808 RESEARCH ARTICLE Global Mapping of the Yeast Genetic Interaction Network (2008)
Amy Hin, Yan Tong, Guillaume Lesage, Gary D. Bader, Huiming Ding, Hong Xu, ...
A genetic interaction network containing �1000 genes and �4000 interactions was mapped by crossing mutations in 132 different query genes into a set of �4700 viable gene yeast deletion mutants...
Reguly, Teresa, Breitkreutz, Ashton, Boucher, Lorrie, Breitkreutz, Bobby-Joe, Hon, Gary C, Myers, Chad L, ...
Abstract Background The study of complex biological networks and prediction of gene function has been enabled by high-throughput (HTP) methods for detection of genetic and protein interactions....
Yeast functional genomics and cell biology: no longer in the dark (2003)
Friesen, Helena, Millman, Jonathan S, Andrews, Brenda J
A report on the Cold Spring Harbor Laboratory meeting 'Yeast Cell Biology', Cold Spring Harbor, USA, 12-17 August 2003.
Hepworth, Shelley R., Friesen, Helena, Segall, Jacqueline
Distinct classes of sporulation-specific genes are sequentially expressed during the process of spore formation in Saccharomyces cerevisiae. The transition from expression of early meiotic genes to...
Regulation of the Yeast Amphiphysin Homologue Rvs167p by Phosphorylation
Friesen, Helena, Murphy, Kelly, Breitkreutz, Ashton, Tyers, Mike, Andrews, Brenda
The yeast amphiphysin homologue Rvs167p plays a role in regulation of the actin cytoskeleton, endocytosis, and sporulation. Rvs167p is a phosphoprotein in vegetatively growing cells and shows...
Yeast functional genomics and cell biology: no longer in the dark
Friesen, Helena, Millman, Jonathan S, Andrews, Brenda J
A report on the Cold Spring Harbor Laboratory meeting 'Yeast Cell Biology', Cold Spring Harbor, USA, 12-17 August 2003.
Rothfels, Karen, Tanny, Jason C., Molnar, Enikö, Friesen, Helena, Commisso, Cosimo, Segall, Jacqueline
The divergently transcribed DIT1 and DIT2 genes of Saccharomyces cerevisiae, which belong to the mid-late class of sporulation-specific genes, are subject to Ssn6-Tup1-mediated repression in mitotic...
Friesen, Helena, Humphries, Christine, Ho, Yuen, Schub, Oliver, Colwill, Karen, Andrews, Brenda
We have used comprehensive synthetic lethal screens and biochemical assays to examine the biological role of the yeast amphiphysin homologues Rvs161p and Rvs167p, two proteins that play a role in...
Friesen, Helena, Colwill, Karen, Robertson, Karen, Schub, Oliver, Andrews, Brenda
We have used affinity chromatography to identify two proteins that bind to the SH3 domain of the actin cytoskeleton protein Rvs167p: Gyp5p and Gyl1p. Gyp5p has been shown to be a GTPase activating...
Comprehensive curation and analysis of global interaction networks in Saccharomyces cerevisiae
Reguly, Teresa, Breitkreutz, Ashton, Boucher, Lorrie, Breitkreutz, Bobby-Joe, Hon, Gary C, Myers, Chad L, ...
Hepworth, Shelley R., Friesen, Helena, Segall, Jacqueline
Distinct classes of sporulation-specific genes are sequentially expressed during the process of spore formation in Saccharomyces cerevisiae. The transition from expression of early meiotic genes to...
Regulation of the Yeast Amphiphysin Homologue Rvs167p by Phosphorylation
Friesen, Helena, Murphy, Kelly, Breitkreutz, Ashton, Tyers, Mike, Andrews, Brenda
The yeast amphiphysin homologue Rvs167p plays a role in regulation of the actin cytoskeleton, endocytosis, and sporulation. Rvs167p is a phosphoprotein in vegetatively growing cells and shows...
Yeast functional genomics and cell biology: no longer in the dark
Friesen, Helena, Millman, Jonathan S, Andrews, Brenda J
A report on the Cold Spring Harbor Laboratory meeting 'Yeast Cell Biology', Cold Spring Harbor, USA, 12-17 August 2003.
Rothfels, Karen, Tanny, Jason C., Molnar, Enikö, Friesen, Helena, Commisso, Cosimo, Segall, Jacqueline
The divergently transcribed DIT1 and DIT2 genes of Saccharomyces cerevisiae, which belong to the mid-late class of sporulation-specific genes, are subject to Ssn6-Tup1-mediated repression in mitotic...
Friesen, Helena, Humphries, Christine, Ho, Yuen, Schub, Oliver, Colwill, Karen, Andrews, Brenda
We have used comprehensive synthetic lethal screens and biochemical assays to examine the biological role of the yeast amphiphysin homologues Rvs161p and Rvs167p, two proteins that play a role in...
Friesen, Helena, Colwill, Karen, Robertson, Karen, Schub, Oliver, Andrews, Brenda
We have used affinity chromatography to identify two proteins that bind to the SH3 domain of the actin cytoskeleton protein Rvs167p: Gyp5p and Gyl1p. Gyp5p has been shown to be a GTPase activating...
Comprehensive curation and analysis of global interaction networks in Saccharomyces cerevisiae
Reguly, Teresa, Breitkreutz, Ashton, Boucher, Lorrie, Breitkreutz, Bobby-Joe, Hon, Gary C, Myers, Chad L, ...
Huang, Dongqing, Kaluarachchi, Supipi, Van Dyk, Dewald, Friesen, Helena, Sopko, Richelle, Ye, Wei, ...
Initiation of the cell division cycle in yeast is controlled by two distinct kinases that coordinately regulate the interaction of Whi5, a repressor of initiation, with histone deacetylases.
Zou, Jian, Friesen, Helena, Larson, Jennifer, Huang, Dongqing, Cox, Mike, Tatchell, Kelly, ...
In the budding yeast Saccharomyces cerevisiae, the G1-specific cyclin-dependent kinases (Cdks) Cln1,2-Cdc28 and Pcl1,2-Pho85 are essential for ensuring that DNA replication and cell division are...