Henry R Kranzler, Current Cap, Previous Cap, Affleck Glenn Phd, Aguila Leonardo Phd, Albert David Phd, ...
Bao-zhu Yang, Henry R. Kranzler, Hongyu Zhao, Jeffrey R. Gruen, Xingguang Luo, Joel Gelernter
This is an Open Access article distributed under the terms of the Creative Commons Attribution
Luo, Xingguang, Zuo, Lingjun, Kranzler, Henry R, Wang, Shuang, Anton, Raymond F, Gelernter, Joel
Abstract Background In our previous studies, we reported positive associations between seven ADH4 polymorphisms and substance dependence [i.e., alcohol dependence (AD) and/or drug dependence (DD)] in...
Yang, Bao-Zhu, Kranzler, Henry R., Zhao, Hongyu, Gruen, Jeffrey R., Luo, Xingguang, Gelernter, Joel
There have been many conflicting reports concerning the association of the DRD2 locus with alcohol dependence (AD). To investigate whether these findings could be reconciled by considering the...
Hirunsatit, Rungnapa, Ilomäki, Risto, Malison, Robert, Räsänen, Pirkko, Ilomäki, Essi, Kranzler, Henry R, ...
Abstract Background GABA transporter-1 (GAT-1; genetic locus SLC6A1 ) is emerging as a novel target for treatment of neuropsychiatric disorders. To understand how population differences might...
CHRM2 variation predisposes to personality traits of agreeableness and conscientiousness (2007)
Luo, Xingguang, Kranzler, Henry R., Zuo, Lingjun, Zhang, Huiping, Wang, Shuang, Gelernter, Joel
Personality traits are among the most complex quantitative traits. Certain personality traits have been postulated to be part of the inherited component of substance dependence (SD) risk. Association...
Multiple ADH genes modulate risk for drug dependence in both African- and European-Americans (2007)
Luo, Xingguang, Kranzler, Henry R., Zuo, Lingjun, Wang, Shuang, Schork, Nicholas J., Gelernter, Joel
Drug dependence (DD) is commonly co-morbid with alcohol dependence (AD). Many studies have also shown common genetic risk factors for these disorders. We previously reported associations of AD with...
Variation at APOEand STHloci and Alzheimer's disease (2006)
Zuo, Lingjun, Van Dyck, Christopher H, Luo, Xingguang, Kranzler, Henry R, Yang, Bao-zhu, Gelernter, Joel
Abstract Background The apolipoprotein E (APOE) and tau proteins play important roles in the pathological development of Alzheimer's disease (AD). Many studies have shown an association between the...
Zhang, Huiping, Luo, Xingguang, Kranzler, Henry R., Lappalainen, Jaakko, Yang, Bao-Zhu, Krupitsky, Evgeny, ...
We examined 13 single nucleotide polymorphisms (SNPs) spanning the coding region of the µ-opioid receptor gene (OPRM1), among 382 European Americans (EAs) affected with substance dependence [alcohol...
Yu, Yi, Panhuysen, Carolien, Kranzler, Henry R., Hesselbrock, Victor, Rounsaville, Bruce, Weiss, Roger, ...
We report here a study considering association of alleles and haplotypes at the DOPA decarboxylase (DDC) locus with the DSM-IV diagnosis of nicotine dependence (ND) or a quantitative measure for ND...
Gelernter, Joel, Yu, Yi, Weiss, Roger, Brady, Kathleen, Panhuysen, Carolien, Yang, Bao-zhu, ...
Nicotine dependence (ND) is a moderately heritable trait. We ascertained a set of 1615 subjects in 632 families [319 African-American (AA) and 313 European-American (EA)] based on affected sibling...
Zhang, Huiping, Luo, Xingguang, Kranzler, Henry R., Lappalainen, Jaakko, Yang, Bao-Zhu, Krupitsky, Evgeny, ...
We examined 13 single nucleotide polymorphisms (SNPs) spanning the coding region of the µ-opioid receptor gene (OPRM1), among 382 European Americans (EAs) affected with substance dependence [alcohol...
Yu, Yi, Panhuysen, Carolien, Kranzler, Henry R., Hesselbrock, Victor, Rounsaville, Bruce, Weiss, Roger, ...
We report here a study considering association of alleles and haplotypes at the DOPA decarboxylase (DDC) locus with the DSM-IV diagnosis of nicotine dependence (ND) or a quantitative measure for ND...
Gelernter, Joel, Yu, Yi, Weiss, Roger, Brady, Kathleen, Panhuysen, Carolien, Yang, Bao-zhu, ...
