Heike Bickeböller

Do genetic factors protect for early onset lung cancer? A case control study before the age of 50 years (2008)

Rosenberger, Albert, Illig, Thomas, Korb, Katrin, Klopp, Norman, Zietemann, Vera, Wölke, Gabi, ...

Abstract Background Early onset lung cancer shows some familial aggregation, pointing to a genetic predisposition. This study was set up to investigate the role of candidate genes in the...

Case-control studies with affected sibships (2007)

Köhler, Karola, Sohns, Melanie, Bickeböller, Heike

Abstract Related cases may be included in case-control association studies if correlations between related individuals due to identity-by-descent (IBD) sharing are taken into account. We derived a...

Meta analysis of whole-genome linkage scans with data uncertainty: an application to Parkinson's disease (2007)

Rosenberger, Albert, Sharma, Manu, Müller-Myhsok, Bertram, Gasser, Thomas, Bickeböller, Heike

Abstract Background Genome wide linkage scans have often been successful in the identification of genetic regions containing susceptibility genes for a disease. Meta analysis is used to synthesize...

Genetic Analysis Workshop 15: gene expression analysis and approaches to detecting multiple functional loci ; Proceedings ; Preface (2007)

Cordell, Heather J., Andrade, Mariza De, Babron, Marie-Claude, Bartlett, Christopher W., Beyene, Joseph, Bickeböller, Heike, ...

First paragraph (this article has no abstract) This issue of BMC Proceedings contains the proceedings of Genetic Analysis Workshop (GAW) 15, which was held November 1115, 2006, in St. Pete Beach,...

Case-control studies with affected sibships ; Proceedings (2007)

Köhler, Karola, Sohns, Melanie, Bickeböller, Heike

Related cases may be included in case-control association studies if correlations between related individuals due to identity-by-descent (IBD) sharing are taken into account. We derived a framework...

Surrogate phenotype definition for alcohol use disorders: a genome-wide search for linkage and association (2005)

Rosenberger, Albert, Janicke, Nico, Köhler, Karola, Korb, Katrin, Kulle, Bettina, Bickeböller, Heike

Abstract For the identification of susceptibility loci in complex diseases the choice of the target phenotype is very important. We compared results of genome-wide searches for linkage or for...

NAD(P)H oxidase and multidrug resistance protein genetic polymorphisms are associated with doxorubicin-induced cardiotoxicity (2005)

Wojnowski, Leszek, Kulle, Bettina, Schirmer, Markus, Schlüter, Gregor, Schmidt, Albrecht, Rosenberger, Albert, ...

Background: A significant number of patients treated with anthracyclines develop cardiotoxicity (anthracycline-induced cardiotoxicity [ACT]), mainly presenting as arrhythmias (acute ACT) or...

Nonparametric longitudinal allele-sharing model (2003)

Kulle, Bettina, Köhler, Karola, Rosenberger, Albert, Loesgen, Sabine, Bickeböller, Heike

Abstract Basically no methods are available for the analysis of quantitative traits in longitudinal genetic epidemiological studies. We introduce a nonparametric factorial design for longitudinal...

Nonparametric longitudinal allele-sharing model

Kulle, Bettina, Köhler, Karola, Rosenberger, Albert, Loesgen, Sabine, Bickeböller, Heike

Basically no methods are available for the analysis of quantitative traits in longitudinal genetic epidemiological studies. We introduce a nonparametric factorial design for longitudinal data on...

Case-control studies with affected sibships

Köhler, Karola, Sohns, Melanie, Bickeböller, Heike

Related cases may be included in case-control association studies if correlations between related individuals due to identity-by-descent (IBD) sharing are taken into account. We derived a framework...

The Tumorigenicity of Mouse Embryonic Stem Cells and In Vitro Differentiated Neuronal Cells Is Controlled by the Recipients' Immune Response

Dressel, Ralf, Schindehütte, Jan, Kuhlmann, Tanja, Elsner, Leslie, Novota, Peter, Baier, Paul Christian, ...

Embryonic stem (ES) cells have the potential to differentiate into all cell types and are considered as a valuable source of cells for transplantation therapies. A critical issue, however, is the...