Harry B. Hines

Toe clipping of Anurans for mark-recapture studies: acceptable if justified. That’s what we said! (2008)

Phillott, Andrea D., Skerratt, Lee F., McDonald, Keith R., Lemckert, Frank L., Hines, Harry B., Clarke, John M., ...

Parris and McCarthy (2008) have over-simplified the arguments of Phillott et al. (2007) that toe-clipping is an acceptable method of marking anurans. We discussed six points in defending toe clipping...

Surveillance for batrachochytrium dendrobatidis using mixophyes (anura: myobatrachidae) larvae (2007)

Symonds, Emma P., Hines, Harry B., Bird, Philip S., Morton, John M., Mills, Paul C.

Fourteen populations of anuran larvae (tadpoles), including three populations of the endangered Fleay's Barred Frog (Mixophyes fleayi) and 11 populations of the common Great Barred Frog (Mixophyes...

Surveillance for batrachochytrium dendrobatidis using mixophyes (anura: myobatrachidae) larvae (2007)

Symonds, Emma P., Hines, Harry B., Bird, Philip S., Morton, John M., Mills, Paul C.

Fourteen populations of anuran larvae (tadpoles), including three populations of the endangered Fleay's Barred Frog (Mixophyes fleayi) and 11 populations of the common Great Barred Frog (Mixophyes...

(3H)-Saxitoxinol Metabolism and Elimination in the Rat (2006)

Hines, Harry B., Naseem, Syed M.

Tritiated saxitoxinol was used to obtain preliminary information on saxitoxin metabolism in the rat. Sublethal doses of tritiated saxitoxinol (18.9- micro Ci/kg; 3.8 micrograms/kg) were injected i.v....

Effects of Toxins on Arachidonic Acid Metabolism in Cultured Rat Pulmonary Alveolar Macrophages (2003)

Naseem, Syed M., Hines, Harry B., Creasia, Donald A.

The action of a trichothecene (T-2), microcystin-LR and saxitoxin on arachidonic acid metabolism in cultured rat alveolar macrophages was studied. Pulmonary macrophages exposed to 1 micromole T-2...

Inhibition of Microcystin-Induced Release of Cyclooxygenase Products from Rat Hepatocytes by Anti-Inflammatory Steriods (2003)

Naseem, Syed M., Hines, Harry B., Creasia, Donald A.

We showed previously that exposure to microcystin causes eicosanoid release from rat hepatocytes. That study was extended further to test the effect of glucocorticoids on microcystin-induced release...

Toxin-Induced Activation of Rat Hepatocyte Prostaglandin Synthesis and Phospholipid Metabolism. (1998)

Naseem, Syed M., Mereish, Kulthoum A., Solow, Rikki, Hines, Harry B.

The effects of microcystin-LR a trichothecene (T-2 toxin) and saxitoxin on membrane lipid mediators of inflammatory processes were evaluated in cultured rat hepatocytes. Microcystin-LR significantly...

Quorum Sensing: A transcriptional Regulatory System Involved in the Pathogenicity of Burkholderia mallei (1998)

Ulrich, Ricky L., DeShazer, David, Hines, Harry B., Jeddeloh, Jeffrey A.

Numerous gram-negative bacterial pathogens regulate virulence factor expression by using a cell density mechanism termed quorum sensing (QS). An in silico analysis of the Burkholderia mallei ATCC...

Quorum Sensing: A Transcriptional Regulatory System Involved in the Pathogenicity of Burkholderia mallei (1998)

Ulrich, Ricky L., DeShazer, David, Hines, Harry B., Jeddeloh, Jeffrey A.

Numerous gram-negative bacterial pathogens regulate virulence factor expression by using a cell density mechanism termed quorum sensing (QS). An in silico analysis of the Burkholderia mallei ATCC...

Characterization of Beta-leptinotarsin-h and the Effects of Calcium Flux Antagonists on its Activity (1998)

Crosland, Richard D., Fitch, Richard W., Hines, Harry B.

Beta-Leptinotarsin-h, purifed from the hemolymph of the beetle Leptinotarsa haldemani, is a potent neuroactive protein that stimulates Ca2+ influx and neurotransmitter release. Our goals were to...

Characterization of Botulinum Progenitor Toxins by Mass Spectrometry (1998)

Hines, Harry B., Lebeda, Frank, Hale, Martha, Brueggemann, Ernst E.

