WOUND HEALING, COLLAGEN, AND HUMORAL GROWTH-PROMOTING AGENTS (2003)
ROSEN, H., BERARD, C. W., GREEVER, E. F., LEVENSON, S. M.
Physical, biochemical, surgical and histological techniques were used in a series of studies on many aspects of wound healing. Acetic acid solubilized collagen is polydisperse and this mixture was...
Technology and classroom applications (2000)
Clark, C, Dancer, J, Sinclair, S, Clymer, E, McKee, BG, ...
To request individual papers in any of the sections, please include the full citation and the AN number found in brackets at the end of the citation. Contact the Department of Educational Resources...
Technology and classroom applications (2000)
Clark, C., Dancer, J., Sinclair, S., Clymer, E., McKee, Barbara, ...
To request individual papers in any of the sections, please include the full citation and the AN number found in brackets at the end of the citation. Contact the Department of Educational Resources...
Moderate alcohol consumption and bone density among postmenopausal women (1999)
Feskanich, D., Korrick, S., Greenspan, S.L., Rosen, H., Colditz, G. A.
Moderate alcohol consumption and bone density among postmenopausal women (1999)
Feskanich, D., Korrick, S., Greenspan, S.L., Rosen, H., Colditz, G. A.
Strohscheer, I., Kleinert, R., Westphal, C., Schüller, J., Werner, K., Anders, O., ...
Peer Reviewed
Primary structure of the human proenkephalin gene (1983)
Comb,M., Rosen,H., Seeburg,Peter H., Adelman,John P., Herbert,E.
Primary structure of the human proenkephalin gene (1983)
Comb, M., Rosen, H., Seeburg, Peter H., Adelman, John P., Herbert, E.
The doctrine of part performance / (1935)
Thesis (Jacob Joseph Scholarship, Law)--Victoria University College, 1935.
Siciliano, S J, Rollins, T E, DeMartino, J, Konteatis, Z, Malkowitz, L, Van Riper, G, ...
The guanine nucleotide-binding protein-coupled receptor superfamily binds a vast array of biological messengers including lipids, odorants, catecholamines, peptides, and proteins. While some small...
Proenkephalin A in bone-derived cells.
Rosen, H, Polakiewicz, R D, Benzakine, S, Bar-Shavit, Z
Enkephalins, a group of small peptides with opiate-like activity, have been defined originally as neuropeptides. Recent reports showed, using in situ hybridization, that the enkephalin-encoding gene,...
Rosen, H, Orman, J, Rakita, R M, Michel, B R, VanDevanter, D R
Neutrophils and monocytes employ a diverse array of antimicrobial effector systems to support their host defense functions. The mechanisms of action of most of these systems are incompletely...
Gill, Charles J., Jackson, Jesse J., Gerckens, Lynn S., Pelak, Barbara A., Thompson, Randall K., Sundelof, Jon G., ...
MK-826 (formerly L-749,345), is a potent 1-β-methyl carbapenem with a long half-life and broad spectrum of activity. This compound is presently in phase-II clinical trials. Its activity against a...
Bowman, J. C., Hicks, P. Scott, Kurtz, M. B., Rosen, H., Schmatz, D. M., Liberator, P. A., ...
Caspofungin acetate is an antifungal antibiotic that inhibits synthesis of 1,3-β-d-glucan, an essential component of the fungal cell wall. While caspofungin causes cell death in yeasts and dimorphic...
Pharmacokinetics of L-749,345, a long-acting carbapenem antibiotic, in primates.
Sundelof, J G, Hajdu, R, Gill, C J, Thompson, R, Rosen, H, Kropp, H
L-749,345 is a carbapenem antibiotic, currently in phase II clinical trials, which possesses a broad antibacterial spectrum and extended half-life. The time courses of levels of the drugs in plasma...
Abruzzo, G K, Flattery, A M, Gill, C J, Kong, L, Smith, J G, Pikounis, V B, ...
The in vivo activity of the Merck antifungal echinocandin drug candidate MK-0991 (L-743,872) was evaluated in mouse models of disseminated candidiasis, aspergillosis, and cryptococcosis. The...
Neutrophil microbicidal activity is a consequence of overlapping antimicrobial systems that vary in prominence according to the conditions of the neutrophil-microbe interaction, the nature of the...
Inactivation of Escherichia coli penicillin-binding proteins by human neutrophils.
