Hajo Grundmann

Polymorphism, genetic exchange and intragenic recombination of the aureolysin gene among Staphylococcus aureusstrains (2008)

Sabat, Artur J, Wladyka, Benedykt, Kosowska-Shick, Klaudia, Grundmann, Hajo, Van Dijl, Jan, Kowal, Julia, ...

Abstract Background Staphylococcus aureus expresses several proteases, which are thought to contribute to the virulence of this bacterium. Here we focus on aureolysin, the major thermolysin-like...

Risk factors for the development of nosocomial pneumonia and mortality on intensive care units: application of competing risks models (2008)

Wolkewitz, Martin, Vonberg, Ralf, Grundmann, Hajo, Beyersmann, Jan, Gastmeier, Petra, Bärwolff, Sina, ...

Abstract Introduction Pneumonia is a very common nosocomial infection in intensive care units (ICUs). Many studies have investigated risk factors for the development of infection and its...

Do We Need to Put Society First? The Potential for Tragedy in Antimicrobial Resistance (2006)

Kevin R. Foster, Hajo Grundmann

Antimicrobial use presents a dilemma, say Foster and Grundmann. Appropriate use can benefit individual patients but carries a cost to society by selecting for resistant strains that are difficult to...

Multicenter Evaluation of Epidemiological Typing of Methicillin-Resistant Staphylococcus aureus Strains by Repetitive-Element PCR Analysis

Deplano, Ariane, Schuermans, Annette, Van Eldere, Johan, Witte, Wolfgang, Meugnier, Hèléne, Etienne, Jerome, ...

Rapid and efficient epidemiologic typing systems would be useful to monitor transmission of methicillin-resistant Staphylococcus aureus (MRSA) at both local and interregional levels. To evaluate the...

Determining Confidence Intervals When Measuring Genetic Diversity and the Discriminatory Abilities of Typing Methods for Microorganisms

Grundmann, Hajo, Hori, Satoshi, Tanner, Gregor

We describe here a method for determining confidence intervals for a commonly used index of diversity. This approach facilitates the comparison of the genetic population structure of microorganisms...

The evolutionary history of methicillin-resistant Staphylococcus aureus (MRSA)

Enright, Mark C., Robinson, D. Ashley, Randle, Gaynor, Feil, Edward J., Grundmann, Hajo, Spratt, Brian G.

Methicillin-resistant Staphylococcus aureus (MRSA) is a major cause of hospital-acquired infections that are becoming increasingly difficult to combat because of emerging resistance to all current...

Determining the Genetic Structure of the Natural Population of Staphylococcus aureus: a Comparison of Multilocus Sequence Typing with Pulsed-Field Gel Electrophoresis, Randomly Amplified Polymorphic DNA Analysis, and Phage Typing

Grundmann, Hajo, Hori, Satoshi, Enright, Mark C., Webster, Carol, Tami, Adriana, Feil, Edward J., ...

We used a sample of Staphylococcus aureus strains that are carried by humans and that are representative of the natural population of S. aureus strains in order to assess the value of multilocus...

Development of a Multilocus Sequence Typing Scheme for the Opportunistic Pathogen Pseudomonas aeruginosa

Curran, Barry, Jonas, Daniel, Grundmann, Hajo, Pitt, Tyrone, Dowson, Christopher G.

A multilocus sequence typing (MLST) scheme has been developed for Pseudomonas aeruginosa which provides molecular typing data that are highly discriminatory and electronically portable between...

Do We Need to Put Society First? The Potential for Tragedy in Antimicrobial Resistance

Foster, Kevin R, Grundmann, Hajo

Antimicrobial use presents a dilemma, say Foster and Grundmann. Appropriate use can benefit individual patients but carries a cost to society by selecting for resistant strains that are difficult to...

How Clonal Is Staphylococcus aureus?

Feil, Edward J., Cooper, Jessica E., Grundmann, Hajo, Robinson, D. Ashley, Enright, Mark C., Berendt, Tony, ...

