568 Production of Radioactive Nuclides in a Lead Assembly with 500 MeV Protons (2009)
H. Takada, I. Kanno, K. Hasegawa
It is a cument interest to transmute long-lived radioactive wastes by the use of an intense proton accelerator. There proposed several concepts for the accelerator-based transmutation system. ( l-s)...
T. Nishida, H. Takada, Y. Nakahara, T. Takizuka
Recently it is often said that there are some disagreemennts in the computational results between spallation reaction simulation codes such as NMTC, HETC and their modified versions. We examined the...
Application Of 14C Wiggle-Matching To Support Dendrochronological Analysis In Japan (2007)
T. Nakamura, M. Okuno, K. Kimura, T. Mitsutani, H. Moriwaki, Y. Ishizuka, ...
14C wiggle-matching was applied to two wood samples closely related to geological and archaeological events with associated dendrochronological dates, to demonstrate the accuracy of 14C dating with...
Sideward Peak of Intermediate Mass Fragments in High Energy Proton Induced Reactions (2001)
Hirata, Yuichi, Ohnishi, A., Nara, Y., Kido, T., Maruyama, Toshiki, Otuka, N., ...
Intermediate mass fragment (IMF) formation in the 12 GeV proton induced reaction on Au target is analyzed by using a combined framework of a transport model (JAM/MF) and a newly developed...
Result of the tests conducted by a newly developed helicopter borne gravimeter system (2001)
Segawa, J., Joseph, John E., Kusumoto, S., Ishihara, Takemi, Komazawa, M., Hasegawa, H., ...
Copyright (c) 2006-2007 Japan Science and Technology Agency
Result of the tests conducted by a newly developed helicopter borne gravimeter system (2001)
Segawa, J., Joseph, John E., Kusumoto, S., Ishihara, Takemi, Komazawa, M., Hasegawa, H., ...
Copyright (c) 2006-2007 Japan Science and Technology Agency
AN EVALUATION OF THE ELECTROSLAG REMELTED INGOT. (1998)
TAKADA,H., FUKUHARA,Y., MIURA,M.
PAPER PRESENTED AT THE SECOND INTERNATIONAL SYMPOSIUM ON ELECTROSLAG REMELTING TECHNOLOGY, MELLON INSTITUTE, PITTSBURGH, PENNSYLVANIA, 23-25 SEP 69, JOINTLY SPONSORED BY AF MATERIALS LABORATORY AND...
Self-Sustained Oscillation of Gas-Liquid Flow in a Centrifugal Pump with Semi-Open Impeller (1996)
Kurokawa, Junichi, Matsui, J., Takada, H., Hirayama, T., 黒川, 淳一, クロカワ, ジュンイチ, ...
Effects of granulocyte colony-stimulating factor upon coxsackievirus B3 myocarditis in mice (1995)
HIRAOKA, Y., KISHIMOTO, C., TAKADA, H., SUZAKI, N., SHIRAKI, K.
Granulocyte colony-stimulating factor is a potent activator of mature granulocytes, and subsequently enhances superoxide release. The purpose of this study was to investigate the effects of...
Effects of granulocyte colony-stimulating factor upon coxsackievirus B3 myocarditis in mice (1995)
HIRAOKA, Y., KISHIMOTO, C., TAKADA, H., SUZAKI, N., SHIRAKI, K.
Granulocyte colony-stimulating factor is a potent activator of mature granulocytes, and subsequently enhances superoxide release. The purpose of this study was to investigate the effects of...
Ohba, K., Takada, H., Kawakami, N., Nagae, K.
A twin fiber optic liquid film sensor system has been developed, which is able to measure the local thickness and the interfacial wave velocity of liquid film in gas-liquid annular two-phase flows...
Matsushita, K., Motani, R., Sakuta, T., Nagaoka, S., Matsuyama, T., Abeyama, K., ...
We investigated whether vascular endothelial growth factor (VEGF) production by human pulp cells (HPC) is regulated by lipopolysaccharide (LPS) in relation to the pathogenesis of pulpitis. Although...
Takada, H, Kawabata, Y, Arakaki, R, Kusumoto, S, Fukase, K, Suda, Y, ...
