Hamsa Puthalakath

Gefitinib-Induced Killing of NSCLC Cell Lines Expressing Mutant EGFR Requires BIM and Can Be Enhanced by BH3 Mimetics (2007)

Mark S. Cragg, Junya Kuroda, Hamsa Puthalakath, Andreas Strasser

BackgroundThe epidermal growth factor receptor (EGFR) plays a critical role in the control of cellular proliferation, differentiation, and survival. Abnormalities in EGF-EGFR signaling, such as...

Interleukin 15–mediated survival of natural killer cells is determined by interactions among Bim, Noxa and Mcl-1 (2007)

Nicholas D Huntington, Hamsa Puthalakath, Priscilla Gunn, Edwina Naik, Ewa M Michalak, Mark J Smyth, ...

Gefitinib-induced killing of NSCLC cell lines expressing mutant EGFR requires BIM and can be enhanced by BH3 mimetics (2007)

Cragg, Mark S., Kuroda, Junya, Puthalakath, Hamsa, Huang, David C.S., Strasser, Andreas

Background: The epidermal growth factor receptor (EGFR) plays a critical role in the control of cellular proliferation, differentiation, and survival. Abnormalities in EGF-EGFR signaling, such as...

Bim and Bad mediate imatinib-induced killing of Bcr/Abl+ leukemic cells, and resistance due to their loss is overcome by a BH3 mimetic (2006)

Kuroda, Junya, Puthalakath, Hamsa, Cragg, Mark S., Kelly, Priscilla N., Bouillet, Philippe, Huang, David C.S., ...

Cell killing is a critical pharmacological activity of imatinib to eradicate Bcr/Abl+ leukemias. We found that imatinib kills Bcr/Abl+ leukemic cells by triggering the Bcl-2-regulated apoptotic...

CD45 links the B cell receptor with cell survival and is required for the persistence of germinal centers (2005)

Nicholas D Huntington, Yuekang Xu, Hamsa Puthalakath, Amanda Light, Simon N Willis, Andreas Strasser, ...

Egalitarian binds dynein light chain to establish oocyte polarity and maintain oocyte fate (2004)

Caryn Navarro, Hamsa Puthalakath, Jerry M. Adams, Andreas Strasser, Ruth Lehmann

corrigenda: BH3-only Bcl-2 family member Bim is required for apoptosis of autoreactive thymocytes (2002)

Philippe Bouillet, Jared F. Purton, Dale I. Godfrey, Li-Chen Zhang, Leigh Coultas, Hamsa Puthalakath, ...

Localization of dynein light chains 1 and 2 and their pro-apoptotic ligands.

Day, Catherine L, Puthalakath, Hamsa, Skea, Gretchen, Strasser, Andreas, Barsukov, Igor, Lian, Lu-Yun, ...

The dynein and myosin V motor complexes are multi-protein structures that function to transport molecules and organelles within the cell. DLC (dynein light-chain) proteins, found as components of...

Localization of dynein light chains 1 and 2 and their pro-apoptotic ligands.

Day, Catherine L, Puthalakath, Hamsa, Skea, Gretchen, Strasser, Andreas, Barsukov, Igor, Lian, Lu-Yun, ...

The dynein and myosin V motor complexes are multi-protein structures that function to transport molecules and organelles within the cell. DLC (dynein light-chain) proteins, found as components of...

Bim and Bad mediate imatinib-induced killing of Bcr/Abl+ leukemic cells, and resistance due to their loss is overcome by a BH3 mimetic

Kuroda, Junya, Puthalakath, Hamsa, Cragg, Mark S., Kelly, Priscilla N., Bouillet, Philippe, Huang, David C. S., ...

Cell killing is a critical pharmacological activity of imatinib to eradicate Bcr/Abl+ leukemias. We found that imatinib kills Bcr/Abl+ leukemic cells by triggering the Bcl-2-regulated apoptotic...

Gefitinib-Induced Killing of NSCLC Cell Lines Expressing Mutant EGFR Requires BIM and Can Be Enhanced by BH3 Mimetics

Cragg, Mark S, Kuroda, Junya, Puthalakath, Hamsa, Huang, David C. S, Strasser, Andreas

Andreas Strasser and colleagues demonstrate that activation of the proapoptotic BH3-only protein BIM is essential for tumor cell killing and that shutdown of the EGFR−MEK−ERK signaling cascade is...

Loss of the Pro-Apoptotic BH3-only Bcl-2 Family Member Bim Inhibits BCR Stimulation–induced Apoptosis and Deletion of Autoreactive B Cells

Enders, Anselm, Bouillet, Philippe, Puthalakath, Hamsa, Xu, Yuekang, Tarlinton, David M., Strasser, Andreas

During development, the stochastic process assembling the genes encoding antigen receptors invariably generates B and T lymphocytes that can recognize self-antigens. Several mechanisms have evolved...

Endogenous bcl-2 is not required for the development of Eμ-myc–induced B-cell lymphoma

Kelly, Priscilla N., Puthalakath, Hamsa, Adams, Jerry M., Strasser, Andreas

Although myc and bcl-2 synergize in tumor development, particularly lymphomagenesis, it is not known whether endogenous bcl-2 is required for myc-induced tumorigenesis. To investigate the role of...

A novel BH3 ligand that selectively targets Mcl-1 reveals that apoptosis can proceed without Mcl-1 degradation

Lee, Erinna F., Czabotar, Peter E., Van Delft, Mark F., Michalak, Ewa M., Boyle, Michelle J., Willis, Simon N., ...

Like Bcl-2, Mcl-1 is an important survival factor for many cancers, its expression contributing to chemoresistance and disease relapse. However, unlike other prosurvival Bcl-2–like proteins, Mcl-1...