Biochemical characterization of Plasmodium falciparum Sir2,a $NAD^+$-dependent deacetylase (2008)
Chakrabarty, Subhra Prakash, Saikumari, Yegnisettipalli Krishnaiah, Bopanna, Monnanda P, Balaram, Hemalatha
In Plasmodium falciparum, the causative agent of cerebral malaria, silent information regulator 2 (Sir2) has been implicated in pathogenesis through its role in var gene silencing. P. falciparum Sir2...
Structural biology of plasmodial proteins (2007)
Gayathri, P, Balaram, Hemalatha, Murthy, MRN
Malaria is a global disease infecting several million individuals annually. Malarial infection is particularly severe in the poorest parts of the world and is a major drain on their limited...
Structure of triosephosphate isomerase (TIM) from Methanocaldococcus jannaschii (2007)
Gayathri, P, Banerjee, Mousumi, Vijayalakshmi, A, Azeez, Shamina, Balaram, Hemalatha, Balaram, P, ...
The crystal structure of a recombinant triosephosphate isomerase (TIM) from the archaeabacterium Methanocaldococcus jannaschii has been determined at a resolution of 2.3 \AA using X-ray diffraction...
Structure of triosephosphate isomerase (TIM) from Methanocaldococcus jannaschii (2007)
Gayathri, P, Banerjee, Mousumi, Vijayalakshmi, A, Azeez, Shamina, Balaram, Hemalatha, Balaram, P, ...
The crystal structure of a recombinant triosephosphate isomerase (TIM) from the archaeabacterium Methanocaldococcus jannaschii has been determined at a resolution of 2.3 \AA using X-ray diffraction...
Structural biology of plasmodial proteins (2007)
Gayathri, P, Balaram, Hemalatha, Murthy, MRN
Malaria is a global disease infecting several million individuals annually. Malarial infection is particularly severe in the poorest parts of the world and is a major drain on their limited...
Parthasarathy, Sampathkumar, Eaazhisai, Kandiah, Balaram, Hemalatha, Balaram, Padmanabhan, Murthy, Mathur RN
Triose-phosphate isomerase, a key enzyme of the glycolytic pathway, catalyzes the isomerization of dihydroxy acetone phosphate and glyceraldehyde 3-phosphate. In this communication we report the...
Pattanaik, Priyaranjan, Jain, Bimba, Ravindra, Gudihal, Gopi, Hosahudya N, Pal, Prajna P, Balaram, Hemalatha, ...
Novel internally quenched fluorescence peptide substrates containing sequence specific sites for cleavage by multiple proteases were designed and synthesized. The 28 and 29 residue peptides contain...
Pattanaik, Priyaranjan, Ravindra, Gudihal, Sengupta, Chandana, Maithal, Kapil, Balaram, Padmanabhan, Balaram, Hemalatha
Plasmodium falciparum triosephosphate isomerase (PfTIM) contains two tryptophan residues, W11 and W168. One is positioned in the interior of the protein, and the other is located on the active-site...
Gopi, Hosahudya N, Ravindra, Gudihal, Pal, Prajna P, Pattanaik, Priyaranjan, Balaram, Hemalatha, Balaram, Padmanabhan
A set of designed internally quenched fluorescence peptide substrates has been used to probe the e¡ects of insertion of beta-peptide bonds into peptide sequences. The test sequence chosen...
Parthasarathy, Sampathkumar, Eaazhisai, Kandiah, Balaram, Hemalatha, Balaram, Padmanabhan, Murthy, Mathur RN
Triose-phosphate isomerase, a key enzyme of the glycolytic pathway, catalyzes the isomerization of dihydroxy acetone phosphate and glyceraldehyde 3-phosphate. In this communication we report the...
Pattanaik, Priyaranjan, Jain, Bimba, Ravindra, Gudihal, Gopi, Hosahudya N, Pal, Prajna P, Balaram, Hemalatha, ...
Novel internally quenched fluorescence peptide substrates containing sequence specific sites for cleavage by multiple proteases were designed and synthesized. The 28 and 29 residue peptides contain...
Pattanaik, Priyaranjan, Ravindra, Gudihal, Sengupta, Chandana, Maithal, Kapil, Balaram, Padmanabhan, Balaram, Hemalatha
Plasmodium falciparum triosephosphate isomerase (PfTIM) contains two tryptophan residues, W11 and W168. One is positioned in the interior of the protein, and the other is located on the active-site...
Gopi, Hosahudya N, Ravindra, Gudihal, Pal, Prajna P, Pattanaik, Priyaranjan, Balaram, Hemalatha, Balaram, Padmanabhan
A set of designed internally quenched fluorescence peptide substrates has been used to probe the e¡ects of insertion of beta-peptide bonds into peptide sequences. The test sequence chosen...
Parthasarathy, S, Balaram, Hemalatha, Balaram, P, Murthy, MRN
The glycolytic enzymes of Plasmodium falciparum (Pf) are attractive drug targets as the parasites lack a functional tricarboxylic cycle and hence depend heavily on glycolysis for their energy...
