Von Zur Muhlen, Constantin, Schiffer, Eric, Zuerbig, Petra, Kellmann, Marcus, Brasse, Mario, Meert, Natalie, ...
Coronary artery disease (CAD) is a major cause of mortality and morbidity. Noninvasive proteome analysis could guide clinical evaluation and early/preventive treatment. Under routine clinical...
Urinary proteome pattern in children with renal Fanconi syndrome (2009)
Drube, Jens, Schiffer, Eric, Mischak, Harald, Kemper, Markus J., Neuhaus, Thomas, Pape, Lars, ...
Background. The renal Fanconi syndrome (FS) is characterized by renal glucosuria, loss of electrolytes, bicarbonate and lactate, generalized hyperaminoaciduria and low-molecular-weight proteinuria....
Urine in clinical proteomics. (2008)
Decramer, Stéphane, Gonzalez De Peredo, Anne, Breuil, Benjamin, Mischak, Harald, Monsarrat, Bernard, Bascands, Jean-Loup, ...
Urine has become one of the most attractive biofluids in clinical proteomics as it can be obtained non-invasively in large quantities and is stable compared with other biofluids. The urinary proteome...
Urine in clinical proteomics. (2008)
Decramer, Stéphane, Gonzalez De Peredo, Anne, Breuil, Benjamin, Mischak, Harald, Monsarrat, Bernard, Bascands, Jean-Loup, ...
Urine has become one of the most attractive biofluids in clinical proteomics as it can be obtained non-invasively in large quantities and is stable compared with other biofluids. The urinary proteome...
Urine in clinical proteomics. (2008)
Decramer, Stéphane, Gonzalez De Peredo, Anne, Breuil, Benjamin, Mischak, Harald, Monsarrat, Bernard, Bascands, Jean-Loup, ...
Urine has become one of the most attractive biofluids in clinical proteomics as it can be obtained non-invasively in large quantities and is stable compared with other biofluids. The urinary proteome...
Review on uraemic solutes II Variability in reported concentrations: causes and consequences (2007)
Vanholder, Raymond, Meert, Nathalie, Schepers, Eva, Glorieux, Griet, Argiles, Angel, Brunet, Philippe, ...
The aim of this manuscript is to initiate a constructive discussion about deviations in measured concentrations of uraemic solutes; these deviations, if not perceived or handled appropriately, may...
Petra Zürbig, Joshua Coon, Hartwig Bauer, Georg Behrens, Mohammed Dakna, Anna Dominiczak, ...
Owing to its availability, ease of collection and correlation with (patho-) physiology, urine is an attractive source for clinical proteomics. However, the lack of comparable datasets from large...
Proteomics: a novel tool to unravel the patho-physiology of uraemia (2004)
Weissinger, Eva M., Kaiser, Thorsten, Meert, Natalie, De Smet, Rita, Walden, Michael, Mischak, Harald, ...
Background. Uraemic toxicity results in the dysfunction of many organ systems, provoking an increase in morbidity and mortality. To date, only ∼90 uraemic retention solutes have been described. To...
Proteomics: a novel tool to unravel the patho-physiology of uraemia (2004)
Weissinger, Eva M., Kaiser, Thorsten, Meert, Natalie, De Smet, Rita, Walden, Michael, Mischak, Harald, ...
Background. Uraemic toxicity results in the dysfunction of many organ systems, provoking an increase in morbidity and mortality. To date, only 90 uraemic retention solutes have been described. To...
Suppression of Raf-1 kinase activity and MAP kinase signalling by RKIP (1999)
Yeung, Kam, Seitz, Thomas, Li, Shengfeng, Janosch, Petra, McFerran, Brian, Kaiser, Christian, ...
Raf-1 phosphorylates and activates MEK-1, a kinase that activates the extracellular signal regulated kinases (ERK). This kinase cascade controls the proliferation and differentiation of different...
Untersuchungen zur Signalübertragung durch Protein Kinase C / (1995)
München, Techn. Univ., Habil.-Schr., 1995.
Suppression of Raf-1 kinase activity and MAP kinase signalling by RKIP
Yeung, Kam, Seitz, Thomas, Li, Shengfeng, Janosch, Petra, McFerran, Brian, Kaiser, Christian, ...
Raf-1 phosphorylates and activates MEK-1, a kinase that activates the extracellular signal regulated kinases (ERK). This kinase cascade controls the proliferation and differentiation of different...
Caloca, Maria José, Garcia-Bermejo, Maria Laura, Blumberg, Peter M., Lewin, Nancy E., Kremmer, Elisabeth, Mischak, Harald, ...
The members of the chimaerin family of Rac-GTPase-activating proteins possess a single C1 domain with high homology to those present in protein kinase C (PKC) isozymes. This domain in PKCs is...
Yeung, Kam, Janosch, Petra, McFerran, Brian, Rose, David W., Mischak, Harald, Sedivy, John M., ...
We have recently identified the Raf kinase inhibitor protein (RKIP) as a physiological endogenous inhibitor of the Raf-1/MEK/extracellular signal-regulated kinase (ERK) pathway. RKIP interfered with...
