Mitochondrial changes within axons in multiple sclerosis (2009)
Mahad, Don J., Ziabreva, Iryna, Campbell, Graham, Lax, Nichola, White, Katherine, Hanson, Peter S., ...
Multiple sclerosis is the most common cause of non-traumatic neurological impairment in young adults. An energy deficient state has been implicated in the degeneration of axons, the pathological...
The relation between inflammation and neurodegeneration in multiple sclerosis brains (2009)
Frischer, Josa M., Bramow, Stephan, Dal-Bianco, Assunta, Lucchinetti, Claudia F., Rauschka, Helmut, Schmidbauer, Manfred, ...
Some recent studies suggest that in progressive multiple sclerosis, neurodegeneration may occur independently from inflammation. The aim of our study was to analyse the interdependence of...
Diagnosis of inflammatory demyelination in biopsy specimens: a practical approach (2008)
Kuhlmann, Tanja, Lassmann, Hans, Brück, Wolfgang
Multiple sclerosis is the most frequent demyelinating disease in adults. It is characterized by demyelination, inflammation, gliosis and a variable loss of axons. Clinically and histologically, it...
Metz, Imke, Lucchinetti, Claudia F., Openshaw, Harry, Garcia-Merino, Antonio, Lassmann, Hans, Freedman, Marc S., ...
Lesion genesis in a subset of patients with multiple sclerosis: a role for innate immunity? (2007)
Marik, Christina, Felts, Paul A., Bauer, Jan, Lassmann, Hans, Smith, Kenneth J.
Lesions obtained early in the course of multiple sclerosis (MS) have been studied immunocytochemically, and compared with the early stages of the experimental lesion induced in rats by the...
Multiple sclerosis: T-cell receptor expression in distinct brain regions (2007)
Junker, Andreas, Ivanidze, Jana, Malotka, Joachim, Eiglmeier, Ingrid, Lassmann, Hans, Wekerle, Hartmut, ...
Multiple sclerosis (MS) is an inflammatory demyelinating disease where T cells attack the brain and the spinal cord. It is known that often particular T-cell clones are expanded in the target tissue,...
Roemer, Shanu F., Parisi, Joseph E., Lennon, Vanda A., Benarroch, Eduardo E., Lassmann, Hans, Bruck, Wolfgang, ...
Neuromyelitis optica (NMO) is an inflammatory demyelinating disease that typically affects optic nerves and spinal cord. Its pathogenic relationship to multiple sclerosis (MS) is uncertain. Unlike...
Metz, Imke, Lucchinetti, Claudia F., Openshaw, Harry, Garcia-Merino, Antonio, Lassmann, Hans, Freedman, Marc S., ...
The present study analyses autopsy material from five multiple sclerosis patients who received autologous stem cell transplantation. A total of 53 white matter lesions were investigated using routine...
Metz, Imke, Lucchinetti, Claudia F., Openshaw, Harry, Garcia-Merino, Antonio, Lassmann, Hans, Freedman, Marc S., ...
The present study analyses autopsy material from five multiple sclerosis patients who received autologous stem cell transplantation. A total of 53 white matter lesions were investigated using routine...
Roemer, Shanu F., Parisi, Joseph E., Lennon, Vanda A., Benarroch, Eduardo E., Lassmann, Hans, Bruck, Wolfgang, ...
Neuromyelitis optica (NMO) is an inflammatory demyelinating disease that typically affects optic nerves and spinal cord. Its pathogenic relationship to multiple sclerosis (MS) is uncertain. Unlike...
Hohlfeld, Reinhard, Kerschensteiner, Martin, Stadelmann, Christine, Lassmann, Hans, Wekerle, Hartmut
Remyelination is extensive in a subset of multiple sclerosis patients (2006)
Patrikios, Peter, Stadelmann, Christine, Kutzelnigg, Alexandra, Rauschka, Helmut, Schmidbauer, Manfred, Laursen, Henning, ...
