Scientific Commons: Harold McClure

ADAPTATION OF A STRAIN OF PLASMODIUM VIVAX FROM INDIA TO NEW WORLD MONKEYS, CHIMPANZEES, AND ANOPHELINE MOSQUITOES (2001)

JoAnn S. Sullivan, Elizabeth Strobert, Chunfu Yang, Carla L. Morris, G. Gale Galland, Bettye B. Richardson, ...

A strain of Plasmodium vivax from India was adapted to develop in splenectomized Saimiri boliviensis, Aotus lemurinus griseimembra, A vociferans, A. nancymai, A. azarae boliviensis, hybrid Aotus...

Diverse Host Responses and Outcomes following Simian Immunodeficiency Virus SIVmac239 Infection in Sooty Mangabeys and Rhesus Macaques

Kaur, Amitinder, Grant, Robert M., Means, Robert E., McClure, Harold, Feinberg, Mark, Johnson, R. Paul

Sooty mangabeys naturally infected with simian immunodeficiency virus (SIV) do not develop immunodeficiency despite the presence of viral loads of 105 to 107 RNA copies/ml. To investigate the basis...

A Molecularly Cloned Schwarz Strain of Measles Virus Vaccine Induces Strong Immune Responses in Macaques and Transgenic Mice

Combredet, Chantal, Labrousse, Valérie, Mollet, Lucile, Lorin, Clarisse, Delebecque, Frédéric, Hurtrel, Bruno, ...

Live attenuated RNA viruses make highly efficient vaccines. Among them, measles virus (MV) vaccine has been given to a very large number of children and has been shown to be highly efficacious and...

Blockade of T cell costimulation reveals interrelated actions of CD4+ and CD8+ T cells in control of SIV replication

Garber, David A., Silvestri, Guido, Barry, Ashley P., Fedanov, Andrew, Kozyr, Natalia, McClure, Harold, ...

In vivo blockade of CD28 and CD40 T cell costimulation pathways during acute simian immunodeficiency virus (SIV) infection of rhesus macaques was performed to assess the relative contributions of...

Enhanced SIV replication and accelerated progression to AIDS in macaques primed to mount a CD4 T cell response to the SIV envelope protein

Staprans, Silvija I., Barry, Ashley P., Silvestri, Guido, Safrit, Jeffrey T., Kozyr, Natalia, Sumpter, Beth, ...

Given the dual role of CD4 T cells as both immune effectors and targets for HIV infection, the balance of CD4 versus CD8 T cell-mediated responses induced by candidate AIDS vaccines may be critical...

Divergent Host Responses during Primary Simian Immunodeficiency Virus SIVsm Infection of Natural Sooty Mangabey and Nonnatural Rhesus Macaque Hosts

Silvestri, Guido, Fedanov, Andrew, Germon, Stephanie, Kozyr, Natalia, Kaiser, William J., Garber, David A., ...

To understand how natural sooty mangabey hosts avoid AIDS despite high levels of simian immunodeficiency virus (SIV) SIVsm replication, we inoculated mangabeys and nonnatural rhesus macaque hosts...

Mechanism of Anti-Human Immunodeficiency Virus Activity of β-d-6-Cyclopropylamino-2′,3′-Didehydro-2′,3′-Dideoxyguanosine

Ray, Adrian S., Hernandez-Santiago, Brenda I., Mathew, Judy S., Murakami, Eisuke, Bozeman, Carey, Xie, Meng-Yu, ...

To better understand the importance of the oxygen in the ribose ring of planar unsaturated nucleoside analogs that target human immunodeficiency virus (HIV), a 6-cyclopropyl-substituted prodrug of...

Molecular Epidemiology of Simian Immunodeficiency Virus SIVsm in U.S. Primate Centers Unravels the Origin of SIVmac and SIVstm

Apetrei, Cristian, Kaur, Amitinder, Lerche, Nicholas W., Metzger, Michael, Pandrea, Ivona, Hardcastle, Johnny, ...

Retrospective molecular epidemiology was performed on samples from four sooty mangabey (SM) colonies in the United States to characterize simian immunodeficiency virus SIVsm diversity in SMs and to...

Th-1-Type Cytotoxic CD8+ T-Lymphocyte Responses to Simian Immunodeficiency Virus (SIV) Are a Consistent Feature of Natural SIV Infection in Sooty Mangabeys

Wang, Zichun, Metcalf, Benjamin, Ribeiro, Ruy M., McClure, Harold, Kaur, Amitinder

Sooty mangabeys are a natural host of simian immunodeficiency virus (SIV) that remain asymptomatic and do not exhibit increased immune activation or increased T-lymphocyte turnover despite sustained...