Against Some Clinical Pathogens (2008)

S. Maleki, S.M. Seyyednejad, N. Mirzaie Damabi, H. Motamedi

The aim of this study was to examine the antimicrobial activity of the methanolic extract of Torilis leptophylla was tested on eleven bacteria (Bacillus anthracis, Bacillus subtilis, Bacillus...

Torilis leptophylla Against Some Clinical Pathogens]]> (2008)

S. Maleki, S.M. Seyyednejad, N. Mirzaie Damabi, H. Motamedi

Torilis leptophylla was tested on eleven bacteria (Bacillus anthracis, Bacillus subtilis, Bacillus pumilus, Staphylococcus aureus, Bacillus licheniformis, Brucella melitensis, Escherichia coli,...

Antibacterial Activity of the Fruits of Iranian <i>Torilis leptophylla </i>Against Some Clinical Pathogens (2008)

S. Maleki, S.M. Seyyednejad, N. Mirzaie Damabi, H. Motamedi

The aim of this study was to examine the antimicrobial activity of the methanolic extract of <i>Torilis leptophylla</i> was tested on eleven bacteria (<i>Bacillus...

Characterization of methyltransferase and hydroxylase genes involved in the biosynthesis of the immunosuppressants FK506 and FK520.

Motamedi, H, Shafiee, A, Cai, S J, Streicher, S L, Arison, B H, Miller, R R

FK506 and FK520 are 23-membered macrocyclic polyketides with potent immunosuppressive and antifungal activities. The gene encoding 31-O-demethyl-FK506 methyltransferase, fkbM, was isolated from...

Nucleotide sequences and heterologous expression of tcmG and tcmP, biosynthetic genes for tetracenomycin C in Streptomyces glaucescens.

Decker, H, Motamedi, H, Hutchinson, C R

The nucleotide sequence of the tcmIII, tcmIc, and tcmVII region of the tetracenomycin (TCM) C gene cluster of Streptomyces glaucescens ETH 22794 (GLA.0) revealed the presence of two genes, tcmP and...

Nucleotide sequence of the tcmII-tcmIV region of the tetracenomycin C biosynthetic gene cluster of Streptomyces glaucescens and evidence that the tcmN gene encodes a multifunctional cyclase-dehydratase-O-methyl transferase.

Summers, R G, Wendt-Pienkowski, E, Motamedi, H, Hutchinson, C R

Mutations in the tcmII-tcmIV region of the Streptomyces glaucescens chromosome block the C-3 and C-8 O-methylations of the polyketide antibiotic tetracenomycin C (Tcm C). The nucleotide sequence of...

The tcmVI region of the tetracenomycin C biosynthetic gene cluster of Streptomyces glaucescens encodes the tetracenomycin F1 monooxygenase, tetracenomycin F2 cyclase, and, most likely, a second cyclase.

Summers, R G, Wendt-Pienkowski, E, Motamedi, H, Hutchinson, C R

Certain mutations in the tcmVI region of the Streptomyces glaucescens chromosome affect formation of the D ring of the polyketide antibiotic tetracenomycin C (TCM C). This region lies immediately...

Isolation of tetracenomycin C-nonproducing Streptomyces glaucescens mutants.

Motamedi, H, Wendt-Pienkowski, E, Hutchinson, C R

We analyzed the properties of tetracenomycin C (TcmC)-nonproducing mutants of Streptomyces glaucescens to establish the nature of pathway intermediates and to provide some information about the...

Anthracycline metabolites of tetracenomycin C-nonproducing Streptomyces glaucescens mutants.

Yue, S, Motamedi, H, Wendt-Pienkowski, E, Hutchinson, C R

Mutants of Streptomyces glaucescens GLA.0 which are blocked in the production of tetracenomycin C (compound 1), an anthracycline antibiotic having significant antitumor activity, accumulated several...

Cloning and heterologous expression of a gene cluster for the biosynthesis of tetracenomycin C, the anthracycline antitumor antibiotic of Streptomyces glaucescens.

Motamedi, H, Hutchinson, C R

Through complementation of mutations specifically blocking the biosynthesis of tetracenomycin C by Streptomyces glaucescens and selecting for resistance to tetracenomycin C in Streptomyces lividans,...

Tandem promoters preceding the gene for the M1 RNA component of Escherichia coli ribonuclease P.

