Hans-Uwe Simon

Treatment of patients with the hypereosinophilic syndrome with mepolizumab (2008)

Klion, Amy D, Roufosse, Florence E, Kahn, Jean Emmanuel, Weller, Peter F, Simon, Hans-Uwe, ...

BACKGROUND: The hypereosinophilic syndrome is a group of diseases characterized by persistent blood eosinophilia, defined as more than 1500 cells per microliter with end-organ involvement and no...

Guidelines for the use and interpretation of assays for monitoring autophagy in higher eukaryotes (2008)

Spanel-Borowski, Katharina, Smith, Mark A., Simone, Cristiano, Simonsen, Anne, Simon, Hans-Uwe, ...

Research in autophagy continues to accelerate, and as a result many new scientists are entering the field. Accordingly, it is important to establish a standard set of criteria for monitoring...

Post-translational Tyrosine Nitration of Eosinophil Granule Toxins Mediated by Eosinophil Peroxidase (2008)

Ulrich, Martina, Petre, Alina, Youhnovski, Nikolay, Prömm, Franziska, Schirle, Markus, Schumm, Michael, ...

Nitration of tyrosine residues has been observed during various acute and chronic inflammatory diseases. However, the mechanism of tyrosine nitration and the nature of the proteins that become...

Inflammation-associated cell cycle-independent block of apoptosis by survivin in terminally differentiated neutrophils (2004)

Martinelli, Sibylla, Yousefi, Shida, Thürig, Christine, Schmid, Inès, ...

Survivin has received great attention due to its expression in many human tumors and its potential as a therapeutic target in cancer. Survivin expression has been described to be cell cycle-dependent...

Post-translational Tyrosine Nitration of Eosinophil Granule Toxins Mediated by Eosinophil Peroxidase*

Ulrich, Martina, Petre, Alina, Youhnovski, Nikolay, Prömm, Franziska, Schirle, Markus, Schumm, Michael, ...

Nitration of tyrosine residues has been observed during various acute and chronic inflammatory diseases. However, the mechanism of tyrosine nitration and the nature of the proteins that become...