Rakita, R M, Michel, B R, Rosen, H
Neutrophils use a variety of microbicidal mechanisms in their role as one of the primary arms of the human host defense system. We have previously observed that a cell-free system containing...
Mielke, M E, Rosen, H, Brocke, S, Peters, C, Hahn, H
Listeria-immune mice are able to express protective immunity in the absence of CD4+ T cells and an apparent granulomatous inflammation. Using a monoclonal antibody (5C6) able to inhibit the...
Oxidation of microbial iron-sulfur centers by the myeloperoxidase-H2O2-halide antimicrobial system.
Myeloperoxidase, H2O2, and a halide (chloride, bromide, or iodide) form a potent microbicidal system that contributes to the antimicrobial activity of neutrophils. The mechanism of toxicity is not...
Endocarditis caused by Rochalimaea quintana in a patient infected with human immunodeficiency virus.
Spach, D H, Callis, K P, Paauw, D S, Houze, Y B, Schoenknecht, F D, Welch, D F, ...
Rochalimaea quintana and Rochalimaea henselae are closely related, fastidious, gram-negative rickettsiae. Thus far, the spectrum of human Rochalimaea sp. infections has not included endocarditis. We...
Effector role of blood monocytes in experimental visceral leishmaniasis.
Cervia, J S, Rosen, H, Murray, H W
In BALB/c mice, liver granulomas provoked by visceral infection with intracellular Leishmania donovani are rapidly populated by influxing blood monocytes. To determine the host defense effector role...
MORPHOLOGICAL, CHEMICAL, AND SEROLOGICAL STUDIES OF THE CELL WALLS OF RICKETTSIA MOOSERI
Schaechter, M., Tousimis, A. J., Cohn, Z. A., Rosen, H., Campbell, J., Hahn, F. E.
Heyworth, P G, Curnutte, J T, Nauseef, W M, Volpp, B D, Pearson, D W, Rosen, H, ...
Two of the cytosolic NADPH oxidase components, p47-phox and p67-phox, translocate to the plasma membrane in normal neutrophils stimulated with phorbol myristate acetate (PMA). We have now studied the...
Penicillin-binding protein inactivation by human neutrophil myeloperoxidase.
Myeloperoxidase (MPO), H2O2, and chloride comprise a potent antimicrobial system believed to contribute to the antimicrobial functions of neutrophils and monocytes. The mechanisms of microbicidal...
Dinauer, M C, Curnutte, J T, Rosen, H, Orkin, S H
A membrane-bound cytochrome b, a heterodimer formed by a 91-kD glycoprotein and a 22-kD polypeptide, is a critical component of the phagocyte NADPH-oxidase responsible for the generation of...
Berton, G, Rosen, H, Ezekowitz, R A, Bellavite, P, Serra, M C, Rossi, F, ...
Monoclonal rat antibodies were produced against a subcellular preparation of phorbol 12-myristate 13-acetate (PMA)-stimulated guinea pig neutrophils that retains NADPH-oxidase activity. Two...
Chemiluminescence and superoxide production by myeloperoxidase-deficient leukocytes.
The role of superoxide anion- and myeloperoxidase-dependent reactions in the light emission by phagocytosing polymorphonuclear leukocytes has been investigated using leukocytes that lack...
Nuclear factor kappa B activates proenkephalin transcription in T lymphocytes.
Rattner, A, Korner, M, Rosen, H, Baeuerle, P A, Citri, Y
Upon activation, T lymphocytes accumulate high levels of the neuropeptide enkephalin which correlate with high levels of proenkephalin mRNA in the cells. Here we investigated the transcriptional...
Proenkephalin A (PEA), a neuropeptide-encoding gene, is widely expressed in the nervous and endocrine systems. Recently, we demonstrated that in addition to its abundance in fetal brain tissue; PEA...
Electron spin resonance spectroscopy using the spin trap 5,5-dimethyl-1-pyrroline-N-oxide (DMPO) was employed to detect the formation of hydroxyl radicals (OH.) by phagocytosing polymorphonuclear...
Proenkephalin A is expressed in mesodermal lineages during organogenesis.
Keshet, E, Polakiewicz, R D, Itin, A, Ornoy, A, Rosen, H
Proenkephalin A (PEA) encodes several neuropeptides with an opioid activity, as well as other peptides with as yet unknown functions. As an initial step toward finding possible roles for PEA gene...
