Lovric, Svjetlana, Erdbruegger, Uta, Kümpers, Philipp, Woywodt, Alexander, Koenecke, Christian, Wedemeyer, Heiner, ...
Background. B-cell depletion with rituximab, a chimeric anti-CD20 antibody, is a novel treatment for refractory and relapsing ANCA-associated small-vessel vasculitis. Data are limited and most...
Wiegand, Johannes, Deterding, Katja, Cornberg, Markus, Wedemeyer, Heiner
Early control in the acute phase of hepatitis C infection is an attractive therapeutic goal in order to shorten disease duration and infectivity, to prevent chronicity and progression to advanced...
Clearance of low levels of HCV viremia in the absence of a strong adaptive immune response (2007)
Meyer, Manuela F, Lehmann, Marc, Cornberg, Markus, Wiegand, Johannes, Manns, Michael P, Klade, Christoph, ...
Abstract Spontaneous clearance of hepatitis C virus (HCV) has frequently been associated with the presence of HCV-specific cellular immunity. However, there had been also reports in chimpanzees...
Lehmann, Ulrich, Wingen, Luzie U., Brakensiek, Kai, Wedemeyer, Heiner, Becker, Thomas, Heim, Albert, ...
Gene silencing through aberrant CpG island methylation is a frequent epigenetic defect in hepatocellular carcinoma (HCC). However, nothing is known as yet whether aberrant hypermethylation occurs...
Wiegand, Johannes, Buggisch, Peter, Boecher, Wulf, Zeuzem, Stefan, Gelbmann, Cornelia M., Berg, Thomas, ...
Early treatment of acute hepatitis C with interferon alpha-2b for 24 weeks prevents chronic infection in almost all patients. Because pegylated interferons have replaced conventional interferon in...
Enth. ausserdem 6 Sonderabdr. aus verschiedenen Zeitschr. - Beitr. teilw. dt., teilw. engl.
Göttingen, Univ., Diss., 1996.
He, Xiao-Song, Rehermann, Barbara, López-Labrador, F. Xavier, Boisvert, Judie, Cheung, Ramsey, Mumm, John, ...
It is believed that the hepatitis C virus (HCV)-specific CD8+ cytotoxic T lymphocytes (CTLs) play a role in the development of liver cell injury and in the clearance of the virus. To develop a direct...
Wedemeyer, Heiner, Mizukoshi, Eishiro, Davis, Anthony R., Bennink, Jack R., Rehermann, Barbara
The cellular immune response contributes to viral clearance as well as to liver injury in acute and chronic hepatitis C virus (HCV) infection. An immunodominant determinant frequently recognized by...
Satoi, Jujin, Murata, Kazumoto, Lechmann, Martin, Manickan, Elanchezhiyan, Zhang, Zhensheng, Wedemeyer, Heiner, ...
To study the effect of genetic immunization on transgenic expression of hepatitis C virus (HCV) proteins, we evaluated the immunological response of HCV transgenic mice to HCV expression plasmids....
Hepatitis C virus mutation affects proteasomal epitope processing
Seifert, Ulrike, Liermann, Heike, Racanelli, Vito, Halenius, Anne, Wiese, Manfred, Wedemeyer, Heiner, ...
The high incidence of hepatitis C virus (HCV) persistence raises the question of how HCV interferes with host immune responses. Studying a single-source HCV outbreak, we identified an HCV mutation...
He, Xiao-Song, Rehermann, Barbara, López-Labrador, F. Xavier, Boisvert, Judie, Cheung, Ramsey, Mumm, John, ...
It is believed that the hepatitis C virus (HCV)-specific CD8+ cytotoxic T lymphocytes (CTLs) play a role in the development of liver cell injury and in the clearance of the virus. To develop a direct...
Wedemeyer, Heiner, Mizukoshi, Eishiro, Davis, Anthony R., Bennink, Jack R., Rehermann, Barbara
The cellular immune response contributes to viral clearance as well as to liver injury in acute and chronic hepatitis C virus (HCV) infection. An immunodominant determinant frequently recognized by...
Satoi, Jujin, Murata, Kazumoto, Lechmann, Martin, Manickan, Elanchezhiyan, Zhang, Zhensheng, Wedemeyer, Heiner, ...
To study the effect of genetic immunization on transgenic expression of hepatitis C virus (HCV) proteins, we evaluated the immunological response of HCV transgenic mice to HCV expression plasmids....
Hepatitis C virus mutation affects proteasomal epitope processing
Seifert, Ulrike, Liermann, Heike, Racanelli, Vito, Halenius, Anne, Wiese, Manfred, Wedemeyer, Heiner, ...
The high incidence of hepatitis C virus (HCV) persistence raises the question of how HCV interferes with host immune responses. Studying a single-source HCV outbreak, we identified an HCV mutation...
Clearance of low levels of HCV viremia in the absence of a strong adaptive immune response
Meyer, Manuela F, Lehmann, Marc, Cornberg, Markus, Wiegand, Johannes, Manns, Michael P, Klade, Christoph, ...
Spontaneous clearance of hepatitis C virus (HCV) has frequently been associated with the presence of HCV-specific cellular immunity. However, there had been also reports in chimpanzees demonstrating...
Cooksley, Helen, Chokshi, Shilpa, Maayan, Yafit, Wedemeyer, Heiner, Andreone, Pietro, Gilson, Richard, ...
Weak T-cell reactivity to hepatitis B virus (HBV) is thought to be the dominant cause for chronic HBV infection. Treatment with adefovir dipivoxil (ADV) increases the rate of HBV e antigen (HBeAg)...