Baumann, Matthias, Mischak, Harald, Dammeier, Sascha, Kolch, Walter, Gires, Olivier, Pich, Dagmar, ...
BZLF1 is a member of the extended AP-1 family of transcription factors which binds to specific BZLF1 sequence motifs within early Epstein-Barr virus (EBV) promoters and to closely related AP-1...
Cyclic AMP-Dependent Kinase Regulates Raf-1 Kinase Mainly by Phosphorylation of Serine 259
Dhillon, Amardeep S., Pollock, Claire, Steen, Helge, Shaw, Peter E., Mischak, Harald, Kolch, Walter
The Raf-1 kinase activates the ERK (extracellular-signal-regulated kinase) pathway. The cyclic AMP (cAMP)-dependent protein kinase (PKA) can inhibit Raf-1 by direct phosphorylation. We have mapped...
Dhillon, Amardeep S., Meikle, Sharon, Peyssonnaux, Carole, Grindlay, Joan, Kaiser, Christian, Steen, Helge, ...
It is widely thought that the biological outcomes of Raf-1 activation are solely attributable to the activation of the MEK/extracellular signal-regulated kinase (ERK) pathway. However, an increasing...
Chromosomal and Extrachromosomal Instability of the cyclin D2 Gene is Induced by Myc Overexpression
Mai, Sabine, Hanley-Hyde, Joan, Rainey, G Jonah, Kuschak, Theodore I, Paul, James T, Littlewood, Trevor D, ...
We examined the expression of cyclins D1, D2, D3, and E in mouse B-lymphocytic tumors. Cyclin D2 mRNA was consistently elevated in plasmacytomas, which characteristically contain Myc-activating...
Caloca, Maria José, Garcia-Bermejo, Maria Laura, Blumberg, Peter M., Lewin, Nancy E., Kremmer, Elisabeth, Mischak, Harald, ...
The members of the chimaerin family of Rac-GTPase-activating proteins possess a single C1 domain with high homology to those present in protein kinase C (PKC) isozymes. This domain in PKCs is...
Yeung, Kam, Janosch, Petra, McFerran, Brian, Rose, David W., Mischak, Harald, Sedivy, John M., ...
We have recently identified the Raf kinase inhibitor protein (RKIP) as a physiological endogenous inhibitor of the Raf-1/MEK/extracellular signal-regulated kinase (ERK) pathway. RKIP interfered with...
Baumann, Matthias, Mischak, Harald, Dammeier, Sascha, Kolch, Walter, Gires, Olivier, Pich, Dagmar, ...
BZLF1 is a member of the extended AP-1 family of transcription factors which binds to specific BZLF1 sequence motifs within early Epstein-Barr virus (EBV) promoters and to closely related AP-1...
Cyclic AMP-Dependent Kinase Regulates Raf-1 Kinase Mainly by Phosphorylation of Serine 259
Dhillon, Amardeep S., Pollock, Claire, Steen, Helge, Shaw, Peter E., Mischak, Harald, Kolch, Walter
The Raf-1 kinase activates the ERK (extracellular-signal-regulated kinase) pathway. The cyclic AMP (cAMP)-dependent protein kinase (PKA) can inhibit Raf-1 by direct phosphorylation. We have mapped...
Dhillon, Amardeep S., Meikle, Sharon, Peyssonnaux, Carole, Grindlay, Joan, Kaiser, Christian, Steen, Helge, ...
It is widely thought that the biological outcomes of Raf-1 activation are solely attributable to the activation of the MEK/extracellular signal-regulated kinase (ERK) pathway. However, an increasing...
Chromosomal and Extrachromosomal Instability of the cyclin D2 Gene is Induced by Myc Overexpression
Mai, Sabine, Hanley-Hyde, Joan, Rainey, G Jonah, Kuschak, Theodore I, Paul, James T, Littlewood, Trevor D, ...
We examined the expression of cyclins D1, D2, D3, and E in mouse B-lymphocytic tumors. Cyclin D2 mRNA was consistently elevated in plasmacytomas, which characteristically contain Myc-activating...
Suppression of Raf-1 kinase activity and MAP kinase signalling by RKIP
Yeung, Kam, Seitz, Thomas, Li, Shengfeng, Janosch, Petra, McFerran, Brian, Kaiser, Christian, ...
Raf-1 phosphorylates and activates MEK-1, a kinase that activates the extracellular signal regulated kinases (ERK). This kinase cascade controls the proliferation and differentiation of different...
Jiang, Hong, Schiffer, Eric, Song, Zhangfa, Wang, Jianwei, Zürbig, Petra, Thedieck, Kathrin, ...
Telomere dysfunction limits the proliferative capacity of human cells by activation of DNA damage responses, inducing senescence or apoptosis. In humans, telomere shortening occurs in the vast...
Urinary Proteomics in Diabetes and CKD
Rossing, Kasper, Mischak, Harald, Dakna, Mohammed, Zürbig, Petra, Novak, Jan, Julian, Bruce A., ...
Urinary biomarkers for diabetes, diabetic nephropathy, and nondiabetic proteinuric renal diseases were sought. For 305 individuals, biomarkers were defined and validated in blinded data sets using...