Comparison was made between the immunobiological and antigenic properties of two lipoteichoic acid (LTA) fractions (LTA-1 and -2) from Enterococcus hirae ATCC 9790, their glycolipid portions, and...
Matsushita, K, Fujimaki, W, Kato, H, Uchiyama, T, Igarashi, H, Ohkuni, H, ...
Previously, we prepared extracellular products, fractions F-1 and F-2 of Streptococcus mitis 108, an isolate from the tooth surface of an infant, and showed that F-1 exhibited inflammatory...
Takada, H, Kawabata, Y, Kawata, S, Kusumoto, S
Structural characteristics of peptidoglycan fragments required to prime mice for the induction of anaphylactoid reactions by Salmonella abortusequi lipopolysaccharide were examined in...
Sugiyama, A, Arakaki, R, Ohnishi, T, Arakaki, N, Daikuhara, Y, Takada, H
Lipoteichoic acids (LTA) from various gram-positive bacteria, including oral streptococci such as Streptococcus sanguis, enhanced the production of hepatocyte growth factor (HGF) (scatter factor) by...
Iki, K, Kawahara, K, Sawamura, S, Arakaki, R, Sakuta, T, Sugiyama, A, ...
A novel immunobiologically active fraction was prepared from a phenol-water extract of Prevotella intermedia ATCC 25611 by Sephadex G-100 column chromatography. The fraction consisted mainly of...
Matsushita, K, Nagaoka, S, Arakaki, R, Kawabata, Y, Iki, K, Kawagoe, M, ...
A protein was extracted from whole cells of Prevotella intermedia ATCC 25611 with sodium lauroylsarcosine and purified by chromatography on a DEAE-Sepharose fast-flow column. The The apparent...
Obuchi, M, Ohara, Y, Takegami, T, Murayama, T, Takada, H, Iizuka, H
We compared infection of a murine macrophage-like cell line, J774-1, with two Theiler's murine encephalomyelitis virus subgroup strains. The GDVII strain, which is highly virulent and produces acute...
Ohshima, T, Takada, H, Yoshimura, T, Esaki, N, Soda, K
Phenylalanine dehydrogenase (L-phenylalanine:NAD oxidoreductase, deaminating; EC 1.4.1.-) was found in various thermophilic actinomycetes. We purified the enzyme to homogeneity from Thermoactinomyces...
Takagi, M, Takada, H, Imanaka, T
The regulatory gene (degT) from Bacillus stearothermophilus NCA1503 which enhanced production of extracellular alkaline protease (Apr) was cloned in Bacillus subtilis with pTB53 as a vector. When B....
Takada, H, Mihara, J, Morisaki, I, Hamada, S
Normal human gingival fibroblasts stimulated in vitro by lipopolysaccharides (LPS) from oral Bacteroides species produced cell-free and cell-associated thymocyte-activating factors (TAF)....
Tamura, M, Tokuda, M, Nagaoka, S, Takada, H
Lipopolysaccharides (LPS) prepared from Bacteroides intermedius (Prevotella intermedia) and Bacteroides (Porphyromonas) gingivalis by hot phenol-water extraction induced interleukin-8 (IL-8) mRNA in...
Immunobiological activities of a porin fraction isolated from Fusobacterium nucleatum ATCC 10953.
Takada, H, Ogawa, T, Yoshimura, F, Otsuka, K, Kokeguchi, S, Kato, K, ...
From Fusobacterium nucleatum ATCC 10953 cell envelope fraction whose inner membranes had been removed by treatment with sodium N-lauroyl sarcosinate, an outer membrane protein (37,000 Mr in a native...
Immunobiological activities of synthetic lipid A analogs with low endotoxicity.
Kotani, S, Takada, H, Takahashi, I, Ogawa, T, Tsujimoto, M, Shimauchi, H, ...
Synthetic lipid A analogs, beta(1-6)glucosamine disaccharide 1,4'-bisphosphates, which possesses four tetradecanoyl groups at the 2- and 2'-amino, and 3- and 3'-hydroxyl groups (LA-17-PP), and each...
Takahashi, I, Kotani, S, Takada, H, Tsujimoto, M, Ogawa, T, Shiba, T, ...
Several synthetic acylated glucosamine monophosphates, with structures corresponding to the nonreducing or reducing moiety of the lipid A of the Escherichia coli or Salmonella minnesota type, and a...
