Yin, Hong, Radomska, Hanna S, Tenen, Daniel G, Glass, Jonathan
Abstract Background C/EBPα is a transcription factor essential for terminal differentiation of several cell types. It has not known if C/EBPα protein is expressed and functions in the prostate...
Negative cross-talk between hematopoietic regulators: GATA proteins repress PU.1
Zhang, Pu, Behre, Gerhard, Pan, Jing, Iwama, Atsushi, Wara-aswapati, Nawarat, Radomska, Hanna S., ...
The process through which multipotential hematopoietic cells commit to distinct lineages involves the induction of specific transcription factors. PU.1 (also known as Spi-1) and GATA-1 are...
Yamanaka, Ryuya, Kim, Gun-Do, Radomska, Hanna S., Lekstrom-Himes, Julie, Smith, Laura T., Antonson, Per, ...
CCAAT/enhancer binding protein (C/EBP) ɛ is a recently cloned member of the C/EBP family of transcription factors and is expressed exclusively in cells of hematopoietic origin. The human C/EBPɛ...
Radomska, Hanna S., Huettner, Claudia S., Zhang, Pu, Cheng, Tao, Scadden, David T., Tenen, Daniel G.
The transcription factor CCAAT/enhancer binding protein α (C/EBPα) regulates a number of myeloid cell-specific genes. To delineate the role of C/EBPα in human granulopoiesis, we studied its...
Differential regulation of the human and murine CD34 genes in hematopoietic stem cells
Okuno, Yutaka, Iwasaki, Hiromi, Huettner, Claudia S., Radomska, Hanna S., Gonzalez, David A., Tenen, Daniel G., ...
Human CD34 (hCD34)-positive cells are used currently as a source for hematopoietic transplantation in humans. However, in steady-state murine hematopoiesis, hematopoietic stem cells (HSCs) with...
Phosphorylation of C/EBPα Inhibits Granulopoiesis
Ross, Sarah E., Radomska, Hanna S., Wu, Bo, Zhang, Pu, Winnay, Jonathon N., Bajnok, Laszlo, ...
CCAAT/enhancer-binding protein α (C/EBPα) is one of the key transcription factors that mediate lineage specification and differentiation of multipotent myeloid progenitors into mature granulocytes....
Potential Autoregulation of Transcription Factor PU.1 by an Upstream Regulatory Element
Okuno, Yutaka, Huang, Gang, Rosenbauer, Frank, Evans, Erica K., Radomska, Hanna S., Iwasaki, Hiromi, ...
Regulation of the hematopoietic transcription factor PU.1 (Spi-1) plays a critical role in the development of white cells, and abnormal expression of PU.1 can lead to leukemia. We previously reported...
Wagner, Katharina, Zhang, Pu, Rosenbauer, Frank, Drescher, Bettina, Kobayashi, Susumu, Radomska, Hanna S., ...
The lineage-determining transcription factor CCAAT enhancer binding protein α (C/EBPα) is required for myeloid differentiation. Decreased function or expression of C/EBPα is often found in human...
Negative cross-talk between hematopoietic regulators: GATA proteins repress PU.1
Zhang, Pu, Behre, Gerhard, Pan, Jing, Iwama, Atsushi, Wara-aswapati, Nawarat, Radomska, Hanna S., ...
The process through which multipotential hematopoietic cells commit to distinct lineages involves the induction of specific transcription factors. PU.1 (also known as Spi-1) and GATA-1 are...
Yamanaka, Ryuya, Kim, Gun-Do, Radomska, Hanna S., Lekstrom-Himes, Julie, Smith, Laura T., Antonson, Per, ...
CCAAT/enhancer binding protein (C/EBP) ɛ is a recently cloned member of the C/EBP family of transcription factors and is expressed exclusively in cells of hematopoietic origin. The human C/EBPɛ...
Radomska, Hanna S., Huettner, Claudia S., Zhang, Pu, Cheng, Tao, Scadden, David T., Tenen, Daniel G.
The transcription factor CCAAT/enhancer binding protein α (C/EBPα) regulates a number of myeloid cell-specific genes. To delineate the role of C/EBPα in human granulopoiesis, we studied its...
Differential regulation of the human and murine CD34 genes in hematopoietic stem cells
Okuno, Yutaka, Iwasaki, Hiromi, Huettner, Claudia S., Radomska, Hanna S., Gonzalez, David A., Tenen, Daniel G., ...
Human CD34 (hCD34)-positive cells are used currently as a source for hematopoietic transplantation in humans. However, in steady-state murine hematopoiesis, hematopoietic stem cells (HSCs) with...
Phosphorylation of C/EBPα Inhibits Granulopoiesis
Ross, Sarah E., Radomska, Hanna S., Wu, Bo, Zhang, Pu, Winnay, Jonathon N., Bajnok, Laszlo, ...
CCAAT/enhancer-binding protein α (C/EBPα) is one of the key transcription factors that mediate lineage specification and differentiation of multipotent myeloid progenitors into mature granulocytes....
Potential Autoregulation of Transcription Factor PU.1 by an Upstream Regulatory Element
Okuno, Yutaka, Huang, Gang, Rosenbauer, Frank, Evans, Erica K., Radomska, Hanna S., Iwasaki, Hiromi, ...
Regulation of the hematopoietic transcription factor PU.1 (Spi-1) plays a critical role in the development of white cells, and abnormal expression of PU.1 can lead to leukemia. We previously reported...
Wagner, Katharina, Zhang, Pu, Rosenbauer, Frank, Drescher, Bettina, Kobayashi, Susumu, Radomska, Hanna S., ...
The lineage-determining transcription factor CCAAT enhancer binding protein α (C/EBPα) is required for myeloid differentiation. Decreased function or expression of C/EBPα is often found in human...
Block of C/EBPα function by phosphorylation in acute myeloid leukemia with FLT3 activating mutations
Radomska, Hanna S., Bassères, Daniela S., Zheng, Rui, Zhang, Pu, Dayaram, Tajhal, Yamamoto, Yukiya, ...
Mutations constitutively activating FLT3 kinase are detected in ∼30% of acute myelogenous leukemia (AML) patients and affect downstream pathways such as extracellular signal–regulated kinase...