Kaempfer, R, Rosen, H, Israeli, R
Structural analogs of the methylated 5' end (cap) of eukaryotic mRNA, such as 7-methylguanosine 5'-monophosphate, specifically inhibit both GTP-dependent binding of Met-tRNAfMet and binding of globin...
Functional studies on human peritoneal eosinophils.
Klebanoff, S J, Durack, D T, Rosen, H, Clark, R A
A number of functional studies were performed on essentially pure eosinophil preparations obtained from the ascitic fluid of a patient with eosinophilic gastroenteritis. These cells responded to...
Superoxide-mediated modification of low density lipoprotein by arterial smooth muscle cells.
Heinecke, J W, Baker, L, Rosen, H, Chait, A
Extracellular superoxide was detected in cultures of monkey and human arterial smooth muscle cells as indicated by superoxide dismutase inhibitable reduction of cytochrome c. Superoxide production by...
Heinecke, J W, Rosen, H, Chait, A
Modification of low density lipoproteins by human arterial smooth muscle cells was characterized by increased electrophoretic mobility and increased content of malondialdehyde-like oxidation products...
Comb, M, Liston, D, Martin, M, Rosen, H, Herbert, E
A recombinant plasmid containing the human proenkephalin gene ligated to pBR322 was introduced into a mouse pituitary cell line (AtT-20D16v) that normally expresses pro-opiomelanocortin but not...
Segal, A W, West, I, Wientjes, F, Nugent, J H, Chavan, A J, Haley, B, ...
The NADPH oxidase of phagocytic cells is important for the efficient killing and digestion of ingested microbes. A very unusual low-potential cytochrome b (b-245) is the only redox molecule to have...
Durden, D L, Rosen, H, Cooper, J A
In this report we show that interferon gamma treatment of U937 cells induces increased expression of the gamma-subunit of the high-affinity Fc receptor for IgG (Fc gamma RI). Interferon treatment...
Nitric oxide and septic shock. From bench to bedside.
Refractory hypotension with end-organ hypoperfusion is an ominous feature of inflammatory shock. In the past fifteen years, nitric oxide (a diffusible, short-lived product of arginine metabolism) has...
Stierer, M, Rosen, H, Weber, R, Hanak, H, Spona, J, Tüchler, H
OBJECTIVE: The authors investigated correlations of estrogen-receptor and progesterone-receptor with conventional risk factors as well as histopathology in patients with primary breast cancer....
Gastric secretion and peptic ulcer following portacaval shunt in man.
Orloff, M J, Chandler, J G, Alderman, S J, Keiter, J E, Rosen, H
Scheithauer, W, Rosen, H, Kornek, G V, Sebesta, C, Depisch, D
OBJECTIVES--To compare the length of survival and quality of life in patients given combination chemotherapy in addition to supportive care and in patients given only supportive care....
Siciliano, S J, Rollins, T E, DeMartino, J, Konteatis, Z, Malkowitz, L, Van Riper, G, ...
The guanine nucleotide-binding protein-coupled receptor superfamily binds a vast array of biological messengers including lipids, odorants, catecholamines, peptides, and proteins. While some small...
Proenkephalin A in bone-derived cells.
Rosen, H, Polakiewicz, R D, Benzakine, S, Bar-Shavit, Z
Enkephalins, a group of small peptides with opiate-like activity, have been defined originally as neuropeptides. Recent reports showed, using in situ hybridization, that the enkephalin-encoding gene,...
Rosen, H, Orman, J, Rakita, R M, Michel, B R, VanDevanter, D R
Neutrophils and monocytes employ a diverse array of antimicrobial effector systems to support their host defense functions. The mechanisms of action of most of these systems are incompletely...
Gill, Charles J., Jackson, Jesse J., Gerckens, Lynn S., Pelak, Barbara A., Thompson, Randall K., Sundelof, Jon G., ...
MK-826 (formerly L-749,345), is a potent 1-β-methyl carbapenem with a long half-life and broad spectrum of activity. This compound is presently in phase-II clinical trials. Its activity against a...
Bowman, J. C., Hicks, P. Scott, Kurtz, M. B., Rosen, H., Schmatz, D. M., Liberator, P. A., ...
Caspofungin acetate is an antifungal antibiotic that inhibits synthesis of 1,3-β-d-glucan, an essential component of the fungal cell wall. While caspofungin causes cell death in yeasts and dimorphic...