Although spontaneous remyelination does occur in multiple sclerosis lesions, its extent within the global population with this disease is presently unknown. We have systematically analysed the...
Gold, Ralf, Linington, Christopher, Lassmann, Hans
In view of disease heterogeneity of multiple sclerosis and limited access to ex vivo specimens, different approaches must be undertaken to better understand disease pathogenesis and new therapeutic...
Remyelination is extensive in a subset of multiple sclerosis patients (2006)
Patrikios, Peter, Stadelmann, Christine, Kutzelnigg, Alexandra, Rauschka, Helmut, Schmidbauer, Manfred, Laursen, Henning, ...
Although spontaneous remyelination does occur in multiple sclerosis lesions, its extent within the global population with this disease is presently unknown. We have systematically analysed the...
Gold, Ralf, Linington, Christopher, Lassmann, Hans
In view of disease heterogeneity of multiple sclerosis and limited access to ex vivo specimens, different approaches must be undertaken to better understand disease pathogenesis and new therapeutic...
Cortical demyelination and diffuse white matter injury in multiple sclerosis (2005)
Kutzelnigg, Alexandra, Lucchinetti, Claudia F., Stadelmann, Christine, Brück, Wolfgang, Rauschka, Helmut, Bergmann, Markus, ...
Focal demyelinated plaques in white matter, which are the hallmark of multiple sclerosis pathology, only partially explain the patient's clinical deficits. We thus analysed global brain pathology in...
Tissue preconditioning may explain concentric lesions in Balo's type of multiple sclerosis (2005)
Stadelmann, Christine, Ludwin, Sam, Tabira, Takeshi, Guseo, Andras, Lucchinetti, Claudia F., Leel-Össy, Lorant, ...
Lesions of Baló's concentric sclerosis are characterized by alternating layers of myelinated and demyelinated tissue. The reason for concentric demyelination in this variant of multiple sclerosis is...
Neuropathology of CNS disease in Langerhans cell histiocytosis (2005)
Grois, Nicole, Prayer, Daniela, Prosch, Helmut, Lassmann, Hans
CNS involvement in Langerhans cell histiocytosis (LCH) is a rare but potentially devastating disorder. Different types of involvement have been described by MRI. CNS changes can have space-occupying...
Neuropathology of white matter disease in Leber's hereditary optic neuropathy (2005)
Kovács, Gábor G., Höftberger, Romana, Majtényi, Katalin, Horváth, Rita, Barsi, Péter, Komoly, Sámuel, ...
Leber's hereditary optic neuropathy (LHON) is associated with point mutations in the mitochondrial DNA (mtDNA), coding for a mitochondrial respiratory chain complex I subunit. It is characterized by...
Neuropathology of CNS disease in Langerhans cell histiocytosis (2005)
Grois, Nicole, Prayer, Daniela, Prosch, Helmut, Lassmann, Hans
Summary CNS involvement in Langerhans cell histiocytosis (LCH) is a rare but potentially devastating disorder. Different types of involvement have been described by MRI. CNS changes can have...
Tissue preconditioning may explain concentric lesions in Balo's type of multiple sclerosis (2005)
Stadelmann, Christine, Ludwin, Sam, Tabira, Takeshi, Guseo, Andras, Lucchinetti, Claudia F., Leel-Össy, Lorant, ...
Summary Lesions of Baló's concentric sclerosis are characterized by alternating layers of myelinated and demyelinated tissue. The reason for concentric demyelination in this variant of multiple...
Cortical demyelination and diffuse white matter injury in multiple sclerosis (2005)
Kutzelnigg, Alexandra, Lucchinetti, Claudia F., Stadelmann, Christine, Brück, Wolfgang, Rauschka, Helmut, Bergmann, Markus, ...
Focal demyelinated plaques in white matter, which are the hallmark of multiple sclerosis pathology, only partially explain the patient's clinical deficits. We thus analysed global brain pathology in...
