Volman, Vladislav, Levine, Herbert
We study the characteristics of weak signal detection by a recurrent neuronal network with plastic synaptic coupling. It is shown that in the presence of an asynchronous component in synaptic...
Wylie, C. Scott, Ghim, Cheol-Min, Kessler, David A., Levine, Herbert
This supplementary information contains detailed derivations, comparison to experiment, and discussion of other miscellaneous issues omitted from the main text.
Abstracts 1 2 Plenary Dark matter or new gravitational physics? (2008)
Jacob Bekenstein, Herbert Levine
It is now clear that Milgrom’s MOND paradigm, which purports to supplant dark matter with new physics, has surprisingly large predictive power for disk galaxies. Its success for larger systems,...
Sichun Yang, Herbert Levine, José N. Onuchic
Domain swapping has shown to be an important mechanism controlling multi-protein assembling. Recently it has been suggested as a possible mechanism un-derlying protein aggregation. Understanding...
Eshel Ben Jacob, Israela Becker, Yoash Shapira, Herbert Levine
Bacteria have developed intricate communication capabilities (e.g. quorum-sensing, chemotactic signaling and plasmid exchange) to cooperatively self-organize into highly structured colonies with...
Active dendritic conductances enhance processing of plastic synaptic stimuli (2008)
Volman, Vladislav, Levine, Herbert, Sejnowski, Terrence J
No abstract available.
Coexistence of amplitude and frequency modulations in intracellular calcium dynamics (2008)
De Pitta, Maurizio, Volman, Vladislav, Levine, Herbert, Pioggia, Giovanni, De Rossi, Danilo, Ben-Jacob, Eshel
The complex dynamics of intracellular calcium regulates cellular responses to information encoded in extracellular signals. Here, we study the encoding of these external signals in the context of the...
Activity-dependent stochastic resonance in recurrent neuronal networks (2008)
Volman, Vladislav, Levine, Herbert
We use a biophysical model of a local neuronal circuit to study the implications of synaptic plasticity for the detection of weak sensory stimuli. Networks with fast plastic coupling show behavior...
Pablo Blinder, Itay Baruchi, Vladislav Volman, Herbert Levine, Danny Baranes, Eshel Ben Jacob
Abstract. Current analyses of complex biological networks focus either on their global statistical connectivity properties (e.g. topological path lengths and nodes connectivity ranks) or the...
The fixation probability of rare mutators in finite asexual populations (2008)
Wylie, C. Scott, Ghim, Cheol-Min, Kessler, David A., Levine, Herbert
A mutator is an allele that increases the mutation rate throughout the genome by disrupting some aspect of DNA replication or repair. Mutators that increase the mutation rate by the order of 100 fold...
Raymond Goldstein, Robert Austin, Denis Rousseau, Peter Jung, Paul Gailey, ...
sday, June G. Decher, G. Decher, G. Decher, G. Decher, G. Polyectrolyte Multi Layers In Life Sciences 16:30-1700 S. Satija, S. Satija, S. Satija, S. Satija, S. Adsorption to Functionalized Lipid...
Correlated Phenotypic Transitions to Competence in Bacterial Colonies (2007)
Hecht, Inbal, Ben-Jacob, Eshel, Levine, Herbert
Genetic competence is a phenotypic state of a bacterial cell in which it is capable of importing DNA, presumably to hasten its exploration of alternate genes in its quest for survival under stress....
Small Regulatory RNAs May Sharpen Spatial Expression Patterns (2007)
Erel Levine, Peter McHale, Herbert Levine
The precise establishment of gene expression patterns is a crucial step in development. Formation of a sharp boundary between high and low spatial expression domains requires a genetic mechanism that...
microRNAs may sharpen spatial expression patterns (2007)
Levine, Erel, McHale, Peter, Levine, Herbert
The precise layout of gene expression patterns is a crucial step in development. Formation of a sharp boundary between high and low expression domains requires a genetic mechanism which is both...
