Wild, Beate, Friederich, Hans-Christoph, Gross, Gaby, Teufel, Martin, Herzog, Wolfgang, Giel, Katrin E, ...
Abstract Background Anorexia nervosa is a serious eating disorder leading to high morbidity and mortality as a result of both malnutrition and suicide. The seriousness of the disorder requires...
Vogel, Carla IG, Scherag, André, Brönner, Günter, Nguyen, Thuy T, Wang, Hai-Jun, Grallert, Harald, ...
Abstract Background Gastric inhibitory polypeptide (GIP) is postulated to be involved in type 2 diabetes mellitus and obesity. It exerts its function through its receptor, GIPR. We genotyped three...
Vogel, Carla IG, Greene, Brandon, Scherag, André, Müller, Timo D, Friedel, Susann, Grallert, Harald, ...
Abstract Background A recent genome-wide association (GWA) study of U.S. Caucasians suggested that eight single nucleotide polymorphisms (SNPs) in CTNNBL1 are associated with obesity and increased...
Optimal multistage designs--a general framework for efficient genome-wide association studies (2009)
Pahl, Roman, Schäfer, Helmut, Müller, Hans-Helge
Genome-wide association studies (GWAS) have become increasingly affordable but they are still costly. Therefore, cost saving 2-stage designs were proposed in the literature. The restriction to 2...
Helmut Schäfer, Pavel Ptacek, Henning Eickmeier, Markus Haase
Cs Y2F7: 78% Y3+, 20% Yb3+, 2% Er3+ nanocrystals with a mean diameter of approximately 8 nm were synthesized at 185°C in the high boiling organic solvent...
Zhou, Kaixin, Dempfle, Astrid, Arcos-Burgos, Mauricio, Bakker, Steven C., Banaschewski, Tobias, Biederman, Joseph, ...
Genetic contribution to the development of attention deficit hyperactivity disorder (ADHD) is well established. Seven independent genome-wide linkage scans have been performed to map loci that...
Müller, Timo, Reichwald, Kathrin, Brönner, Günter, Kirschner, Jeanette, Nguyen, Thuy, Scherag, André, ...
Abstract Background Several lines of evidence indicate that the central cannabinoid receptor 1 (CNR1) as well as the major endocannabinoid degrading enzymes fatty acid amide hydrolase (FAAH),...
Müller, Timo D, Hinney, Anke, Scherag, André, Nguyen, Thuy T, Schreiner, Felix, Schäfer, Helmut, ...
Abstract Background We have previously identified strong association of six single nucleotide polymorphisms (SNPs) in FTO (fat mass and obesity associated gene) to early onset extreme obesity within...
Dempfle, Astrid, Hein, Rebecca, Beckmann, Lars, Scherag, André, Nguyen, Thuy, Schäfer, Helmut, ...
Abstract Accounting for interactions with environmental factors in association studies may improve the power to detect genetic effects and may help identifying important environmental effect...
Refining the impact of TCF7L2 gene variants on type 2 diabetes and adaptive evolution (2007)
Helgason, Agnar, Palsson, Snaebjorn, Thorleifsson, Gudmar, Grant, Struan F A, Emilsson, Valur, Gunnarsdottir, Steinunn, ...
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Astrid Dempfle, Stefan A. Wudy, Kathrin Saar, Ra Hagemann, Susann Friedel, Lars D. Berthold, ...
Evidence for involvement of the vitamin D receptor gene in
Dempfle, Astrid, Wudy, Stefan A., Saar, Kathrin, Hagemann, Sandra, Friedel, Susann, Scherag, André, ...
Stature is a highly heritable trait under both polygenic and major gene control. We aimed to identify genetic regions linked to idiopathic short stature (ISS) in childhood, through a whole genome...
Hilgers, Ralf-Dieter, Feldmann, Uwe, Jöckel, Karl-Heinz, Klar, Rüdiger, Rienhoff, Otto, Schäfer, Helmut, ...
In the Approbationsordnung für Ärzte (German regulation for the Curriculum in Medicine) of 27th June, 2002 the disciplines Epidemiology, Medical Biometry and Medical Informatics are combined in one...
Reaktionsweisen eines Tetraaryldigermens (2001)
Ziel der vorliegenden Arbeit war es, das erste Molekül mit konjugierten Ge-Ge-Doppelbindungen herzustellen. Dazu wurde zunächst eine ergiebige Synthese für ein Tetraaryldigermen erarbeitet und...
Normalisation of gene-expression data 13 (2001)
Biometric Society, Anne Whitehead, Lutz Edler, Hans-peter Piepho, Astrid Dempfle, Sabine Loesgen, ...
Some approaches for mapping quqantitative trait loci (QTL) in plant breeding populations 12
Mutual Interference of Adenovirus Infection and myc Expression†
Löhr, Kristina, Hartmann, Oliver, Schäfer, Helmut, Dobbelstein, Matthias
During infection with adenovirus, massive changes in the transcription of virus genes are observed, suggesting that the expression of cellular genes may also be modulated. To characterize the levels...
König, Inke R., Schäfer, Helmut, Müller, Hans-Helge, Ziegler, Andreas
The study of genetic linkage or association in complex traits requires large sample sizes, as the expected effect sizes are small and extremely low significance levels need to be adopted. One...
Mutual Interference of Adenovirus Infection and myc Expression†
Löhr, Kristina, Hartmann, Oliver, Schäfer, Helmut, Dobbelstein, Matthias
During infection with adenovirus, massive changes in the transcription of virus genes are observed, suggesting that the expression of cellular genes may also be modulated. To characterize the levels...
Melanocortin-4 Receptor Gene Variant I103 Is Negatively Associated with Obesity
Geller, Frank, Reichwald, Kathrin, Dempfle, Astrid, Illig, Thomas, Vollmert, Caren, Herpertz, Stephan, ...
Several rare mutations in the melanocortin-4 receptor gene (MC4R) predispose to obesity. For the most common missense variant V103I (rs2229616), however, the previously reported similar carrier...
König, Inke R., Schäfer, Helmut, Müller, Hans-Helge, Ziegler, Andreas
The study of genetic linkage or association in complex traits requires large sample sizes, as the expected effect sizes are small and extremely low significance levels need to be adopted. One...
Hinney, Anke, Nguyen, Thuy Trang, Scherag, André, Friedel, Susann, Brönner, Günter, Müller, Timo Dirk, ...
Dempfle, Astrid, Hein, Rebecca, Beckmann, Lars, Scherag, André, Nguyen, Thuy Trang, Schäfer, Helmut, ...
Accounting for interactions with environmental factors in association studies may improve the power to detect genetic effects and may help identifying important environmental effect modifiers. The...
Müller, Timo D, Hinney, Anke, Scherag, André, Nguyen, Thuy T, Schreiner, Felix, Schäfer, Helmut, ...
Lack of association of genetic variants in genes of the endocannabinoid system with anorexia nervosa
Müller, Timo Dirk, Reichwald, Kathrin, Brönner, Günter, Kirschner, Jeanette, Nguyen, Thuy Trang, Scherag, André, ...
Vogel, Carla IG, Scherag, André, Brönner, Günter, Nguyen, Thuy T, Wang, Hai-Jun, Grallert, Harald, ...