Löhr, Ulrike, Chung, Ho-Ryun, Beller, Mathias, Jäckle, Herbert
Bicoid (Bcd) is the anterior determinant in Drosophila. Accordingly, loss of Bcd causes loss of head and thorax and their replacement with posterior structures. bcd mRNA is maternally deposited at...
COPI Complex Is a Regulator of Lipid Homeostasis (2008)
Mathias Beller, Carole Sztalryd, Noel Southall, Ming Bell, Herbert Jäckle, Douglas S. Auld, ...
Lipid droplets are ubiquitous triglyceride and sterol ester storage organelles required for energy storage homeostasis and biosynthesis. Although little is known about lipid droplet formation and...
Lineage-specific expansion of the Zinc Finger Associated Domain ZAD (2007)
Chung, Ho-Ryun, Löhr, Ulrike, Jäckle, Herbert
The zinc finger associated domain (ZAD), present in almost 100 distinct proteins, characterizes the largest subgroup of C2H2 zinc finger proteins in Drosophila melanogaster and was initially found to...
Dual Lipolytic Control of Body Fat Storage and Mobilization in Drosophila (2007)
Sebastian Grönke, Günter Müller, Jochen Hirsch, Sonja Fellert, Alexandra Andreou, Tobias Haase, ...
Energy homeostasis is a fundamental property of animal life, providing a genetically fixed balance between fat storage and mobilization. The importance of body fat regulation is emphasized by...
ZAD, Zinc Finger Associated Domain Corresponding Autor: (2007)
Ulrike Löhr, Herbert Jäckle, Ho-ryun Chung
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License
Gain-of-Function Screen for Genes That Affect Drosophila Muscle Pattern Formation (2005)
Nicole Staudt, Andreas Molitor, Kalman Somogyi, Juan Mata, Silvia Curado, Karsten Eulenberg, ...
This article reports the production of an EP-element insertion library with more than 3,700 unique target sites within the Drosophila melanogaster genome and its use to systematically identify genes...
Control of triglyceride storage by a WD40/TPR-domain protein (2003)
Häder,Thomas, Müller,Sandra, Aguilera,Miguel, Eulenberg,Karsten G., Steuernagel,Arnd, Ciossek,Thomas, ...
Control of triglyceride storage by a WD40/TPR-domain protein (2003)
Häder, Thomas, Müller, Sandra, Aguilera, Miguel, Eulenberg, Karsten G., Steuernagel, Arnd, Ciossek, Thomas, ...
Carrera, Pilar, Moshkin, Yuri M., Grönke, Sebastian, Silljé, Herman H.W., Nigg, Erich A., Jäckle, Herbert, ...
Tousled-like kinases (TLKs) constitute a family of serine/threonine kinases conserved in plants and animals that act in a cell cycle-dependent manner. In mammals, their activity peaks during S phase,...
mBtd is required to maintain signaling during murine limb development (2003)
Treichel, Dieter, Schöck, Frieder, Jäckle, Herbert, Gruss, Peter, Mansouri, Ahmed
buttonhead (btd) encodes an SP1-like transcription factor required for the generation and specification of Drosophila head segments. We identified a murine btd homolog, termed mouse Btd (mBtd), which...
Benos, Panayiotis V., Gatt, Melanie K., Murphy, Lee, Harris, David, Barrell, Bart, Ferraz, Concepcion, ...
Phenotypic suppression of empty spiracles is prevented by buttonhead (2000)
Frieder Schöck, Joachim Reischl, Ernst Wimmer, Heike Taubert, Beverly A. Purnell, Herbert Jäckle
Häder, Thomas, Wainwright, David, Shandala, Tatiana, Saint, Robert Bryce, Taubert, Heike, Brönner, Günter, ...
Transcriptional control of the Drosophila terminal gap gene huckebein (hkb) depends on Torso (Tor) receptor tyrosine kinase (RTK) signaling and the Rel/NFκB homolog Dorsal (Dl) [1, 2, 3 and 4]. Dl...
Häder, Thomas, Wainwright, David, Shandala, Tatiana, Saint, Robert Bryce, Taubert, Heike, Brönner, Günter, ...
Transcriptional control of the Drosophila terminal gap gene huckebein (hkb) depends on Torso (Tor) receptor tyrosine kinase (RTK) signaling and the Rel/NFκB homolog Dorsal (Dl) [1, 2, 3 and 4]. Dl...
Häder, Thomas, Wainwright, David, Shandala, Tatiana, Saint, Robert Bryce, Taubert, Heike, Brönner, Günter, ...
