Román-Trufero, Mónica, Méndez-Gómez, Héctor R., Pérez, Claudia, Hijikata, Atsushi, Fujimura, Yu-ichi, Endo, Takaho, ...
12 pages, 7 figures.-- PMID: 19544461 [PubMed].-- Printed version published Jul 2009.
The FASEB Journal FJ Express Full-Length Article (2008)
Manabu Nakayama, Midori Iida, Haruhiko Koseki, Osamu Ohara
A gene-targeting approach for functional characterization of KIAA genes encoding extremely large proteins
Kim, Sei-Eun, Tsubaki, Yao, Mitsuhashi, Shinya, Nomura, Miyuki, ...
Pre-mRNA splicing entails reversible phosphorylation of spliceosomal proteins. Recent work has revealed essential roles for Ser/Thr phosphatases, such as protein phosphatase-1 (PP1), in splicing, but...
Hong, Zehui, Jiang, Jie, Lan, Li, Nakajima, Satoshi, Kanno, Shin-ichiro, Koseki, Haruhiko, ...
DNA double-strand breaks (DSBs) represent the most toxic DNA damage arisen from endogenous and exogenous genotoxic stresses and are known to be repaired by either homologous recombination or...
Hijikata, Atsushi, Kitamura, Hiroshi, Kimura, Yayoi, Yokoyama, Ryo, Aiba, Yuichi, Bao, Yanyuan, ...
Motivation: Although a huge amount of mammalian genomic data does become publicly available, there are still hurdles for biologists to overcome before such data can be fully exploited. One of the...
Dynamic Reprogramming of DNA Methylation at an Epigenetically Sensitive Allele in Mice (2006)
Marnie E. Blewitt, Nicola K. Vickaryous, Andras Paldi, Haruhiko Koseki, Emma Whitelaw
There is increasing evidence in both plants and animals that epigenetic marks are not always cleared between generations. Incomplete erasure at genes associated with a measurable phenotype results in...
Isono, Kyoichi, Mizutani-Koseki, Yoko, Komori, Toshihisa, Schmidt-Zachmann, Marion S., Koseki, Haruhiko
Polycomb group (PcG) proteins are responsible for the stable repression of homeotic (Hox) genes by forming multimeric protein complexes. We show (1) physical interaction between components of the U2...
Okazaki, Noriko, F-Kikuno, Reiko, Ohara, Reiko, Inamoto, Susumu, Koseki, Haruhiko, Hiraoka, Shuichi, ...
We have been conducting a mouse cDNA project to predict protein-coding sequences of mouse homologues of human KIAA and FLJ genes since 2001. As an extension of these projects, we herein present the...
Expression of recombination-activating gene in mature peripheral T cells in Peyer's patch (2003)
Kondo, Eisuke, Wakao, Hiroshi, Koseki, Haruhiko, Takemori, Toshitada, Kojo, Satoshi, Harada, Michishige, ...
Recombination‐activating gene (RAG) 1 and 2 are essential for the gene rearrangement of antigen receptors of both T and B cells. To investigate RAG gene expression in peripheral lymphoid organs...
Growth retardation and skin abnormalities of the Recql4-deficient mouse (2003)
Hoki, Yuko, Araki, Ryoko, Fujimori, Akira, Ohhata, Tatsuya, Koseki, Haruhiko, Fukumura, Ryutaro, ...
Mutations in the Recql4 gene are very likely responsible for a subset of Rothmund-Thomson syndrome (RTS) cases, but until now there has been no animal model to confirm this. Knockout mice in which...
Growth retardation and skin abnormalities of the Recql4-deficient mouse (2003)
Hoki, Yuko, Araki, Ryoko, Fujimori, Akira, Ohhata, Tatsuya, Koseki, Haruhiko, Fukumura, Ryutaro, ...
Mutations in the Recql4 gene are very likely responsible for a subset of Rothmund–Thomson syndrome (RTS) cases, but until now there has been no animal model to confirm this. Knockout mice in which...
