Hans Lilja

Increase in percent free prostate-specific antigen in men with chronic kidney disease (2009)

Bruun, Laila, Savage, Caroline, Cronin, Angel M., Hugosson, Jonas, Lilja, Hans, Christensson, Anders

Background. Prostate-specific antigen (PSA) occurs in different molecular forms in serum: free PSA (fPSA) and complexed PSA (cPSA), the sum of which corresponds to total PSA (tPSA). In addition to...

A panel of kallikrein markers can reduce unnecessary biopsy for prostate cancer: data from the European Randomized Study of Prostate Cancer Screening in Göteborg, Sweden (2008)

Vickers, Andrew J, Cronin, Angel M, Aus, Gunnar, Pihl, Carl-Gustav, Becker, Charlotte, Pettersson, Kim, ...

Abstract Background Prostate-specific antigen (PSA) is widely used to detect prostate cancer. The low positive predictive value of elevated PSA results in large numbers of unnecessary prostate...

Prostate-specific antigen at or before age 50 as a predictor of advanced prostate cancer diagnosed up to 25 years later: A case-control study (2008)

Ulmert, David, Cronin, Angel M, Björk, Thomas, O'Brien, Matthew F, Scardino, Peter T, Eastham, James A, ...

Abstract Background Based on a large, representative unscreened cohort from Malmö, Sweden, we have recently reported that a single prostate-specific antigen (PSA) measurement at or before age 50 is...

Needle Biopsies on Autopsy Prostates: Sensitivity of Cancer Detection Based on True Prevalence (2007)

Haas, Gabriel P., Delongchamps, Nicolas Barry, Jones, Richard F., Chandan, Vishal, Serio, Angel M., Vickers, Andrew J., ...

Background It is difficult to estimate the diagnostic accuracy of biopsy for prostate cancer because men with negative biopsy do not undergo radical prostatectomy and thus have no confirmation of...

Novel Protein Microarray Technology to Examine Men with Prostate Cancer (2006)

Lilja, Hans

The authors developed a novel macro and nanoporous silicon surface for protein microarrays to facilitate high-throughput biomarker discovery, and high-density protein-chip array analyses of complex...

A frequent allele codes for a truncated variant of semenogelin I, the major protein component of human semen coagulum (2003)

Lundwall, Åke, Giwercman, Aleksander, Ruhayel, Yasir, Giwercman, Yvonne, Lilja, Hans, Halldén, Christer, ...

Human semen coagulum predominantly consists of high molecular mass complexes of the seminal vesicle secreted semenogelin I (SgI) and semenogelin II (SgII). Here we describe a previously unknown...

Prostate-Specific Antigen-Activated Thapsigargin Prodrug as Targeted Therapy for Prostate Cancer (2003)

Denmeade, Samuel R., Jakobsen, Carsten M., Janssen, Samuel, Khan, Saeed R., Garrett, Elizabeth S., Lilja, Hans, ...

Background: Standard anti-proliferative chemotherapy is relatively ineffective against slowly proliferating androgen-independent prostate cancer cells within metastatic sites. In contrast, the...

Percent-free prostate specific antigen is elevated in men on haemodialysis or peritoneal dialysis treatment (2003)

Bruun, Laila, Björk, Thomas, Lilja, Hans, Becker, Charlotte, Gustafsson, Ove, Christensson, Anders

Background. Men with chronic renal failure evaluated for transplantation are often tested for prostate specific antigen (PSA) to detect prostate cancer. PSA occurs in several different...

Comparability of the tandem-R andIMx assays for the measurement of serum prostate-specific antigen (1994)

Jacobsen, Steven J., Lilja, Hans, Klee, George G., Pettersson, Kim, Oesterling, Joseph E.

Objectives.To assess the comparability of the Tandem-R and IMx serumprostate-specific antigen (PSA) assays across levels of the ratio of free-to-total serum PSA found in a community-based population...