Intravenous injection of muramyl dipeptide (MDP) and Salmonella lipopolysaccharides (LPS) enhanced lethal toxicity of the LPS in C57BL/6 mice. This was true for S (smooth)- and R (rough)-form LPS and...
Nagao, S, Takada, H, Yagawa, K, Kutsukake, H, Shiba, T, Kusumoto, S, ...
Intracutaneous injection of N-acetylmuramyl-L-alanyl-D-isoglutamine (MDP) in guinea pigs caused an extensive necrotic reaction in footpads prepared by injection of heat-killed Mycobacterium...
Kotani, S, Takada, H, Takahashi, I, Tsujimoto, M, Ogawa, T, Ikeda, T, ...
A synthetic lipid A (Salmonella type, compound 516), beta (1-6)-linked D-glucosamine disaccharide 1,4'-bisphosphate, with three acyloxyacyl groups and one hydroxyacyl group, i.e.,...
Synthetic Salmonella-type lipid A antigen with high serological specificity.
Kasai, N, Arata, S, Mashimo, J, Okuda, K, Aihara, Y, Kotani, S, ...
A synthetic compound (compound 516), beta(1-6)-linked D-glucosamine disaccharide 1,4'-bisphosphate, which is acylated by (R)-3-hexadecanoyloxytetradecanoyl, (R)-3-hydroxytetradecanoyl,...
Takada, H, Kotani, S, Tsujimoto, M, Ogawa, T, Takahashi, I, Harada, K, ...
Synthetic lipid A analogs (compounds 404 through 406) were examined for their immunopharmacological activities. These compounds had two amide-bound and two ester-bound (R)-3-hydroxytetradecanoyl...
Kotani, S, Takada, H, Tsujimoto, M, Ogawa, T, Takahashi, I, Ikeda, T, ...
A synthetic compound (506), beta (1-6) D-glucosamine disaccharide 1,4'-bisphosphate, which is acylated at 2'-amino and 3'-hydroxyl groups with (R)-3-dodecanoyloxytetradecanoyl and...
Kotani, S, Takada, H, Tsujimoto, M, Ogawa, T, Harada, K, Mori, Y, ...
Synthetic lipid A analogs which have two amide-bound and two ester-bound (R)-3-hydroxytetradecanoyl groups at the C-2 and -2' and C-3 and -3' positions of beta(1-6)glucosamine disaccharide mono- or...
Hotta, H, Hotta, S, Takada, H, Kotani, S, Tanaka, S, Ohki, M
The effects of bacterial cell walls, peptidoglycans, and a water-soluble polymer of peptidoglycan subunits on dengue virus type 2 replication in cultured mouse peritoneal macrophages were studied....
Kotani, S, Takada, H, Tsujimoto, M, Ogawa, T, Mori, Y, Sakuta, M, ...
Thirteen acylated and phosphorylated derivatives of beta-1,6-linked glucosamine disaccharide (lipid A analogs), which were synthesized after the structural model of Salmonella-type lipid A, and seven...
Novel biological property of pertussis toxin: chemotactic activity on human monocytes.
Ogawa, T, Takada, H, Kotani, S, Sato, H, Sato, Y
Pertussis toxin isolated from Bordetella pertussis phase I strain Tohama enhanced the migration of human blood monocytes in an assay with a multiwell chemotaxis assembly. The monocyte migration...
Cytokine induction by extracellular products of oral viridans group streptococci.
Takada, H, Kawabata, Y, Tamura, M, Matsushita, K, Igarashi, H, Ohkuni, H, ...
During an etiological study of Kawasaki disease (mucocutaneous lymph node syndrome [MCLS]), we found that dominant viridans streptococcal strains on tooth surfaces and in the throat of both MCLS...
Liberation of serotonin from rabbit blood platelets by bacterial cell walls and related compounds.
Harada, K, Kotani, S, Takada, H, Tsujimoto, M, Hirachi, Y, Kusumoto, S, ...
A study was made on the activity of various bacterial cell walls and peptidoglycans to liberate serotonin from rabbit blood platelets. All of the test cell walls or peptidoglycans prepared from 27...
Chemical and biological properties of a peptidoglycan isolated from Treponema pallidum kazan.