CD69-null mice protected from arthritis induced with anti-type II collagen antibodies (2003)
Murata, Kaoru, Inami, Masamichi, Hasegawa, Akihiro, Kubo, Shuichi, Kimura, Motoko, Yamashita, Masakatsu, ...
CD69, known as an early activation marker antigen on T and B cells, is also expressed on platelets and activated neutrophils, suggesting certain roles in inflammatory diseases. In order to address...
Okazaki, Noriko, Kikuno, Reiko, Ohara, Reiko, Inamoto, Susumu, Koseki, Haruhiko, Hiraoka, Shuichi, ...
We have conducted a human cDNA project to predict protein-coding sequences (CDSs) in large cDNAs (> 4 kb) since 1994, and the number of newly identified genes, known as KIAA genes, already exceeds...
Growth retardation and skin abnormalities of the Recql4-deficient mouse (2003)
Hoki, Yuko, Araki, Ryoko, Fujimori, Akira, Ohhata, Tatsuya, Koseki, Haruhiko, Fukumura, Ryutaro, ...
Mutations in the Recql4 gene are very likely responsible for a subset of Rothmund-Thomson syndrome (RTS) cases, but until now there has been no animal model to confirm this. Knockout mice in which...
Ohara, Osamu, Nagase, Takahiro, Mitsui, Gaku, Kohga, Hiroshi, Kikuno, Reiko, Hiraoka, Shuichi, ...
We here modified a previously reported method for the construction of cDNA libraries by employing an in vitro recombination reaction to make it more suitable for comprehensive cDNA analysis. For the...
Hiraoka, Shuichi, Furumoto, Yasuko, Koseki, Haruhiko, Takagaki, Yohtaro, Taniguchi, Masaru, Okumura, Ko, ...
The high-affinity IgE receptor (FcεRI) and the low-affinity IgG receptor (FcγRIII) on mast cells are the key molecules involved in triggering the allergic reaction. These receptors share the...
The role of Bcl6 in mature cardiac myocytes (1999)
Yoshida, Takehiko, Fukuda, Tetsuya, Hatano, Masahiko, Koseki, Haruhiko, Okabe, Shin-ichiro, Ishibashi, Kazuki, ...
Objective: The Bcl6 gene encodes a sequence-specific transcriptional repressor and is ubiquitously expressed in adult murine tissues including heart muscle. The objective of this study was to examine...
TCR repertoire in early fetal mouse thymus (1995)
Ohki-Hamazaki, Hiroko, Makino, Yasuhiko, Kanno, Masamoto, Koseki, Haruhiko, Akasaka, Takeshi, Taniguchi, Masaru, ...
We investigated the rearrangement and expression of TCR genes in mouse fetal thymus organ culture, a system that avoids subsequent entry of hematopoietic precursor cells. The first observable...
Inaba, Tsuneyoshi, Koseki, Haruhiko, Suzuki, Masahiko, Taniguchi, Masaru
We have developed a sensitive and rapid method for detection and cloning of cDNA amplified by double-step and inverse polymerase chain reaction (PCR) techniques. The blunt-ended double-strand cDNA...
Ito, Toshihiro, Ishibashi, Kaname, Imai, Kenji, Koseki, Haruhiko, Ra, Chisei, Fernandez, Edgar, ...
A monoclonal antibody against V14+ α-chain of murine T cell receptor (TCR) was established by fusing spleen cells from a rat immunized with a soluble chimeric TCR/lgG3 protein containing...
Autoreactive T-cell clones which suppress cytotoxic T cell responses (1991)
Sakatsume, Minoru, Harada, Yoshitada, Ling, Xhang, Yasumoto, Akihiko, Kurosu, Akihiro, Koseki, Haruhiko, ...