The astrocyte as a gatekeeper of synaptic information transfer (2006)
Volman, Vladislav, Ben-Jacob, Eshel, Levine, Herbert
We present a simple biophysical model for the coupling between synaptic transmission and the local calcium concentration on an enveloping astrocytic domain. This interaction enables the astrocyte to...
Wylie, Christopher Scott, Levine, Herbert, Kessler, D A, Levine, H
We study two-dimensional (2D) fronts propagating up a comoving reaction rate gradient in finite number reaction-diffusion systems. We show that in a 2D rectangular channel, planar solutions to the...
Wylie, C. Scott, Levine, Herbert, Kessler, David A.
We study 2D fronts propagating up a co-moving reaction rate gradient in finite number reaction-diffusion systems. We show that in a 2D rectangular channel, planar solutions to the deterministic...
Self-engineering capabilities of bacteria (2006)
Ben-Jacob, Eshel, Levine, Herbert
Under natural growth conditions, bacteria can utilize intricate communication capabilities (e.g. quorum-sensing, chemotactic signalling and plasmid exchange) to cooperatively form (self-organize)...
Embryonic Pattern Scaling Achieved by Oppositely Directed Morphogen Gradients (2006)
McHale, Peter, Rappel, Wouter-Jan, Levine, Herbert
Morphogens are proteins, often produced in a localised region, whose concentrations spatially demarcate regions of differing gene expression in developing embryos. The boundaries of expression must...
Analytic approach to the evolutionary effects of genetic exchange (2005)
Cohen, Elisheva, Kessler, David A., Levine, Herbert
We present an approximate analytic study of our previously introduced model of evolution including the effects of genetic exchange. This model is motivated by the process of bacterial transformation....
Front Propagation up a Reaction Rate Gradient (2005)
Cohen, Elisheva, Kessler, David A., Levine, Herbert
We expand on a previous study of fronts in finite particle number reaction-diffusion systems in the presence of a reaction rate gradient in the direction of the front motion. We study the system via...
Recombination dramatically speeds up evolution of finite populations (2004)
Cohen, Elisheva, Kessler, David A., Levine, Herbert
We study the role of recombination, as practiced by genetically-competent bacteria, in speeding up Darwinian evolution. This is done by adding a new process to a previously-studied Markov model of...
Physical Schemata Underlying Biological Pattern Formation - Examples, Issues and Strategies (2004)
Levine, Herbert, Ben-Jacob, Eshel
Biological systems excel at building spatial structures on scales ranging from nanometers to kilometers and exhibit temporal patterning from milliseconds to years. One approach that nature has taken...
Fluctuation-regularized Front Propagation Dynamics (2004)
Cohen, Elisheva, Kessler, David A., Levine, Herbert
We introduce and study a new class of fronts in finite particle number reaction-diffusion systems, corresponding to propagating up a reaction rate gradient. We show that these systems have no...
Dynamic instabilities of fracture under biaxial strain using a phase field model (2004)
We present a phase field model of the propagation of fracture under plane strain. This model, based on simple physical considerations, is able to accurately reproduce the different behavior of cracks...
Performance Monitoring of MNA Remedies for VOCs in Ground Water (2004)
Daniel F. Pope, Steven D. Acree, Herbert Levine, Stephen Mangion, Jeffrey Van Ee, Kelly Hurt, ...
Prepared under contract to Dynamac Corporation
Phase field approach for modeling intracellular dynamics (2003)
Kockelkoren, Julien, Levine, Herbert, Rappel, Wouter-Jan
We introduce a phase field approach for diffusion inside and outside a closed cell with damping and with source terms at the interface. The method is compared to exact solutions (where possible) and...
Analytical study of the effect of recombination on evolution via DNA shuffling (2003)
Peng, Weiqun, Levine, Herbert, Hwa, Terence, Kessler, David A.
We investigate a multi-locus evolutionary model which is based on the DNA shuffling protocol widely applied in \textit{in vitro} directed evolution. This model incorporates selection, recombination...