Pharmacokinetics of L-749,345, a long-acting carbapenem antibiotic, in primates.
Sundelof, J G, Hajdu, R, Gill, C J, Thompson, R, Rosen, H, Kropp, H
L-749,345 is a carbapenem antibiotic, currently in phase II clinical trials, which possesses a broad antibacterial spectrum and extended half-life. The time courses of levels of the drugs in plasma...
Abruzzo, G K, Flattery, A M, Gill, C J, Kong, L, Smith, J G, Pikounis, V B, ...
The in vivo activity of the Merck antifungal echinocandin drug candidate MK-0991 (L-743,872) was evaluated in mouse models of disseminated candidiasis, aspergillosis, and cryptococcosis. The...
Neutrophil microbicidal activity is a consequence of overlapping antimicrobial systems that vary in prominence according to the conditions of the neutrophil-microbe interaction, the nature of the...
Inactivation of Escherichia coli penicillin-binding proteins by human neutrophils.
Rakita, R M, Michel, B R, Rosen, H
Neutrophils use a variety of microbicidal mechanisms in their role as one of the primary arms of the human host defense system. We have previously observed that a cell-free system containing...
Mielke, M E, Rosen, H, Brocke, S, Peters, C, Hahn, H
Listeria-immune mice are able to express protective immunity in the absence of CD4+ T cells and an apparent granulomatous inflammation. Using a monoclonal antibody (5C6) able to inhibit the...
Oxidation of microbial iron-sulfur centers by the myeloperoxidase-H2O2-halide antimicrobial system.
Myeloperoxidase, H2O2, and a halide (chloride, bromide, or iodide) form a potent microbicidal system that contributes to the antimicrobial activity of neutrophils. The mechanism of toxicity is not...
Endocarditis caused by Rochalimaea quintana in a patient infected with human immunodeficiency virus.
Spach, D H, Callis, K P, Paauw, D S, Houze, Y B, Schoenknecht, F D, Welch, D F, ...
Rochalimaea quintana and Rochalimaea henselae are closely related, fastidious, gram-negative rickettsiae. Thus far, the spectrum of human Rochalimaea sp. infections has not included endocarditis. We...
Effector role of blood monocytes in experimental visceral leishmaniasis.
Cervia, J S, Rosen, H, Murray, H W
In BALB/c mice, liver granulomas provoked by visceral infection with intracellular Leishmania donovani are rapidly populated by influxing blood monocytes. To determine the host defense effector role...
MORPHOLOGICAL, CHEMICAL, AND SEROLOGICAL STUDIES OF THE CELL WALLS OF RICKETTSIA MOOSERI
Schaechter, M., Tousimis, A. J., Cohn, Z. A., Rosen, H., Campbell, J., Hahn, F. E.
Heyworth, P G, Curnutte, J T, Nauseef, W M, Volpp, B D, Pearson, D W, Rosen, H, ...
Two of the cytosolic NADPH oxidase components, p47-phox and p67-phox, translocate to the plasma membrane in normal neutrophils stimulated with phorbol myristate acetate (PMA). We have now studied the...
Penicillin-binding protein inactivation by human neutrophil myeloperoxidase.
Myeloperoxidase (MPO), H2O2, and chloride comprise a potent antimicrobial system believed to contribute to the antimicrobial functions of neutrophils and monocytes. The mechanisms of microbicidal...
Dinauer, M C, Curnutte, J T, Rosen, H, Orkin, S H
A membrane-bound cytochrome b, a heterodimer formed by a 91-kD glycoprotein and a 22-kD polypeptide, is a critical component of the phagocyte NADPH-oxidase responsible for the generation of...
Berton, G, Rosen, H, Ezekowitz, R A, Bellavite, P, Serra, M C, Rossi, F, ...
Monoclonal rat antibodies were produced against a subcellular preparation of phorbol 12-myristate 13-acetate (PMA)-stimulated guinea pig neutrophils that retains NADPH-oxidase activity. Two...
Chemiluminescence and superoxide production by myeloperoxidase-deficient leukocytes.
The role of superoxide anion- and myeloperoxidase-dependent reactions in the light emission by phagocytosing polymorphonuclear leukocytes has been investigated using leukocytes that lack...
Nuclear factor kappa B activates proenkephalin transcription in T lymphocytes.
