Herman Mielants

Clinical Observations programme in SpA: disease parameters, treatment options and practical management issues (2009)

Elewaut, Dirk, VAN DEN BOSCH, FILIP, Verbruggen, August, De Keyser, Filip, Vander Cruyssen, Bert, Mielants, Herman

Spondyloarthritides (SpAs) are a cluster of chronic inflammatory rheumatic diseases that typically involve inflammation of axial and peripheral joint or tendon and ligament insertions, distinct...

The development of assessment of spondyloarthritis international society classification criteria for axial spondyloarthritis (part I): classification of paper patients by expert opinion including uncertainty appraisal (2009)

Rudwaleit, M, Landewe, Rene, Listing, J, Brandt, J, Braun, J, ...

Objective: Non-radiographic axial spondyloarthritis (SpA) is characterised by a lack of definitive radiographic sacroiliitis and is considered an early stage of ankylosing spondylitis. The objective...

The development of assessment of spondyloarthritis international society classification criteria for axial spondyloarthritis (part II): validation and final selection (2009)

Rudwaleit, M, Landewe, R, Listing, J, Akkoc, N, Brandt, J, ...

Objective: To validate and refine two sets of candidate criteria for the classification/diagnosis of axial spondyloarthritis (SpA). Methods: All assessment of SpondyloArthritis international Society...

New criteria for inflammatory back pain in patients with chronic back pain: a real patient exercise by experts from the Assessment of Spondyloarthritis international Society (ASAS) (2009)

Sieper, J, Landewe, R, Brandt, J, Burgos-Vagas, R, Collantes-Estevez, E, ...

Objective: Inflammatory back pain (IBP) is an important clinical symptom in patients with axial spondyloarthritis (SpA), and relevant for classification and diagnosis. In the present report, a new...

Classification models for disease: the effect of associations between markers on calculating the risk for disease by likelihood ratio products (2009)

Wittoek, Ruth, De Keyser, Filip, Boonen, A, De Vlam, Kurt, Vastesaeger, Nathan, Mielants, Herman, ...

The risk, for disease or a bad prognosis cart be calculated by means of prediction or classification models that take into account multiple variables. Different methods exist to construct such...

Physical function in ankylosing spondylitis is independently determined by both disease activity and radiographic damage of the spine (2009)

Landewe, R, Dougados, M, Mielants, Herman

Aim: To study the relationship between disease activity, radiographic damage and physical function in patients with ankylosing spondylitis (AS) Patients and methods: Baseline and 2-year data of the...

Clinical assessment in the spondyloarthropathies (2009)

Wittoek, Ruth, Mielants, Herman

In order to measure disease activity, progression and response to therapy, it is important to use accurate, reliable and feasible outcome measures that can ideally be used in longitudinal cohorts,...

Gastroenterology - Clinical and genetic factors associated with sacroiliitis in Crohn's disease (2008)

Peeters, Harald, Cruyssen, Bert Vander, Mielants, Herman, De Vlam, Kurt, Vermeire, Séverine, Louis, Edouard, ...

Background and Aim: Radiographic sacroiliitis (SI), often asymptomatic, is considered the most frequent extra-intestinal manifestation (EIM) of Crohn's disease (CD). Data on the association of SI...

Gastroenterology - Clinical and genetic factors associated with sacroiliitis in Crohn's disease (2008)

Cruyssen, Bert Vander, Mielants, Herman, De Vlam, Kurt, Louis, Edouard, ...

Background and Aim: Radiographic sacroiliitis (SI), often asymptomatic, is considered the most frequent extra-intestinal manifestation (EIM) of Crohn's disease (CD). Data on the association of SI...

Clinical and genetic factors associated with sacroiliitis in Crohn’s disease (2008)

PEETERS, HARALD, Vander Cruyssen, Bert, Mielants, Herman, De Vlam, Kurt, Vermeire, Séverine, Louis, Edouard, ...

Background and Aim: Radiographic sacroiliitis (SI), often asymptomatic, is considered the most frequent extra-intestinal manifestation (EIM) of Crohn's disease (CD). Data on the association of SI...

Spondyloarthropathies: progress and challenges (2008)

Jacques, Peggy, Mielants, Herman, De Vos, Martine, Elewaut, Dirk

The spondyloarthropathies are a group of human rheumatic disorders that are often associated with extra-articular features. Although a substantial number of studies is undertaken each year, many...

Brucellar spondylodiscitis: Case report (2007)

K., Cobbaert, A., Pieters, DEVINCK, MIEKE, M., Devos, Goethals, Ingeborg, Mielants, Herman

Brucellosis is a common zoonosis which still remains a major health problem in certain parts of the world. Osteoarticular involvement is the most frequent complication of brucellosis, in which the...

Four-year follow-up of infliximab therapy in rheumatoid arthritis patients with long-standing refractory disease: attrition and long-term evolution of disease activity (2006)

Van Looy, Stijn, Wyns, Bart, Durez, Patrick, Van Den Bosch, Filip, ...

Although there is strong evidence supporting the short-term efficacy and safety of anti-tumour necrosis factor-alpha agents, few studies have examined the long-term effects. We evaluated 511 patients...

Four-year follow-up of infliximab therapy in rheumatoid arthritis patients with long-standing refractory disease: attrition and long-term evolution of disease activity (2006)

Cruyssen, Bert, Van Looy, Stijn, Wyns, Bart, Westhovens, Rene, Durez, Patrick, Van Den Bosch, Filip, ...

Abstract Although there is strong evidence supporting the short-term efficacy and safety of anti-tumour necrosis factor-α agents, few studies have examined the long-term effects. We evaluated 511...