Wave nucleation rate in excitable systems in the low noise limit (2003)
Motivated by recent experiments on intracellular calcium dynamics, we study the general issue of fluctuation-induced nucleation of waves in excitable media. We utilize a stochastic Fitzhugh-Nagumo...
Raymond Goldstein, Robert Austin, Denis Rousseau, Peter Jung, Paul Gailey, Aps Councilor, ...
(a.k.a. “Sonya’s Desk”) wishes you a new year filled with publications of high impact factor! This issue of The Biological Physicist brings you a profile of research at the Interdisciplinary...
Does the continuum theory of dynamic fracture work? (2002)
Kessler, David A., Levine, Herbert
We investigate the validity of the Linear Elastic Fracture Mechanics approach to dynamic fracture. We first test the predictions in a lattice simulation, using a formula of Eshelby for the...
Dynamics of Competitive Evolution on a Smooth Landscape (2002)
Peng, Weiqun, Gerland, Ulrich, Hwa, Terence, Levine, Herbert
We study competitive DNA sequence evolution directed by {\it in vitro} protein binding. The steady-state dynamics of this process is well described by a shape-preserving pulse which decelerates and...
Non-native beta-sheet formation: insights into protein amyloidosis (2002)
Guo, Chinlin, Levine, Herbert, Kessler, David A.
Protein amyloidosis is a cytopathological process characterized by the formation of highly beta-sheet-rich fibrils. How this process occurs and how to prevent/treat the associated diseases are not...
Mode I fracture in a nonlinear lattice with viscoelastic forces (2001)
Heizler, Shay I., Kessler, David A., Levine, Herbert
We study Mode I fracture in a viscoelastic lattice model with a nonlinear force law, with a focus on the velocity and linear stability of the steady-state propagating solution. This study is a...
Phase-Field Model of Mode III Dynamic Fracture (2001)
Karma, Alain, Kessler, David A., Levine, Herbert
We introduce a phenomenological continuum model for mode III dynamic fracture that is based on the phase-field methodology used extensively to model interfacial pattern formation. We couple a scalar...
Mechanisms underlying sequence-independent beta-sheet formation (2001)
Guo, Chinlin, Levine, Herbert, Cheung, Margaret S., Kessler, David A.
We investigate the formation of beta-sheet structures in proteins without taking into account specific sequence-dependent hydrophobic interactions. To accomplish this, we introduce a model which...
Microscopic Selection of Fluid Fingering Pattern (2001)
Kessler, David A., Levine, Herbert
We study the issue of the selection of viscous fingering patterns in the limit of small surface tension. Through detailed simulations of anisotropic fingering, we demonstrate conclusively that no...
Nonlinear lattice model of viscoelastic Mode III fracture (2000)
Kessler, David A., Levine, Herbert
We study the effect of general nonlinear force laws in viscoelastic lattice models of fracture, focusing on the existence and stability of steady-state Mode III cracks. We show that the hysteretic...
Self-organization in systems of self-propelled particles (2000)
Levine, Herbert, Rappel, Wouter-Jan, Cohen, Inon
We investigate a discrete model consisting of self-propelled particles that obey simple interaction rules. We show that this model can self-organize and exhibit coherent localized solutions in one-...
Steady-state mode III cracks in a viscoelastic lattice model (2000)
Pechenik, Leonid, Levine, Herbert, Kessler, David A.
We extend the Slepyan solution of the problem of a steady-state crack in an infinite ideally brittle lattice model to include dissipation in the form of Kelvin viscosity. As a demonstration of this...
Steady-state mode I cracks in a viscoelastic triangular lattice (2000)
Pechenik, Leonid, Levine, Herbert, Kessler, David A.
We continue our study of the exact solutions for steady-state cracks in ideally brittle viscoelastic lattice models by focusing on mode I in a triangular system. The issues we address include the...
