Hayato Kawakami

Change in Long-Spacing Collagen in Descemet's Membrane of Diabetic Goto-Kakizaki Rats and Its Suppression by Antidiabetic Agents (2008)

Yoshihiro Akimoto, Hajime Sawada, Mica Ohara-Imaizumi, Shinya Nagamatsu, Hayato Kawakami

We examined changes in the ultrastructure and localization of major extracellular matrix components, including 5 types of collagen (type I, III, IV, VI, and VIII), laminin, fibronectin, and heparan...

Redundant roles of Sox17 and Sox18 in postnatal angiogenesis in mice (2006)

Matsui, Toshiyasu, Kanai-Azuma,Masami, Hara, Kenshiro, Matoba,Shogo, Hiramatsu,Ryuji, Kawakami,Hayato, ...

Sox7, Sox17 and Sox18 constitute group F of the Sox family of HMG box transcription factor genes. Dominant-negative mutations in Sox18 underlie the cardiovascular defects observed in ragged mutant...

Complement C4b-Binding Protein as a Novel Murine Epididymal Secretory Protein (2003)

Mayumi I. Nonaka, Yoshitaka Hishikawa, Nobuo Moriyama, Takehiko Koji, Ronald T. Ogata, Akihiko Kudo, ...

Complement C4b-binding protein (C4BP) is a plasma protein synthesized in the liver and plays a regulatory role in the host defense complement system. We have previously reported that mRNAs of the...

Stage- and sex-dependent expressions of Usp9x, and X-linked mouse ortholog of Drosophila Fat facets, during gonadal development and oogenesis in mice (2002)

Noma, Takashi, Kanai, Yoshiakira, Kanai-Azuma, Masami, Ishii, Maki, Fujisawa, Masahiko, Kurohmaru, Masamichi, ...

During the Drosophila oogenic processes, Fat facets (Faf), an ubiquitin-specific protease essential for normal development of oocyte and eye, becomes localized at the posterior pole and is...

Stage- and sex-dependent expressions of Usp9x, and X-linked mouse ortholog of Drosophila Fat facets, during gonadal development and oogenesis in mice (2002)

Noma, Takashi, Kanai, Yoshiakira, Kanai-Azuma, Masami, Ishii, Maki, Fujisawa, Masahiko, Kurohmaru, Masamichi, ...

During the Drosophila oogenic processes, Fat facets (Faf), an ubiquitin-specific protease essential for normal development of oocyte and eye, becomes localized at the posterior pole and is...

Molecular basis of ocular abnormalities associated with proximal renal tubular acidosis

Usui, Tomohiko, Hara, Masumi, Satoh, Hiroaki, Moriyama, Nobuo, Kagaya, Humie, Amano, Shiro, ...

Proximal renal tubular acidosis associated with ocular abnormalities such as band keratopathy, glaucoma, and cataracts is caused by mutations in the Na+-HCO3– cotransporter (NBC-1). However, the...

Mouse Na+/K+-ATPase β1-subunit has a K+-dependent cell adhesion activity for β-GlcNAc-terminating glycans

Kitamura, Noriaki, Ikekita, Masahiko, Sato, Takeshi, Akimoto, Yoshihiro, Hatanaka, Yasumaru, Kawakami, Hayato, ...

A 48-kDa β-N-acetylglucosamine (GlcNAc)-binding protein was isolated from mouse brain by GlcNAc-agarose column chromatography. The N-terminal amino acid residues showed the protein to be a mouse...

Molecular basis of ocular abnormalities associated with proximal renal tubular acidosis

Usui, Tomohiko, Hara, Masumi, Satoh, Hiroaki, Moriyama, Nobuo, Kagaya, Humie, Amano, Shiro, ...

Proximal renal tubular acidosis associated with ocular abnormalities such as band keratopathy, glaucoma, and cataracts is caused by mutations in the Na+-HCO3– cotransporter (NBC-1). However, the...

Mouse Na+/K+-ATPase β1-subunit has a K+-dependent cell adhesion activity for β-GlcNAc-terminating glycans

Kitamura, Noriaki, Ikekita, Masahiko, Sato, Takeshi, Akimoto, Yoshihiro, Hatanaka, Yasumaru, Kawakami, Hayato, ...

A 48-kDa β-N-acetylglucosamine (GlcNAc)-binding protein was isolated from mouse brain by GlcNAc-agarose column chromatography. The N-terminal amino acid residues showed the protein to be a mouse...

Imaging analysis reveals mechanistic differences between first- and second-phase insulin exocytosis

Ohara-Imaizumi, Mica, Fujiwara, Tomonori, Nakamichi, Yoko, Okamura, Tadashi, Akimoto, Yoshihiro, Kawai, Junko, ...

The mechanism of glucose-induced biphasic insulin release is unknown. We used total internal reflection fluorescence (TIRF) imaging analysis to reveal the process of first- and second-phase insulin...

The GPCR modulator protein RAMP2 is essential for angiogenesis and vascular integrity

Ichikawa-Shindo, Yuka, Sakurai, Takayuki, Kamiyoshi, Akiko, Kawate, Hisaka, Iinuma, Nobuyoshi, Yoshizawa, Takahiro, ...

Adrenomedullin (AM) is a peptide involved both in the pathogenesis of cardiovascular diseases and in circulatory homeostasis. The high-affinity AM receptor is composed of receptor...

Change in Long-Spacing Collagen in Descemet's Membrane of Diabetic Goto-Kakizaki Rats and Its Suppression by Antidiabetic Agents

Akimoto, Yoshihiro, Sawada, Hajime, Ohara-Imaizumi, Mica, Nagamatsu, Shinya, Kawakami, Hayato

We examined changes in the ultrastructure and localization of major extracellular matrix components, including 5 types of collagen (type I, III, IV, VI, and VIII), laminin, fibronectin, and heparan...

Chlamydia pneumoniae Growth Inhibition in Cells by the Steroid Receptor Antagonist RU486 (Mifepristone)▿

Yamaguchi, Hiroyuki, Kamiya, Shigeru, Uruma, Tomonori, Osaki, Takako, Taguchi, Haruhiko, Hanawa, Tomoko, ...

Since steroids are powerful anti-inflammatory agents and increase susceptibility to a variety of infections, including Chlamydia (Chlamydophila) pneumoniae respiratory tract infections, the effect of...