Autoreactive T-cell clones (Thy 1+ , CD4 + , CD3+) which suppress generation of cytotoxic T lymphocytes (CTL) were established in long-term in vitro culture by stimulation with...
Koseki, Haruhiko, Imal, Kenji, Ichikawa, Tomohiko, Hayata, Isamu, Taniguchi, Masaru, Davis, M M
We isolated and sequenced the rearranged genomic variable (V) and joining (J) gene segments of T cell receptor α-chain gene from two independent keyhole limpet hemocyanin (KLH)-specific suppressor T...
Mouse model of Prinzmetal angina by disruption of the inward rectifier Kir6.1
三木, 隆司, ミキ, タカシ, Miki, Takashi, Suzuki, Masashi, 柴崎, 忠雄, シバサキ, タダオ, ...
The inwardly rectifying K+ channel Kir6.1 forms K+ channels by coupling with a sulfonylurea receptor in reconstituted systems, but the physiological roles of Kir6.1-containing K+ channels have not...
Mouse model of Prinzmetal angina by disruption of the inward rectifier Kir6.1
Miki, Takashi, Suzuki, Masashi, 柴崎, 忠雄, Shibasaki, Tadao, 佐藤, 俊明, Sato, Toshiaki, ...
Mouse model of Prinzmetal angina by disruption of the inward rectifier Kir6.1
三木, 隆司, ミキ, タカシ, Miki, Takashi, Suzuki, Masashi, 柴崎, 忠雄, シバサキ, タダオ, ...
The inwardly rectifying K+ channel Kir6.1 forms K+ channels by coupling with a sulfonylurea receptor in reconstituted systems, but the physiological roles of Kir6.1-containing K+ channels have not...
Mouse model of Prinzmetal angina by disruption of the inward rectifier Kir6.1
三木, 隆司, ミキ, タカシ, Miki, Takashi, Suzuki, Masashi, 柴崎, 忠雄, シバサキ, タダオ, ...
The inwardly rectifying K+ channel Kir6.1 forms K+ channels by coupling with a sulfonylurea receptor in reconstituted systems, but the physiological roles of Kir6.1-containing K+ channels have not...
Mouse model of Prinzmetal angina by disruption of the inward rectifier Kir6.1
Miki, Takashi, Suzuki, Masashi, 柴崎, 忠雄, Shibasaki, Tadao, 佐藤, 俊明, Sato, Toshiaki, ...
Involvement of decidual Vα14 NKT cells in abortion
Ito, Katsura, Karasawa, Mika, Kawano, Tetsu, Akasaka, Takeshi, Koseki, Haruhiko, Akutsu, Yasunori, ...
The immunological mechanisms that regulate abortion are largely unknown. Here, we found that a distinct subset of lymphocytes, Vα14 NKT cells expressing an invariant antigen receptor encoded by...
Kawano, Tetsu, Cui, Junqing, Koezuka, Yasuhiko, Toura, Isao, Kaneko, Yoshikatsu, Sato, Hiroshi, ...
We have recently identified α-galactosylceramide (α-GalCer) as a specific ligand for an invariant Vα14/Vβ8.2 T cell receptor exclusively expressed on the majority of Vα14 NKT cells, a novel...
Targeted disruption of Traf5 gene causes defects in CD40- and CD27-mediated lymphocyte activation
Nakano, Hiroyasu, Sakon, Sachiko, Koseki, Haruhiko, Takemori, Toshitada, Tada, Kurisu, Matsumoto, Mitsuru, ...
TRAF5 [tumor necrosis factor (TNF) receptor-associated factor 5] is implicated in NF-κB and c-Jun NH2-terminal kinase/stress-activated protein kinase activation by members of the TNF receptor...
Yamamoto, Katsushi, Fujii, Rika, Toyofuku, Yukiko, Saito, Takashi, Koseki, Haruhiko, Hsu, Victor W., ...
Newly synthesized proteins in the endoplasmic reticulum (ER) must fold and assemble correctly before being transported to their final cellular destination. While some misfolded or partially assembled...
