Possible mechanisms involved in the protective effect of staphylococcal enterotoxin B (SEB) injection on the subsequent development of experimental autoimmune encephalomyelitis (EAE) were...
Verdot, L, Huang, S, Sobis, H, ...
Mice with a disruption of the IFN-gamma receptor alpha-chain gene (IFN-gamma R alpha o/o mice) were found to be significantly more sensitive than their wild-type counterparts to induction of the...
The hormone 1 alpha, 25-dihydroxyvitamin D3 (1,25(OH)2D3) has immune modulatory activities in vitro and in vivo, and can prevent or delay the onset of experimental or spontaneous autoimmune diseases....
Goebels, J, Sobis, H, ...
9-(2-phosphonylmethoxyethyl)adenine (PMEA) is the prototype compound of a series of acyclic nucleoside phosphonate derivatives endowed with potent and selective anti-retroviral activity in vitro and...
Laboratory for Experimental Transplantation, University of Leuven, Belgium.
Laboratory for Experimental Transplantation, University of Leuven, Belgium.
Matthys, P., Froyen, G., Verdot, L., Huang, S., Sobis, H., Van Damme, J., ...
Mice with a disruption of the IFN-gamma receptor alpha-chain gene (IFN-gamma R alpha o/o mice) were found to be significantly more sensitive than their wild-type counterparts to induction of the...
Transplantation Laboratory, Rega Institute, University of Leuven, Belgium.
Transplantation Laboratory, University of Leuven, Belgium.
The efficacy of HPMPC and DHPG against systemic and intracerebral murine cytomegalovirus (MCMV) infections was examined in immunocompetent NMRI mice and in mice with severe combined immunodeficiency...
Influence of different growth factors on a rat choriocarcinoma cell line (1993)
The influence of epidermal growth factor, insulin-like growth factors I and II, insulin, transforming growth factor beta 1 and transferrin on the growth of a postgestational rat choriocarcinoma was...
1,25-Dihydroxyvitamin D3 prevents insulitis in NOD mice (1992)
The active form of vitamin D, 1,25(OH)2D3, can prevent various forms of experimentally induced autoimmune disorders. The aim of this study was to confirm these findings in NOD mice that spontaneously...
A rat cytotrophoblast antigen defined by a monoclonal antibody (1992)
A monoclonal antibody that recognizes specifically a cytotrophoblast antigen was obtained. The monoclonal antibody 22H6 was tested on rat choriocarcinoma (in vivo, in vitro), normal placenta,...
Fuse, A, Sobis, H, De Meurichy, W, Syrjanen, S M, ...
An epizoötic of focal epithelial hyperplasia (FEH) or Morbus Heck in a pygmy chimpanzee (Pan paniscus) colony is described. Papovavirus-like particles were observed in the nuclei of epithelial...
Severe cachexia in mice inoculated with interferon-gamma-producing tumor cells (1991)
Dijkmans, R, Sobis, H, ...
Nude mice were inoculated with CHO/IFN-gamma cells, a line of Chinese hamster ovary tumor cells, that had been genetically engineered to produce murine IFN-gamma. Severe cachexia, as evident from...
In three different murine models of bone marrow (BM) transplantation the capacity of asialo GM1+ cells to suppress graft-vs-host disease (GVHD) was investigated. In a first model, total lymphoid...
Department of Nephrology, University of Leuven, Belgium.
Discussion still continues regarding whether self-tolerance is imparted within the thymus by the thymic epithelial cells (TEC) or by the bone marrow-derived (BMD) dendritic cells and macrophages....
The use of allogeneic thymus transplantation as a means of inducing tolerance across MHC barriers was investigated in thymectomized, total lymphoid irradiated BALB/c mice. In 90% of the animals long...
Establishment and characterization of a continuous in vitro line from a rat choriocarcinoma (1990)
Verstuyf, Annemieke; U0005176, Sobis, H, Goebels, J, Fonteyn, E, Cassiman, Jean-Jacques; U0013884, Vandeputte, M
A continuous in vitro cell line of rat choriocarcinoma has been established. It is composed of pure trophoblast cells which multiply and differentiate. The morphology of the cells is very similar to...
9-(2-Phosphonylmethoxyethyl)adenine (PMEA), a potent inhibitor of human immunodeficiency virus (HIV), caused a dose-dependent suppression of tumor formation, and mortality associated therewith, in...
Morphological and immunological characteristics of a rat choriocarcinoma (1989)
A post-gestational rat choriocarcinoma has been studied for its immunological and morphological characteristics. The tumor can be transplanted in syngeneic (WKA/H rats) as well as in allogeneic rats...
Vandekerckhove, F, Dijkmans, R, Sobis, H, ...
Acute experimental allergic encephalomyelitis (EAE) was induced in C57BL/6J and SJL/J mice by injection of isologous spinal cord homogenate given in conjunction with Bordetella pertussis and Freund's...
Regulation by interferons of the local inflammatory response to bacterial lipopolysaccharide (1987)
Dijkmans, R, Sobis, H, Vandekerckhove, F
Footpad swelling developing in mice after local injection of LPS (S. marcescens) was found to consist of two phases with peaks occurring on days 2 to 3 and 6 to 8, respectively. Histopathologically,...
Facilitation of yolk-sac carcinoma (YSCa) development in fetectomized rats by the Moloney murine sarcoma virus/murine leukemia virus (Mo-MSV/MLV) complex was found to be closely associated with the...