Isolation of a Breast Cancer Tumor Suppressor Gene From Chromosome 3p (2001)
Loss of tumor suppressor genes (TSGs) represent critical molecular events in the development and progression of breast cancer. Based on loss of heterozygosity (LOH) studies as well as direct...
Isolation of a Breast Cancer Tumor Suppressor Gene from Chromosome 3p (2001)
Loss of tumor suppressor genes (TSGs) represent critical molecular events in the development and progression of breast cancer. Based on loss of heterozygosity (LOH) studies as well as direct...
Isolation of a Breast Cancer Tumor Suppressor Gene from Chromosome 3p (2001)
Loss of tumor suppressor genes (TSGs) represent critical molecular events in the development and progression of breast cancer. Based on loss of heterozygosity (LOH) studies as well as direct...
Isolation of a Breast Cancer Tumor Suppressor Gene from Chromosome 3p (2000)
Loss of tumor suppressor genes by genetic mechanisms represent critical molecular events in the development and progression of breast cancer. One or more of these tumor suppressor genes likely...
Wilke, Charles M., Guo, Sun-Wei, Hall, Bryan K., Boldog, Ferenc, Gemmill, Robert M., Chandrasekharappa, Settara C., ...
Human chromosome band 3p14 contains two tightly linked cytogenetic markers of broad interest, FRA3B and the t(3;8) breakpoint associated with hereditary renal cell carcinoma (RCC). The common fragile...
Tantravahi, Umadevi, Drabkin, Harry A., Stewart, Gordon D., McNeil, Gerard, Patterson, David, Roy, Sayon, ...
By merging two efficient technologies, bivariate flow sorting of human metaphase chromosomes and a recombination-based assay for sequence complexity, we isolated 28 cloned DNA segments homologous to...
Chromosomal location of human genes encoding major heat-shock protein HSP70 (1987)
Drabkin, Harry A., Chu, Ernest H. Y., Kao, Fa -Ten, Hartz, Judith, Harrison, Gail Singer, Hart, Iris M., ...
The HSP70 family of heat-shock proteins constitutes the major proteins synthesized in response to elevated temperatures and other forms of stress. In eukaryotes members of the HSP70 family also...
Altered HOX and WNT7A expression in human lung cancer
Calvo, Roser, West, James, Franklin, Wilbur, Erickson, Paul, Bemis, Lynne, Li, Efang, ...
HOX genes encode transcription factors that control patterning and cell fates. Alterations in HOX expression have been clearly implicated in leukemia, but their role in most other malignant diseases...
The hereditary renal cell carcinoma 3;8 translocation fuses FHIT to a patched-related gene, TRC8
Gemmill, Robert M., West, James D., Boldog, Ferenc, Tanaka, Naotake, Robinson, Linda J., Smith, David I., ...
The 3;8 chromosomal translocation, t(3;8)(p14.2;q24.1), was described in a family with classical features of hereditary renal cell carcinoma. Previous studies demonstrated that the 3p14.2 breakpoint...
WNT7a induces E-cadherin in lung cancer cells
Ohira, Tatsuo, Gemmill, Robert M., Ferguson, Kevin, Kusy, Sophie, Roche, Joëlle, Brambilla, Elisabeth, ...
E-cadherin loss in cancer is associated with de-differentiation, invasion, and metastasis. Drosophila DE-cadherin is regulated by Wnt/β-catenin signaling, although this has not been demonstrated in...
The Molecular Biology of Chromosome Alterations in Myelogenous Leukemia
In the past few years, new developments have rapidly emerged that promise to unravel the pathogenesis of malignant transformation. By understanding the molecular events in neoplastic transformation,...
Nasarre, Patrick, Kusy, Sophie, Constantin, Bruno, Castellani, Valérie, Drabkin, Harry A, Bagnard, Dominique, ...
Previously, we demonstrated that loss of SEMA3F, a secreted semaphorin encoded in 3p21.3, is associated with higher stages in lung cancer and primary tumor cells studied with anti-vascular...
Selective Suppression of In Vivo Tumorigenicity by Semaphorin SEMA3F in Lung Cancer Cells1
Kusy, Sophie, Nasarre, Patrick, Chan, Daniel, Potiron, Vincent, Meyronet, David, Gemmill, Robert M, ...
Loss of the 3p21.3-encoded semaphorins, SEMA3B and SEMA3F is implicated in lung cancer development. Although both antagonize VEGF binding/response to neuropilin (NRP) receptors, in lung cancer...
Semaphorin SEMA3F and VEGF Have Opposing Effects on Cell Attachment and Spreading
Nasarre, Patrick, Constantin, Bruno, Rouhaud, Lydie, Harnois, Thomas, Raymond, Guy, Drabkin, Harry A, ...
SEMA3F, isolated from a 3p21.3 deletion, has antitumor activity in transfected cells, and protein expression correlates with tumor stage and histology. In primary tumors, SEMA3F and VEGF surface...
Altered HOX and WNT7A expression in human lung cancer
Calvo, Roser, West, James, Franklin, Wilbur, Erickson, Paul, Bemis, Lynne, Li, Efang, ...
HOX genes encode transcription factors that control patterning and cell fates. Alterations in HOX expression have been clearly implicated in leukemia, but their role in most other malignant diseases...
The hereditary renal cell carcinoma 3;8 translocation fuses FHIT to a patched-related gene, TRC8
Gemmill, Robert M., West, James D., Boldog, Ferenc, Tanaka, Naotake, Robinson, Linda J., Smith, David I., ...
The 3;8 chromosomal translocation, t(3;8)(p14.2;q24.1), was described in a family with classical features of hereditary renal cell carcinoma. Previous studies demonstrated that the 3p14.2 breakpoint...
WNT7a induces E-cadherin in lung cancer cells
Ohira, Tatsuo, Gemmill, Robert M., Ferguson, Kevin, Kusy, Sophie, Roche, Joëlle, Brambilla, Elisabeth, ...
E-cadherin loss in cancer is associated with de-differentiation, invasion, and metastasis. Drosophila DE-cadherin is regulated by Wnt/β-catenin signaling, although this has not been demonstrated in...
The Molecular Biology of Chromosome Alterations in Myelogenous Leukemia
In the past few years, new developments have rapidly emerged that promise to unravel the pathogenesis of malignant transformation. By understanding the molecular events in neoplastic transformation,...
Nasarre, Patrick, Kusy, Sophie, Constantin, Bruno, Castellani, Valérie, Drabkin, Harry A, Bagnard, Dominique, ...
Previously, we demonstrated that loss of SEMA3F, a secreted semaphorin encoded in 3p21.3, is associated with higher stages in lung cancer and primary tumor cells studied with anti-vascular...
Selective Suppression of In Vivo Tumorigenicity by Semaphorin SEMA3F in Lung Cancer Cells1
Kusy, Sophie, Nasarre, Patrick, Chan, Daniel, Potiron, Vincent, Meyronet, David, Gemmill, Robert M, ...
Loss of the 3p21.3-encoded semaphorins, SEMA3B and SEMA3F is implicated in lung cancer development. Although both antagonize VEGF binding/response to neuropilin (NRP) receptors, in lung cancer...
Semaphorin SEMA3F and VEGF Have Opposing Effects on Cell Attachment and Spreading
Nasarre, Patrick, Constantin, Bruno, Rouhaud, Lydie, Harnois, Thomas, Raymond, Guy, Drabkin, Harry A, ...
SEMA3F, isolated from a 3p21.3 deletion, has antitumor activity in transfected cells, and protein expression correlates with tumor stage and histology. In primary tumors, SEMA3F and VEGF surface...