Köhler, Fabian, Hug, Eva, Eschbach, Cathrin, Meixlsperger, Sonja, Hobeika, Elias, Kofer, Juliane, ...
Yin Yang 1 is a critical regulator of B-cell development (2007)
Liu, Huifei, Schmidt-Supprian, Marc, Shi, Yujiang, Hobeika, Elias, Barteneva, Natasha, Jumaa, Hassan, ...
The role of the transcription factor Yin Yang 1 (YY1) in development is largely unknown. Here we show that specific ablation of YY1 in mouse B cells caused a defect in somatic rearrangement in the...
Deficiency of Bruton's tyrosine kinase in B cell precursor leukemia cells
Feldhahn, Niklas, Río, Paula, Soh, Bonaventure Ndikung Bejeng, Liedtke, Stefanie, Sprangers, Mieke, Klein, Florian, ...
Bruton's tyrosine kinase (BTK) deficiency results in a differentiation block at the pre-B cell stage. Likewise, acute lymphoblastic leukemia cells are typically arrested at early stages of B cell...
The pre-B-cell receptor induces silencing of VpreB and λ5 transcription
Parker, Mathew J, Licence, Steve, Erlandsson, Lena, Galler, Gunther R, Chakalova, Lyubomira, Osborne, Cameron S, ...
The pre-B-cell receptor (pre-BCR), composed of Ig heavy and surrogate light chain (SLC), signals pre-BII-cell proliferative expansion. We have investigated whether the pre-BCR also signals...
Deficiency of Bruton's tyrosine kinase in B cell precursor leukemia cells
Feldhahn, Niklas, Río, Paula, Soh, Bonaventure Ndikung Bejeng, Liedtke, Stefanie, Sprangers, Mieke, Klein, Florian, ...
Bruton's tyrosine kinase (BTK) deficiency results in a differentiation block at the pre-B cell stage. Likewise, acute lymphoblastic leukemia cells are typically arrested at early stages of B cell...
The pre-B-cell receptor induces silencing of VpreB and λ5 transcription
Parker, Mathew J, Licence, Steve, Erlandsson, Lena, Galler, Gunther R, Chakalova, Lyubomira, Osborne, Cameron S, ...
The pre-B-cell receptor (pre-BCR), composed of Ig heavy and surrogate light chain (SLC), signals pre-BII-cell proliferative expansion. We have investigated whether the pre-BCR also signals...
Yin Yang 1 is a critical regulator of B-cell development
Liu, Huifei, Schmidt-Supprian, Marc, Shi, Yujiang, Hobeika, Elias, Barteneva, Natasha, Jumaa, Hassan, ...
The role of the transcription factor Yin Yang 1 (YY1) in development is largely unknown. Here we show that specific ablation of YY1 in mouse B cells caused a defect in somatic rearrangement in the...
Wossning, Thomas, Herzog, Sebastian, Köhler, Fabian, Meixlsperger, Sonja, Kulathu, Yogesh, Mittler, Gerhard, ...
The nonreceptor protein spleen tyrosine kinase (Syk) is a key mediator of signal transduction in a variety of cell types, including B lymphocytes. We show that deregulated Syk activity allows growth...
Feldhahn, Niklas, Henke, Nadine, Melchior, Kai, Duy, Cihangir, Soh, Bonaventure Ndikung, Klein, Florian, ...
The Philadelphia chromosome (Ph) encoding the oncogenic BCR-ABL1 kinase defines a subset of acute lymphoblastic leukemia (ALL) with a particularly unfavorable prognosis. ALL cells are derived from B...
Mimicry of a constitutively active pre–B cell receptor in acute lymphoblastic leukemia cells
Feldhahn, Niklas, Klein, Florian, Mooster, Jana L., Hadweh, Paul, Sprangers, Mieke, Wartenberg, Maria, ...
Pre–B cells undergo apoptosis unless they are rescued by pre–B cell receptor–dependent survival signals. We previously showed that the BCR-ABL1 kinase that is expressed in pre–B lymphoblastic...
Identification of a Pre-BCR Lacking Surrogate Light Chain
Su, Yu-wen, Flemming, Alexandra, Wossning, Thomas, Hobeika, Elias, Reth, Michael, Jumaa, Hassan
SLP-65−/− pre-B cells show a high proliferation rate in vitro. We have shown previously that λ5 expression and consequently a conventional pre-B cell receptor (pre-BCR) are essential for this...
Kersseboom, Rogier, Middendorp, Sabine, Dingjan, Gemma M., Dahlenborg, Katarina, Reth, Michael, Jumaa, Hassan, ...
Expression of the pre-B cell receptor (pre-BCR) leads to activation of the adaptor molecule SLP-65 and the cytoplasmic kinase Btk. Mice deficient for one of these signaling proteins have an...
Wienands, Jürgen, Schweikert, Jutta, Wollscheid, Bernd, Jumaa, Hassan, Nielsen, Peter J., Reth, Michael
The B cell antigen receptor (BCR) consists of the membrane-bound immunoglobulin (Ig) molecule as antigen-binding subunit and the Ig-α/Ig-β heterodimer as signaling subunit. BCR signal transduction...
Huck, Kirsten, Feyen, Oliver, Niehues, Tim, Rüschendorf, Franz, Hübner, Norbert, Laws, Hans-Jürgen, ...
The fatal immune dysregulation that sometimes follows EBV infection in boys has been linked to mutations in two X chromosome–encoded genes, SLAM-associated protein (SAP) and X-linked inhibitor of...