Bosch, FX, Rohan, T, Schneider, A, Frazer, I, Pfister, H, Castellsague, X, ...
The 18th international papillomavirus conference took place in Barcelona, Spain in July 2000. The HPV clinical workshop was jointly organised with the annual meeting of the Spanish Association of...
Human cytomegalovirus induces JC virus DNA replication in human fibroblasts.
Heilbronn, R, Albrecht, I, Stephan, S, Bürkle, A, Zur Hausen, H
JC virus, a human papovavirus, is the causative agent of the demyelinating brain disease progressive multifocal leucoencephalopathy (PML). PML is a rare but fatal disease which develops as a...
Bauknecht, T, Bartsch, D, Zur Hausen, H
In most cervical carcinoma cells the E6 and E7 genes of specific human papillomaviruses are transcribed from viral sequences integrated into host cell chromosomes. Glucocorticoids activate the...
Bauknecht, T, Jundt, F, Herr, I, Oehler, T, Delius, H, Shi, Y, ...
YY1 is a zinc finger transcription factor which acts as either a repressor or an activator dependent on the promoter context. YY1 is a potent activator of the genuine human papillomavirus type 18...
Rösl, F, Das, B C, Lengert, M, Geletneky, K, Zur Hausen, H
Considering the involvement of a redox-regulatory pathway in the expression of human papillomaviruses (HPVs), HPV type 16 (HPV-16)-immortalized human keratinocytes were treated with the antioxidant...
Hermanns, J, Schulze, A, Kleinschmidt, J A, Schmidt, R, Zur Hausen, H
It has been demonstrated that infection of primary human cells with adeno-associated viruses (AAV) leads to a decrease in cellular proliferation and to growth arrest. We analyzed the molecular basis...
Rösl, F, Lengert, M, Albrecht, J, Kleine, K, Zawatzky, R, Schraven, B, ...
Malignant human papillomavirus type 18 (HPV18)-positive cervical carcinoma cells can be reverted to a nonmalignant phenotype by generation of somatic cell hybrids with normal human fibroblasts....
Dürst, M, Bosch, F X, Glitz, D, Schneider, A, Zur Hausen, H
Two human papillomavirus type 16 (HPV 16)-immortalized human keratinocyte cell lines (HPK) were shown to have retained the ability for differentiation after subcutaneous injection into nude mice....
Klein-Bauernschmitt, P, Zur Hausen, H, Schlehofer, J R
The nonpathogenic human defective parvovirus adeno-associated virus (AAV) type 2 induced differentiation-associated antigens in cells of the human leukemia cell line HL60 (CD 67), as well as in two...
Bosch, F X, Schwarz, E, Boukamp, P, Fusenig, N E, Bartsch, D, Zur Hausen, H
The E6 and E7 genes of the cancer-associated human papillomavirus (HPV) types 16 (HPV16) and 18 (HPV18) can induce cell immortalization in vitro in normal human keratinocytes. This, however, is not...
Characterization of a novel human papillomavirus DNA in the cervical carcinoma cell line ME180.
Reuter, S, Delius, H, Kahn, T, Hofmann, B, Zur Hausen, H, Schwarz, E
The human cervical carcinoma cell line ME180 was examined for human papillomavirus (HPV) DNA and RNA. The integrated DNA of a presumably new HPV type showing a relationship closer to HPV39 than to...
Repression of the human papillomavirus type 18 enhancer by the cellular transcription factor Oct-1.
Hoppe-Seyler, F, Butz, K, Zur Hausen, H
The role of cellular factors involved in the transcriptional regulation of the cancer-associated human papillomavirus type 18 (HPV18) is yet poorly understood. The presence of an Oct-1-binding site...
The adeno-associated virus rep gene suppresses herpes simplex virus-induced DNA amplification.
Heilbronn, R, Bürkle, A, Stephan, S, Zur Hausen, H
Herpes simplex virus (HSV) induces within the host cell genome DNA amplification which can be suppressed by coinfection with adeno-associated virus (AAV). To characterize the AAV functions mediating...
Faisst, S, Schlehofer, J R, Zur Hausen, H
Parvovirus H-1 has been shown to suppress spontaneous and chemically or virally induced tumorigenesis in hamsters. In human cell culture systems propagation of H-1 is restricted to transformed cells,...
Herpes simplex virus (HSV) induces DNA amplification of target genes within the host cell chromosome. To characterize the HSV genes that mediate the amplification effect, combinations of cloned DNA...
Six Buschke-Löwenstein tumors, i.e., highly differentiated squamous cell tumors of the genital region, were shown to contain human papillomavirus 6 (HPV 6) or HPV 11 genomes. The viral DNA was found...
Structure of defective DNA molecules in Epstein-Barr virus preparations from P3HR-1 cells.
