A reassessment of methylcholanthrene transformation in the C3H10T1/2 cell culture system (1990)
Chen, Anne C., Brankow, David W., Herschman, Harvey R.
We previously demonstrated that four tumorigenic methylcholanthrene (MCA) transformed cell lines derived from C3H10T1/2 cells each contain a common G34 – T nucleotide alteration in the c-Ki-ras...
Metal-dependent binding of a nuclear factor to the rat metallothionein-I promoter (1990)
Andersen, Robert D., Taplitz, Susan J., Oberbauer, Anita M., Calame, Kathryn L., Herschman, Harvey R.
Genomic footprintlng studies in vivo and experiments using synthetic metal regulatory elements (MREs) in vitro suggest protein binding to the MREs of the mouse and rat metallothionein I (MT-I) genes....
Herschman, Harvey R., Lim, Robert W., Brankow, David W., Fujiki, Hirota
Okadaic acid (OA) and 12-O-tetradecanoylphorbol-13-acetate (TPA) are both potent tumor promoters in a mouse skin carcinogenesis experiment. OA was much more toxic than TPA for murine embryo cell...
A continuum of transformed phenotypes in C3H/10T1/2 derivatives (1988)
Chen, Anne C., Herschman, Harvey R.
Two-stage transformants have been isolated from C3H/10T1/2 cells exposed to UV-irradiation followed by treatment with TPA. These UV-TDTx cells form foci in co-culture with C3H/10T1/2...
Herschman, Harvey R., Brankow, David W.
UV-TDTx cells are cloned from foci arising after C3H10T1/2 cells are sequentially exposed to u.v. irradiation followed by tetradecanoylphorbol acetate (TPA). When grown in pure culture, UV-TDTx...
Regulation of the rat metallothionein-I gene by sodium butyrate (1986)
Birren, Bruce W., Herschman, Harvey R.
Sodium butyrate selectively induces accumulation of metallothionein-I (MT-I) RNA in H4IIE rat hepatoma cells. The induction 1s rapid; significant elevation in cytoplasnric MT-I RNA can be observed...
Teleocidin and 12-O-tetradecanoylphorbol-acetate (TPA), two potent tumor promoters, are also excellent mitogens for 3T3 cells. I now demonstrate that teleocidin is unable stimulate mitogenesis in TPA...
Campbell, Robert J., Wilson, Linda G. M., Herschman, Harvey R., DiCara, Leo V., Stone, Eric A.
Peer Reviewed
Gambhir, Sanjiv S., Bauer, Eileen, Black, Margaret E., Liang, Qianwa, Kokoris, Mark S., Barrio, Jorge R., ...
We are developing assays for noninvasive, quantitative imaging of reporter genes with positron emission tomography (PET), for application both in animal models and in human gene therapy. We report...
Functional and Biochemical Analysis of the C2 Domains of Synaptotagmin IV
Thomas, David M., Ferguson, Gregory D., Herschman, Harvey R., Elferink, Lisa A.
Synaptotagmins (Syts) are a family of vesicle proteins that have been implicated in both regulated neurosecretion and general membrane trafficking. Calcium-dependent interactions mediated through...
Deficits in memory and motor performance in synaptotagmin IV mutant mice
Ferguson, Gregory D., Anagnostaras, Stephan G., Silva, Alcino J., Herschman, Harvey R.
Synaptotagmin (Syt) IV is a synaptic vesicle protein. Syt IV expression is induced in the rat hippocampus after systemic kainic acid treatment. To examine the functional role of this protein in vivo,...
Gambhir, Sanjiv S., Barrio, Jorge R., Phelps, Michael E., Iyer, Meera, Namavari, Mohammad, Satyamurthy, Nagichettiar, ...
We are developing quantitative assays to repeatedly and noninvasively image expression of reporter genes in living animals, using positron emission tomography (PET). We synthesized positron-emitting...
Comparative Study of the Events Associated with Colicin Induction
Herschman, Harvey R., Helinski, Donald R.
Colicinogenic factors ColI and ColV, which have been shown to behave as sex factors, could not be induced with mitomycin C. In contrast, the ColE1, ColE2, and ColE3 factors, which do not exhibit any...
Effect of Rec− Mutations on the Activity of Colicinogenic Factors
Helinski, Donald R., Herschman, Harvey R.
The effect of two Rec− mutations (AB2463 and JC1553) on the ability of a cell to accept, maintain, and express the colicinogenic factors ColE1, ColE2, and ColV was examined in Escherichia coli....
Modulation of Cell-Surface Antigens of a Murine Neuroblastoma
Akeson, Richard, Herschman, Harvey R.
Antisera were produced in rabbits to morphologically differentiated cells from the C1300 murine neuroblastoma (i.e., cells in which process formation was induced by maintenance on serum-free medium...
Gambhir, Sanjiv S., Bauer, Eileen, Black, Margaret E., Liang, Qianwa, Kokoris, Mark S., Barrio, Jorge R., ...
We are developing assays for noninvasive, quantitative imaging of reporter genes with positron emission tomography (PET), for application both in animal models and in human gene therapy. We report...
Functional and Biochemical Analysis of the C2 Domains of Synaptotagmin IV
Thomas, David M., Ferguson, Gregory D., Herschman, Harvey R., Elferink, Lisa A.
Synaptotagmins (Syts) are a family of vesicle proteins that have been implicated in both regulated neurosecretion and general membrane trafficking. Calcium-dependent interactions mediated through...
Deficits in memory and motor performance in synaptotagmin IV mutant mice
Ferguson, Gregory D., Anagnostaras, Stephan G., Silva, Alcino J., Herschman, Harvey R.
Synaptotagmin (Syt) IV is a synaptic vesicle protein. Syt IV expression is induced in the rat hippocampus after systemic kainic acid treatment. To examine the functional role of this protein in vivo,...
Gambhir, Sanjiv S., Barrio, Jorge R., Phelps, Michael E., Iyer, Meera, Namavari, Mohammad, Satyamurthy, Nagichettiar, ...
We are developing quantitative assays to repeatedly and noninvasively image expression of reporter genes in living animals, using positron emission tomography (PET). We synthesized positron-emitting...
Comparative Study of the Events Associated with Colicin Induction
Herschman, Harvey R., Helinski, Donald R.
Colicinogenic factors ColI and ColV, which have been shown to behave as sex factors, could not be induced with mitomycin C. In contrast, the ColE1, ColE2, and ColE3 factors, which do not exhibit any...
Effect of Rec− Mutations on the Activity of Colicinogenic Factors
Helinski, Donald R., Herschman, Harvey R.
The effect of two Rec− mutations (AB2463 and JC1553) on the ability of a cell to accept, maintain, and express the colicinogenic factors ColE1, ColE2, and ColV was examined in Escherichia coli....
Modulation of Cell-Surface Antigens of a Murine Neuroblastoma
Akeson, Richard, Herschman, Harvey R.
Antisera were produced in rabbits to morphologically differentiated cells from the C1300 murine neuroblastoma (i.e., cells in which process formation was induced by maintenance on serum-free medium...
Noninvasive prediction of tumor responses to gemcitabine using positron emission tomography
Laing, Rachel E., Walter, Martin A., Campbell, Dean O., Herschman, Harvey R., Satyamurthy, Nagichettiar, Phelps, Michael E., ...
Gemcitabine (2′,2′-difluorodeoxycytidine, dFdC) and cytosine arabinoside (cytarabine, ara-C) represent a class of nucleoside analogs used in cancer chemotherapy. Administered as prodrugs, dFdC...