Accurate whole human genome sequencing using reversible terminator chemistry (2008)
Bentley, David R., Balasubramanian, Shankar, Swerdlow, Harold P., Smith, Geoffrey P., Milton, John, Brown, Clive G., ...
DNA sequence information underpins genetic research, enabling discoveries of important biological or medical benefit. Sequencing projects have traditionally used long (400-800 base pair) reads, but...
A Capillary Instrument for High Speed DNA-Based Tumor Diagnosis. (1998)
In order to test individuals for familial breast-cancer susceptibility, a fluidic 96-channel capillary DNA sequencing and analysis instrument is under development. The major subsystems of this...
A Capillary Instrument for High Speed DNA-Based Tumor Diagnosis (1998)
This project addresses the design and prototyping of a multiple-capillary (ultimately 96- channel) electrophoresis system that will be ideally suited for the rapid and inexpensive analysis of...
High-Throughput Array Instrument for DNA-Based Breast Cancer Diagnostics (1998)
The aim of this project is to develop improved methods for the production, processing, and analysis of microarrays (gene-chips) for breast-cancer diagnostics. These methods are based upon large...