Nielsen, Maartje, De Miranda, Noel FCC, Van Puijenbroek, Marjo, Jordanova, Ekaterina S, Middeldorp, Anneke, Van Wezel, Tom, ...
Abstract Background MUTYH-associated polyposis (MAP) is a recessively inherited disorder which predisposes biallelic carriers for a high risk of polyposis and colorectal carcinoma (CRC). Since about...
The colorectal cancer risk at 18q21 is caused by a novel variant altering SMAD7 expression (2009)
Pittman, Alan M., Naranjo, Silvia, Webb, Emily, Broderick, Peter, Lips, Esther H., Van Wezel, Tom, ...
Article in press.
The colorectal cancer risk at 18q21 is caused by a novel variant altering SMAD7 expression (2009)
Pittman, Alan M., Naranjo, Silvia, Webb, Emily, Broderick, Peter, Lips, Esther H., Van Wezel, Tom, ...
Recent genome-wide scans for colorectal cancer (CRC) have revealed the SMAD7 (mothers against decapentaplegic homolog 7) gene as a locus associated with a modest, but highly significant increase in...
Lips, Esther H, Van Eijk, Ronald, De Graaf, Eelco JR, Oosting, Jan, De Miranda, Noel FCC, Karsten, Tom, ...
Abstract Background Accurate staging of rectal tumors is essential for making the correct treatment choice. In a previous study, we found that loss of 17p, 18q and gain of 8q, 13q and 20q could...
Pittman, Alan M., Webb, Emily, Carvajal-Carmona, Luis, Howarth, Kimberley, Di Bernardo, Maria Chiara, Broderick, Peter, ...
The common single-nucleotide polymorphism (SNP) rs3802842 at 11q23.1 has recently been reported to be associated with risk of colorectal cancer (CRC). To examine this association in detail we...
Dierssen, Jan, De Miranda, Noel FCC, Ferrone, Soldano, Van Puijenbroek, Marjo, Cornelisse, Cees J, Fleuren, Gert, ...
Abstract Background Abnormalities in Human Leukocyte Antigen (HLA) class I expression are common in colorectal cancer. Since HLA expression is required to activate tumor antigen-specific cytotoxic...
Middeldorp, Anneke, Jagmohan-Changur, Shantie, Helmer, Quinta, Van Der Klift, Heleen M, Tops, Carli MJ, Vasen, Hans FA, ...
Abstract Background The apparent dominant model of colorectal cancer (CRC) inheritance in several large families, without mutations in known CRC susceptibility genes, suggests the presence of so far...
Oosting, Jan, Lips, Esther H., Van Eijk, Ronald, Eilers, Paul H.C., Szuhai, Károly, Wijmenga, Cisca, ...
High-density SNP microarrays provide insight into the genomic events that occur in diseases like cancer through their capability to measure both LOH and genomic copy numbers. Where currently...
High-resolution analysis of HLA class I alterations in colorectal cancer (2006)
Dierssen, Jan Willem F, De Miranda, Noel FCC, Mulder, Arend, Van Puijenbroek, Marjo, Verduyn, Willem, Claas, Frans HJ, ...
Abstract Background Previous studies indicate that alterations in Human Leukocyte Antigen (HLA) class I expression are frequent in colorectal tumors. This would suggest serious limitations for...
Genomic profiling by DNA amplification of laser capture microdissected tissues and array CGH (2004)
Cardoso, Joana, Molenaar, Lia, De Menezes, Renée X., Rosenberg, Carla, Morreau, Hans, Möslein, Gabriela, ...
Comparative genomic hybridization by means of BAC microarrays (array CGH) allows high-resolution profiling of copy-number aberrations in tumor DNA. However, specific genetic lesions associated with...
Genomic profiling by DNA amplification of laser capture microdissected tissues and array CGH
Cardoso, Joana, Molenaar, Lia, De Menezes, Renée X., Rosenberg, Carla, Morreau, Hans, Möslein, Gabriela, ...
Comparative genomic hybridization by means of BAC microarrays (array CGH) allows high-resolution profiling of copy-number aberrations in tumor DNA. However, specific genetic lesions associated with...