Discrete stochastic modeling of calcium channel dynamics (1999)
Baer, Markus, Falcke, Martin, Levine, Herbert, Tsimring, Lev S.
We propose a simple discrete stochastic model for calcium dynamics in living cells. Specifically, the calcium concentration distribution is assumed to give rise to a set of probabilities for the...
A Thermodynamic Model for Receptor Clustering (1999)
Intracellular signaling often arises from ligand-induced oligomerization of cell surface receptors. This oligomerization or clustering process is fundamentally a cooperative behavior between...
Two State Behavior in a Solvable Model of $\beta$-hairpin folding (1999)
Guo, Chinlin, Levine, Herbert, Kessler, David
Understanding the mechanism of protein secondary structure formation is an essential part of protein-folding puzzle. Here we describe a simple model for the formation of the $\beta$-hairpin,...
Arrested Cracks in Nonlinear Lattice Models of Brittle Fracture (1999)
Kessler, David A., Levine, Herbert
We generalize lattice models of brittle fracture to arbitrary nonlinear force laws and study the existence of arrested semi-infinite cracks. Unlike what is seen in the discontinuous case studied to...
A thermodynamic model for receptor clustering (1999)
ABSTRACT Intracellular signaling often arises from ligand-induced oligomerization of cell surface receptors. This oligomerization or clustering process is fundamentally a cooperative behavior between...
Steady-State Cracks in Viscoelastic Lattice Models (1998)
Kessler, David A., Levine, Herbert
We study the steady-state motion of mode III cracks propagating on a lattice exhibiting viscoelastic dynamics. The introduction of a Kelvin viscosity $\eta$ allows for a direct comparison between...
Self-organized Vortex State in Two-dimensional Dictyostelium Dynamics (1998)
Rappel, Wouter-Jan, Nicol, Alastair, Sarkissian, Armand, Levine, Herbert, Loomis, William F.
We present results of experiments on the dynamics of Dictyostelium discoideum in a novel set-up which constraints cell motion to a plane. After aggregation, the amoebae collect into round ''pancake"...
Interfacial Velocity Corrections due to Multiplicative Noise (1998)
Pechenik, Leonid, Levine, Herbert
The problem of velocity selection for reaction fronts has been intensively investigated, leading to the successful marginal stability approach for propagation into an unstable state. Because the...
Rodin, Burt, Freedman, Michael, Levine, Herbert, Arbarbanel, Henry
Contents: A note on topology and magnetic energy in incompressible perfectly conducting fluids; Links of tori and the energy of incompressible flows; Factoring the Iogarithmic spiral; A remark on...
Research in Chaotic and Turbulent Fluid Dynamics. (1998)
Abarbanel, Henry D., Gharib, Morteza, Levine, Herbert
Fundamental problems in vortex dynamics: Additional results on both integrable and chaotic point vortex dynamics have been obtained. These include the elucidation of chaotic scattering within point...
Yi Jiang, Herbert Levine, James Glazier
ABSTRACT In the mound stage of Dictyostelium discoideum, pre-stalk cells sort and form a tip at the apex. How this pattern forms is as yet unknown. A cellular level model allows us to simulate both...
Mutator Dynamics on a Smooth Evolutionary Landscape (1997)
Kessler, David A., Levine, Herbert
We investigate a model of evolutionary dynamics on a smooth landscape which features a ``mutator'' allele whose effect is to increase the mutation rate. We show that the expected proportion of...
Unicellular algal growth: A biomechanical approach to cell wall dynamics (1997)
We present a model for unicellular algal growth as motivated by several experiments implicating the importance of calcium ions and ``loosening'' enzymes in morphogenesis. A growing cell at rest in a...
Quantum Nucleation of Phase Slips in a 1d Model of a Superfluid (1997)
Freire, Jose A., Arovas, Daniel P., Levine, Herbert
We use a 1d model of a superfluid based on the Gross-Pitaevskii Lagrangian to illustrate a general numerical method designed to find quantum tunneling rates in extended bosonic systems. Specifically,...