Pellkofer, Hannah, Schubart, Anna S., Hoftberger, Ramona, Schutze, Nadine, Pagany, Maria, Schuller, Martina, ...
Aboul-Enein, Fahmy, Bauer, Jan, Klein, Matthias, Schubart, Anna, Flügel, Alexander, Ritter, Thomas, ...
T cell infiltration in the intact and neuro-degenerative CNS (2004)
Grundtner, R., Bauer, Jan, Flügel, Alexander, Wekerle, Hartmut, Lassmann, Hans, Bradl, Monika
Odoardi, Francesca, Li, Zhaoxia, Kawakami, Naoto, Klinkert, Wolfgang, Bauer, Jan, Lassmann, Hans, ...
Pellkofer, Hannah, Schubart, Anna S., Höftberger, Romana, Schutze, Nadine, Pagany, Maria, Schüller, Martina, ...
Summary Antibodies directed against onconeuronal antigens provide a specific diagnostic marker for paraneoplastic neurological syndromes (PNS) and suggest that these autoantigens are targeted during...
Neuropathology of white matter disease in Leber's hereditary optic neuropathy (2004)
Kovács, Gábor G., Höftberger, Romana, Majtényi, Katalin, Horváth, Rita, Barsi, Péter, Komoly, Sámuel, ...
Summary Leber's hereditary optic neuropathy (LHON) is associated with point mutations in the mitochondrial DNA (mtDNA), coding for a mitochondrial respiratory chain complex I subunit. It is...
Pellkofer, Hannah, Schubart, Anna S., Höftberger, Romana, Schutze, Nadine, Pagany, Maria, Schüller, Martina, ...
Antibodies directed against onconeuronal antigens provide a specific diagnostic marker for paraneoplastic neurological syndromes (PNS) and suggest that these autoantigens are targeted during disease...
Pellkofer, Hannah, Schubart, Anna S., Höftberger, Romana, Schutze, Nadine, Pagany, Maria, Schüller, Martina, ...
Summary Antibodies directed against onconeuronal antigens provide a specific diagnostic marker for paraneoplastic neurological syndromes (PNS) and suggest that these autoantigens are targeted during...
Neuropathology of white matter disease in Leber's hereditary optic neuropathy (2004)
Kovács, Gábor G., Höftberger, Romana, Majtényi, Katalin, Horváth, Rita, Barsi, Péter, Komoly, Sámuel, ...
Summary Leber's hereditary optic neuropathy (LHON) is associated with point mutations in the mitochondrial DNA (mtDNA), coding for a mitochondrial respiratory chain complex I subunit. It is...
A new paraclinical CSF marker for hypoxia-like tissue damage in multiple sclerosis lesions (2003)
Lassmann, Hans, Reindl, Markus, Rauschka, Helmut, Berger, Johannes, Aboul-Enein, Fahmy, Berger, Thomas, ...
Recent studies on the immunopathology of multiple sclerosis revealed a heterogeneity in the patterns of demyelination, suggesting interindividual differences in the mechanism responsible for myelin...
Wanschitz, Julia, Maier, Hans, Lassmann, Hans, Budka, Herbert, Berger, Thomas
Humoural and cellular immune mechanisms are involved in the pathogenesis of Guillain-Barré syndrome (GBS). While activation of complement has been implicated in the initiation of myelin damage, we...
Wanschitz, Julia, Maier, Hans, Lassmann, Hans, Budka, Herbert, Berger, Thomas
Humoural and cellular immune mechanisms are involved in the pathogenesis of Guillain–Barré syndrome (GBS). While activation of complement has been implicated in the initiation of myelin damage, we...
A new paraclinical CSF marker for hypoxia-like tissue damage in multiple sclerosis lesions (2003)
Lassmann, Hans, Reindl, Markus, Rauschka, Helmut, Berger, Johannes, Aboul-Enein, Fahmy, Berger, Thomas, ...
Recent studies on the immunopathology of multiple sclerosis revealed a heterogeneity in the patterns of demyelination, suggesting interindividual differences in the mechanism responsible for myelin...