Maithal, Kapil, Ravindra, Gudihal, Nagaraj, G, Singh, Kumar S, Balaram, Hemalatha, Balaram, P
A mutation at the dimer interface of Plasmodium falciparum triosephosphate isomerase (PfTIM) was created by mutating a tyrosine residue at position 74, at the subunit interface, to glycine. Tyr74 is...
Maithal, Kapil, Ravindra, Gudihal, Balaram, Hemalatha, Balaram, Padmanabhan
Plasmodium falciparum triose-phosphate isomerase, a homodimeric enzyme, contains four cysteine residues at positions 13, 126, 196, and 217 per subunit. Among these, Cys-13 is present at the dimer...
Parthasarathy, S, Balaram, Hemalatha, Balaram, P, Murthy, MRN
The glycolytic enzymes of Plasmodium falciparum (Pf) are attractive drug targets as the parasites lack a functional tricarboxylic cycle and hence depend heavily on glycolysis for their energy...
Maithal, Kapil, Ravindra, Gudihal, Nagaraj, G, Singh, Kumar S, Balaram, Hemalatha, Balaram, P
A mutation at the dimer interface of Plasmodium falciparum triosephosphate isomerase (PfTIM) was created by mutating a tyrosine residue at position 74, at the subunit interface, to glycine. Tyr74 is...
Maithal, Kapil, Ravindra, Gudihal, Balaram, Hemalatha, Balaram, Padmanabhan
Plasmodium falciparum triose-phosphate isomerase, a homodimeric enzyme, contains four cysteine residues at positions 13, 126, 196, and 217 per subunit. Among these, Cys-13 is present at the dimer...
Singh, Kumar S, Maithal, Kapil, Balaram, Hemalatha, Balaram, P
Synthetic peptides corresponding to two distinct segments of the subunit interface of the homodimeric enzyme triosephosphate isomerase (residues 9–18, ANWKCNGTLE, peptide I; residues 68–79,...
Antimalarial Activities of Peptide Antibiotics Isolated from Fungi (2001)
Nagaraj, G, Uma, MV, Shivayogi, MS, Balaram, Hemalatha
Malaria caused by Plasmodium falciparum is a major public health problem in the developing countries of the world. Clinical treatment of malaria has become complicated due to the occurrence of...
Singh, Kumar S, Maithal, Kapil, Balaram, Hemalatha, Balaram, P
Synthetic peptides corresponding to two distinct segments of the subunit interface of the homodimeric enzyme triosephosphate isomerase (residues 9–18, ANWKCNGTLE, peptide I; residues 68–79,...
Antimalarial Activities of Peptide Antibiotics Isolated from Fungi (2001)
Nagaraj, G, Uma, MV, Shivayogi, MS, Balaram, Hemalatha
Malaria caused by Plasmodium falciparum is a major public health problem in the developing countries of the world. Clinical treatment of malaria has become complicated due to the occurrence of...
Ray, Soumya S, Balaram, Hemalatha, Balaram, P
The limited proteolytic cleavage of proteins can result in distinct polypeptides that remain noncovalently associated so that the structural and biochemical properties of the ‘nicked’ protein are...
Ray, Soumya S, Balaram, Hemalatha, Balaram, P
The limited proteolytic cleavage of proteins can result in distinct polypeptides that remain noncovalently associated so that the structural and biochemical properties of the ‘nicked’ protein are...
Velanker, Sameer S, Ray, Soumya S, Gokhale, Rajesh S, Suma, S, Balaram, Hemalatha, Balaram, P, ...
Background: Malaria caused by the parasite Plasmodium falciparum is a major public health concern. The parasite lacks a functional tricarboxylic acid cycle, making glycolysis its sole energy source....
Velanker, Sameer S, Ray, Soumya S, Gokhale, Rajesh S, Suma, S, Balaram, Hemalatha, Balaram, P, ...
Background: Malaria caused by the parasite Plasmodium falciparum is a major public health concern. The parasite lacks a functional tricarboxylic acid cycle, making glycolysis its sole energy source....
Karle, Isabella L, Flippen-Anderson, Judith L, Uma, K, Balaram, Hemalatha, Balaram, P
The peptide Boc-Val-Val-Aib-Pro-Val-Val-Val-OMe has been synthesized to investigate the effect of introduction of a strong \beta-turn promoting guest segment into an oligopeptide with a tendency to...
Karle, Isabella L, Flippen-Anderson, Judith L, Uma, K, Balaram, Hemalatha, Balaram, P
The peptide Boc-Val-Val-Aib-Pro-Val-Val-Val-OMe has been synthesized to investigate the effect of introduction of a strong \beta-turn promoting guest segment into an oligopeptide with a tendency to...