Cho, M S, Bornkamm, G W, Zur Hausen, H
Epstein-Barr virus (EBV), isolated from P3HR-1 cells, induces early antigen and viral capsid antigen upon infection of human B-lymphoblasts. The strong early antigen- and viral capsid...
Skare, J, Farley, J, Strominger, J L, Fresen, K O, Cho, M S, Zur Hausen, H
Eight independent recombinant Epstein-Barr virus genomes, each of which was a transforming strain, were made by superinfecting cell lines containing Epstein-Barr virus DNA (Raji or B95-8 strain) with...
Heilbronn, R, Jahn, G, Bürkle, A, Freese, U K, Fleckenstein, B, Zur Hausen, H
The human cytomegalovirus (HCMV)-induced DNA polymerase has been well characterized biochemically and functionally, but its genomic location has not yet been assigned. To identify the coding...
Gissmann, L, Diehl, V, Schultz-Coulon, H J, Zur Hausen, H
Papilloma virus DNA from a laryngeal papilloma was cloned in phage lambda L 47 and characterized after cleavage with different restriction enzymes. Hybridization with the DNAs of human papilloma...
Molecular cloning of viral DNA from human genital warts.
De Villiers, E M, Gissmann, L, Zur Hausen, H
The DNA of human papilloma virus type 6 (HPV 6) has been cloned in Escherichia coli K-12 by using pBR322 as vector. The DNA was cloned at the BamHI and EcoRI cleavage sites. This DNA was mapped by...
Adeno-associated virus sensitizes HeLa cell tumors to gamma rays.
Walz, C, Schlehofer, J R, Flentje, M, Rudat, V, Zur Hausen, H
Infection with the helper virus-dependent human parvovirus adeno-associated virus (AAV) is known to interfere with cellular transformation in vitro and oncogenesis in vivo. Here we report on...
Infection of cells of the Epstein-Barr virus (EBV)-negative human B-lymphoma lines BJAB and Ramos with EBV preparations from P3HR-1 or B 95-8 cells converted these cells to EBV genome carriers...
Gissmann, L, Wolnik, L, Ikenberg, H, Koldovsky, U, Schnürch, H G, Zur Hausen, H
Human genital tumors as well as recurrent laryngeal papillomas were analyzed for the presence of human papillomavirus (HPV) 6 and HPV 11 sequences. HPV 11 DNA was found in 7 of 14 laryngeal...
Dürst, M, Gissmann, L, Ikenberg, H, Zur Hausen, H
DNA from one biopsy sample of invasive cancer of the cervix contained sequences hybridizing with human papillomavirus (HPV) type 11 DNA only under nonstringent conditions. This DNA was molecularly...
Rösl, F, Achtstätter, T, Bauknecht, T, Hutter, K J, Futterman, G, Zur Hausen, H
'Universal fuser' clones of a human papillomavirus type 16 positive cervical carcinoma cell line (SiHa) were established to study the effect of a non-tumorigenic fusion partner on the regulation of a...
Rösl, F, Dürst, M, Zur Hausen, H
The transcription of human papillomavirus type 18 (HPV 18) is selectively suppressed in non-tumorigenic HeLa x fibroblast or HeLa x keratinocyte cell hybrids by 5-azacytidine. In contrast, viral gene...
DNA sequence and genome organization of genital human papillomavirus type 6b.
Schwarz, E, Dürst, M, Demankowski, C, Lattermann, O, Zech, R, Wolfsperger, E, ...
The complete nucleotide sequence of the circular double-stranded DNA of the genital human papillomavirus type 6b (HPV6b) comprising 7902 bp was determined and compared with the DNA sequences of human...
Bartsch, D, Boye, B, Baust, C, Zur Hausen, H, Schwarz, E
Human papillomavirus type 18 (HPV18) belongs to the group of genital papillomaviruses involved in the development of cervical carcinomas. Since retinoic acid (RA) is a key regulator of epithelial...
Bauknecht, T, Angel, P, Royer, H D, Zur Hausen, H
The human papillomavirus type 18 (HPV-18) promoter contains a TPA responsive element (TRE) which confers TPA responsiveness on a heterologous promoter. In the context of the HPV-18 promoter, however,...
Boshart, M, Gissmann, L, Ikenberg, H, Kleinheinz, A, Scheurlen, W, Zur Hausen, H
DNA of a new papillomavirus type was cloned from a cervical carcinoma biopsy. Two EcoRI clones of 7.8 and 6.9 kb in length were obtained, the latter contained a 900-bp deletion. The BamHI fragments...
Human cytomegalovirus induces JC virus DNA replication in human fibroblasts.