Rattner, A, Korner, M, Rosen, H, Baeuerle, P A, Citri, Y
Upon activation, T lymphocytes accumulate high levels of the neuropeptide enkephalin which correlate with high levels of proenkephalin mRNA in the cells. Here we investigated the transcriptional...
Proenkephalin A (PEA), a neuropeptide-encoding gene, is widely expressed in the nervous and endocrine systems. Recently, we demonstrated that in addition to its abundance in fetal brain tissue; PEA...
Electron spin resonance spectroscopy using the spin trap 5,5-dimethyl-1-pyrroline-N-oxide (DMPO) was employed to detect the formation of hydroxyl radicals (OH.) by phagocytosing polymorphonuclear...
Proenkephalin A is expressed in mesodermal lineages during organogenesis.
Keshet, E, Polakiewicz, R D, Itin, A, Ornoy, A, Rosen, H
Proenkephalin A (PEA) encodes several neuropeptides with an opioid activity, as well as other peptides with as yet unknown functions. As an initial step toward finding possible roles for PEA gene...
Kaempfer, R, Rosen, H, Israeli, R
Structural analogs of the methylated 5' end (cap) of eukaryotic mRNA, such as 7-methylguanosine 5'-monophosphate, specifically inhibit both GTP-dependent binding of Met-tRNAfMet and binding of globin...
Functional studies on human peritoneal eosinophils.
Klebanoff, S J, Durack, D T, Rosen, H, Clark, R A
A number of functional studies were performed on essentially pure eosinophil preparations obtained from the ascitic fluid of a patient with eosinophilic gastroenteritis. These cells responded to...
Superoxide-mediated modification of low density lipoprotein by arterial smooth muscle cells.
Heinecke, J W, Baker, L, Rosen, H, Chait, A
Extracellular superoxide was detected in cultures of monkey and human arterial smooth muscle cells as indicated by superoxide dismutase inhibitable reduction of cytochrome c. Superoxide production by...
Heinecke, J W, Rosen, H, Chait, A
Modification of low density lipoproteins by human arterial smooth muscle cells was characterized by increased electrophoretic mobility and increased content of malondialdehyde-like oxidation products...
Comb, M, Liston, D, Martin, M, Rosen, H, Herbert, E
A recombinant plasmid containing the human proenkephalin gene ligated to pBR322 was introduced into a mouse pituitary cell line (AtT-20D16v) that normally expresses pro-opiomelanocortin but not...
Segal, A W, West, I, Wientjes, F, Nugent, J H, Chavan, A J, Haley, B, ...
The NADPH oxidase of phagocytic cells is important for the efficient killing and digestion of ingested microbes. A very unusual low-potential cytochrome b (b-245) is the only redox molecule to have...
Durden, D L, Rosen, H, Cooper, J A
In this report we show that interferon gamma treatment of U937 cells induces increased expression of the gamma-subunit of the high-affinity Fc receptor for IgG (Fc gamma RI). Interferon treatment...
Stierer, M, Rosen, H, Weber, R, Hanak, H, Spona, J, Tüchler, H
OBJECTIVE: The authors investigated correlations of estrogen-receptor and progesterone-receptor with conventional risk factors as well as histopathology in patients with primary breast cancer....
Nitric oxide and septic shock. From bench to bedside.
Refractory hypotension with end-organ hypoperfusion is an ominous feature of inflammatory shock. In the past fifteen years, nitric oxide (a diffusible, short-lived product of arginine metabolism) has...
Gastric secretion and peptic ulcer following portacaval shunt in man.
Orloff, M J, Chandler, J G, Alderman, S J, Keiter, J E, Rosen, H
Scheithauer, W, Rosen, H, Kornek, G V, Sebesta, C, Depisch, D
OBJECTIVES--To compare the length of survival and quality of life in patients given combination chemotherapy in addition to supportive care and in patients given only supportive care....
Cooper, A, Rosen, H, Blackwell, J M
The macrophage receptor CR3 has been shown by several investigators to be involved in the binding of Leishmania promastigotes to host macrophages. This receptor is known to recognize iC3b and to...
Al Attiyah, R, Rosen, H, Rook, G A
Mycobacterial lesions and skin sites challenged with soluble mycobacterial antigen are very sensitive to the necrotizing effect of tumour necrosis factor (TNF). We have used a model that permits...