Umemoto, T, Ota, T, Sagawa, H, Kato, K, Takada, H, Tsujimoto, M, ...
A peptidoglycan layer of Treponema pallidum kazan was isolated by solubilization of whole cells with 1% warm sodium dodecyl sulfate and subsequent digestion of an insoluble residue with proteases....
Macrophage activation by bacterial cell walls and related synthetic compounds.
Takada, H, Tsujimoto, M, Kato, K, Kotani, S, Kusumoto, S, Inage, M, ...
Activation of peritoneal macrophages from guinea pigs by various bacterial cell walls, M-1 endo-N-acetylmuramidase enzymatically digested bacterial cell walls and synthetic muramyl dipeptides was...
Hara, T, Mizuno, Y, Takaki, K, Takada, H, Akeda, H, Aoki, T, ...
Gamma delta T cell receptor-positive cells (gamma delta T cells) have recently been implicated to play a role in the protection against infectious pathogens. Serial studies on gamma delta T cells in...
Immunological activities of Capnocytophaga cellular components.
Murayama, Y, Muranishi, K, Okada, H, Kato, K, Kotani, S, Takada, H, ...
Whole cells of a clinical isolate (strain S-3) of the genus Capnocytophaga were divided into cell envelope (CE) and cytoplasm (CP) fractions by mechanical disintegration followed by differential...
Matsushita, K., Motani, R., Sakuta, T., Nagaoka, S., Matsuyama, T., Abeyama, K., ...
We investigated whether vascular endothelial growth factor (VEGF) production by human pulp cells (HPC) is regulated by lipopolysaccharide (LPS) in relation to the pathogenesis of pulpitis. Although...
Takada, H, Kawabata, Y, Arakaki, R, Kusumoto, S, Fukase, K, Suda, Y, ...
Comparison was made between the immunobiological and antigenic properties of two lipoteichoic acid (LTA) fractions (LTA-1 and -2) from Enterococcus hirae ATCC 9790, their glycolipid portions, and...
Matsushita, K, Fujimaki, W, Kato, H, Uchiyama, T, Igarashi, H, Ohkuni, H, ...
Previously, we prepared extracellular products, fractions F-1 and F-2 of Streptococcus mitis 108, an isolate from the tooth surface of an infant, and showed that F-1 exhibited inflammatory...
Takada, H, Kawabata, Y, Kawata, S, Kusumoto, S
Structural characteristics of peptidoglycan fragments required to prime mice for the induction of anaphylactoid reactions by Salmonella abortusequi lipopolysaccharide were examined in...
Sugiyama, A, Arakaki, R, Ohnishi, T, Arakaki, N, Daikuhara, Y, Takada, H
Lipoteichoic acids (LTA) from various gram-positive bacteria, including oral streptococci such as Streptococcus sanguis, enhanced the production of hepatocyte growth factor (HGF) (scatter factor) by...
Iki, K, Kawahara, K, Sawamura, S, Arakaki, R, Sakuta, T, Sugiyama, A, ...
A novel immunobiologically active fraction was prepared from a phenol-water extract of Prevotella intermedia ATCC 25611 by Sephadex G-100 column chromatography. The fraction consisted mainly of...
Matsushita, K, Nagaoka, S, Arakaki, R, Kawabata, Y, Iki, K, Kawagoe, M, ...
A protein was extracted from whole cells of Prevotella intermedia ATCC 25611 with sodium lauroylsarcosine and purified by chromatography on a DEAE-Sepharose fast-flow column. The The apparent...
Obuchi, M, Ohara, Y, Takegami, T, Murayama, T, Takada, H, Iizuka, H
We compared infection of a murine macrophage-like cell line, J774-1, with two Theiler's murine encephalomyelitis virus subgroup strains. The GDVII strain, which is highly virulent and produces acute...
Ohshima, T, Takada, H, Yoshimura, T, Esaki, N, Soda, K
Phenylalanine dehydrogenase (L-phenylalanine:NAD oxidoreductase, deaminating; EC 1.4.1.-) was found in various thermophilic actinomycetes. We purified the enzyme to homogeneity from Thermoactinomyces...