Motamedi, H, Lee, Y, Schmidt, F J

The nucleotide sequence of a cloned gene for the RNA component of Escherichia coli ribonuclease P, M1 RNA, is presented. The sequence determined extends 320 nucleotides upstream of the 377-base-pair...

Analysis of the nucleotide sequence of the Streptomyces glaucescens tcmI genes provides key information about the enzymology of polyketide antibiotic biosynthesis.

Bibb, M J, Biró, S, Motamedi, H, Collins, J F, Hutchinson, C R

Key information about the biosynthesis of polyketide metabolites has been uncovered by sequence analysis of the tetracenomycin C polyketide synthase genes (tcml) from Streptomyces glaucescens GLA.0....

Characterization of methyltransferase and hydroxylase genes involved in the biosynthesis of the immunosuppressants FK506 and FK520.

Motamedi, H, Shafiee, A, Cai, S J, Streicher, S L, Arison, B H, Miller, R R

FK506 and FK520 are 23-membered macrocyclic polyketides with potent immunosuppressive and antifungal activities. The gene encoding 31-O-demethyl-FK506 methyltransferase, fkbM, was isolated from...

Nucleotide sequences and heterologous expression of tcmG and tcmP, biosynthetic genes for tetracenomycin C in Streptomyces glaucescens.

Decker, H, Motamedi, H, Hutchinson, C R

The nucleotide sequence of the tcmIII, tcmIc, and tcmVII region of the tetracenomycin (TCM) C gene cluster of Streptomyces glaucescens ETH 22794 (GLA.0) revealed the presence of two genes, tcmP and...

Nucleotide sequence of the tcmII-tcmIV region of the tetracenomycin C biosynthetic gene cluster of Streptomyces glaucescens and evidence that the tcmN gene encodes a multifunctional cyclase-dehydratase-O-methyl transferase.

Summers, R G, Wendt-Pienkowski, E, Motamedi, H, Hutchinson, C R

Mutations in the tcmII-tcmIV region of the Streptomyces glaucescens chromosome block the C-3 and C-8 O-methylations of the polyketide antibiotic tetracenomycin C (Tcm C). The nucleotide sequence of...

The tcmVI region of the tetracenomycin C biosynthetic gene cluster of Streptomyces glaucescens encodes the tetracenomycin F1 monooxygenase, tetracenomycin F2 cyclase, and, most likely, a second cyclase.

Summers, R G, Wendt-Pienkowski, E, Motamedi, H, Hutchinson, C R

Certain mutations in the tcmVI region of the Streptomyces glaucescens chromosome affect formation of the D ring of the polyketide antibiotic tetracenomycin C (TCM C). This region lies immediately...

Isolation of tetracenomycin C-nonproducing Streptomyces glaucescens mutants.

Motamedi, H, Wendt-Pienkowski, E, Hutchinson, C R

We analyzed the properties of tetracenomycin C (TcmC)-nonproducing mutants of Streptomyces glaucescens to establish the nature of pathway intermediates and to provide some information about the...

Anthracycline metabolites of tetracenomycin C-nonproducing Streptomyces glaucescens mutants.

Yue, S, Motamedi, H, Wendt-Pienkowski, E, Hutchinson, C R

Mutants of Streptomyces glaucescens GLA.0 which are blocked in the production of tetracenomycin C (compound 1), an anthracycline antibiotic having significant antitumor activity, accumulated several...

Cloning and heterologous expression of a gene cluster for the biosynthesis of tetracenomycin C, the anthracycline antitumor antibiotic of Streptomyces glaucescens.

Motamedi, H, Hutchinson, C R

Through complementation of mutations specifically blocking the biosynthesis of tetracenomycin C by Streptomyces glaucescens and selecting for resistance to tetracenomycin C in Streptomyces lividans,...

Tandem promoters preceding the gene for the M1 RNA component of Escherichia coli ribonuclease P.

Motamedi, H, Lee, Y, Schmidt, F J

The nucleotide sequence of a cloned gene for the RNA component of Escherichia coli ribonuclease P, M1 RNA, is presented. The sequence determined extends 320 nucleotides upstream of the 377-base-pair...

Analysis of the nucleotide sequence of the Streptomyces glaucescens tcmI genes provides key information about the enzymology of polyketide antibiotic biosynthesis.

Bibb, M J, Biró, S, Motamedi, H, Collins, J F, Hutchinson, C R

Key information about the biosynthesis of polyketide metabolites has been uncovered by sequence analysis of the tetracenomycin C polyketide synthase genes (tcml) from Streptomyces glaucescens GLA.0....