High-resolution analysis of HLA class I alterations in colorectal cancer
Dierssen, Jan Willem F, De Miranda, Noel FCC, Mulder, Arend, Van Puijenbroek, Marjo, Verduyn, Willem, Claas, Frans HJ, ...
Genomic profiling by DNA amplification of laser capture microdissected tissues and array CGH
Cardoso, Joana, Molenaar, Lia, De Menezes, Renée X., Rosenberg, Carla, Morreau, Hans, Möslein, Gabriela, ...
Comparative genomic hybridization by means of BAC microarrays (array CGH) allows high-resolution profiling of copy-number aberrations in tumor DNA. However, specific genetic lesions associated with...
Wagner, Anja, Barrows, Alicia, Wijnen, Juul Th., Van der Klift, Heleen, Franken, Patrick F., Verkuijlen, Paul, ...
The identification of germline mutations in families with HNPCC is hampered by genetic heterogeneity and clinical variability. In previous studies, MSH2 and MLH1 mutations were found in approximately...
High-resolution analysis of HLA class I alterations in colorectal cancer
Dierssen, Jan Willem F, De Miranda, Noel FCC, Mulder, Arend, Van Puijenbroek, Marjo, Verduyn, Willem, Claas, Frans HJ, ...
Middeldorp, Anneke, Jagmohan-Changur, Shantie, Helmer, Quinta, Van Der Klift, Heleen M, Tops, Carli MJ, Vasen, Hans FA, ...
Dierssen, Jan Willem F, De Miranda, Noel FCC, Ferrone, Soldano, Van Puijenbroek, Marjo, Cornelisse, Cees J, Fleuren, Gert Jan, ...
Hendriks, Yvonne, Franken, Patrick, Dierssen, Jan Willem, De Leeuw, Wiljo, Wijnen, Juul, Dreef, Enno, ...
Immunohistochemistry (IHC) of mismatch repair (MMR) proteins in colorectal tumors together with microsatellite analysis (MSI) can be helpful in identifying families eligible for mutation analysis....
Van Puijenbroek, Marjo, Dierssen, Jan Willem F., Stanssens, Patrick, Van Eijk, Ronald, Van Wezel, Tom, ...
As the number of identified single-nucleotide polymorphisms (SNPs) increases, high-throughput methods are required to characterize the informative loci in large patient series. We investigated the...
Vrolijk, Hans, Sloos, Willem, Mesker, Wilma, Franken, Patrick, Fodde, Riccardo, Morreau, Hans, ...
At present, limiting factors in the use of tissue microarrays (TMAs) for high-throughput analysis relate to the visual evaluation of the staining patterns of each of the individual cores in the array...
High-resolution copy number analysis of paraffin-embedded archival tissue using SNP BeadArrays
Oosting, Jan, Lips, Esther H., Van Eijk, Ronald, Eilers, Paul H.C., Szuhai, Károly, Wijmenga, Cisca, ...
High-density SNP microarrays provide insight into the genomic events that occur in diseases like cancer through their capability to measure both LOH and genomic copy numbers. Where currently...
Clinical impact of HLA class I expression in rectal cancer
Speetjens, Frank M., De Bruin, Elza C., Morreau, Hans, Zeestraten, Eliane C.M., Putter, Hein, Van Krieken, J. Han, ...
Gaspar, Claudia, Cardoso, Joana, Franken, Patrick, Molenaar, Lia, Morreau, Hans, Möslein, Gabriela, ...
Expression profiling is a well established tool for the genome-wide analysis of human cancers. However, the high sensitivity of this approach combined with the well known cellular and molecular...
Integrating chromosomal aberrations and gene expression profiles to dissect rectal tumorigenesis
Lips, Esther H, Van Eijk, Ronald, De Graaf, Eelco JR, Oosting, Jan, De Miranda, Noel FCC, Karsten, Tom, ...
Doekhie, Fania S., Morreau, Hans, De Bock, Geertruida H., Speetjens, Frank M., Dekker-Ensink, N. Geeske, Putter, Hein, ...
Up to 30% of curatively resected colorectal cancer patients with tumor-negative lymph nodes, show disease recurrence. We assessed whether these high-risk patients can be identified by examining...