Randomly inserted and targeted Hox/reporter fusions transcriptionally silenced in Polycomb mutants
De Graaff, Wim, Tomotsune, Daihachiro, Oosterveen, Tony, Takihara, Yoshihiro, Koseki, Haruhiko, Deschamps, Jacqueline
Polycomb-group (Pc-G) proteins ensure late maintenance of transcriptional repression outside the expression domain of target genes in flies and vertebrates. They act in complexes, presumably by...
Noc2 is essential in normal regulation of exocytosis in endocrine and exocrine cells
Matsumoto, Masanari, Miki, Takashi, Shibasaki, Tadao, Kawaguchi, Miho, Shinozaki, Hidehiro, Nio, Junko, ...
Rab3 is a subfamily of the small GTP-binding protein Rab family and plays an important role in exocytosis. Several potential effectors of Rab3, including rabphilin3 and Rims (Rim1 and Rim2), have...
Masuda, Keiji, Ouchida, Rika, Takeuchi, Arata, Saito, Takashi, Koseki, Haruhiko, Kawamura, Kiyoko, ...
Somatic hypermutation of Ig variable region genes is initiated by activation-induced cytidine deaminase; however, the activity of multiple DNA polymerases is required to ultimately introduce...
Hamada, Hiromichi, Suzuki, Masashi, Yuasa, Shigeki, Mimura, Naoya, Shinozuka, Norihiro, Takada, Yuki, ...
Aberrant protein folding beyond the capacity of endoplasmic reticulum (ER) quality control leads to stress response in the ER. The Lys-Asp-Glu-Leu (KDEL) receptor, a retrieval receptor for ER...
Isono, Kyo-ichi, Fujimura, Yu-ichi, Shinga, Jun, Yamaki, Makoto, O-Wang, Jiyang, Takihara, Yoshihiro, ...
The Polycomb group (PcG) gene products form multimeric protein complexes and contribute to anterior-posterior (A-P) specification via the transcriptional regulation of Hox cluster genes. The...
Isono, Kyoichi, Nemoto, Kazumi, Li, Yuanyuan, Takada, Yuki, Suzuki, Rie, Katsuki, Motoya, ...
Homeodomain-interacting protein kinase 1 (Hipk1), 2, and 3 genes encode evolutionarily conserved nuclear serine/threonine kinases, which were originally identified as interacting with...
Isono, Kyoichi, Mizutani-Koseki, Yoko, Komori, Toshihisa, Schmidt-Zachmann, Marion S., Koseki, Haruhiko
Polycomb group (PcG) proteins are responsible for the stable repression of homeotic (Hox) genes by forming multimeric protein complexes. We show (1) physical interaction between components of the U2...
Dynamic Reprogramming of DNA Methylation at an Epigenetically Sensitive Allele in Mice
Blewitt, Marnie E, Vickaryous, Nicola K, Paldi, Andras, Koseki, Haruhiko, Whitelaw, Emma
There is increasing evidence in both plants and animals that epigenetic marks are not always cleared between generations. Incomplete erasure at genes associated with a measurable phenotype results in...
Involvement of decidual Vα14 NKT cells in abortion
Ito, Katsura, Karasawa, Mika, Kawano, Tetsu, Akasaka, Takeshi, Koseki, Haruhiko, Akutsu, Yasunori, ...
The immunological mechanisms that regulate abortion are largely unknown. Here, we found that a distinct subset of lymphocytes, Vα14 NKT cells expressing an invariant antigen receptor encoded by...
Kawano, Tetsu, Cui, Junqing, Koezuka, Yasuhiko, Toura, Isao, Kaneko, Yoshikatsu, Sato, Hiroshi, ...
We have recently identified α-galactosylceramide (α-GalCer) as a specific ligand for an invariant Vα14/Vβ8.2 T cell receptor exclusively expressed on the majority of Vα14 NKT cells, a novel...
