Harald von Boehmer

Early Deletion and Late Positive Selection of T-Cells Expressing a Male-Specific Receptor in T-Cell Receptor Transgenic Mice (1990)

Hung Sia Teh, Hiroyuki Kishi, Bernadette Scott, Peter Borgulya, Harald Von Boehmer, Pawel Kisielow

The ontogeny of T cells in T-cell receptor (TCR) transgenic mice, which express a transgenic αβ heterodimer, specific for the male (H-Y) antigen in association with H-2Db, was determined. The...

Role of Different T Cell Receptors in the Development of Pre–T Cells

Buer, Jan, Aifantis, Iannis, DiSanto, James P., Fehling, Hans Joerg, Boehmer, Harald Von

The development of pre–T cells with productive TCR-β rearrangements can be mediated by each the pre–T cell receptor (pre-TCR), the TCR-αβ as well as the TCR-γδ, albeit by distinct...

Allelic Exclusion in pTα-deficient Mice: No Evidence for Cell Surface Expression of Two T Cell Receptor (TCR)-β Chains, but Less Efficient Inhibition of Endogeneous Vβ→ (D)Jβ Rearrangements in the Presence of a Functional TCR-β Transgene

Krotkova, Anna, Boehmer, Harald Von, Fehling, Hans Jörg

Although individual T lymphocytes have the potential to generate two distinct T cell receptor (TCR)-β chains, they usually express only one allele, a phenomenon termed allelic exclusion. Expression...

Peripheral T Cell Survival Requires Continual Ligation of the T Cell Receptor to Major Histocompatibility Complex–Encoded Molecules

Kirberg, Jörg, Berns, Anton, Boehmer, Harald Von

In the thymus, T cells are selected according to their T cell receptor (TCR) specificity. After positive selection, mature cells are exported from primary lymphoid organs to seed the secondary...

Interleukin 10 Secretion and Impaired Effector Function of Major Histocompatibility Complex Class II–restricted T Cells Anergized In Vivo

Buer, Jan, Lanoue, Astrid, Franzke, Anke, Garcia, Corinne, Boehmer, Harald Von, Sarukhan, Adelaida

Continuous antigenic stimulation in vivo can result in the generation of so-called “anergic” CD4+ or CD8+ T cells that fail to proliferate upon antigenic stimulation and fail to develop cytolytic...