Botulinum toxin analysis has renewed importance. This study included the use of nanochromatography-nanoelectrospray-mass spectrometry/mass spectrometry to characterize the protein composition of...

Chytridiomycosis causes amphibian mortality associated with population declines in the rain forests of Australia and Central America

Berger, Lee, Speare, Rick, Daszak, Peter, Green, D. Earl, Cunningham, Andrew A., Goggin, C. Louise, ...

Epidermal changes caused by a chytridiomycete fungus (Chytridiomycota; Chytridiales) were found in sick and dead adult anurans collected from montane rain forests in Queensland (Australia) and Panama...

Mutational Analysis and Biochemical Characterization of the Burkholderia thailandensis DW503 Quorum-Sensing Network

Ulrich, Ricky L., Hines, Harry B., Parthasarathy, N., Jeddeloh, Jeffrey A.

Numerous gram-negative bacteria communicate and regulate gene expression through a cell density-responsive mechanism termed quorum sensing (QS), which involves the synthesis and perception of...

Quorum Sensing: a Transcriptional Regulatory System Involved in the Pathogenicity of Burkholderia mallei

Ulrich, Ricky L., DeShazer, David, Hines, Harry B., Jeddeloh, Jeffrey A.

Numerous gram-negative bacterial pathogens regulate virulence factor expression by using a cell density mechanism termed quorum sensing (QS). An in silico analysis of the Burkholderia mallei ATCC...

Characterization of Botulinum Progenitor Toxins by Mass Spectrometry†

Hines, Harry B., Lebeda, Frank, Hale, Martha, Brueggemann, Ernst E.

Botulinum toxin analysis has renewed importance. This study included the use of nanochromatography-nanoelectrospray-mass spectrometry/mass spectrometry to characterize the protein composition of...

Chytridiomycosis causes amphibian mortality associated with population declines in the rain forests of Australia and Central America

Berger, Lee, Speare, Rick, Daszak, Peter, Green, D. Earl, Cunningham, Andrew A., Goggin, C. Louise, ...

Epidermal changes caused by a chytridiomycete fungus (Chytridiomycota; Chytridiales) were found in sick and dead adult anurans collected from montane rain forests in Queensland (Australia) and Panama...

Mutational Analysis and Biochemical Characterization of the Burkholderia thailandensis DW503 Quorum-Sensing Network

Ulrich, Ricky L., Hines, Harry B., Parthasarathy, N., Jeddeloh, Jeffrey A.

Numerous gram-negative bacteria communicate and regulate gene expression through a cell density-responsive mechanism termed quorum sensing (QS), which involves the synthesis and perception of...

Quorum Sensing: a Transcriptional Regulatory System Involved in the Pathogenicity of Burkholderia mallei

Ulrich, Ricky L., DeShazer, David, Hines, Harry B., Jeddeloh, Jeffrey A.

Numerous gram-negative bacterial pathogens regulate virulence factor expression by using a cell density mechanism termed quorum sensing (QS). An in silico analysis of the Burkholderia mallei ATCC...

Characterization of Botulinum Progenitor Toxins by Mass Spectrometry†

Hines, Harry B., Lebeda, Frank, Hale, Martha, Brueggemann, Ernst E.

Botulinum toxin analysis has renewed importance. This study included the use of nanochromatography-nanoelectrospray-mass spectrometry/mass spectrometry to characterize the protein composition of...

Use of a Recombinant Fluorescent Substrate with Cleavage Sites for All Botulinum Neurotoxins in High-Throughput Screening of Natural Product Extracts for Inhibitors of Serotypes A, B, and E▿ †

Hines, Harry B., Kim, Alexander D., Stafford, Robert G., Badie, Shirin S., Brueggeman, Ernst E., Newman, David J., ...

The seven serotypes of botulinum neurotoxin (BoNTs) are zinc metalloproteases that cleave and inactivate proteins critical for neurotransmission. The synaptosomal protein of 25 kDa (SNAP-25) is...

In Vitro Intracellular Trafficking of Virulence Antigen during Infection by Yersinia pestis

DiMezzo, Tracy L., Ruthel, Gordon, Brueggemann, Ernst E., Hines, Harry B., Ribot, Wilson J., Chapman, Carol E., ...

Yersinia pestis, the causative agent of plague, encodes several essential virulence factors on a 70 kb plasmid, including the Yersinia outer proteins (Yops) and a multifunctional virulence antigen...