Wanschitz, Julia, Maier, Hans, Lassmann, Hans, Budka, Herbert, Berger, Thomas
Humoural and cellular immune mechanisms are involved in the pathogenesis of Guillain-Barré syndrome (GBS). While activation of complement has been implicated in the initiation of myelin damage, we...
Abdul-Majid, K. B., Stefferl, Andreas, Bourquin, Carole, Lassmann, Hans, Linington, Christopher, Olsson, T., ...
Multiple sclerosis (MS) is simulated by various forms of experimental autoimmune encephalomyelitis, in which T cells, antibodies, cytokines and complementary factors interact with the central nervous...
Bauer, Jan, Bradl, Monika, Klein, Matthias, Leisser, M., Deckwerth, T. L., Wekerle, Hartmut, ...
Studies dealing with transport of proteins from the oligodendrocyte cell body it) the myelin sheath reveal the presence of different transport pathways. Proteolipid protein (PLP) is synthesized at...
Holzfeind, Paul J., Grewal, Prabhjit K., Reitsamer, Herbert A., Kechvar, Jasmin, Lassmann, Hans, Hoeger, Harald, ...
We have recently shown that a deletion in the Large gene, encoding a putative glycosyltransferase, is the molecular defect underlying the myodystrophy (previously myd; now Largemyd) mouse. Here we...
Stadelmann, Christine, Kerschensteiner, Martin, Misgeld, Thomas, Brück, Wolfgang, Hohlfeld, Reinhard, Lassmann, Hans
Recent immunohistological and imaging studies emphasize the crucial role of axonal injury in determining the extent of permanent neurological deficits in patients with multiple sclerosis. We have...
A role for humoral mechanisms in the pathogenesis of Devic's neuromyelitis optica (2002)
Lucchinetti, Claudia F., Mandler, Raul N., McGavern, Dorian, Bruck, Wolfgang, Gleich, Gerald, Ransohoff, Richard M., ...
Devic’s disease [neuromyelitis optica (NMO)] is an idiopathic inflammatory demyelinating disease of the CNS, characterized by attacks of optic neuritis and myelitis. The mechanisms that...
Kornek, Barbara, Storch, Maria K., Bauer, Jan, Djamshidian, Atbin, Weissert, Robert, Wallstroem, Erik, ...
Multiple sclerosis and experimental autoimmune encephalomyelitis (EAE) are immune-mediated diseases of the CNS. They are characterized by widespread inflammation, demyelination and a variable degree...
Probert, Lesley, Eugster, Hans-Pietro, Akassoglou, Katerina, Bauer, Jan, Frei, Karl, Lassmann, Hans, ...
In this review we summarize the essential findings about the function of tumour necrosis factor (TNF) and its cognate receptors TNFR1 and TNFR2, and lymphotoxin α (LT-α) ligands in immune-mediated...
Lucchinetti, Claudia, Brück, Wolfgang, Parisi, Joseph, Scheithauer, Bernd, Rodriguez, Moses, Lassmann, Hans
We studied quantitatively the fate of oligodendrocytes (OGs) during lesion formation in 395 lesion areas from biopsy and autopsy tissue of 113 multiple sclerosis cases. The density of OGs in multiple...
Andrä, Kerstin, Lassmann, Hans, Bittner, Reginald, Shorny, Sigrid, Fässler, Reinhard, Propst, Friedrich, ...
Morrissey, Sean P., Stodal, Horst, Zettl, Uwe, Simonis, Claudia, Jung, Stefan, Kiefer, Reinhard, ...
In vivo proton MRI was carried out on a 7 Tesla system at 2–3 day intervals over 10 days in rats with adoptive transfer experimental allergic encephalomyelitis (AT-EAE), an animal model of some...
Aus: 108. Jahresbericht des Historischen Vereins Bamberg
Kerschensteiner, Martin, Gallmeier, Eike, Behrens, Lüder, Leal, Vivian Vargas, Misgeld, Thomas, Klinkert, Wolfgang E.F., ...
