Multiple sclerosis: T-cell receptor expression in distinct brain regions (2007)
Junker, A., Ivanidze, J., Malotka, J., Eiglmeier, I., Lassmann, H., Wekerle, H., ...
Aboul-Enein,F., Bauer,J., Klein,M., Schubart,A., Flugel,A., Ritter,T., ...
Weber, F, Meinl, E, Drexler, K, Czlonkowska, A, Huber, S, Fickenscher, H, ...
Herpesvirus saimiri has recently been shown to immortalize human T cells. It was unknown, however, whether Herpesvirus saimiri transformation affects T-cell receptor (TCR) expression and signal...
Pette, M, Fujita, K, Wilkinson, D, Altmann, D M, Trowsdale, J, Giegerich, G, ...
A panel of 20 human myelin basic protein (hMBP)-specific T-lymphocyte lines was generated from the peripheral blood of eight multiple sclerosis (MS) patients and two healthy donors, most of them...
Melms, A, Chrestel, S, Schalke, B C, Wekerle, H, Mauron, A, Ballivet, M, ...
Oligoclonal and cloned T lines from peripheral blood or thymuses of patients with myasthenia gravis (MG) were selected for reactivity against nicotinic acetylcholine receptors (AChR) from Torpedo...
Constitutive NF-kappa B activity in neurons.
Kaltschmidt, C, Kaltschmidt, B, Neumann, H, Wekerle, H, Baeuerle, P A
NF-kappa B is inducible transcription factor present in many cell types in a latent cytoplasmic form. So far, only immune cells including mature B cells, thymocytes, and adherent macrophages have...
Wekerle, H., Lonai, P., Feldman, M.
Monolayers of mouse fibroblasts were used as cellular immunoadsorbents to separate rat lymphocytes that recognize specific mouse histocompatibility antigens. Normal lymphocytes were incubated on...
Wekerle, H, Eshhar, Z, Lonai, P, Feldman, M
Recognition of cell surface antigens by nonsensitized thymus-derived rat lymphocytes is not affected by antisera against immunoglobulin, yet can be effectively blocked by treatment of the lymphocytes...
Melms, A, Schalke, B C, Kirchner, T, Müller-Hermelink, H K, Albert, E, Wekerle, H
The thymus is believed to play a central role in the pathogenesis of Myasthenia gravis (MG). According to a previous hypothesis, MG is initiated within the thymus by immunogenic presentation of...
Schönbeck, S, Padberg, F, Hohlfeld, R, Wekerle, H
To study the role of the thymus in the cellular pathogenesis of myasthenia gravis (MG) we transplanted thymus tissue fragments from MG thymuses beneath the kidney capsule of severe combined...
Goebels, N, Michaelis, D, Engelhardt, M, Huber, S, Bender, A, Pongratz, D, ...
Polymyositis (PM) and dermatomyositis (DM) are the prototypical inflammatory diseases of skeletal muscle. In PM, CD8+ T cells invade and destroy muscle fibers, whereas humoral effector mechanisms...
Weber, F, Meinl, E, Drexler, K, Czlonkowska, A, Huber, S, Fickenscher, H, ...
Herpesvirus saimiri has recently been shown to immortalize human T cells. It was unknown, however, whether Herpesvirus saimiri transformation affects T-cell receptor (TCR) expression and signal...
Pette, M, Fujita, K, Wilkinson, D, Altmann, D M, Trowsdale, J, Giegerich, G, ...
A panel of 20 human myelin basic protein (hMBP)-specific T-lymphocyte lines was generated from the peripheral blood of eight multiple sclerosis (MS) patients and two healthy donors, most of them...
Melms, A, Chrestel, S, Schalke, B C, Wekerle, H, Mauron, A, Ballivet, M, ...
Oligoclonal and cloned T lines from peripheral blood or thymuses of patients with myasthenia gravis (MG) were selected for reactivity against nicotinic acetylcholine receptors (AChR) from Torpedo...
Constitutive NF-kappa B activity in neurons.
Kaltschmidt, C, Kaltschmidt, B, Neumann, H, Wekerle, H, Baeuerle, P A
NF-kappa B is inducible transcription factor present in many cell types in a latent cytoplasmic form. So far, only immune cells including mature B cells, thymocytes, and adherent macrophages have...
