Gruber, Helen E, Bornstein, Paul, Sage, E Helene, Ingram, Jane A, Zinchenko, Natalia, Norton, H James, ...
Abstract Introduction The biological basis for the avascular state of the intervertebral disc is not well understood. Previous work has suggested that the presence of thrombospondin-1 (TSP-1), a...
Tapp, Hazel, Deepe, Ray, Ingram, Jane A, Kuremsky, Marshall, Hanley, Edward N, Gruber, Helen E
Abstract Introduction Adult mesenchymal stem cell therapy has a potential application in the biological treatment of disc degeneration. Our objectives were: to direct adipose-derived mesenchymal stem...
Gruber, Helen E, Ingram, Jane A, Hoelscher, Gretchen, Zinchenko, Natalia, Norton, H James, Hanley, Edward N
Abstract Introduction Brain-derived neurotrophic factor (BDNF) was first identified in the intervertebral disc (IVD) when its molecular upregulation was observed in sections of nucleus pulposus...
Gruber, Helen E, Mauerhan, David, Chow, Yin, Ingram, Jane A, Norton, H James, Hanley, Edward N, ...
Abstract Background The meniscus is a complex tissue whose cell biology has only recently begun to be explored. Published models rely upon initial culture in the presence of added growth factors. The...
Do We Need Biomarkers for Disc Degeneration? (2006)
Disc degeneration plays a major role in this country's medical, social and economic structure. The life-time prevalence of low back pain, which has disc degeneration as its cause, is about 80% in the...
Rude, Robert K, Gruber, Helen E, Wei, Livia Y, Frausto, Angelica
Abstract Background Epidemiological studies have linked low dietary magnesium (Mg) to low bone mineral density and osteoporosis. Mg deficiency in animal models has demonstrated a reduction in bone...
Magnesium deficiency: effect on bone mineral density in the mouse appendicular skeleton (2003)
Gruber, Helen E, Rude, Robert K, Wei, L, Frausto, A, Mills, Barbara G, Norton, H James
Abstract Background Dietary magnesium (Mg) deficiency in the mouse perturbs bone and mineral homeostasis. The objective of the present study was to evaluate bone mineral density of the femur in...
Wilson, Christy, Brown, Darien, Najarian, Kayvan, Hanley, Edward N, Gruber, Helen E
Abstract Background The purpose of this study is to present an automated system that analyzes digitized x-ray images of small animal spines identifying the effects of disc degeneration. The...
Gruber, Helen E, Hanley, Edward N
Abstract Background In the annulus, collagen fibers that make up the lamellae have a wavy, planar crimped pattern. This crimping plays a role in disc biomechanical function by allowing collagen...
Gruber, Helen E, Yamaguchi, Dean, Ingram, Jane, Leslie, Kelly, Huang, Weibiao, Miller, Timothy A, ...
Abstract Background Recent evidence suggests that estrogens exert effects in different tissues throughout the body, and that the estrogen receptor β (ERβ) may be important for the action of...
Gruber, Helen E, Puzanov, Igor J, Bennett, Michael, Kumar, Vinay, Gordon, Brian
Abstract Background Although the role of the osteoclast in bone resorption is becoming better understood, much remains to be learned about osteoclastogenesis and the exact mechanism of action of...
Human disc cells in monolayer vs 3D culture: cell shape, division and matrix formation (2000)
Gruber, Helen E, Hanley, Edward N
Abstract Background The relationship between cell shape, proliferation, and extracellular matrix (ECM) production, important aspects of cell behavior, is examined in a little-studied cell type, the...
Gruber, Helen E, Yamaguchi, Dean, Ingram, Jane, Leslie, Kelly, Huang, Weibiao, Miller, Timothy A, ...
Magnesium deficiency: effect on bone mineral density in the mouse appendicular skeleton
Gruber, Helen E, Rude, Robert K, Wei, L, Frausto, A, Mills, Barbara G, Norton, H James
Gruber, Helen E, Yamaguchi, Dean, Ingram, Jane, Leslie, Kelly, Huang, Weibiao, Miller, Timothy A, ...
Magnesium deficiency: effect on bone mineral density in the mouse appendicular skeleton
Gruber, Helen E, Rude, Robert K, Wei, L, Frausto, A, Mills, Barbara G, Norton, H James
Kurihara, Noriyoshi, Hiruma, Yuko, Zhou, Hua, Subler, Mark A., Dempster, David W., Singer, Frederick R., ...
Paget disease is the most exaggerated example of abnormal bone remodeling, with the primary cellular abnormality in the osteoclast. Mutations in the p62 (sequestosome 1) gene occur in one-third of...
Three-dimensional culture of human meniscal cells: Extracellular matrix and proteoglycan production
Gruber, Helen E, Mauerhan, David, Chow, Yin, Ingram, Jane A, Norton, H James, Hanley, Edward N, ...