Hana Koutnikova

The Pro12Ala PPARgamma2 variant determines metabolism at the gene-environment interface. (2009)

Heikkinen, Sami, Argmann, Carmen, Feige, Jérôme N, Koutnikova, Hana, Champy, Marie-France, Dali-Youcef, Nassim, ...

The metabolic impact of the common peroxisome proliferator-activated receptor gamma isoform 2 (PPARgamma2) variant Pro12Ala in human populations has been widely debated. We demonstrate, using a...

Identification of the UBP1 locus as a critical blood pressure determinant using a combination of mouse and human genetics (2009)

Koutnikova, Hana, Laakso, Markku, Lu, Lu, Combe, Roy, Paananen, Jussi, Kuulasmaa, Teemu, ...

Hypertension is a major health problem of largely unknown genetic origins. To identify new genes responsible for hypertension, genetic analysis of recombinant inbred strains of mice followed by human...

Visceral obesity is associated with high levels of serum squalene. (2006)

Peltola, Paula, Pihlajamäki, Jussi, Koutnikova, Hana, Ruotsalainen, Eija, Salmenniemi, Urpu, Vauhkonen, Ilkka, ...

OBJECTIVE: To investigate the impact of visceral obesity on cholesterol metabolism in normoglycemic offspring of patients with type 2 diabetes. RESEARCH METHODS AND PROCEDURES: The proportion of...

Adipose tissue expression of the lipid droplet-associating proteins S3-12 and perilipin is controlled by peroxisome proliferator-activated receptor-gamma. (2004)

Dalen, Knut Tomas, Schoonjans, Kristina, Ulven, Stine M, Weedon-Fekjaer, Mina Susanne, Bentzen, Trine Gjesti, Koutnikova, Hana, ...

In a systematic search for peroxisome proliferator-activated receptor-gamma (PPAR-gamma) target genes, we identified S3-12 and perilipin as novel direct PPAR-gamma target genes. Together with...

Compensation by the muscle limits the metabolic consequences of lipodystrophy in PPAR gamma hypomorphic mice. (2003)

Koutnikova, Hana, Cock, Terrie-Anne, Watanabe, Mitsuhiro, Houten, Sander M, Champy, Marie-France, Dierich, Andreé, ...

Peroxisome proliferator-activated receptor gamma (PPAR gamma) is a nuclear receptor, which controls adipocyte differentiation. We targeted with homologous recombination the PPAR gamma 2-specific exon...

Inactivation of the Friedreich ataxia mouse gene leads to early embryonic lethality without iron accumulation (2000)

Cossée, Mireille, Puccio, Hélène, Gansmuller, Anne, Koutnikova, Hana, Dierich, Andrée, LeMeur, Marianne, ...

Friedreich ataxia (FRDA), the most common autosomal recessive ataxia, is caused in almost all cases by homozygous intronic expansions resulting in the loss of frataxin, a mitochondrial protein...

Compensation by the muscle limits the metabolic consequences of lipodystrophy in PPARγ hypomorphic mice

Koutnikova, Hana, Cock, Terrie-Anne, Watanabe, Mitsuhiro, Houten, Sander M., Champy, Marie-France, Dierich, Andrée, ...

Peroxisome proliferator-activated receptor γ (PPARγ) is a nuclear receptor, which controls adipocyte differentiation. We targeted with homologous recombination the PPARγ2-specific exon B,...

Compensation by the muscle limits the metabolic consequences of lipodystrophy in PPARγ hypomorphic mice

Koutnikova, Hana, Cock, Terrie-Anne, Watanabe, Mitsuhiro, Houten, Sander M., Champy, Marie-France, Dierich, Andrée, ...

Peroxisome proliferator-activated receptor γ (PPARγ) is a nuclear receptor, which controls adipocyte differentiation. We targeted with homologous recombination the PPARγ2-specific exon B,...

Identification of the UBP1 Locus as a Critical Blood Pressure Determinant Using a Combination of Mouse and Human Genetics

Koutnikova, Hana, Laakso, Markku, Lu, Lu, Combe, Roy, Paananen, Jussi, Kuulasmaa, Teemu, ...

Hypertension is a major health problem of largely unknown genetic origins. To identify new genes responsible for hypertension, genetic analysis of recombinant inbred strains of mice followed by human...