Takagi, M, Takada, H, Imanaka, T
The regulatory gene (degT) from Bacillus stearothermophilus NCA1503 which enhanced production of extracellular alkaline protease (Apr) was cloned in Bacillus subtilis with pTB53 as a vector. When B....
Takada, H, Mihara, J, Morisaki, I, Hamada, S
Normal human gingival fibroblasts stimulated in vitro by lipopolysaccharides (LPS) from oral Bacteroides species produced cell-free and cell-associated thymocyte-activating factors (TAF)....
Tamura, M, Tokuda, M, Nagaoka, S, Takada, H
Lipopolysaccharides (LPS) prepared from Bacteroides intermedius (Prevotella intermedia) and Bacteroides (Porphyromonas) gingivalis by hot phenol-water extraction induced interleukin-8 (IL-8) mRNA in...
Immunobiological activities of a porin fraction isolated from Fusobacterium nucleatum ATCC 10953.
Takada, H, Ogawa, T, Yoshimura, F, Otsuka, K, Kokeguchi, S, Kato, K, ...
From Fusobacterium nucleatum ATCC 10953 cell envelope fraction whose inner membranes had been removed by treatment with sodium N-lauroyl sarcosinate, an outer membrane protein (37,000 Mr in a native...
Immunobiological activities of synthetic lipid A analogs with low endotoxicity.
Kotani, S, Takada, H, Takahashi, I, Ogawa, T, Tsujimoto, M, Shimauchi, H, ...
Synthetic lipid A analogs, beta(1-6)glucosamine disaccharide 1,4'-bisphosphates, which possesses four tetradecanoyl groups at the 2- and 2'-amino, and 3- and 3'-hydroxyl groups (LA-17-PP), and each...
Takahashi, I, Kotani, S, Takada, H, Tsujimoto, M, Ogawa, T, Shiba, T, ...
Several synthetic acylated glucosamine monophosphates, with structures corresponding to the nonreducing or reducing moiety of the lipid A of the Escherichia coli or Salmonella minnesota type, and a...
Intravenous injection of muramyl dipeptide (MDP) and Salmonella lipopolysaccharides (LPS) enhanced lethal toxicity of the LPS in C57BL/6 mice. This was true for S (smooth)- and R (rough)-form LPS and...
Nagao, S, Takada, H, Yagawa, K, Kutsukake, H, Shiba, T, Kusumoto, S, ...
Intracutaneous injection of N-acetylmuramyl-L-alanyl-D-isoglutamine (MDP) in guinea pigs caused an extensive necrotic reaction in footpads prepared by injection of heat-killed Mycobacterium...
Kotani, S, Takada, H, Takahashi, I, Tsujimoto, M, Ogawa, T, Ikeda, T, ...
A synthetic lipid A (Salmonella type, compound 516), beta (1-6)-linked D-glucosamine disaccharide 1,4'-bisphosphate, with three acyloxyacyl groups and one hydroxyacyl group, i.e.,...
Synthetic Salmonella-type lipid A antigen with high serological specificity.
Kasai, N, Arata, S, Mashimo, J, Okuda, K, Aihara, Y, Kotani, S, ...
A synthetic compound (compound 516), beta(1-6)-linked D-glucosamine disaccharide 1,4'-bisphosphate, which is acylated by (R)-3-hexadecanoyloxytetradecanoyl, (R)-3-hydroxytetradecanoyl,...
Takada, H, Kotani, S, Tsujimoto, M, Ogawa, T, Takahashi, I, Harada, K, ...
Synthetic lipid A analogs (compounds 404 through 406) were examined for their immunopharmacological activities. These compounds had two amide-bound and two ester-bound (R)-3-hydroxytetradecanoyl...
Kotani, S, Takada, H, Tsujimoto, M, Ogawa, T, Takahashi, I, Ikeda, T, ...
A synthetic compound (506), beta (1-6) D-glucosamine disaccharide 1,4'-bisphosphate, which is acylated at 2'-amino and 3'-hydroxyl groups with (R)-3-dodecanoyloxytetradecanoyl and...
Kotani, S, Takada, H, Tsujimoto, M, Ogawa, T, Harada, K, Mori, Y, ...
Synthetic lipid A analogs which have two amide-bound and two ester-bound (R)-3-hydroxytetradecanoyl groups at the C-2 and -2' and C-3 and -3' positions of beta(1-6)glucosamine disaccharide mono- or...