Transcriptional control of the Drosophila terminal gap gene huckebein (hkb) depends on Torso (Tor) receptor tyrosine kinase (RTK) signaling and the Rel/NFκB homolog Dorsal (Dl) [1, 2, 3 and 4]. Dl...
A Drosophila homologue of human Sp1 is a head-specific segmentation gene (1993)
Ernst A. Wimmer, Herbert Jäckle, Christine Pfeifle, Stephen M. Cohen
Cross-regulatory interactions among the gap genes of Drosophila (1986)
Herbert Jäckle, Diethard Tautz, Reinhard Schuh, Eveline Seifert, Ruth Lehmann
Spatial and temporal patterns of Krüppel gene expression in early Drosophila embryos (1985)
Douglas C. Knipple, Eveline Seifert, Urs B. Rosenberg, Anette Preiss, Herbert Jäckle
Molecular genetics of Krüppel, a gene required for segmentation of the Drosophila embryo (1985)
Anette Preiss, Urs B. Rosenberg, Andrea Kienlin, Eveline Seifert, Herbert Jäckle
Schöck, Frieder, Sauer, Frank, Jäckle, Herbert, Purnell, Beverly A.
The Drosophila gene buttonhead (btd) is required for the establishment of three embryonic head segments. It encodes a zinc-finger-type transcription factor expressed in the corresponding head segment...
The anterior determinant bicoid of Drosophila is a derived Hox class 3 gene
Stauber, Michael, Jäckle, Herbert, Schmidt-Ott, Urs
The Drosophila gene bicoid functions as the anterior body pattern organizer of Drosophila. Embryos lacking maternally expressed bicoid fail to develop anterior segments including head and thorax. In...
Vorbrüggen, Gerd, Jäckle, Herbert
The egr-type zinc-finger transcription factor encoded by the Drosophila gene stripe (sr) is expressed in a subset of epidermal cells to which muscles attach during late stages of embryogenesis. We...
A modifier screen in the eye reveals control genes for Krüppel activity in the Drosophila embryo
Carrera, Pilar, Abrell, Sarah, Kerber, Birgit, Walldorf, Uwe, Preiss, Anette, Hoch, Michael, ...
Irregular facets (If) is a dominant mutation of Drosophila that results in small eyes with fused ommatidia. Previous results showed that the gene Krüppel (Kr), which is best known for its early...
Bicoid associates with the 5′-cap-bound complex of caudal mRNA and represses translation
Niessing, Dierk, Blanke, Stephen, Jäckle, Herbert
Translational control plays a key role in many biological processes including pattern formation during early Drosophila embryogenesis. In this process, the anterior determinant Bicoid (BCD) acts not...
mBtd is required to maintain signaling during murine limb development
Treichel, Dieter, Schöck, Frieder, Jäckle, Herbert, Gruss, Peter, Mansouri, Ahmed
buttonhead (btd) encodes an SP1-like transcription factor required for the generation and specification of Drosophila head segments. We identified a murine btd homolog, termed mouse Btd (mBtd), which...
Benos, Panayiotis V., Gatt, Melanie K., Murphy, Lee, Harris, David, Barrell, Bart, Ferraz, Concepcion, ...
We present the sequence of a contiguous 2.63 Mb of DNA extending from the tip of the X chromosome of Drosophila melanogaster. Within this sequence, we predict 277 protein coding genes, of which 94...
Frei, Erich, Schuh, Reinhard, Baumgartner, Stefan, Burri, Maya, Noll, Markus, Jürgens, Gerd, ...
The isolation, identification and structure of the spalt gene is described. This novel homeotic gene of Drosophila is required for the establishment of the posterior-most head and the anterior-most...
Côté, Serge, Preiss, Anette, Haller, Jochen, Schuh, Reinhard, Kienlin, Andrea, Seifert, Eveline, ...
Genetic analysis of the Drosophila chromosome region 60 E9-F1 identified two functions affecting embryonic development; gooseberry (gsb), a segment polarity gene, and zipper (zip), an unclassified...
Molecular cloning of microdissected lampbrush loop DNA sequences of Drosophila hydei
Hennig, Wolfgang, Huijser, Peter, Vogt, Peter, Jäckle, Herbert, Edström, Jan-Erik
We microdissected a Y chromosomal lampbrush loop pair from primary spermatocyte nuclei of Drosophila hydei and cloned the DNA directly at the microscale. Four of the 12 recombinant DNA clones...
González-Gaitán, Marcos, Jäckle, Herbert
The stomatogastric nervous system (SNS) of Drosophila is a simply organized neural circuitry that innervates the anterior enteric system. Unlike the central and the peripheral nervous systems, the...
