Immunological Outcomes of New Tuberculosis Vaccine Trials: WHO Panel Recommendations (2008)
Willem A. Hanekom, Hazel M. Dockrell, T. Mark Doherty, Helen Fletcher, Helen McShane, ...
Persistence of the immune response induced by BCG vaccination (2008)
Weir, Rosemary E, Gorak-Stolinska, Patricia, Floyd, Sian, Lalor, Maeve K, Stenson, Sally, Branson, Keith, ...
Abstract Background Although BCG vaccination is recommended in most countries of the world, little is known of the persistence of BCG-induced immune responses. As novel TB vaccines may be given to...
Lawn, Stephen D, Bangani, Nonzwakazi, Vogt, Monica, Bekker, Linda-Gail, Badri, Motasim, Ntobongwana, Marjorie, ...
Abstract Background Interferon-gamma (IFN-γ) ELISPOT assays incorporating Mycobacterium tuberculosis -specific antigens are useful in the diagnosis of tuberculosis (TB) or latent infection. However,...
The majority of tuberculosis (TB) exists in the worldâs poorest countries, where costly biosafety level three facilities for containment of infectious TB patients and diagnostic facilities are...
Macfarlane, Anne, Mondragon-Gonzalez, Rafael, Vega-Lopez, Francisco, Wieles, Brigitte, De Pena, Josefina, Rodriguez, Obdulia, ...
The ability of the 45-kDa serine-rich Mycobacterium leprae antigen to stimulate peripheral blood mononuclear cell (PBMC) proliferation and gamma interferon (IFN-γ) production was measured in leprosy...
Characterization of Human Mycobacterium bovis Bacille Calmette-Guérin-Reactive CD8+ T Cells
Smith, Steven M., Malin, Adam S., Pauline T., Atkinson, Sara E., Content, Jean, ...
Gamma interferon (IFN-γ)-secreting CD4+ T cells have long been established as an essential component of the protective immune response against Mycobacterium tuberculosis. It is now becoming evident...
Smith, Steven M., Klein, Michèl R., Malin, Adam S., Sillah, Jackson, Huygen, Kris, Andersen, Peter, ...
Intracellular flow cytometry analysis of perforin production by CD8+ T cells showed levels were greatly reduced in tuberculosis (TB) patients compared to healthy controls. Reduced...
Dockrell, Hazel M., Brahmbhatt, Shweta, Robertson, Brian D., Britton, Sven, Fruth, Uli, Gebre, Negussie, ...
To identify Mycobacterium leprae-specific human T-cell epitopes, which could be used to distinguish exposure to M. leprae from exposure to Mycobacterium tuberculosis or to environmental mycobacteria...
Black, Gillian F., Weir, Rosemary E., Chaguluka, Steven D., Warndorff, David, Crampin, Amelia C., Mwaungulu, Lorren, ...
We have previously shown that young adults living in a rural area of northern Malawi showed greater gamma interferon (IFN-γ) responses to purified protein derivatives (PPD) prepared from...
Killing of Blood-Stage Murine Malaria Parasites by Hydrogen Peroxide
Dockrell, Hazel M., Playfair, John H. L.
Both nonlethal Plasmodium yoelii and lethal Plasmodium berghei were killed in vitro by hydrogen peroxide at concentrations as low as 10−5 M. Higher concentrations were required in the presence of...
Weir, Rosemary E., Black, Gillian F., Dockrell, Hazel M., Floyd, Sian, Fine, Paul E. M., Chaguluka, Steven D., ...
To investigate the role of innate immunity in variable efficacy of Mycobacterium bovis BCG vaccination in Malawi and the United Kingdom, we examined 24-h tumor necrosis factor alpha, interleukin-1β...
Holland, Martin J., Faal, Nkoyo, Sarr, Isatou, Joof, Hassan, Laye, Mass, Cameron, Ewen, ...
Chlamydia-specific cytotoxic T lymphocytes are able to control model infections but may be implicated in disease pathogenesis. HLA-A2 peptide tetramers to Chlamydia trachomatis major outer membrane...
Macfarlane, Anne, Mondragon-Gonzalez, Rafael, Vega-Lopez, Francisco, Wieles, Brigitte, De Pena, Josefina, Rodriguez, Obdulia, ...
The ability of the 45-kDa serine-rich Mycobacterium leprae antigen to stimulate peripheral blood mononuclear cell (PBMC) proliferation and gamma interferon (IFN-γ) production was measured in leprosy...