Staphylococcus aureus is an important human pathogen and represents a growing public health burden owing to the emergence and spread of antibiotic-resistant clones, particularly within the hospital...

Distribution of the Serine-Aspartate Repeat Protein-Encoding sdr Genes among Nasal-Carriage and Invasive Staphylococcus aureus Strains

Sabat, Artur, Melles, Damian C., Martirosian, Gayane, Grundmann, Hajo, Van Belkum, Alex, Hryniewicz, Waleria

The sdr locus was found in all 497 investigated Staphylococcus aureus strains, although in 29 strains it contained only the sdrC gene (sdrD negative, sdrE negative). The sdrC-positive, sdrD-negative,...

Multicenter Evaluation of Epidemiological Typing of Methicillin-Resistant Staphylococcus aureus Strains by Repetitive-Element PCR Analysis

Deplano, Ariane, Schuermans, Annette, Van Eldere, Johan, Witte, Wolfgang, Meugnier, Hèléne, Etienne, Jerome, ...

Rapid and efficient epidemiologic typing systems would be useful to monitor transmission of methicillin-resistant Staphylococcus aureus (MRSA) at both local and interregional levels. To evaluate the...

Determining Confidence Intervals When Measuring Genetic Diversity and the Discriminatory Abilities of Typing Methods for Microorganisms

Grundmann, Hajo, Hori, Satoshi, Tanner, Gregor

We describe here a method for determining confidence intervals for a commonly used index of diversity. This approach facilitates the comparison of the genetic population structure of microorganisms...

The evolutionary history of methicillin-resistant Staphylococcus aureus (MRSA)

Enright, Mark C., Robinson, D. Ashley, Randle, Gaynor, Feil, Edward J., Grundmann, Hajo, Spratt, Brian G.

Methicillin-resistant Staphylococcus aureus (MRSA) is a major cause of hospital-acquired infections that are becoming increasingly difficult to combat because of emerging resistance to all current...

Determining the Genetic Structure of the Natural Population of Staphylococcus aureus: a Comparison of Multilocus Sequence Typing with Pulsed-Field Gel Electrophoresis, Randomly Amplified Polymorphic DNA Analysis, and Phage Typing

Grundmann, Hajo, Hori, Satoshi, Enright, Mark C., Webster, Carol, Tami, Adriana, Feil, Edward J., ...

We used a sample of Staphylococcus aureus strains that are carried by humans and that are representative of the natural population of S. aureus strains in order to assess the value of multilocus...

How Clonal Is Staphylococcus aureus?

Feil, Edward J., Cooper, Jessica E., Grundmann, Hajo, Robinson, D. Ashley, Enright, Mark C., Berendt, Tony, ...

Staphylococcus aureus is an important human pathogen and represents a growing public health burden owing to the emergence and spread of antibiotic-resistant clones, particularly within the hospital...

Development of a Multilocus Sequence Typing Scheme for the Opportunistic Pathogen Pseudomonas aeruginosa

Curran, Barry, Jonas, Daniel, Grundmann, Hajo, Pitt, Tyrone, Dowson, Christopher G.

A multilocus sequence typing (MLST) scheme has been developed for Pseudomonas aeruginosa which provides molecular typing data that are highly discriminatory and electronically portable between...

Do We Need to Put Society First? The Potential for Tragedy in Antimicrobial Resistance

Foster, Kevin R, Grundmann, Hajo

Antimicrobial use presents a dilemma, say Foster and Grundmann. Appropriate use can benefit individual patients but carries a cost to society by selecting for resistant strains that are difficult to...

Distribution of the Serine-Aspartate Repeat Protein-Encoding sdr Genes among Nasal-Carriage and Invasive Staphylococcus aureus Strains

Sabat, Artur, Melles, Damian C., Martirosian, Gayane, Grundmann, Hajo, Van Belkum, Alex, Hryniewicz, Waleria

The sdr locus was found in all 497 investigated Staphylococcus aureus strains, although in 29 strains it contained only the sdrC gene (sdrD negative, sdrE negative). The sdrC-positive, sdrD-negative,...