The class 2 selenophosphate synthetase gene of Drosophila contains a functional mammalian-type SECIS
Hirosawa-Takamori, Mitsuko, Jäckle, Herbert, Vorbrüggen, Gerd
Synthesis of monoselenophosphate, the selenium donor required for the synthesis of selenocysteine (Sec) is catalyzed by the enzyme selenophosphate synthetase (SPS), first described in Escherichia...
Linder, Britta, Gerlach, Nina, Jäckle, Herbert
In chromosomal rearrangements of acute myeloid leukaemia patients the mixed lineage leukaemia (MLL) gene, a human homolog of the Drosophila gene trithorax, is frequently fused to AF10. Here we...
Mapping and identification of essential gene functions on the X chromosome of Drosophila
Peter, Annette, Schöttler, Petra, Werner, Meike, Beinert, Nicole, Dowe, Gordon, Burkert, Peter, ...
The Drosophila melanogaster genome consists of four chromosomes that contain 165 Mb of DNA, 120 Mb of which are euchromatic. The two Drosophila Genome Projects, in collaboration with Celera Genomics...
Gain-of-Function Screen for Genes That Affect Drosophila Muscle Pattern Formation
Staudt, Nicole, Molitor, Andreas, Somogyi, Kalman, Mata, Juan, Curado, Silvia, Eulenberg, Karsten, ...
This article reports the production of an EP-element insertion library with more than 3,700 unique target sites within the Drosophila melanogaster genome and its use to systematically identify genes...
Hirosawa-Takamori, Mitsuko, Chung, Ho-Ryun, Jäckle, Herbert
Selenoprotein synthesis is conserved from bacteria to man. It involves the differential decoding of the UGA stop codon as selenocysteine. The proteomes of both prokaryotes and eukaryotes, with the...
Pflanz, Ralf, Peter, Annette, Schäfer, Ulrich, Jäckle, Herbert
Cellular localization of organelles, protein complexes and single mRNAs depends on the directed transport along microtubule tracks, a process mediated by ATP-driven molecular motor proteins of the...
Genomic expansion and clustering of ZAD-containing C2H2 zinc-finger genes in Drosophila
Chung, Ho-Ryun, Schäfer, Ulrich, Jäckle, Herbert, Böhm, Siegfried
C2H2 zinc-finger proteins (ZFPs) constitute the largest family of nucleic acid binding factors in higher eukaryotes. In silico analysis identified a total of 326 putative ZFP genes in the Drosophila...
Control of triglyceride storage by a WD40/TPR-domain protein
Häder, Thomas, Müller, Sandra, Aguilera, Miguel, Eulenberg, Karsten G., Steuernagel, Arnd, Ciossek, Thomas, ...
Obesity is a metabolic disorder related to improper control of energy uptake and expenditure, which results in excessive accumulation of body fat. Initial insights into the genetic pathways that...
Tousled-like kinase functions with the chromatin assembly pathway regulating nuclear divisions
Carrera, Pilar, Moshkin, Yuri M., Grönke, Sebastian, Silljé, Herman H.W., Nigg, Erich A., Jäckle, Herbert, ...
Tousled-like kinases (TLKs) constitute a family of serine/threonine kinases conserved in plants and animals that act in a cell cycle-dependent manner. In mammals, their activity peaks during S phase,...
Staudt, Nicole, Fellert, Sonja, Chung, Ho-Ryun, Jäckle, Herbert, Vorbrüggen, Gerd
We describe the molecular characterization and function of vielfältig (vfl), a X-chromosomal gene that encodes a nuclear protein with six Krüppel-like C2H2 zinc finger motifs. vfl transcripts are...
Schöck, Frieder, Sauer, Frank, Jäckle, Herbert, Purnell, Beverly A.
The Drosophila gene buttonhead (btd) is required for the establishment of three embryonic head segments. It encodes a zinc-finger-type transcription factor expressed in the corresponding head segment...
The anterior determinant bicoid of Drosophila is a derived Hox class 3 gene
Stauber, Michael, Jäckle, Herbert, Schmidt-Ott, Urs
The Drosophila gene bicoid functions as the anterior body pattern organizer of Drosophila. Embryos lacking maternally expressed bicoid fail to develop anterior segments including head and thorax. In...
Vorbrüggen, Gerd, Jäckle, Herbert
The egr-type zinc-finger transcription factor encoded by the Drosophila gene stripe (sr) is expressed in a subset of epidermal cells to which muscles attach during late stages of embryogenesis. We...
