Heng-Yu Fan

Synergistic effects of Pten loss and WNT/CTNNB1 signaling pathway activation in ovarian granulosa cell tumor development and progression (2008)

Laguë, Marie-Noëlle, Paquet, Marilène, Fan, Heng-Yu, Kaartinen, M. Johanna, Chu, Simon, Jamin, Soazik P., ...

The mechanisms of granulosa cell tumor (GCT) development may involve the dysregulation of signaling pathways downstream of follicle-stimulating hormone, including the phosphoinosite-3 kinase...

Regulation of Ubiquitin-Proteasome Pathway on Pig Oocyte Meiotic Maturation and Fertilization1 (2004)

Li-Jun Huo, Heng-Yu Fan, Cheng-Guang Liang, Ling-Zhu Yu, Zhi-Sheng Zhong, Da-Yuan Chen, ...

Degradation of proteins mediated by the ubiquitin-proteasome pathway (UPP) plays essential roles in the eukaryotic cell cycle. The main aim of the present study was to analyze the functional roles...

Protein Kinase C and Mitogen-Activated Protein Kinase Cascade in Mouse Cumulus Cells: Cross Talk and Effect on Meiotic Resumption of Oocyte1 (2004)

Heng-Yu Fan, Li-Jun Huo, Da-Yuan Chen, Heide Schatten, Qing-Yuan Sun

Protein kinase C (PKC) and mitogen-activated protein kinase (MAPK) in cumulus cells are involved in FSH-induced meiotic resumption of cumulus-enclosed oocytes (CEOs), but their regulation and cross...

Involvement of Mitogen-Activated Protein Kinase Cascade During Oocyte Maturation and Fertilization in Mammals1 (2004)

Heng-Yu Fan, Qing-Yuan Sun

Mitogen-activated protein kinase (MAPK) is a family of Ser/Thr protein kinases that are widely distributed in eukaryotic cells. Studies in the last decade revealed that MAPK cascade plays pivotal...

Involvement of Calcium/Calmodulin-Dependent Protein Kinase II (CaMKII) in Meiotic Maturation and Activation of Pig Oocytes1 (2003)

Heng-Yu Fan, Li-Jun Huo, Xiao-Qian Meng, Zhi-Sheng Zhong, Yi Hou, Da-Yuan Chen, ...

Calcium signal is important for the regulation of meiotic cell cycle in oocytes, but its downstream mechanism is not well known. The functional roles of calcium/calmodulin-dependent protein kinase II...

Characterization of Ribosomal S6 Protein Kinase p90rsk During Meiotic Maturation and Fertilization in Pig Oocytes: Mitogen-Activated Protein Kinase-Associated Activation and Localization1 (2003)

Heng-Yu Fan, Chao Tong, Li Lian, Shi-Wen Li, Wen-Xue Gao, Yong Cheng, ...

Mitogen-activated protein kinase (MAPK) becomes activated during the meiotic maturation of pig oocytes, but its physiological substrate is unknown. The 90-kDa ribosome S6 protein kinase (p90rsk) is...

Targeted Disruption of Pten in Ovarian Granulosa Cells Enhances Ovulation and Extends the Life Span of Luteal Cells

Fan, Heng-Yu, Liu, Zhilin, Cahill, Nicola, Richards, JoAnne S.

FSH activates the phosphatidylinositol-3 kinase (PI3K)/acute transforming retrovirus thymoma protein kinase pathway and thereby enhances granulosa cell differentiation in culture. To identify the...

Synergistic effects of Pten loss and WNT/CTNNB1 signaling pathway activation in ovarian granulosa cell tumor development and progression

Laguë, Marie-Noëlle, Paquet, Marilène, Fan, Heng-Yu, Kaartinen, M. Johanna, Chu, Simon, Jamin, Soazik P., ...

The mechanisms of granulosa cell tumor (GCT) development may involve the dysregulation of signaling pathways downstream of follicle-stimulating hormone, including the phosphoinosite-3 kinase...