Brain-derived neurotrophic factor (BDNF) has potent effects on neuronal survival and plasticity during development and after injury. In the nervous system, neurons are considered the major cellular...
Babbe, Holger, Roers, Axel, Waisman, Ari, Lassmann, Hans, Goebels, Norbert, Hohlfeld, Reinhard, ...
Clonal composition and T cell receptor (TCR) repertoire of CD4+ and CD8+ T cells infiltrating actively demyelinating multiple sclerosis (MS) lesions were determined with unprecedented resolution at...
Lobell, Anna, Weissert, Robert, Storch, Maria K., Svanholm, Cecilia, De Graaf, Katrien L., Lassmann, Hans, ...
We explore here if vaccination with DNA encoding an autoantigenic peptide can suppress autoimmune disease. For this purpose we used experimental autoimmune encephalomyelitis (EAE), which is an...
Meixner, Arabella, Haverkamp, Silke, Wässle, Heinz, Führer, Susanne, Thalhammer, Johann, Kropf, Nina, ...
Microtubule-associated proteins such as MAP1B have long been suspected to play an important role in neuronal differentiation, but proof has been lacking. Previous MAP1B gene targeting studies yielded...
Schmidt, Wolfgang M, Kraus, Cornelia, Höger, Harald, Hochmeister, Sonja, Oberndorfer, Felicitas, Branka, Manuela, ...
Here, we show that the murine neurodegenerative disease mdf (autosomal recessive mouse mutant ‘muscle deficient') is caused by a loss-of-function mutation in Scyl1, disrupting the expression of...
Mitochondrial defects in acute multiple sclerosis lesions
Mahad, Don, Ziabreva, Iryna, Lassmann, Hans, Turnbull, Douglas
Multiple sclerosis is a chronic inflammatory disease, which leads to focal plaques of demyelination and tissue injury in the CNS. The structural and immunopathological patterns of demyelination...
Aharonowiz, Michal, Einstein, Ofira, Fainstein, Nina, Lassmann, Hans, Reubinoff, Benjamin, Ben-Hur, Tamir
Litzenburger, Tobias, Fässler, Reinhard, Bauer, Jan, Lassmann, Hans, Linington, Christopher, Wekerle, Hartmut, ...
We studied the cellular basis of self tolerance of B cells specific for brain autoantigens using transgenic mice engineered to produce high titers of autoantibodies against the myelin oligodendrocyte...
Diagnosis of inflammatory demyelination in biopsy specimens: a practical approach
Kuhlmann, Tanja, Lassmann, Hans, Brück, Wolfgang
Multiple sclerosis is the most frequent demyelinating disease in adults. It is characterized by demyelination, inflammation, gliosis and a variable loss of axons. Clinically and histologically, it...
Hochmeister, Sonja, Zeitelhofer, Manuel, Bauer, Jan, Nicolussi, Eva-Maria, Fischer, Marie-Therese, Heinke, Bernhard, ...
The prototypic migratory trail of tissue-resident dendritic cells (DCs) is via lymphatic drainage. Since the central nervous system (CNS) lacks classical lymphatic vessels, and antigens and cells...
The relation between inflammation and neurodegeneration in multiple sclerosis brains
Frischer, Josa M., Bramow, Stephan, Dal-Bianco, Assunta, Lucchinetti, Claudia F., Rauschka, Helmut, Schmidbauer, Manfred, ...
Some recent studies suggest that in progressive multiple sclerosis, neurodegeneration may occur independently from inflammation. The aim of our study was to analyse the interdependence of...
Derfuss, Tobias, Parikh, Khyati, Velhin, Sviataslau, Braun, Magdalena, Mathey, Emily, Krumbholz, Markus, ...
Gray matter pathology is increasingly recognized as an important feature of multiple sclerosis (MS), but the nature of the immune response that targets the gray matter is poorly understood. Starting...