A modifier screen in the eye reveals control genes for Krüppel activity in the Drosophila embryo
Carrera, Pilar, Abrell, Sarah, Kerber, Birgit, Walldorf, Uwe, Preiss, Anette, Hoch, Michael, ...
Irregular facets (If) is a dominant mutation of Drosophila that results in small eyes with fused ommatidia. Previous results showed that the gene Krüppel (Kr), which is best known for its early...
Bicoid associates with the 5′-cap-bound complex of caudal mRNA and represses translation
Niessing, Dierk, Blanke, Stephen, Jäckle, Herbert
Translational control plays a key role in many biological processes including pattern formation during early Drosophila embryogenesis. In this process, the anterior determinant Bicoid (BCD) acts not...
Tousled-like kinase functions with the chromatin assembly pathway regulating nuclear divisions
Carrera, Pilar, Moshkin, Yuri M., Grönke, Sebastian, Silljé, Herman H.W., Nigg, Erich A., Jäckle, Herbert, ...
Tousled-like kinases (TLKs) constitute a family of serine/threonine kinases conserved in plants and animals that act in a cell cycle-dependent manner. In mammals, their activity peaks during S phase,...
mBtd is required to maintain signaling during murine limb development
Treichel, Dieter, Schöck, Frieder, Jäckle, Herbert, Gruss, Peter, Mansouri, Ahmed
buttonhead (btd) encodes an SP1-like transcription factor required for the generation and specification of Drosophila head segments. We identified a murine btd homolog, termed mouse Btd (mBtd), which...
Benos, Panayiotis V., Gatt, Melanie K., Murphy, Lee, Harris, David, Barrell, Bart, Ferraz, Concepcion, ...
We present the sequence of a contiguous 2.63 Mb of DNA extending from the tip of the X chromosome of Drosophila melanogaster. Within this sequence, we predict 277 protein coding genes, of which 94...
Frei, Erich, Schuh, Reinhard, Baumgartner, Stefan, Burri, Maya, Noll, Markus, Jürgens, Gerd, ...
The isolation, identification and structure of the spalt gene is described. This novel homeotic gene of Drosophila is required for the establishment of the posterior-most head and the anterior-most...
Côté, Serge, Preiss, Anette, Haller, Jochen, Schuh, Reinhard, Kienlin, Andrea, Seifert, Eveline, ...
Genetic analysis of the Drosophila chromosome region 60 E9-F1 identified two functions affecting embryonic development; gooseberry (gsb), a segment polarity gene, and zipper (zip), an unclassified...
Molecular cloning of microdissected lampbrush loop DNA sequences of Drosophila hydei
Hennig, Wolfgang, Huijser, Peter, Vogt, Peter, Jäckle, Herbert, Edström, Jan-Erik
We microdissected a Y chromosomal lampbrush loop pair from primary spermatocyte nuclei of Drosophila hydei and cloned the DNA directly at the microscale. Four of the 12 recombinant DNA clones...
González-Gaitán, Marcos, Jäckle, Herbert
The stomatogastric nervous system (SNS) of Drosophila is a simply organized neural circuitry that innervates the anterior enteric system. Unlike the central and the peripheral nervous systems, the...
The class 2 selenophosphate synthetase gene of Drosophila contains a functional mammalian-type SECIS
Hirosawa-Takamori, Mitsuko, Jäckle, Herbert, Vorbrüggen, Gerd
Synthesis of monoselenophosphate, the selenium donor required for the synthesis of selenocysteine (Sec) is catalyzed by the enzyme selenophosphate synthetase (SPS), first described in Escherichia...
Linder, Britta, Gerlach, Nina, Jäckle, Herbert
In chromosomal rearrangements of acute myeloid leukaemia patients the mixed lineage leukaemia (MLL) gene, a human homolog of the Drosophila gene trithorax, is frequently fused to AF10. Here we...
Mapping and identification of essential gene functions on the X chromosome of Drosophila
Peter, Annette, Schöttler, Petra, Werner, Meike, Beinert, Nicole, Dowe, Gordon, Burkert, Peter, ...
The Drosophila melanogaster genome consists of four chromosomes that contain 165 Mb of DNA, 120 Mb of which are euchromatic. The two Drosophila Genome Projects, in collaboration with Celera Genomics...
Gain-of-Function Screen for Genes That Affect Drosophila Muscle Pattern Formation
Staudt, Nicole, Molitor, Andreas, Somogyi, Kalman, Mata, Juan, Curado, Silvia, Eulenberg, Karsten, ...
This article reports the production of an EP-element insertion library with more than 3,700 unique target sites within the Drosophila melanogaster genome and its use to systematically identify genes...