Hotta, H, Hotta, S, Takada, H, Kotani, S, Tanaka, S, Ohki, M
The effects of bacterial cell walls, peptidoglycans, and a water-soluble polymer of peptidoglycan subunits on dengue virus type 2 replication in cultured mouse peritoneal macrophages were studied....
Kotani, S, Takada, H, Tsujimoto, M, Ogawa, T, Mori, Y, Sakuta, M, ...
Thirteen acylated and phosphorylated derivatives of beta-1,6-linked glucosamine disaccharide (lipid A analogs), which were synthesized after the structural model of Salmonella-type lipid A, and seven...
Novel biological property of pertussis toxin: chemotactic activity on human monocytes.
Ogawa, T, Takada, H, Kotani, S, Sato, H, Sato, Y
Pertussis toxin isolated from Bordetella pertussis phase I strain Tohama enhanced the migration of human blood monocytes in an assay with a multiwell chemotaxis assembly. The monocyte migration...
Cytokine induction by extracellular products of oral viridans group streptococci.
Takada, H, Kawabata, Y, Tamura, M, Matsushita, K, Igarashi, H, Ohkuni, H, ...
During an etiological study of Kawasaki disease (mucocutaneous lymph node syndrome [MCLS]), we found that dominant viridans streptococcal strains on tooth surfaces and in the throat of both MCLS...
Liberation of serotonin from rabbit blood platelets by bacterial cell walls and related compounds.
Harada, K, Kotani, S, Takada, H, Tsujimoto, M, Hirachi, Y, Kusumoto, S, ...
A study was made on the activity of various bacterial cell walls and peptidoglycans to liberate serotonin from rabbit blood platelets. All of the test cell walls or peptidoglycans prepared from 27...
Chemical and biological properties of a peptidoglycan isolated from Treponema pallidum kazan.
Umemoto, T, Ota, T, Sagawa, H, Kato, K, Takada, H, Tsujimoto, M, ...
A peptidoglycan layer of Treponema pallidum kazan was isolated by solubilization of whole cells with 1% warm sodium dodecyl sulfate and subsequent digestion of an insoluble residue with proteases....
Macrophage activation by bacterial cell walls and related synthetic compounds.
Takada, H, Tsujimoto, M, Kato, K, Kotani, S, Kusumoto, S, Inage, M, ...
Activation of peritoneal macrophages from guinea pigs by various bacterial cell walls, M-1 endo-N-acetylmuramidase enzymatically digested bacterial cell walls and synthetic muramyl dipeptides was...
Hara, T, Mizuno, Y, Takaki, K, Takada, H, Akeda, H, Aoki, T, ...
Gamma delta T cell receptor-positive cells (gamma delta T cells) have recently been implicated to play a role in the protection against infectious pathogens. Serial studies on gamma delta T cells in...
Immunological activities of Capnocytophaga cellular components.
Murayama, Y, Muranishi, K, Okada, H, Kato, K, Kotani, S, Takada, H, ...
Whole cells of a clinical isolate (strain S-3) of the genus Capnocytophaga were divided into cell envelope (CE) and cytoplasm (CP) fractions by mechanical disintegration followed by differential...
Nomura, A, Matsuzaki, G, Takada, H, Hiromatsu, K, Nabeshima, S, Nakamura, T, ...
The role of T-cell receptor (TCR) gammadelta T cells in the induction of protective TCR alphabeta T cells against infection by the intracellular bacteria Listeria monocytogenes was analysed. We found...
Takada, H, Matsuzaki, G, Hiromatsu, K, Nomoto, K
We have reported that T cells bearing T-cell receptors (TcR) of gamma delta type (gamma delta T cells) appear in the peritoneal cavity in a relatively early stage of primary intraperitoneal (i.p.)...
Nabeshima, S, Hiromatsu, K, Matsuzaki, G, Mukasa, A, Takada, H, Yoshida, S, ...
To evaluate the hypothesis that gamma delta T cells participate in protective immunity against mycobacterial infection, we depleted gamma delta T cells from mice by administration of anti-T-cell...