Targeted disruption of Traf5 gene causes defects in CD40- and CD27-mediated lymphocyte activation
Nakano, Hiroyasu, Sakon, Sachiko, Koseki, Haruhiko, Takemori, Toshitada, Tada, Kurisu, Matsumoto, Mitsuru, ...
TRAF5 [tumor necrosis factor (TNF) receptor-associated factor 5] is implicated in NF-κB and c-Jun NH2-terminal kinase/stress-activated protein kinase activation by members of the TNF receptor...
Yamamoto, Katsushi, Fujii, Rika, Toyofuku, Yukiko, Saito, Takashi, Koseki, Haruhiko, Hsu, Victor W., ...
Newly synthesized proteins in the endoplasmic reticulum (ER) must fold and assemble correctly before being transported to their final cellular destination. While some misfolded or partially assembled...
Randomly inserted and targeted Hox/reporter fusions transcriptionally silenced in Polycomb mutants
De Graaff, Wim, Tomotsune, Daihachiro, Oosterveen, Tony, Takihara, Yoshihiro, Koseki, Haruhiko, Deschamps, Jacqueline
Polycomb-group (Pc-G) proteins ensure late maintenance of transcriptional repression outside the expression domain of target genes in flies and vertebrates. They act in complexes, presumably by...
Noc2 is essential in normal regulation of exocytosis in endocrine and exocrine cells
Matsumoto, Masanari, Miki, Takashi, Shibasaki, Tadao, Kawaguchi, Miho, Shinozaki, Hidehiro, Nio, Junko, ...
Rab3 is a subfamily of the small GTP-binding protein Rab family and plays an important role in exocytosis. Several potential effectors of Rab3, including rabphilin3 and Rims (Rim1 and Rim2), have...
Hamada, Hiromichi, Suzuki, Masashi, Yuasa, Shigeki, Mimura, Naoya, Shinozuka, Norihiro, Takada, Yuki, ...
Aberrant protein folding beyond the capacity of endoplasmic reticulum (ER) quality control leads to stress response in the ER. The Lys-Asp-Glu-Leu (KDEL) receptor, a retrieval receptor for ER...
Isono, Kyoichi, Mizutani-Koseki, Yoko, Komori, Toshihisa, Schmidt-Zachmann, Marion S., Koseki, Haruhiko
Polycomb group (PcG) proteins are responsible for the stable repression of homeotic (Hox) genes by forming multimeric protein complexes. We show (1) physical interaction between components of the U2...
Isono, Kyo-ichi, Fujimura, Yu-ichi, Shinga, Jun, Yamaki, Makoto, O-Wang, Jiyang, Takihara, Yoshihiro, ...
The Polycomb group (PcG) gene products form multimeric protein complexes and contribute to anterior-posterior (A-P) specification via the transcriptional regulation of Hox cluster genes. The...
Masuda, Keiji, Ouchida, Rika, Takeuchi, Arata, Saito, Takashi, Koseki, Haruhiko, Kawamura, Kiyoko, ...
Somatic hypermutation of Ig variable region genes is initiated by activation-induced cytidine deaminase; however, the activity of multiple DNA polymerases is required to ultimately introduce...
Dynamic Reprogramming of DNA Methylation at an Epigenetically Sensitive Allele in Mice
Blewitt, Marnie E, Vickaryous, Nicola K, Paldi, Andras, Koseki, Haruhiko, Whitelaw, Emma
There is increasing evidence in both plants and animals that epigenetic marks are not always cleared between generations. Incomplete erasure at genes associated with a measurable phenotype results in...
Isono, Kyoichi, Nemoto, Kazumi, Li, Yuanyuan, Takada, Yuki, Suzuki, Rie, Katsuki, Motoya, ...
Homeodomain-interacting protein kinase 1 (Hipk1), 2, and 3 genes encode evolutionarily conserved nuclear serine/threonine kinases, which were originally identified as interacting with...