Hirosawa-Takamori, Mitsuko, Chung, Ho-Ryun, Jäckle, Herbert
Selenoprotein synthesis is conserved from bacteria to man. It involves the differential decoding of the UGA stop codon as selenocysteine. The proteomes of both prokaryotes and eukaryotes, with the...
Pflanz, Ralf, Peter, Annette, Schäfer, Ulrich, Jäckle, Herbert
Cellular localization of organelles, protein complexes and single mRNAs depends on the directed transport along microtubule tracks, a process mediated by ATP-driven molecular motor proteins of the...
Genomic expansion and clustering of ZAD-containing C2H2 zinc-finger genes in Drosophila
Chung, Ho-Ryun, Schäfer, Ulrich, Jäckle, Herbert, Böhm, Siegfried
C2H2 zinc-finger proteins (ZFPs) constitute the largest family of nucleic acid binding factors in higher eukaryotes. In silico analysis identified a total of 326 putative ZFP genes in the Drosophila...
Control of triglyceride storage by a WD40/TPR-domain protein
Häder, Thomas, Müller, Sandra, Aguilera, Miguel, Eulenberg, Karsten G., Steuernagel, Arnd, Ciossek, Thomas, ...
Obesity is a metabolic disorder related to improper control of energy uptake and expenditure, which results in excessive accumulation of body fat. Initial insights into the genetic pathways that...
Staudt, Nicole, Fellert, Sonja, Chung, Ho-Ryun, Jäckle, Herbert, Vorbrüggen, Gerd
We describe the molecular characterization and function of vielfältig (vfl), a X-chromosomal gene that encodes a nuclear protein with six Krüppel-like C2H2 zinc finger motifs. vfl transcripts are...
Dual Lipolytic Control of Body Fat Storage and Mobilization in Drosophila
Grönke, Sebastian, Müller, Günter, Hirsch, Jochen, Fellert, Sonja, Andreou, Alexandra, Haase, Tobias, ...
Energy homeostasis is a fundamental property of animal life, providing a genetically fixed balance between fat storage and mobilization. The importance of body fat regulation is emphasized by...
Grieder, Nicole C., Charlafti, Ilias, Kloter, Urs, Jäckle, Herbert, Schäfer, Ulrich, Gehring, Walter J.
To identify novel factors that lead a fly imaginal disc to adopt its developmental fate, we carried out a modular dominant misexpression screen in imaginal discs. We have identified two factors that...
Jauch, Ralf, Cho, Min-Kyu, Jäkel, Stefan, Netter, Catharina, Schreiter, Kay, Aicher, Babette, ...
Autoinhibition is a recurring mode of protein kinase regulation and can be based on diverse molecular mechanisms. Here, we show by crystal structure analysis, nuclear magnetic resonance (NMR)-based...
COPI Complex Is a Regulator of Lipid Homeostasis
Beller, Mathias, Sztalryd, Carole, Southall, Noel, Bell, Ming, Jäckle, Herbert, Auld, Douglas S, ...
Lipid droplets are ubiquitous triglyceride and sterol ester storage organelles required for energy storage homeostasis and biosynthesis. Although little is known about lipid droplet formation and...
curled Encodes the Drosophila Homolog of the Vertebrate Circadian Deadenylase Nocturnin
Grönke, Sebastian, Bickmeyer, Iris, Wunderlich, Roman, Jäckle, Herbert, Kühnlein, Ronald P.
Drosophila melanogaster curled, one of the first fly mutants described by T. H. Morgan >90 years ago, is the founding member of a series of curled wing phenotype mutants widely used as markers in...
Hirosawa-Takamori, Mitsuko, Ossipov, Dmitri, Novoselov, Sergey V., Turanov, Anton A., Zhang, Yan, Gladyshev, Vadim N., ...
Translational read-through of the UGA stop codon is an evolutionarily conserved feature that most prominently represents the basis of selenoprotein biosynthesis. It requires a specific cis-acting...
Löhr, Ulrike, Chung, Ho-Ryun, Beller, Mathias, Jäckle, Herbert
Bicoid (Bcd) is the anterior determinant in Drosophila. Accordingly, loss of Bcd causes loss of head and thorax and their replacement with posterior structures. bcd mRNA is maternally deposited at...
Chanana, Bhavna, Steigemann, Patrick, Jäckle, Herbert, Vorbrüggen, Gerd
Syndecan (Sdc) is a conserved transmembrane heparan sulfate proteoglycan (HSPG) bearing additional chondroitin sulfate (CS) modifications on its extracellular domain. In vertebrates, this...