Takada, H, Matsuzaki, G, Yoshida, H, Sumichika, H, Nomoto, K
There is an increase in number of gamma delta T cells in the peritoneal cavity after intraperitoneal (i.p.) inoculation with Escherichia coli. The E. coli-induced gamma delta T cells in C3H/He mice...
Suzuki, M, Shinohara, F, Sato, K, Taniguchi, T, Takada, H, Rikiishi, H
To investigate the underlying mechanism for induction of CD86 molecules, we analysed the ability of the histone deacetylase (HDAC) inhibitor, sodium butyrate (NaB), to induce CD86 at the...
Th1 and Th1-inducing cytokines in Salmonella infection
MIZUNO, Y, TAKADA, H, NOMURA, A, JIN, C-H, HATTORI, H, IHARA, K, ...
Thl and Thl-inducing cytokines and T cell responses were investigated in human salmonellosis. Serum IFN-γ, IL-12 and IL-18 levels were increased significantly in patients with salmonellosis. The...
TAKADA, H, TAKAHATA, Y, NOMURA, A, OHGA, S, MIZUNO, Y, HARA, T
We measured serum interferon-gamma-inducible protein 10 (IP-10) and monokine induced by gamma interferon (MIG) levels to investigate the role of these molecules in the pathophysiology of...
Kimura, J, Takada, H, Nomura, A, Ohno, T, Mizuno, Y, Saito, M, ...
To clarify the functional state of T cells in Kawasaki disease, we analysed mRNA expression levels of Th1/Th2 cytokines (IFN-γ and IL-4) along with Th1/Th2-inducing transcription factors, T-bet and...
NAGATOMO, T, OHGA, S, TAKADA, H, NOMURA, A, HIKINO, S, IMURA, M, ...
To continue the search for immunological roles of breast milk, cDNA microarray analysis on cytokines and growth factors was performed for human milk cells. Among the 240 cytokine-related genes,...
Distinct gene expression patterns of peripheral blood cells in hyper–IgE syndrome
Tanaka, T, Takada, H, Nomura, A, Ohga, S, Shibata, R, Hara, T
Hyper-immunoglobulin E (IgE) syndrome (HIES) is one of the primary immunodeficiency syndromes. Although the cytokine dysregulation is suggested to play a role in its pathophysiology, the causative...
Novel roles of osteopontin and CXC chemokine ligand 7 in the defence against mycobacterial infection
Khajoee, V, Saito, M, Takada, H, Nomura, A, Kusuhara, K, Yoshida, S-I, ...
Granulocyte-macrophage colony-stimulating factor (GM-CSF)-induced human monocyte-derived macrophage (GM-Mφ) or macrophage CSF (M-CSF)-induced human monocyte-derived Mφ (M-Mφ) are distinct in terms...
Kanaya, Y, Ohga, S, Ikeda, K, Furuno, K, Ohno, T, Takada, H, ...
Chromosome 22q11.2 deletion syndrome is a common disorder characterized by thymic hypoplasia, conotruncal cardiac defect and hypoparathyroidism. Patients have a risk of infections and autoimmunity...
"Pseudo" hypertrophic neuropathy of childhood.
Baba, M, Takada, H, Miura, H, Okushima, T, Matsunaga, M
A 9 year old boy had chronic progressive motor-sensory neuropathy that started in early infancy. He had enlarged nerves and pes cavus deformity. Motor conduction studies showed very dispersed,...
Yamamoto, K, Ishii, E, Sako, M, Ohga, S, Furuno, K, Suzuki, N, ...
Background: Familial haemophagocytic lymphohistiocytosis (FHL) has an autosomal recessive mode of inheritance and consists of at least three subtypes. FHL2 subtype with perforin (PRF1) mutation...
Acute cerebellar ataxia with human parvovirus B19 infection
Shimizu, Y., Ueno, T., Komatsu, H., Takada, H., Nunoue, T.
A 2 year old boy developed acute cerebellar ataxia in association with erythema infectiosum. During the disease, genomic DNA and antibodies against human parvovirus B19 were detected in serum but not...
Kai, K, Rikiishi, H, Sugawara, S, Takahashi, M, Takada, H, Kumagai, K
To investigate the mechanisms underlying T-cell responses during superantigen (SAg) stimulation, we analysed the effects of SAg on CD27 expression with or without lipopolysaccharide (LPS) as a novel...