Moretto, V, Crisma, M, Bonora, GM, Toniolo, C, Balaram, Hemalatha, Balaram, P
The synthesis, characterization, and IR absorption, 'H NMR, and CD properties of ${(L-Val)}_n$, host tetra-, penta-, and hexapeptides containing an L-Ile, L-Ala, D-Val, L-Pro, or Aib guest residue...
Karle, Isabella L, Flippen-Anderson, Judith L, Uma, Kuchibhotla, Balaram, Hemalatha, Balaram, Padmanabhan
Two molecules of Boc-Aib-Val-Aib-Aib-Val-Val-Val-Aib-Val-Aib-OMe (where Boc is t-butoxycarbonyl and Aib is \alpha-aminoisobutyryl) cocrystallize in a triclinic cell with different helical...
Karle, Isabella L, Flippen-Anderson, Judith L, Uma, Kuchibhotla, Balaram, Hemalatha, Balaram, Padmanabhan
Two molecules of Boc-Aib-Val-Aib-Aib-Val-Val-Val-Aib-Val-Aib-OMe (where Boc is t-butoxycarbonyl and Aib is \alpha-aminoisobutyryl) cocrystallize in a triclinic cell with different helical...
Moretto, V, Crisma, M, Bonora, GM, Toniolo, C, Balaram, Hemalatha, Balaram, P
The synthesis, characterization, and IR absorption, 'H NMR, and CD properties of ${(L-Val)}_n$, host tetra-, penta-, and hexapeptides containing an L-Ile, L-Ala, D-Val, L-Pro, or Aib guest residue...
Balaram, Hemalatha, Sukumar, M, Balaram, P
The decapeptides $Boc-Aib-L-Val-Aib-Aib-{(L-Val)}_3-Aib-L-Val-Aib-OMe$ and $Boc-Aib-L-Leu- Aib-Aib-{(L-Leu)}_3-Aib-L-Leu-Aib-OMe$ have been studied in $CD{Cl}_3$ and ${({CD}_3)}_2SO$ solutions by...
Balaram, Hemalatha, Sukumar, M, Balaram, P
The decapeptides $Boc-Aib-L-Val-Aib-Aib-{(L-Val)}_3-Aib-L-Val-Aib-OMe$ and $Boc-Aib-L-Leu- Aib-Aib-{(L-Leu)}_3-Aib-L-Leu-Aib-OMe$ have been studied in $CD{Cl}_3$ and ${({CD}_3)}_2SO$ solutions by...
Balaram, Hemalatha, Prasad, Venkataram BV, Balaram, P
The solid-state and solution conformations of the model peptide Boc-Aib-Pro-Pro-NHMe have been studied by X-ray diffraction and NMR. The peptide adopts a poly(pro1ine 11) conformation in the solid...
Balaram, Hemalatha, Prasad, Venkataram BV, Balaram, P
The solid-state and solution conformations of the model peptide Boc-Aib-Pro-Pro-NHMe have been studied by X-ray diffraction and NMR. The peptide adopts a poly(pro1ine 11) conformation in the solid...
Rao, Narasinga BN, Kumar, Anil, Balaram, Hemalatha, Ravi, A, Balaram, P
Nuclear Overhauser effects (NOE) and (CD) techniques have been used to probe \beta-turn conformations in acyclic and cyclic peptides containing Pro-X sequences. The model peptides studied are of the...
Rao, Narasinga BN, Kumar, Anil, Balaram, Hemalatha, Ravi, A, Balaram, P
Nuclear Overhauser effects (NOE) and (CD) techniques have been used to probe \beta-turn conformations in acyclic and cyclic peptides containing Pro-X sequences. The model peptides studied are of the...
Prasad, Venkataram BV, Balaram, Hemalatha, Balaram, P
Pivaloyl-L-Pro-Aib-N-methylamide has been shown to possess one intramolecular hydrogen bond in ${({CD}_3)}_2SO$ solution, by 'H-nmr methods, suggesting the existence of \beta-turns, with Pro-Aib as...
Prasad, Venkataram BV, Balaram, Hemalatha, Balaram, P
Pivaloyl-L-Pro-Aib-N-methylamide has been shown to possess one intramolecular hydrogen bond in ${({CD}_3)}_2SO$ solution, by 'H-nmr methods, suggesting the existence of \beta-turns, with Pro-Aib as...
Antimalarial Activities of Peptide Antibiotics Isolated from Fungi
Nagaraj, G., Uma, M. V., Shivayogi, M. S., Balaram, Hemalatha
Malaria caused by Plasmodium falciparum is a major public health problem in the developing countries of the world. Clinical treatment of malaria has become complicated due to the occurrence of...
Antimalarial Activities of Peptide Antibiotics Isolated from Fungi
Nagaraj, G., Uma, M. V., Shivayogi, M. S., Balaram, Hemalatha
Malaria caused by Plasmodium falciparum is a major public health problem in the developing countries of the world. Clinical treatment of malaria has become complicated due to the occurrence of...