Catalytic Anitoxidants and Methods of Use (2004)
Weissbach, Herbert, Brot, Nathan
The invention provides small molecules that act as catalytic antioxidants and methods of use therof. The compounds can repeatedly bind and destroy reactive oxygen species by serving as substates for...
Methods for plant Molecular biology / edited by Arthur Weissbach and Herbert Weissbach (1988)
Weissbach, Arthur, Weissbach, Herbert
Incluye índice
Cohen, Bennett N., Coleman, Tomothy A., Schmitt, John J., Weissbach, Herbert
The psbA gene from higher plants, which codes for the atrazine herbi cide binding protein of photosystem II (QB protein), has been recently sequenced by various laboratories. From these data there...
Studies on 5-hydroxyindole metabolism /--by Herbert Weissbach. (1957)
Abstract and vita inserted.
SOLUBLE MONOAMINE OXIDASE; ITS PROPERTIES AND ACTIONS ON SEROTONIN (1957)
Herbert Weissbach, Betty G. Redfield
5-Hydroxyindoleacetic acid (5HIAA) has been shown to be the major metabolite of 5-hydroxytryptamine (serotonin) (1). In man 2 to 8 mg. of the acid are normally excreted in the urine per day (2). This...
The metabolism of serotonin to 5-hydroxyindole acetic acid /--by Herbert Weissbach. (1955)
Thesis (M.S.)--George Washington University, 1955.
Lowther, W. Todd, Brot, Nathan, Weissbach, Herbert, Honek, John F., Matthews, Brian W.
Peptide methionine sulfoxide reductase (MsrA; EC 1.8.4.6) reverses the inactivation of many proteins due to the oxidation of critical methionine residues by reducing methionine sulfoxide, Met(O), to...
Modulation of potassium channel function by methionine oxidation and reduction
Ciorba, Matthew A., Heinemann, Stefan H., Weissbach, Herbert, Brot, Nathan, Hoshi, Toshinori
Oxidation of amino acid residues in proteins can be caused by a variety of oxidizing agents normally produced by cells. The oxidation of methionine in proteins to methionine sulfoxide is implicated...
Reactive oxygen species and nitric oxide mediate plasticity of neuronal calcium signaling
Yermolaieva, Olena, Brot, Nathan, Weissbach, Herbert, Heinemann, Stefan H., Hoshi, Toshinori
Reactive oxygen species (ROS) and nitric oxide (NO) are important participants in signal transduction that could provide the cellular basis for activity-dependent regulation of neuronal excitability....
John, Gregory St., Brot, Nathan, Ruan, Jia, Erdjument-Bromage, Hediye, Tempst, Paul, Weissbach, Herbert, ...
Inducible nitric oxide synthase (iNOS) plays an important role in host defense. Macrophages expressing iNOS release the reactive nitrogen intermediates (RNI) nitrite and S-nitrosoglutathione (GSNO),...
High-quality life extension by the enzyme peptide methionine sulfoxide reductase
Ruan, Hongyu, Tang, Xiang Dong, Joiner, M. A., Sun, Guangrong, Brot, Nathan, ...
Cumulative oxidative damages to cell constituents are considered to contribute to aging and age-related diseases. The enzyme peptide methionine sulfoxide reductase A (MSRA) catalyzes the repair of...
Skaar, Eric P., Tobiason, Deborah M., Quick, J., Judd, Ralph C., Weissbach, Herbert, Etienne, Frantzy, ...
The PilB protein of Neisseria gonorrhoeae has been reported to be involved in the regulation of pilin gene transcription, but it also possesses significant homology to the peptide methionine...
Effect of Structural and Stereochemical Methylproline Isomers on Actinomycin Biosynthesis
Yoshida, Tadashi, Mauger, Anthony, Weissbach, Herbert, Katz, Edward
The inhibitory effect of methylprolines on actinomycin biosynthesis by Streptomyces antibioticus was studied; the order of effectiveness was 3- >4- >5-methyl-dl-proline. Cis-3-methyl-dl-proline was...
Unusual Growth Characteristics of a Methionine-Cyano-B12 Auxotroph of Escherichia coli
Dickerman, Herbert, Taylor, Robert T., Weissbach, Herbert
Escherichia coli K-12, strain AB1172, substrain 2276, a methionine−-cyano-B12− auxotroph grew poorly when placed in a medium containing optimal levels of cyano-B12 and suboptimal amounts of...
Erion, Jack L., Tarnowski, Joseph, Weissbach, Herbert, Brot, Nathan
An 11.2-kilobase pair (kbp) BamHI restriction nuclease fragment from spinach chloroplast DNA has been found to contain the gene for the large subunit (LS) of ribulose-1,5-bisphosphate carboxylase...