Mouse model of Prinzmetal angina by disruption of the inward rectifier Kir6.1
Miki, Takashi, Suzuki, Masashi, 柴崎, 忠雄, Shibasaki, Tadao, 佐藤, 俊明, Sato, Toshiaki, ...
ほ乳類ポリコーム遺伝子Mel-18に相互作用するRing 1 B遺伝子欠損マウスの作製
横田, 剛, 丹沢, 秀樹, タンザワ, ヒデキ, Tanzawa, Hideki, 赤坂, 武, 古関, 明彦, ...
Mel-18結合タンパクMph-2の全長cDNAのクローニングと構造解析
山木, 誠, 丹沢, 秀樹, タンザワ, ヒデキ, Tanzawa, Hideki, 古関, 明彦, コセキ, ハルヒコ, ...
41. Mel-18結合タンパクMph-2の全長cDNAのクローニングと構造解析(第1009回千葉医学会例会・第21回歯科口腔外科例会)
山木, 誠, 丹沢, 秀樹, タンザワ, ヒデキ, Tanzawa, Hideki, 古関, 明彦, コセキ, ハルヒコ, ...
ほ乳類ポリコーム遺伝子Mel-18に相互作用するRing 1 B遺伝子欠損マウスの作製
横田, 剛, 丹沢, 秀樹, タンザワ, ヒデキ, Tanzawa, Hideki, 赤坂, 武, 古関, 明彦, ...
Mel-18結合タンパクMph-2の全長cDNAのクローニングと構造解析
山木, 誠, 丹沢, 秀樹, タンザワ, ヒデキ, Tanzawa, Hideki, 古関, 明彦, コセキ, ハルヒコ, ...
41. Mel-18結合タンパクMph-2の全長cDNAのクローニングと構造解析(第1009回千葉医学会例会・第21回歯科口腔外科例会)
山木, 誠, 丹沢, 秀樹, タンザワ, ヒデキ, Tanzawa, Hideki, 古関, 明彦, コセキ, ハルヒコ, ...
Ishigami, Akihito, Fujita, Toshiko, Handa, Setsuko, Shirasawa, Takuji, Koseki, Haruhiko, Kitamura, Tsuneo, ...
Senescence marker protein-30 (SMP30) is a calcium-binding protein that decreases in an androgen-independent manner with aging. To elucidate the physiological role of this protein, we introduced a...
Recruitment of PRC1 function at the initiation of X inactivation independent of PRC2 and silencing
Schoeftner, Stefan, Sengupta, Aditya K, Kubicek, Stefan, Mechtler, Karl, Spahn, Laura, Koseki, Haruhiko, ...
In mammals X inactivation is initiated by expression of Xist RNA and involves the recruitment of Polycomb repressive complex 1 (PRC1) and 2 (PRC2), which mediate chromosome-wide ubiquitination of...
Aikawa, Yukiko, Nguyen, Lan Anh, Isono, Kyoichi, Takakura, Nobuyuki, Tagata, Yusuke, Schmitz, M Lienhard, ...
Histone acetyltransferases (HATs) p300 and CREB-binding protein (CBP) function as co-activators for a variety of sequence-specific transcription factors, including AML1. Here, we report that...
Novel regulation of MHC class II function in B cells
Matsuki, Yohei, Ohmura-Hoshino, Mari, Goto, Eiji, Aoki, Masami, Mito-Yoshida, Mari, Uematsu, Mika, ...
The presence of post-translational regulation of MHC class II (MHC II) under physiological conditions has been demonstrated recently in dendritic cells (DCs) that potently function as...
Bone Marrow Allograft Rejection Mediated by a Novel Murine NK Receptor, NKG2I
Koike, Junzo, Wakao, Hiroshi, Ishizuka, Yuko, Sato, Taka-aki, Hamaoki, Masaru, Seino, Ken-ichiro, ...