DAS28 best reflects the physician's clinical judgment of response to infliximab therapy in rheumatoid arthritis patients: validation of the DAS28 score in patients under infliximab treatment (2005)

Van Looy, Stijn, Wyns, Bart, Durez, Patrick, Van Den Bosch, Filip, ...

This study is based on an expanded access program in which 511 patients suffering from active refractory rheumatoid arthritis (RA) were treated with intravenous infusions of infliximab (3...

DAS28 best reflects the physician's clinical judgment of response to infliximab therapy in rheumatoid arthritis patients: validation of the DAS28 score in patients under infliximab treatment (2005)

Vander Cruyssen, Bert, Van Looy, Stijn, Wyns, Bart, Westhovens, Rene, Durez, Patrick, Van Den Bosch, Filip, ...

Abstract This study is based on an expanded access program in which 511 patients suffering from active refractory rheumatoid arthritis (RA) were treated with intravenous infusions of infliximab (3...

Tumor necrosis factor-α blockade in ankylosing spondylitis: a potent but expensive anti-inflammatory treatment or true disease modification? (2005)

Van Den Bosch, Filip, De Keyser, Filip, Mielants, Herman, Veys, Eric M

Abstract Blocking tumor necrosis factor-α either with monoclonal antibodies or with soluble receptor constructs has been proven to be effective with an acceptable safety profile in patients with...

Infiltration of the synovial membrane with macrophage subsets and polymorphonuclear cells reflects global disease activity in spondyloarthropathy (2005)

Baeten, Dominique, Kruithof, Elli, De Rycke, Leen, Boots, Anemieke M, Mielants, Herman, Veys, Eric M, ...

Abstract Considering the relation between synovial inflammation and global disease activity in rheumatoid arthritis (RA) and the distinct but heterogeneous histology of spondyloarthropathy (SpA)...

CARD15 polymorphisms are associated with anti-Saccharomyces Cerevisiae antibodies in Caucasian Crohn’s disease patients (2005)

Vander Cruyssen, Bert, PEETERS, HARALD, Hoffman, IEA, Laukens, Debby, Coucke, Paul, Marichal, Denis, ...

Carriage of CARD15 gene polymorphisms and the serological marker anti-Saccharomyces cerevisiae antibodies (ASCA) are two markers for Crohn's disease (CD). Similar phenotypes have been associated with...

Infiltration of the synovial membrane with macrophage subsets and polymorphonuclear cells reflects global disease activity in spondyloarthropathy

Baeten, Dominique, Kruithof, Elli, De Rycke, Leen, Boots, Anemieke M, Mielants, Herman, Veys, Eric M, ...

Considering the relation between synovial inflammation and global disease activity in rheumatoid arthritis (RA) and the distinct but heterogeneous histology of spondyloarthropathy (SpA) synovitis,...

Tumor necrosis factor-α blockade in ankylosing spondylitis: a potent but expensive anti-inflammatory treatment or true disease modification?

Van Den Bosch, Filip, De Keyser, Filip, Mielants, Herman, Veys, Eric M

Blocking tumor necrosis factor-α either with monoclonal antibodies or with soluble receptor constructs has been proven to be effective with an acceptable safety profile in patients with rheumatoid...

DAS28 best reflects the physician's clinical judgment of response to infliximab therapy in rheumatoid arthritis patients: validation of the DAS28 score in patients under infliximab treatment

Vander Cruyssen, Bert, Van Looy, Stijn, Wyns, Bart, Westhovens, Rene, Durez, Patrick, Van Den Bosch, Filip, ...

This study is based on an expanded access program in which 511 patients suffering from active refractory rheumatoid arthritis (RA) were treated with intravenous infusions of infliximab (3...

Infiltration of the synovial membrane with macrophage subsets and polymorphonuclear cells reflects global disease activity in spondyloarthropathy

Baeten, Dominique, Kruithof, Elli, De Rycke, Leen, Boots, Anemieke M, Mielants, Herman, Veys, Eric M, ...

Considering the relation between synovial inflammation and global disease activity in rheumatoid arthritis (RA) and the distinct but heterogeneous histology of spondyloarthropathy (SpA) synovitis,...

Tumor necrosis factor-α blockade in ankylosing spondylitis: a potent but expensive anti-inflammatory treatment or true disease modification?

Van Den Bosch, Filip, De Keyser, Filip, Mielants, Herman, Veys, Eric M

Blocking tumor necrosis factor-α either with monoclonal antibodies or with soluble receptor constructs has been proven to be effective with an acceptable safety profile in patients with rheumatoid...

DAS28 best reflects the physician's clinical judgment of response to infliximab therapy in rheumatoid arthritis patients: validation of the DAS28 score in patients under infliximab treatment

Vander Cruyssen, Bert, Van Looy, Stijn, Wyns, Bart, Westhovens, Rene, Durez, Patrick, Van Den Bosch, Filip, ...

This study is based on an expanded access program in which 511 patients suffering from active refractory rheumatoid arthritis (RA) were treated with intravenous infusions of infliximab (3...

Four-year follow-up of infliximab therapy in rheumatoid arthritis patients with long-standing refractory disease: attrition and long-term evolution of disease activity

Cruyssen, Bert Vander, Van Looy, Stijn, Wyns, Bart, Westhovens, Rene, Durez, Patrick, Van Den Bosch, Filip, ...

Although there is strong evidence supporting the short-term efficacy and safety of anti-tumour necrosis factor-α agents, few studies have examined the long-term effects. We evaluated 511 patients...