Robakis, Nikolaos, Meza-Basso, Luis, Brot, Nathan, Weissbach, Herbert
A simplified DNA-directed in vitro system has been developed to study the regulation of the synthesis of ribosomal protein L10 by measuring the formation of the first dipeptide, fMet-Ala. The results...
Methionine sulfoxide reductase A protects neuronal cells against brief hypoxia/reoxygenation
Yermolaieva, Olena, Xu, Rong, Schinstock, Carrie, Brot, Nathan, Weissbach, Herbert, Heinemann, Stefan H., ...
Hypoxia/reoxygenation induces cellular injury by promoting oxidative stress. Reversible oxidation of methionine in proteins involving the enzyme peptide methionine sulfoxide reductase type A (MSRA)...
The Requirement for Ribosomal Proteins L7 and L12 in Peptide-Chain Termination
Brot, Nathan, Tate, W. P., Caskey, C. T., Weissbach, Herbert
Proteins L7 and L12 from 50S ribosomal subunits of Escherichia coli are required for peptidechain termination. This termination process is inhibited by thiostrepton. Since both thiostrepton-treated...
Role of Phospholipids in the Multiple Forms of Mammalian Elongation Factor 1
Legocki, Andrzej B., Redfield, Betty, Liu, Chen K., Weissbach, Herbert
Evidence is presented that high-molecular-weight aggregates of elongation factor 1 from calf brain and liver contain phospholipids. Sucrose gradient analysis has shown that these...
Translation In Vitro of Total Nuclear RNA from HeLa Cell Nuclei Infected with Adenovirus 2
Chatterjee, Nando K., Weissbach, Herbert
Total heterogeneous nuclear RNA from HeLa cells infected with adenovirus for 18-20 hr stimulates amino acid incorporation into protein in a cell-free system from Ehrlich ascites tumors. This...
Inamine, Gordon, Nash, Barbara, Weissbach, Herbert, Brot, Nathan
The specific activity of ribulose-1,5-bisphosphate carboxylase (EC 4.1.1.39) increases 30- to 50-fold when dark-grown pea seedlings are shifted into the light. The large subunit (LS) of this...
Shoeman, Robert, Redfield, Betty, Coleman, Timothy, Greene, Ronald C., Smith, Albert A., Brot, Nathan, ...
The regulation of the expression of the Escherichia coli metF gene, which codes for 5,10-methylenetet-rahydrofolate reductase (EC 1.1.99.15), has been investigated by using a simplified DNA-directed...
Interaction of Eukaryote Elongation Factor EF 1 with Guanosine Nucleotides and Aminoacyl-tRNA
Moon, Hong-Mo, Redfield, Betty, Weissbach, Herbert
Evidence for two species of elongation factor 1 (EF 1A and EF 1B) from calf brain has been obtained by molecular sieve chromatography on Sephadex G-150. A high molecular weight form, EF 1A, interacts...
Initiation of Protein Synthesis in HeLa Cells
Chatterjee, Nando K., Kerwar, S. S., Weissbach, Herbert
Initiation of protein synthesis in HeLa cells has been synchronized by exposure of the cells to fluoride. Double-labeling of such cells for short pulses with [35S]methionine and a tritiated amino...
Brot, Nathan, Boublik, Miloslav, Yamasaki, Edith, Weissbach, Herbert
In the presence of GTP or GDP, there is a decrease in the circular dichroic absorption of ribosomal proteins L7 and L12 at 221-222 nm, suggesting that these nucleotides influence the helical content...
In Vitro Synthesis of Procollagen on Polysomes
Kerwar, S. S., Kohn, Leonard D., Lapiere, Charles M., Weissbach, Herbert
The major collagenous products synthesized in a cell-free polysome preparation are pro-α1 and pro-α2, formed in a ratio of 2:1. They are the precursor forms of α1 and α2 chains of normal...
Multiple Forms of Elongation Factor 1 from Calf Brain
Moon, Hong-Mo, Redfield, Betty, Millard, Sara, Vane, Floie, Weissbach, Herbert
Heavy and light forms of elongation factor 1 (EF-1) from calf brain have been partially purified. The heterogeneous heavy species (EF-1H) with molecular weights of 2.5 × 105 to over 1 × 106 appears...
Marchetti, Maria A., Pizarro, Gresin O., Sagher, Daphna, DeAmicis, Candida, Brot, Nathan, Hejtmancik, J. Fielding, ...