Wekerle, H., Lonai, P., Feldman, M.
Monolayers of mouse fibroblasts were used as cellular immunoadsorbents to separate rat lymphocytes that recognize specific mouse histocompatibility antigens. Normal lymphocytes were incubated on...
Wekerle, H, Eshhar, Z, Lonai, P, Feldman, M
Recognition of cell surface antigens by nonsensitized thymus-derived rat lymphocytes is not affected by antisera against immunoglobulin, yet can be effectively blocked by treatment of the lymphocytes...
Melms, A, Schalke, B C, Kirchner, T, Müller-Hermelink, H K, Albert, E, Wekerle, H
The thymus is believed to play a central role in the pathogenesis of Myasthenia gravis (MG). According to a previous hypothesis, MG is initiated within the thymus by immunogenic presentation of...
Schönbeck, S, Padberg, F, Hohlfeld, R, Wekerle, H
To study the role of the thymus in the cellular pathogenesis of myasthenia gravis (MG) we transplanted thymus tissue fragments from MG thymuses beneath the kidney capsule of severe combined...
Goebels, N, Michaelis, D, Engelhardt, M, Huber, S, Bender, A, Pongratz, D, ...
Polymyositis (PM) and dermatomyositis (DM) are the prototypical inflammatory diseases of skeletal muscle. In PM, CD8+ T cells invade and destroy muscle fibers, whereas humoral effector mechanisms...
MeinL, E., Hoch, R. M., Dornmair, K., Bontrop, R. E., Jonker, M., ...
Myelin basic protein (MBP)-specific T cells are implicated in the pathogenesis of multiple sclerosis and are targets of selective immunotherapies. However, autoantigen-specific T cells can also be...
Spuler, S., Sarropoulos, A., Marx, A., Hohlfeld, R., Wekerle, H.
To study the possible role of thymomas and of extrathymomal thymic tissue in the development and maintenance of myasthenia gravis, we transplanted fragments of either tissue into SCID mice and...
Zhang, Y. P., Porter, S., Wekerle, H.
The normal neuromuscular synapse is formed by the intimate association of nerve endings, postsynaptic end-plate foldings in the muscle fiber, and nonmyelinating Schwann cells (SC) sealing the...
Kirchner, T., Tzartos, S., Hoppe, F., Schalke, B., Wekerle, H., Müller-Hermelink, H. K.
The authors describe an immunohistologic study of acetylcholine receptor (AChR)-related antigenic determinants in tumor-free thymuses of myasthenia gravis (MG) patients (13 cases) and nonmyasthenic...
Meinl, E., Klinkert, W. E., Wekerle, H.
In human myasthenia gravis (MG) formation of autoantibodies against acetylcholine receptor (AChR) is commonly associated with thymic changes termed lymphofollicular hyperplasia (LFH). To learn...
Schmied, M., Breitschopf, H., Gold, R., Zischler, H., Rothe, G., Wekerle, H., ...
In experimental autoimmune encephalomyelitis (EAE) myelin-specific T lymphocytes attack the myelinated tissue of the central nervous system (CNS). In the Lewis rat, EAE as a rule has an acute,...
Spuler, S., Marx, A., Kirchner, T., Hohlfeld, R., Wekerle, H.
Thymic myoid cells (TMCs) bearing acetylcholine receptors (AchR) on their surface have a central role in the concept of intrathymic autosensitization in the pathogenesis of myasthenia gravis. In a...
Wekerle, H, Ketelsen, U-P, Ernst, M
We describe a new cellular component of normal mouse thymuses, which is isolated by fractionated trypsin dissociation of minced thymus tissue followed by repeated unit gravity sedimentation. These...
Neumann, H., Schmidt, H., Cavalié, A., Jenne, D., Wekerle, H.
This study examined the effect of the pro-inflammatory cytokines interferon-γ (IFN-γ) and tumor necrosis factor-α (TNF-α) on the induction of MHC class I–related genes in functionally mature...
Odoardi, F., Kawakami, N., Klinkert, W. E. F., Wekerle, H., Flügel, A.
We explored the effect of i.v. soluble antigen on autoaggressive, myelin basic protein-specific effector T cells within their target organ during acute experimental autoimmune encephalomyelitis...