Diffusive Boundary Layers in the Free-Surface Excitable Medium Spiral (1997)
Kessler, David A., Levine, Herbert
Spiral waves are a ubiquitous feature of the nonequilibrium dynamics of a great variety of excitable systems. In the limit of a large separation in timescale between fast excitation and slow...
Evolution on a smooth landscape (1996)
Kessler, David A., Levine, Herbert, Ridgway, Douglas, Tsimring, Lev
We study in detail a recently proposed simple discrete model for evolution on smooth landscapes. An asymptotic solution of this model for long times is constructed. We find that the dynamics of the...
A Phase-Field Model of Spiral Dendritic Growth (1996)
Domains of condensed-phase monolayers of chiral molecules exhibit a variety of interesting nonequilibrium structures when formed via pressurization. To model these domain patterns, we add a complex...
Mean Field Theory of the Morphology Transition in Stochastic Diffusion Limited Growth (1995)
We propose a mean-field model for describing the averaged properties of a class of stochastic diffusion-limited growth systems. We then show that this model exhibits a morphology transition from a...
Aggregation Patterns in Stressed Bacteria (1995)
Tsimring, Lev, Levine, Herbert, Aranson, Igor, Ben-Jacob, Eshel, Cohen, Inon, Shochet, Ofer
We study the formation of spot patterns seen in a variety of bacterial species when the bacteria are subjected to oxidative stress due to hazardous byproducts of respiration. Our approach consists of...
Theory of the spiral core in excitable media (1994)
Kessler, David A., Levine, Herbert, Reynolds, William N.
A rigorous asymptotic spiral solution to an excitable reaction diffusion system is found by separating space into two scaling regions: an "outer region", having the same spatial scaling as the...
Signaling function of reconstituted CD16: {zeta}: {gamma} receptor complex isoforms (1992)
Vivier, Eric, Rochet, Nathalie, Ackerly, Melissa, Petrlni, John, Levine, Herbert, Daley, John, ...
Natural killer cells express an Fc receptor for IgG (CD16) in association with disulflde-linked dimers composed of two homologous subunits: the ζ chain of the T cell antigen receptor complex and the...
Spiral selection as a free boundary problem (1991)
Kessler, David A., Levine, Herbert
We present a new formulation of the spiral selection problem for the Belousov-Zhabotinsky reaction. In particular, we focus on deriving an exact integro-differential shape equation and discuss the...
The oscillatory instability in rapid solidification (1991)
Levine, Herbert, Rappel, Wouter-Jan
We modify the usual directional solidification equations for the case of large pulling velocities (rapid solidification). Using these equations we describe a numerical method to analyze the stability...
The oscillatory instability in rapid solidification (1991)
Levine, Herbert, Rappel, Wouter-Jan
We modify the usual directional solidification equations for the case of large pulling velocities (rapid solidification). Using these equations we describe a numerical method to analyze the stability...
The oscillatory instability in rapid solidification (1991)
Levine, Herbert, Rappel, Wouter-Jan
We modify the usual directional solidification equations for the case of large pulling velocities (rapid solidification). Using these equations we describe a numerical method to analyze the stability...
Effect of diffusion on patterns in excitable Belousov-Zhabotinskii systems (1989)
Kessler, David A., Levine, Herbert
Travelling wave patterns occur frequently in chemically reacting systems; these include planar fronts, target patterns and spiral structures. We review the dispersion relation for planar waves,...
Computational approach to steady-state eutectic growth (1989)
Kessler, David A., Levine, Herbert
We formulate a boundary integral approach to the determination of periodic steady-state eutectic growth patterns. The numerical implementation of this method allows us to compute the band of allowed...
Pattern selection in three dimensional dendritic growth (1988)
Kessler, David A., Levine, Herbert
We study the selection of the shape and growth velocity of three dimensional dendritic crystals in cubically anisotropic materials. We demonstrate that aside from minor additional complexities due to...