Thionein can serve as a reducing agent for the methionine sulfoxide reductases
Sagher, Daphna, Brunell, David, Hejtmancik, J. Fielding, Kantorow, Marc, Brot, Nathan, Weissbach, Herbert
It has been generally accepted, primarily from studies on methionine sulfoxide reductase (Msr) A, that the biological reducing agent for the members of the Msr family is reduced thioredoxin (Trx),...
Lowther, W. Todd, Brot, Nathan, Weissbach, Herbert, Honek, John F., Matthews, Brian W.
Peptide methionine sulfoxide reductase (MsrA; EC 1.8.4.6) reverses the inactivation of many proteins due to the oxidation of critical methionine residues by reducing methionine sulfoxide, Met(O), to...
Modulation of potassium channel function by methionine oxidation and reduction
Ciorba, Matthew A., Heinemann, Stefan H., Weissbach, Herbert, Brot, Nathan, Hoshi, Toshinori
Oxidation of amino acid residues in proteins can be caused by a variety of oxidizing agents normally produced by cells. The oxidation of methionine in proteins to methionine sulfoxide is implicated...
Reactive oxygen species and nitric oxide mediate plasticity of neuronal calcium signaling
Yermolaieva, Olena, Brot, Nathan, Weissbach, Herbert, Heinemann, Stefan H., Hoshi, Toshinori
Reactive oxygen species (ROS) and nitric oxide (NO) are important participants in signal transduction that could provide the cellular basis for activity-dependent regulation of neuronal excitability....
John, Gregory St., Brot, Nathan, Ruan, Jia, Erdjument-Bromage, Hediye, Tempst, Paul, Weissbach, Herbert, ...
Inducible nitric oxide synthase (iNOS) plays an important role in host defense. Macrophages expressing iNOS release the reactive nitrogen intermediates (RNI) nitrite and S-nitrosoglutathione (GSNO),...
High-quality life extension by the enzyme peptide methionine sulfoxide reductase
Ruan, Hongyu, Tang, Xiang Dong, Joiner, M. A., Sun, Guangrong, Brot, Nathan, ...
Cumulative oxidative damages to cell constituents are considered to contribute to aging and age-related diseases. The enzyme peptide methionine sulfoxide reductase A (MSRA) catalyzes the repair of...
Skaar, Eric P., Tobiason, Deborah M., Quick, J., Judd, Ralph C., Weissbach, Herbert, Etienne, Frantzy, ...
The PilB protein of Neisseria gonorrhoeae has been reported to be involved in the regulation of pilin gene transcription, but it also possesses significant homology to the peptide methionine...
Effect of Structural and Stereochemical Methylproline Isomers on Actinomycin Biosynthesis
Yoshida, Tadashi, Mauger, Anthony, Weissbach, Herbert, Katz, Edward
The inhibitory effect of methylprolines on actinomycin biosynthesis by Streptomyces antibioticus was studied; the order of effectiveness was 3- >4- >5-methyl-dl-proline. Cis-3-methyl-dl-proline was...
Unusual Growth Characteristics of a Methionine-Cyano-B12 Auxotroph of Escherichia coli
Dickerman, Herbert, Taylor, Robert T., Weissbach, Herbert
Escherichia coli K-12, strain AB1172, substrain 2276, a methionine−-cyano-B12− auxotroph grew poorly when placed in a medium containing optimal levels of cyano-B12 and suboptimal amounts of...
Erion, Jack L., Tarnowski, Joseph, Weissbach, Herbert, Brot, Nathan
An 11.2-kilobase pair (kbp) BamHI restriction nuclease fragment from spinach chloroplast DNA has been found to contain the gene for the large subunit (LS) of ribulose-1,5-bisphosphate carboxylase...
Robakis, Nikolaos, Meza-Basso, Luis, Brot, Nathan, Weissbach, Herbert
A simplified DNA-directed in vitro system has been developed to study the regulation of the synthesis of ribosomal protein L10 by measuring the formation of the first dipeptide, fMet-Ala. The results...
Methionine sulfoxide reductase A protects neuronal cells against brief hypoxia/reoxygenation
Yermolaieva, Olena, Xu, Rong, Schinstock, Carrie, Brot, Nathan, Weissbach, Herbert, Heinemann, Stefan H., ...
Hypoxia/reoxygenation induces cellular injury by promoting oxidative stress. Reversible oxidation of methionine in proteins involving the enzyme peptide methionine sulfoxide reductase type A (MSRA)...