Natural killer (NK) cells mediate bone marrow allograft rejection. However, the molecular mechanisms underlying such a rejection remain elusive. In previous analyses, it has been shown that NK cells...
Koike, Junzo, Wakao, Hiroshi, Ishizuka, Yuko, Sato, Taka-aki, Hamaoki, Masaru, Seino, Ken-ichiro, ...
In vivo costimulatory role of B7-DC in tuning T helper cell 1 and cytotoxic T lymphocyte responses
Shin, Tahiro, Yoshimura, Kiyoshi, Shin, Takako, Crafton, Emily B., Tsuchiya, Haruo, Housseau, Franck, ...
B7-DC, one of the recently described B7 family members, has the capacity to inhibit T cell responses via engagement of the immunoreceptor tyrosine-based inhibitory motif–containing inhibitory PD-1...
Dietrich, Nikolaj, Bracken, Adrian P, Trinh, Emmanuelle, Schjerling, Charlotte K, Koseki, Haruhiko, Rappsilber, Juri, ...
The Polycomb group (PcG) proteins are essential for embryogenesis, and their expression is often found deregulated in human cancer. The PcGs form two major protein complexes, called polycomb...
Shin, Tahiro, Kennedy, Gene, Gorski, Kevin, Tsuchiya, Haruo, Koseki, Haruhiko, Azuma, Miyuki, ...
B7-DC is a recently discovered member of the B7 family that binds to PD-1 and is selectively expressed by dendritic cells (DCs). It has been shown to either costimulate or inhibit T cell responses....
Cui, Junqing, Watanabe, Naohiro, Kawano, Tetsu, Yamashita, Masakatsu, Kamata, Tohru, Shimizu, Chiori, ...
Murine Vα14 natural killer T (NKT) cells are thought to play a crucial role in various immune responses, including infectious, allergic, and autoimmune diseases. Because Vα14 NKT cells produce...
Disruption of the Bcl6 Gene Results in an Impaired Germinal Center Formation
Fukuda, Tetsuya, Yoshida, Takehiko, Okada, Seiji, Hatano, Masahiko, Miki, Tohru, Ishibashi, Kazuki, ...
The Bcl6 gene has been identified from the chromosomal translocation breakpoint in B cell lymphomas, and its products are expressed highly in germinal center (GC) B cells. To investigate the function...
Mimura, Naoya, Yuasa, Shigeki, Soma, Miho, Jin, Hisayo, Kimura, Keita, Goto, Shigemasa, ...
Binding immunoglobulin protein (BiP) is an endoplasmic reticulum (ER) molecular chaperone that is central to ER function. We examined knock-in mice expressing a mutant BiP in order to elucidate...
Hong, Zehui, Jiang, Jie, Lan, Li, Nakajima, Satoshi, Kanno, Shin-ichiro, Koseki, Haruhiko, ...
DNA double-strand breaks (DSBs) represent the most toxic DNA damage arisen from endogenous and exogenous genotoxic stresses and are known to be repaired by either homologous recombination or...
Calés, Carmela, Román-Trufero, Mónica, Pavón, Leticia, Serrano, Iván, Melgar, Teresa, Endoh, Mitsuhiro, ...
Polycomb group (PcG) proteins act as positive regulators of cell proliferation. Ring1B is a PcG gene essential for embryonic development, but its contribution to cell turnover in regenerating tissues...
Genomewide Analysis of PRC1 and PRC2 Occupancy Identifies Two Classes of Bivalent Domains
Ku, Manching, Koche, Richard P., Rheinbay, Esther, Mendenhall, Eric M., Endoh, Mitsuhiro, Mikkelsen, Tarjei S., ...
In embryonic stem (ES) cells, bivalent chromatin domains with overlapping repressive (H3 lysine 27 tri-methylation) and activating (H3 lysine 4 tri-methylation) histone modifications mark the...