Molecular cloning and sequence analysis of the cDNA encoding the human acrosin-trypsin inhibitor (HUSI-II) (1991)

Möritz, Annemarie, Lilja, Hans, Fink, Edwin

A complete cDNA clone encoding the human acrosin-trypsin inhibitor HUSI-II has been isolated from a cDNA library of human testis and completely sequenced. The cDNA of 594 bp contained an open reading...

The Human Cationic Antimicrobial Protein (hCAP-18) Is Expressed in the Epithelium of Human Epididymis, Is Present in Seminal Plasma at High Concentrations, and Is Attached to Spermatozoa

Malm, Johan, Sørensen, Ole, Persson, Terese, Frohm-Nilsson, Margareta, Johansson, Bengt, Bjartell, Anders, ...

Innate immunity is important for the integrity of the host against potentially invasive pathogenic microorganisms in the environment. Antibiotic peptides with broad antimicrobial activity are part of...

A locus on human chromosome 20 contains several genes expressing protease inhibitor domains with homology to whey acidic protein.

Clauss, Adam, Lilja, Hans, Lundwall, Ake

A locus containing 14 genes, encoding protein domains that have homology with whey acidic protein (WAP), has been identified in a region of 678 kb on human chromosome 20q12-13.1. Among them are genes...

Differential exoprotease activities confer tumor-specific serum peptidome patterns

Villanueva, Josep, Shaffer, David R., Philip, John, Chaparro, Carlos A., Erdjument-Bromage, Hediye, Olshen, Adam B., ...

Recent studies have established distinctive serum polypeptide patterns through mass spectrometry (MS) that reportedly correlate with clinically relevant outcomes. Wider acceptance of these signatures...

The Human Cationic Antimicrobial Protein (hCAP-18) Is Expressed in the Epithelium of Human Epididymis, Is Present in Seminal Plasma at High Concentrations, and Is Attached to Spermatozoa

Malm, Johan, Sørensen, Ole, Persson, Terese, Frohm-Nilsson, Margareta, Johansson, Bengt, Bjartell, Anders, ...

Innate immunity is important for the integrity of the host against potentially invasive pathogenic microorganisms in the environment. Antibiotic peptides with broad antimicrobial activity are part of...

A locus on human chromosome 20 contains several genes expressing protease inhibitor domains with homology to whey acidic protein.

Clauss, Adam, Lilja, Hans, Lundwall, Ake

A locus containing 14 genes, encoding protein domains that have homology with whey acidic protein (WAP), has been identified in a region of 678 kb on human chromosome 20q12-13.1. Among them are genes...

Differential exoprotease activities confer tumor-specific serum peptidome patterns

Villanueva, Josep, Shaffer, David R., Philip, John, Chaparro, Carlos A., Erdjument-Bromage, Hediye, Olshen, Adam B., ...

Recent studies have established distinctive serum polypeptide patterns through mass spectrometry (MS) that reportedly correlate with clinically relevant outcomes. Wider acceptance of these signatures...

Anti-Thrombin Is Expressed in the Benign Prostatic Epithelium and in Prostate Cancer and Is Capable of Forming Complexes with Prostate-Specific Antigen and Human Glandular Kallikrein 2

Cao, Yue, Lundwall, Åke, Gadaleanu, Virgil, Lilja, Hans, Bjartell, Anders

Anti-thrombin, a member of the serpin family and an inhibitor of thrombin and blood coagulation factor Xa, was recently shown to inhibit angiogenesis and tumor growth. In the present study, we...

Simultaneous Quantification of Human Glandular Kallikrein 2 and Prostate-Specific Antigen mRNAs in Peripheral Blood from Prostate Cancer Patients

Ylikoski, Alice, Karp, Matti, Pettersson, Kim, Lilja, Hans, Lövgren, Timo

We present a multiplexed and internally calibrated quantitative reverse transcription-PCR (QRT-PCR) assay to detect human glandular kallikrein 2 (hK2) and prostate-specific antigen (PSA) transcripts...