The Requirement for Ribosomal Proteins L7 and L12 in Peptide-Chain Termination
Brot, Nathan, Tate, W. P., Caskey, C. T., Weissbach, Herbert
Proteins L7 and L12 from 50S ribosomal subunits of Escherichia coli are required for peptidechain termination. This termination process is inhibited by thiostrepton. Since both thiostrepton-treated...
Role of Phospholipids in the Multiple Forms of Mammalian Elongation Factor 1
Legocki, Andrzej B., Redfield, Betty, Liu, Chen K., Weissbach, Herbert
Evidence is presented that high-molecular-weight aggregates of elongation factor 1 from calf brain and liver contain phospholipids. Sucrose gradient analysis has shown that these...
Translation In Vitro of Total Nuclear RNA from HeLa Cell Nuclei Infected with Adenovirus 2
Chatterjee, Nando K., Weissbach, Herbert
Total heterogeneous nuclear RNA from HeLa cells infected with adenovirus for 18-20 hr stimulates amino acid incorporation into protein in a cell-free system from Ehrlich ascites tumors. This...
Inamine, Gordon, Nash, Barbara, Weissbach, Herbert, Brot, Nathan
The specific activity of ribulose-1,5-bisphosphate carboxylase (EC 4.1.1.39) increases 30- to 50-fold when dark-grown pea seedlings are shifted into the light. The large subunit (LS) of this...
Shoeman, Robert, Redfield, Betty, Coleman, Timothy, Greene, Ronald C., Smith, Albert A., Brot, Nathan, ...
The regulation of the expression of the Escherichia coli metF gene, which codes for 5,10-methylenetet-rahydrofolate reductase (EC 1.1.99.15), has been investigated by using a simplified DNA-directed...
Interaction of Eukaryote Elongation Factor EF 1 with Guanosine Nucleotides and Aminoacyl-tRNA
Moon, Hong-Mo, Redfield, Betty, Weissbach, Herbert
Evidence for two species of elongation factor 1 (EF 1A and EF 1B) from calf brain has been obtained by molecular sieve chromatography on Sephadex G-150. A high molecular weight form, EF 1A, interacts...
Initiation of Protein Synthesis in HeLa Cells
Chatterjee, Nando K., Kerwar, S. S., Weissbach, Herbert
Initiation of protein synthesis in HeLa cells has been synchronized by exposure of the cells to fluoride. Double-labeling of such cells for short pulses with [35S]methionine and a tritiated amino...
Brot, Nathan, Boublik, Miloslav, Yamasaki, Edith, Weissbach, Herbert
In the presence of GTP or GDP, there is a decrease in the circular dichroic absorption of ribosomal proteins L7 and L12 at 221-222 nm, suggesting that these nucleotides influence the helical content...
In Vitro Synthesis of Procollagen on Polysomes
Kerwar, S. S., Kohn, Leonard D., Lapiere, Charles M., Weissbach, Herbert
The major collagenous products synthesized in a cell-free polysome preparation are pro-α1 and pro-α2, formed in a ratio of 2:1. They are the precursor forms of α1 and α2 chains of normal...
Multiple Forms of Elongation Factor 1 from Calf Brain
Moon, Hong-Mo, Redfield, Betty, Millard, Sara, Vane, Floie, Weissbach, Herbert
Heavy and light forms of elongation factor 1 (EF-1) from calf brain have been partially purified. The heterogeneous heavy species (EF-1H) with molecular weights of 2.5 × 105 to over 1 × 106 appears...
Thionein can serve as a reducing agent for the methionine sulfoxide reductases
Sagher, Daphna, Brunell, David, Hejtmancik, J. Fielding, Kantorow, Marc, Brot, Nathan, Weissbach, Herbert
It has been generally accepted, primarily from studies on methionine sulfoxide reductase (Msr) A, that the biological reducing agent for the members of the Msr family is reduced thioredoxin (Trx),...
Free methionine-(R)-sulfoxide reductase from Escherichia coli reveals a new GAF domain function
Lin, Zhidong, Johnson, Lynnette C., Weissbach, Herbert, Brot, Nathan, Lively, Mark O., Lowther, W. Todd
The reduction of methionine sulfoxide (MetO) is mediated by methionine sulfoxide reductases (Msr). The MsrA and MsrB families can reduce free MetO and MetO within a peptide or protein context. This...
Oxidative Regulation of Large Conductance Calcium-Activated Potassium Channels
Tang, Xiang D., Daggett, Heather, Hanner, Markus, Garcia, Maria L., McManus, Owen B., Brot, Nathan, ...
Reactive oxygen/nitrogen species are readily generated in vivo, playing roles in many physiological and pathological conditions, such as Alzheimer's disease and Parkinson's disease, by oxidatively...