Abnormalities in CD4+ T-lymphocyte subsets in inflammatory rheumatic diseases (1988)
Morimoto, Chikao, Romain, Paul L., Fox, David A., Anderson, Paul, Dimaggio, Marjorie, Levine, Herbert, ...
The monoclonal antibodies anti-2H4 and anti-4B4 identify the suppressor-inducer (CD4+2H4+) and helper-inducer (CD4+4B4+) subpopulations of CD4 (T4+) lymphocytes, respectively. The cell surface...
The geometrical model of dendritic growth: The small velocity limit (1986)
Dashen, Roger F., Kessler, David A., Levine, Herbert, Savit, Robert
We present a systematic analysis of the geometrical model of dendritic growth in the small velocity limit. Velocity selection is demonstrated analytically and the allowed velocities are explicitly...
Higher order effects in semi-classical quantum chromodynamics /--Herbert Levine. (1979)
Thesis (Ph. D.)--Princeton.
How does a β-hairpin fold/unfold? Competition between topology and heterogeneity in a solvable model
Guo, Chinlin, Levine, Herbert, Kessler, David A.
We study the competition between topological effects and sequence inhomogeneities in determining the thermodynamics and the un/folding kinetics of a β-hairpin. Our work utilizes a new exactly...
Spectral mixing of rhythmic neuronal signals in sensory cortex
Ahrens, Kurt F., Levine, Herbert, Suhl, Harry, Kleinfeld, David
The ability to compute the difference between two frequencies depends on a nonlinear operation that mixes two periodic signals. Behavioral and psychophysical evidence suggest that such mixing is...
Domain swapping is a consequence of minimal frustration
Yang, Sichun, Cho, Samuel S., Levy, Yaakov, Cheung, Margaret S., Levine, Herbert, Wolynes, Peter G., ...
The same energy landscape principles associated with the folding of proteins into their monomeric conformations should also describe how these proteins oligomerize into domain-swapped conformations....
Establishing direction during chemotaxis in eukaryotic cells.
Rappel, Wouter-Jan, Thomas, Peter J, Levine, Herbert, Loomis, William F
Several recent studies have demonstrated that eukaryotic cells, including amoeboid cells of Dictyostelium discoideum and neutrophils, respond to chemoattractants by translocation of PH-domain...
Division accuracy in a stochastic model of Min oscillations in Escherichia coli
Kerr, Rex A., Levine, Herbert, Sejnowski, Terrence J., Rappel, Wouter-Jan
Accurate cell division in Escherichia coli requires the Min proteins MinC, MinD, and MinE as well as the presence of nucleoids. MinD and MinE exhibit spatial oscillations, moving from pole to pole of...
Wang, Kai, Tu, Yuhai, Rappel, Wouter-Jan, Levine, Herbert
During calcium-induced calcium-release, the ryanodine receptor (RyR) opens and releases large amounts of calcium from the sarcoplasmic reticulum into the cytoplasm of the myocyte. Recent experiments...
How does a β-hairpin fold/unfold? Competition between topology and heterogeneity in a solvable model
Guo, Chinlin, Levine, Herbert, Kessler, David A.
We study the competition between topological effects and sequence inhomogeneities in determining the thermodynamics and the un/folding kinetics of a β-hairpin. Our work utilizes a new exactly...
Spectral mixing of rhythmic neuronal signals in sensory cortex
Ahrens, Kurt F., Levine, Herbert, Suhl, Harry, Kleinfeld, David
The ability to compute the difference between two frequencies depends on a nonlinear operation that mixes two periodic signals. Behavioral and psychophysical evidence suggest that such mixing is...
Domain swapping is a consequence of minimal frustration
Yang, Sichun, Cho, Samuel S., Levy, Yaakov, Cheung, Margaret S., Levine, Herbert, Wolynes, Peter G., ...