Heilbronn, R, Albrecht, I, Stephan, S, Bürkle, A, Zur Hausen, H
JC virus, a human papovavirus, is the causative agent of the demyelinating brain disease progressive multifocal leucoencephalopathy (PML). PML is a rare but fatal disease which develops as a...
Bauknecht, T, Bartsch, D, Zur Hausen, H
In most cervical carcinoma cells the E6 and E7 genes of specific human papillomaviruses are transcribed from viral sequences integrated into host cell chromosomes. Glucocorticoids activate the...
Bauknecht, T, Jundt, F, Herr, I, Oehler, T, Delius, H, Shi, Y, ...
YY1 is a zinc finger transcription factor which acts as either a repressor or an activator dependent on the promoter context. YY1 is a potent activator of the genuine human papillomavirus type 18...
Rösl, F, Das, B C, Lengert, M, Geletneky, K, Zur Hausen, H
Considering the involvement of a redox-regulatory pathway in the expression of human papillomaviruses (HPVs), HPV type 16 (HPV-16)-immortalized human keratinocytes were treated with the antioxidant...
Hermanns, J, Schulze, A, Kleinschmidt, J A, Schmidt, R, Zur Hausen, H
It has been demonstrated that infection of primary human cells with adeno-associated viruses (AAV) leads to a decrease in cellular proliferation and to growth arrest. We analyzed the molecular basis...
Rösl, F, Lengert, M, Albrecht, J, Kleine, K, Zawatzky, R, Schraven, B, ...
Malignant human papillomavirus type 18 (HPV18)-positive cervical carcinoma cells can be reverted to a nonmalignant phenotype by generation of somatic cell hybrids with normal human fibroblasts....
Dürst, M, Bosch, F X, Glitz, D, Schneider, A, Zur Hausen, H
Two human papillomavirus type 16 (HPV 16)-immortalized human keratinocyte cell lines (HPK) were shown to have retained the ability for differentiation after subcutaneous injection into nude mice....
Klein-Bauernschmitt, P, Zur Hausen, H, Schlehofer, J R
The nonpathogenic human defective parvovirus adeno-associated virus (AAV) type 2 induced differentiation-associated antigens in cells of the human leukemia cell line HL60 (CD 67), as well as in two...
Bosch, F X, Schwarz, E, Boukamp, P, Fusenig, N E, Bartsch, D, Zur Hausen, H
The E6 and E7 genes of the cancer-associated human papillomavirus (HPV) types 16 (HPV16) and 18 (HPV18) can induce cell immortalization in vitro in normal human keratinocytes. This, however, is not...
Characterization of a novel human papillomavirus DNA in the cervical carcinoma cell line ME180.
Reuter, S, Delius, H, Kahn, T, Hofmann, B, Zur Hausen, H, Schwarz, E
The human cervical carcinoma cell line ME180 was examined for human papillomavirus (HPV) DNA and RNA. The integrated DNA of a presumably new HPV type showing a relationship closer to HPV39 than to...
Repression of the human papillomavirus type 18 enhancer by the cellular transcription factor Oct-1.
Hoppe-Seyler, F, Butz, K, Zur Hausen, H
The role of cellular factors involved in the transcriptional regulation of the cancer-associated human papillomavirus type 18 (HPV18) is yet poorly understood. The presence of an Oct-1-binding site...
The adeno-associated virus rep gene suppresses herpes simplex virus-induced DNA amplification.
Heilbronn, R, Bürkle, A, Stephan, S, Zur Hausen, H
Herpes simplex virus (HSV) induces within the host cell genome DNA amplification which can be suppressed by coinfection with adeno-associated virus (AAV). To characterize the AAV functions mediating...
Faisst, S, Schlehofer, J R, Zur Hausen, H
Parvovirus H-1 has been shown to suppress spontaneous and chemically or virally induced tumorigenesis in hamsters. In human cell culture systems propagation of H-1 is restricted to transformed cells,...
Herpes simplex virus (HSV) induces DNA amplification of target genes within the host cell chromosome. To characterize the HSV genes that mediate the amplification effect, combinations of cloned DNA...
Six Buschke-Löwenstein tumors, i.e., highly differentiated squamous cell tumors of the genital region, were shown to contain human papillomavirus 6 (HPV 6) or HPV 11 genomes. The viral DNA was found...
Structure of defective DNA molecules in Epstein-Barr virus preparations from P3HR-1 cells.
Cho, M S, Bornkamm, G W, Zur Hausen, H
Epstein-Barr virus (EBV), isolated from P3HR-1 cells, induces early antigen and viral capsid antigen upon infection of human B-lymphoblasts. The strong early antigen- and viral capsid...
