Hasmik Keshishian

Quantitative, Multiplexed Assays for Low Abundance Proteins in Plasma by Targeted Mass Spectrometry and Stable Isotope Dilution * □S (2008)

Hasmik Keshishian, Terri Addona, Michael Burgess, Eric Kuhn, Steven A. Carr

Biomarker discovery produces lists of candidate markers whose presence and level must be subsequently verified in serum or plasma. Verification represents a paradigm shift from unbiased discovery...

Metabolite profiling of blood from individuals undergoing planned myocardial infarction reveals early markers of myocardial injury

Lewis, Gregory D., Wei, Ru, Liu, Emerson, Yang, Elaine, Shi, Xu, Martinovic, Maryann, ...

Emerging metabolomic tools have created the opportunity to establish metabolic signatures of myocardial injury. We applied a mass spectrometry–based metabolite profiling platform to 36 patients...

Accurate Inclusion Mass Screening: A Bridge from Unbiased Discovery to Targeted Assay Development for Biomarker Verification*S⃞

Jaffe, Jacob D., Keshishian, Hasmik, Chang, Betty, Addona, Theresa A., Gillette, Michael A., Carr, Steven A.

Verification of candidate biomarker proteins in blood is typically done using multiple reaction monitoring (MRM) of peptides by LC-MS/MS on triple quadrupole MS systems. MRM assay development for...