The same energy landscape principles associated with the folding of proteins into their monomeric conformations should also describe how these proteins oligomerize into domain-swapped conformations....
Establishing direction during chemotaxis in eukaryotic cells.
Rappel, Wouter-Jan, Thomas, Peter J, Levine, Herbert, Loomis, William F
Several recent studies have demonstrated that eukaryotic cells, including amoeboid cells of Dictyostelium discoideum and neutrophils, respond to chemoattractants by translocation of PH-domain...
Division accuracy in a stochastic model of Min oscillations in Escherichia coli
Kerr, Rex A., Levine, Herbert, Sejnowski, Terrence J., Rappel, Wouter-Jan
Accurate cell division in Escherichia coli requires the Min proteins MinC, MinD, and MinE as well as the presence of nucleoids. MinD and MinE exhibit spatial oscillations, moving from pole to pole of...
Wang, Kai, Tu, Yuhai, Rappel, Wouter-Jan, Levine, Herbert
During calcium-induced calcium-release, the ryanodine receptor (RyR) opens and releases large amounts of calcium from the sarcoplasmic reticulum into the cytoplasm of the myocyte. Recent experiments...
Directional sensing in eukaryotic chemotaxis: A balanced inactivation model
Levine, Herbert, Kessler, David A., Rappel, Wouter-Jan
Many eukaryotic cells, including Dictyostelium discoideum amoebae, fibroblasts, and neutrophils, are able to respond to chemoattractant gradients with high sensitivity. Recent studies have...
Small Regulatory RNAs May Sharpen Spatial Expression Patterns
Levine, Erel, McHale, Peter, Levine, Herbert
The precise establishment of gene expression patterns is a crucial step in development. Formation of a sharp boundary between high and low spatial expression domains requires a genetic mechanism that...
Self-engineering capabilities of bacteria
Ben-Jacob, Eshel, Levine, Herbert
Under natural growth conditions, bacteria can utilize intricate communication capabilities (e.g. quorum-sensing, chemotactic signalling and plasmid exchange) to cooperatively form (self-organize)...
Levin, Howard A., Levine, Herbert, Schlossman, Stuart F.
The exact specifiicity of anti-DNP antibody produced by Hartley guinea pigs immunized with a series of defined α,DNP and ε,DNP-oligolysines was studied by fluorescence quenching. All responder...
Astrocytes Optimize the Synaptic Transmission of Information
Nadkarni, Suhita, Jung, Peter, Levine, Herbert
Chemical synapses transmit information via the release of neurotransmitter-filled vesicles from the presynaptic terminal. Using computational modeling, we predict that the limited availability of...
Target-Specific and Global Effectors in Gene Regulation by MicroRNA
Levine, Erel, Ben Jacob, Eshel, Levine, Herbert
MicroRNAs are responsible for post-transcriptional gene silencing as part of critical cellular pathways and intercellular coordination, for example during embryonic development. Yet, the basic...
Ventricular Excitability of the Intact Dog Heart *
Sikand, Rajinder S., Nahum, Louis H., Levine, Herbert, Geller, Herman
Receptor noise limitations on chemotactic sensing
Rappel, Wouter-Jan, Levine, Herbert
Chemotactic eukaryotic cells are able to detect chemoattractant gradients that are both shallow and have a low background concentration. Under these conditions, the noise in the number of bound...
The Fixation Probability of Rare Mutators in Finite Asexual Populations
Wylie, C. Scott, Ghim, Cheol-Min, Kessler, David, Levine, Herbert
A mutator is an allele that increases the mutation rate throughout the genome by disrupting some aspect of DNA replication or repair. Mutators that increase the mutation rate by the order of 100-fold...
Determining the scale of the Bicoid morphogen gradient
Hecht, Inbal, Rappel, Wouter-Jan, Levine, Herbert
Bicoid is a morphogen that sets up the anterior-posterior axis in early Drosophila embryos. Although the form of the Bicoid profile is consistent with a simple diffusion/degradation model, the...