Nicotine dependence (ND) is a moderately heritable trait. We ascertained a set of 1615 subjects in 632 families (319 African American [AA] and 313 European American [EA]) based on affected sibling...
Multiple ADH genes modulate risk for drug dependence (2006)
Luo, Xingguang, Kranzler, Henry R., Zuo, Lingjun, Wang, Shuang, Schork, Nicholas J., Gelernter, Joel
Drug dependence (DD) is commonly co-morbid with alcohol dependence (AD). Many studies have also shown common genetic risk factors for these disorders. We previously reported associations of AD with...
Yang, Bao-Zhu, Zhao, Hongyu, Kranzler, Henry R, Gelernter, Joel
BACKGROUND: Detection and evaluation of population stratification are crucial issues in the conduct of genetic association studies. Statistical approaches useful for understanding these issues have...
Yang, Bao-Zhu, Zhao, Hongyu, Kranzler, Henry R, Gelernter, Joel
Abstract Background Detection and evaluation of population stratification are crucial issues in the conduct of genetic association studies. Statistical approaches useful for understanding these...
Luo, Xingguang, Kranzler, Henry R., Zuo, Lingjun, Wang, Shuang, Blumberg, Hilary P., Gelernter, Joel
Cholinergic muscarinic 2 receptor (CHRM2) is implicated in memory and cognition, functions impaired in many neuropsychiatric disorders. Wang et al. (2004) reported that variation in CHRM2 gene...
Luo, Xingguang, Kranzler, Henry R., Zuo, Lingjun, Wang, Shuang, Blumberg, Hilary P., Gelernter, Joel
Cholinergic muscarinic 2 receptor (CHRM2) is implicated in memory and cognition, functions impaired in many neuropsychiatric disorders. Wang et al. [Wang, J.C., Hinrichs, A.L., Stock, H., Budde, J.,...
PHARMACOTHERAPY OF ALCOHOLISM: GAPS IN KNOWLEDGE AND OPPORTUNITIES FOR RESEARCH (2000)
During the past decade, renewed interest in medications to prevent relapse in alcoholics has yielded a number of promising candidates. Although two of these medications, naltrexone and acamprosate,...
Variation at APOE and STH loci and Alzheimer's disease
Zuo, Lingjun, Van Dyck, Christopher H, Luo, Xingguang, Kranzler, Henry R, Yang, Bao-zhu, Gelernter, Joel
Genomewide Linkage Scan for Opioid Dependence and Related Traits
Gelernter, Joel, Panhuysen, Carolien, Wilcox, Marsha, Hesselbrock, Victor, Rounsaville, Bruce, Poling, James, ...
Risk of opioid dependence is genetically influenced. We recruited a sample of 393 small nuclear families (including 250 full-sib and 46 half-sib pairs), each with at least one individual with opioid...
Luo, Xingguang, Kranzler, Henry R., Zuo, Lingjun, Wang, Shuang, Schork, Nicholas J., Gelernter, Joel
The set of alcohol-metabolizing enzymes has considerable genetic and functional complexity. The relationships between some alcohol dehydrogenase (ADH) and aldehyde dehydrogenase (ALDH) genes and...
Genomewide Linkage Scan for Opioid Dependence and Related Traits
Gelernter, Joel, Panhuysen, Carolien, Wilcox, Marsha, Hesselbrock, Victor, Rounsaville, Bruce, Poling, James, ...
Risk of opioid dependence is genetically influenced. We recruited a sample of 393 small nuclear families (including 250 full-sib and 46 half-sib pairs), each with at least one individual with opioid...
Luo, Xingguang, Kranzler, Henry R., Zuo, Lingjun, Wang, Shuang, Schork, Nicholas J., Gelernter, Joel
The set of alcohol-metabolizing enzymes has considerable genetic and functional complexity. The relationships between some alcohol dehydrogenase (ADH) and aldehyde dehydrogenase (ALDH) genes and...
Variation at APOE and STH loci and Alzheimer's disease
Zuo, Lingjun, Van Dyck, Christopher H, Luo, Xingguang, Kranzler, Henry R, Yang, Bao-zhu, Gelernter, Joel
Demographic changes and marker properties affect detection of human population differentiation
Listman, Jennifer B, Malison, Robert T, Sughondhabirom, Atapol, Yang, Bao-Zhu, Raaum, Ryan L, Thavichachart, Nuntika, ...
Hirunsatit, Rungnapa, Ilomäki, Risto, Malison, Robert, Räsänen, Pirkko, Ilomäki, Essi, Kranzler, Henry R, ...