Qiao, Qing, Österholm, Anne-May, He, Bing, Pitkäniemi, Janne, Cordell, Heather J, Sarti, Cinzia, ...
Abstract Background A genome-wide search for genes that predispose to type 1 diabetes using linkage analysis was performed using 900 microsatellite markers in 70 nuclear families with affected...
Biernacka, Joanna M, Charoen, Pimphen, Cordell, Heather J
Abstract In a small chromosomal region, a number of polymorphisms may be both linked to and associated with a disease. Potentially directly associated causal loci may be distinguished from indirectly...
Linkage and association analysis of GAW15 simulated data: fine-mapping of chromosome 6 region (2007)
Charoen, Pimphen, Biernacka, Joanna M, Cordell, Heather J
Abstract We performed linkage and family-based association analysis across chromosomes 1–22 in Replicates 1–5 of the Genetic Analysis Workshop 15 simulated data. Linkage analysis was performed...
Cordell, Heather J, De Andrade, Mariza, Babron, Marie-Claude, Bartlett, Christopher W, Beyene, Joseph, Bickeböller, Heike, ...
No abstract available.
E. Nancy Miller, Manal Fadl, Hiba S. Mohamed, Abier Elzein, Sarra E. Jamieson, Heather J. Cordell, ...
Familial clustering and ethnic differences suggest that visceral leishmaniasis caused by Leishmania donovani is under genetic control. A recent genome scan provided evidence for a major...
E. Nancy Miller, Manal Fadl, Hiba S Mohamed, Abier Elzein, Sarra E Jamieson, Heather J Cordell, ...
Familial clustering and ethnic differences suggest that visceral leishmaniasis (VL) caused by Leishmania donovani is under genetic control. A recent genome scan provided evidence for a major...
Bailey-Wilson, Joan E, Almasy, Laura, De Andrade, Mariza, Bailey, Julia, Bickeböller, Heike, Cordell, Heather J, ...
Barber, Mathew J, Wheeler, Eleanor, Cordell, Heather J
Abstract The purposes of this study were 1) to examine the performance of a new multimarker regression approach for model-free linkage analysis in comparison to a conventional multipoint approach,...
Common polymorphism in H19associated with birthweight and cord blood IGF-II levels in humans (2005)
Petry, Clive J, Ong, Ken K, Barratt, Bryan J, Wingate, Diane, Cordell, Heather J, Ring, Susan M, ...
Abstract Background Common genetic variation at genes that are imprinted and exclusively maternally expressed could explain the apparent maternal-specific inheritance of low birthweight reported in...
Andrew E. Timms, Alison M. Crane, Anne-Marie Sims, Heather J. Cordell, Linda A. Bradbury, Aaron Abbott, ...
This paper reports the identification of the first non-MHC gene to be strongly associated and linked with ankylosing spondylitis, and one of the few in any rheumatic disease. The findings have been...
Andrew E. Timms, Alison M. Crane, Anne-Marie Sims, Heather J. Cordell, Linda A. Bradbury, Aaron Abbott, ...
This paper reports the identification of the first non-MHC gene to be strongly associated and linked with ankylosing spondylitis, and one of the few in any rheumatic disease. The findings have been...
Haplotype tagging for the identification of common disease genes (2001)
Johnson, Gillian C.l., Esposito, Laura, Barratt, Bryan J., Smith, Annabel N., Heward, Joanne, Di Genova, Gianfranco, ...
Genome-wide linkage disequilibrium (LD) mapping of common disease genes could be more powerful than linkage analysis if the appropriate density of polymorphic markers were known and if the genotyping...
Merriman, Terry R., Cordell, Heather J., Eaves, Iain A., Danoy, Patrick A., Coraddu, Francesca, Barber, Rachael, ...
Some immune system disorders, such as type 1 diabetes, multiple sclerosis (MS), and rheumatoid arthritis (RA), share common features: the presence of autoantibodies and self-reactive T-cells, and a...
Merriman, Terry R., Cordell, Heather J., Eaves, Iain A., Danoy, Patrick A., Coraddu, Francesca, Barber, Rachael, ...
Some immune system disorders, such as type 1 diabetes, multiple sclerosis (MS), and rheumatoid arthritis (RA), share common features: the presence of autoantibodies and self-reactive T-cells, and a...
Merriman, Terry R., Cordell, Heather J., Eaves, Iain A., Danoy, Patrick A., Coraddu, Francesca, Barber, Rachael, ...
Some immune system disorders, such as type 1 diabetes, multiple sclerosis (MS), and rheumatoid arthritis (RA), share common features: the presence of autoantibodies and self-reactive T-cells, and a...