Characterization of Human Mycobacterium bovis Bacille Calmette-Guérin-Reactive CD8+ T Cells
Smith, Steven M., Malin, Adam S., Pauline T., Atkinson, Sara E., Content, Jean, ...
Gamma interferon (IFN-γ)-secreting CD4+ T cells have long been established as an essential component of the protective immune response against Mycobacterium tuberculosis. It is now becoming evident...
Smith, Steven M., Klein, Michèl R., Malin, Adam S., Sillah, Jackson, Huygen, Kris, Andersen, Peter, ...
Intracellular flow cytometry analysis of perforin production by CD8+ T cells showed levels were greatly reduced in tuberculosis (TB) patients compared to healthy controls. Reduced...
Dockrell, Hazel M., Brahmbhatt, Shweta, Robertson, Brian D., Britton, Sven, Fruth, Uli, Gebre, Negussie, ...
To identify Mycobacterium leprae-specific human T-cell epitopes, which could be used to distinguish exposure to M. leprae from exposure to Mycobacterium tuberculosis or to environmental mycobacteria...
Black, Gillian F., Weir, Rosemary E., Chaguluka, Steven D., Warndorff, David, Crampin, Amelia C., Mwaungulu, Lorren, ...
We have previously shown that young adults living in a rural area of northern Malawi showed greater gamma interferon (IFN-γ) responses to purified protein derivatives (PPD) prepared from...
Killing of Blood-Stage Murine Malaria Parasites by Hydrogen Peroxide
Dockrell, Hazel M., Playfair, John H. L.
Both nonlethal Plasmodium yoelii and lethal Plasmodium berghei were killed in vitro by hydrogen peroxide at concentrations as low as 10−5 M. Higher concentrations were required in the presence of...
Weir, Rosemary E., Black, Gillian F., Dockrell, Hazel M., Floyd, Sian, Fine, Paul E. M., Chaguluka, Steven D., ...
To investigate the role of innate immunity in variable efficacy of Mycobacterium bovis BCG vaccination in Malawi and the United Kingdom, we examined 24-h tumor necrosis factor alpha, interleukin-1β...
Holland, Martin J., Faal, Nkoyo, Sarr, Isatou, Joof, Hassan, Laye, Mass, Cameron, Ewen, ...
Chlamydia-specific cytotoxic T lymphocytes are able to control model infections but may be implicated in disease pathogenesis. HLA-A2 peptide tetramers to Chlamydia trachomatis major outer membrane...
Hussain, Rabia, Shahid, Firdaus, Zafar, Shahid, Dojki, Maqboola, Dockrell, Hazel M
Mycobacterium leprae (ML) GroES has been shown to induce strong T cell responses in tuberculoid as well as in exposed healthy contacts of leprosy patients, and therefore this antigen has been the...
Aguirre-Blanco, Ana M., Lukey, Pauline T., Cliff, Jacqueline M., Dockrell, Hazel M.
Three commonly used Mycobacterium bovis BCG vaccine strains elicited different magnitudes of T-cell activation and gamma interferon production in vitro in healthy BCG-vaccinated individuals. Glaxo...
Cehovin, Ana, Cliff, Jacqueline M., Hill, Philip C., Brookes, Roger H., Dockrell, Hazel M.
To test the hypothesis that prolonged culture would enhance the sensitivity of latent tuberculosis detection by a gamma interferon release assay, blood samples from 33 household contacts of Gambian...
Lawn, Stephen D, Bangani, Nonzwakazi, Vogt, Monica, Bekker, Linda-Gail, Badri, Motasim, Ntobongwana, Marjorie, ...
Lin, May Young, Geluk, Annemieke, Smith, Steven G., Stewart, Amanda L., Friggen, Annemieke H., ...
Mycobacterium bovis BCG is widely used as a vaccine against tuberculosis (TB), despite its variable protective efficacy. Relatively little is known about the immune response profiles following BCG...
Persistence of the immune response induced by BCG vaccination
Weir, Rosemary E, Gorak-Stolinska, Patricia, Floyd, Sian, Lalor, Maeve K, Stenson, Sally, Branson, Keith, ...
Immunological Outcomes of New Tuberculosis Vaccine Trials: WHO Panel Recommendations
Hanekom, Willem A, Dockrell, Hazel M, Ottenhoff, Tom H. M, Doherty, T. Mark, Fletcher, Helen, McShane, Helen, ...
Willem Hanekom and colleagues make recommendations on assay harmonization for novel tuberculosis vaccine trials.