Skare, J, Farley, J, Strominger, J L, Fresen, K O, Cho, M S, Zur Hausen, H
Eight independent recombinant Epstein-Barr virus genomes, each of which was a transforming strain, were made by superinfecting cell lines containing Epstein-Barr virus DNA (Raji or B95-8 strain) with...
Heilbronn, R, Jahn, G, Bürkle, A, Freese, U K, Fleckenstein, B, Zur Hausen, H
The human cytomegalovirus (HCMV)-induced DNA polymerase has been well characterized biochemically and functionally, but its genomic location has not yet been assigned. To identify the coding...
Gissmann, L, Diehl, V, Schultz-Coulon, H J, Zur Hausen, H
Papilloma virus DNA from a laryngeal papilloma was cloned in phage lambda L 47 and characterized after cleavage with different restriction enzymes. Hybridization with the DNAs of human papilloma...
Molecular cloning of viral DNA from human genital warts.
De Villiers, E M, Gissmann, L, Zur Hausen, H
The DNA of human papilloma virus type 6 (HPV 6) has been cloned in Escherichia coli K-12 by using pBR322 as vector. The DNA was cloned at the BamHI and EcoRI cleavage sites. This DNA was mapped by...
Adeno-associated virus sensitizes HeLa cell tumors to gamma rays.
Walz, C, Schlehofer, J R, Flentje, M, Rudat, V, Zur Hausen, H
Infection with the helper virus-dependent human parvovirus adeno-associated virus (AAV) is known to interfere with cellular transformation in vitro and oncogenesis in vivo. Here we report on...
Infection of cells of the Epstein-Barr virus (EBV)-negative human B-lymphoma lines BJAB and Ramos with EBV preparations from P3HR-1 or B 95-8 cells converted these cells to EBV genome carriers...
Gissmann, L, Wolnik, L, Ikenberg, H, Koldovsky, U, Schnürch, H G, Zur Hausen, H
Human genital tumors as well as recurrent laryngeal papillomas were analyzed for the presence of human papillomavirus (HPV) 6 and HPV 11 sequences. HPV 11 DNA was found in 7 of 14 laryngeal...
Dürst, M, Gissmann, L, Ikenberg, H, Zur Hausen, H
DNA from one biopsy sample of invasive cancer of the cervix contained sequences hybridizing with human papillomavirus (HPV) type 11 DNA only under nonstringent conditions. This DNA was molecularly...
Rösl, F, Achtstätter, T, Bauknecht, T, Hutter, K J, Futterman, G, Zur Hausen, H
'Universal fuser' clones of a human papillomavirus type 16 positive cervical carcinoma cell line (SiHa) were established to study the effect of a non-tumorigenic fusion partner on the regulation of a...
Rösl, F, Dürst, M, Zur Hausen, H
The transcription of human papillomavirus type 18 (HPV 18) is selectively suppressed in non-tumorigenic HeLa x fibroblast or HeLa x keratinocyte cell hybrids by 5-azacytidine. In contrast, viral gene...
DNA sequence and genome organization of genital human papillomavirus type 6b.
Schwarz, E, Dürst, M, Demankowski, C, Lattermann, O, Zech, R, Wolfsperger, E, ...
The complete nucleotide sequence of the circular double-stranded DNA of the genital human papillomavirus type 6b (HPV6b) comprising 7902 bp was determined and compared with the DNA sequences of human...
Bartsch, D, Boye, B, Baust, C, Zur Hausen, H, Schwarz, E
Human papillomavirus type 18 (HPV18) belongs to the group of genital papillomaviruses involved in the development of cervical carcinomas. Since retinoic acid (RA) is a key regulator of epithelial...
Bauknecht, T, Angel, P, Royer, H D, Zur Hausen, H
The human papillomavirus type 18 (HPV-18) promoter contains a TPA responsive element (TRE) which confers TPA responsiveness on a heterologous promoter. In the context of the HPV-18 promoter, however,...
Boshart, M, Gissmann, L, Ikenberg, H, Kleinheinz, A, Scheurlen, W, Zur Hausen, H
DNA of a new papillomavirus type was cloned from a cervical carcinoma biopsy. Two EcoRI clones of 7.8 and 6.9 kb in length were obtained, the latter contained a 900-bp deletion. The BamHI fragments...
Bosch, FX, Rohan, T, Schneider, A, Frazer, I, Pfister, H, Castellsague, X, ...
The 18th international papillomavirus conference took place in Barcelona, Spain in July 2000. The HPV clinical workshop was jointly organised with the annual meeting of the Spanish Association of...
Bosch, F, Rohan, T, Schneider, A, Frazer, I, Pfister, H, Castellsague, X, ...
The 18th international papillomavirus conference took place in Barcelona, Spain in July 2000. The HPV clinical workshop was jointly organised with the annual meeting of the Spanish Association of...