Haplotype Structure, LD Blocks, and Uneven Recombination Within the LRP5 Gene
Twells, Rebecca C.J., Mein, Charles A., Phillips, Michael S., Hess, J. Fred, Veijola, Riitta, Gilbey, Matthew, ...
Patterns of linkage disequilibrium (LD) in the human genome are beginning to be characterized, with a paucity of haplotype diversity in “LD blocks,” interspersed by apparent “hot spots” of...
Common polymorphism in H19 associated with birthweight and cord blood IGF-II levels in humans
Petry, Clive J, Ong, Ken K, Barratt, Bryan J, Wingate, Diane, Cordell, Heather J, Ring, Susan M, ...
Multilocus Linkage Tests Based on Affected Relative Pairs
Cordell, Heather J., Wedig, Geoffrey C., Jacobs, Kevin B., Elston, Robert C.
For complex diseases, recent interest has focused on methods that take into account joint effects at interacting loci. Conditioning on effects of disease loci at known locations can lead to increased...
Cordell, Heather J., Clayton, David G.
A stepwise logistic-regression procedure is proposed for evaluation of the relative importance of variants at different sites within a small genetic region. By fitting statistical models with main...
Haplotype Structure, LD Blocks, and Uneven Recombination Within the LRP5 Gene
Twells, Rebecca C.J., Mein, Charles A., Phillips, Michael S., Hess, J. Fred, Veijola, Riitta, Gilbey, Matthew, ...
Patterns of linkage disequilibrium (LD) in the human genome are beginning to be characterized, with a paucity of haplotype diversity in “LD blocks,” interspersed by apparent “hot spots” of...
Common polymorphism in H19 associated with birthweight and cord blood IGF-II levels in humans
Petry, Clive J, Ong, Ken K, Barratt, Bryan J, Wingate, Diane, Cordell, Heather J, Ring, Susan M, ...
The Interleukin 1 Gene Cluster Contains a Major Susceptibility Locus for Ankylosing Spondylitis
Timms, Andrew E., Crane, Alison M., Sims, Anne-Marie, Cordell, Heather J., Bradbury, Linda A., Abbott, Aaron, ...
Ankylosing spondylitis (AS) is a common and highly heritable inflammatory arthropathy. Although the gene HLA-B27 is almost essential for the inheritance of the condition, it alone is not sufficient...
Recently, it has been suggested that traditional nonparametric multipoint-linkage procedures can show a “bias” toward the null hypothesis of no effect when there is incomplete information about...
Regression Mapping of Association between the Human Leukocyte Antigen Region and Graves Disease
Simmonds, Matthew J., Howson, Joanna M. M., Heward, Joanne M., Cordell, Heather J., Foxall, Helen, Carr-Smith, Jackie, ...
The human leukocyte antigen class II genes DRB1, DQB1, and DQA1 are associated with Graves disease (GD), but, because of strong linkage disequilibrium within this region, the primary etiological...
Multilocus Linkage Tests Based on Affected Relative Pairs
Cordell, Heather J., Wedig, Geoffrey C., Jacobs, Kevin B., Elston, Robert C.
For complex diseases, recent interest has focused on methods that take into account joint effects at interacting loci. Conditioning on effects of disease loci at known locations can lead to increased...
Barber, Mathew J, Wheeler, Eleanor, Cordell, Heather J
The purposes of this study were 1) to examine the performance of a new multimarker regression approach for model-free linkage analysis in comparison to a conventional multipoint approach, and 2) to...
Bailey-Wilson, Joan E, Almasy, Laura, De Andrade, Mariza, Bailey, Julia, Bickeböller, Heike, Cordell, Heather J, ...
Miller, E. Nancy, Fadl, Manal, Mohamed, Hiba S, Elzein, Abier, Jamieson, Sarra E, Cordell, Heather J, ...
Familial clustering and ethnic differences suggest that visceral leishmaniasis caused by Leishmania donovani is under genetic control. A recent genome scan provided evidence for a major...
Qiao, Qing, Österholm, Anne-May, He, Bing, Pitkäniemi, Janne, Cordell, Heather J, Sarti, Cinzia, ...
Linkage and association analysis of GAW15 simulated data: fine-mapping of chromosome 6 region
Charoen, Pimphen, Biernacka, Joanna M, Cordell, Heather J
We performed linkage and family-based association analysis across chromosomes 1–22 in Replicates 1–5 of the Genetic Analysis Workshop 15 simulated data. Linkage analysis was performed using the...
Cordell, Heather J, De Andrade, Mariza, Babron, Marie-Claude, Bartlett, Christopher W, Beyene, Joseph, Bickeböller, Heike, ...
Biernacka, Joanna M, Charoen, Pimphen, Cordell, Heather J
In a small chromosomal region, a number of polymorphisms may be both linked to and associated with a disease. Potentially directly associated causal loci may be distinguished from indirectly...