Antimycobacterial activity of cerulenin and its effects on lipid biosynthesis (1999)
Parrish, Nikki M., Kuhajda, Francis P., Heine, Henry S., Bishai, William R., Dick, James D.
Cerulenin is a potent inhibitor of fatty acid synthase (FAS) in a variety of prokaryotic and eukaryotic cells. Using a standardized mycobacterial susceptibility test, we have observed that cerulenin...
Heine, Henry S., England, Marilyn J., Waag, David M., Byrne, W. Russell
In vitro susceptibilities to 28 antibiotics were determined for 11 strains of Burkholderia mallei by the broth microdilution method. The B. mallei strains demonstrated susceptibility to...
Vietri, Nicholas J., Purcell, Bret K., Lawler, James V., Leffel, Elizabeth K., Rico, Pedro, Gamble, Christopher S., ...
Prevention of inhalational anthrax after Bacillus anthracis spore exposure requires a prolonged course of antibiotic prophylaxis. In response to the 2001 anthrax attack in the United States,...
Heine, Henry S., England, Marilyn J., Waag, David M., Byrne, W. Russell
In vitro susceptibilities to 28 antibiotics were determined for 11 strains of Burkholderia mallei by the broth microdilution method. The B. mallei strains demonstrated susceptibility to...
Vietri, Nicholas J., Purcell, Bret K., Lawler, James V., Leffel, Elizabeth K., Rico, Pedro, Gamble, Christopher S., ...
Prevention of inhalational anthrax after Bacillus anthracis spore exposure requires a prolonged course of antibiotic prophylaxis. In response to the 2001 anthrax attack in the United States,...
Determination of Antibiotic Efficacy against Bacillus anthracis in a Mouse Aerosol Challenge Model▿
Heine, Henry S., Bassett, Jennifer, Miller, Lynda, Hartings, Justin M., Ivins, Bruce E., Pitt, M. Louise, ...
An anthrax spore aerosol infection mouse model was developed as a first test of in vivo efficacy of antibiotics identified as active against Bacillus anthracis. Whole-body, 50% lethal dose (LD50)...
Ambrose, Paul G., Forrest, Alan, Craig, William A., Rubino, Chistopher M., Bhavnani, Sujata M., Drusano, George L., ...
We determined the pharmacokinetic-pharmacodynamic (PK-PD) measure most predictive of gatifloxacin efficacy and the magnitude of this measure necessary for survival in a murine Bacillus anthracis...
Drusano, G. L., Okusanya, Olanrewaju O., Okusanya, Adedoyin, Van Scoy, Brian, Brown, D. L., Kulawy, Robert, ...
Sixty days of ciprofloxacin administration at 500 mg every 12 h is currently recommended for the prophylaxis of inhalational exposure to Bacillus anthracis. We examined Bacillus anthracis (Δ-Sterne...