Hideaki Nakajima

Chemical ozone loss and related processes in the Antarctic winter 2003 based on Improved Limb Atmospheric Spectrometer (ILAS)–II observations (2006)

Tilmes, Simone, Müller, Rolf, Grooß, Jens-Uwe, Spang, Reinhold, Sugita, Takafumi, Nakajima, Hideaki, ...

An edited version of this paper was published by AGU. Copyright 2006 American Geophysical Union. To view the published open abstract, go to http://dx.doi.org/10.1029/2005JD006260

Development of tracer relations and chemical ozone loss (2006)

Tilmes, Simone, Müller, Rolf, Grooß, Jens-Uwe, Nakajima, Hideaki, Sasano, Yasuhiro

An edited version of this paper was published by AGU. Copyright 2006 American Geophysical Union. To view the published open abstract, go to http://dx.doi.org/10.1029/2005JD006726 .

The centrosomal protein TACC3 is essential for hematopoietic stem cell function and genetically interfaces with p53-regulated apoptosis

Piekorz, Roland P., Hoffmeyer, Angelika, Duntsch, Christopher D., McKay, Catriona, Nakajima, Hideaki, Sexl, Veronika, ...

TACC3 is a centrosomal/mitotic spindle-associated protein that is highly expressed in a cell cycle-dependent manner in hematopoietic lineage cells. During embryonic development, TACC3 is expressed in...

Functional interaction of STAT5 and nuclear receptor co-repressor SMRT: implications in negative regulation of STAT5-dependent transcription

Nakajima, Hideaki, Brindle, Paul K., Handa, Makoto, Ihle, James N.

Signal transducers and activators of transcription (STATs) play a central role in cytokine signaling. Activating and repressing gene transcription is a dynamic process involving chromatin remodeling...

Identification, cDNA Cloning, and Targeted Deletion of p70, a Novel, Ubiquitously Expressed SH3 Domain-Containing Protein

Carpino, Nick, Kobayashi, Ryuji, Zang, Heesuk, Takahashi, Yutaka, Jou, Shiann-Tarrng, Feng, Jian, ...

In a screen for proteins that interact with Jak2, we identified a previously uncharacterized 70-kDa protein and cloned the corresponding cDNA. The predicated sequence indicates that p70 contains an...

The distal region and receptor tyrosines of the Epo receptor are non-essential for in vivo erythropoiesis

Zang, Heesuk, Sato, Ken, Nakajima, Hideaki, McKay, Catriona, Ney, Paul A., Ihle, James N.

The erythropoietin receptor (EpoR) is required for the proliferation and survival of committed erythroid lineage cells. Previous studies have utilized receptor mutations to show the requirement for...

Mammalian Twisted Gastrulation Is Essential for Skeleto-Lymphogenesis

Nosaka, Tetsuya, Morita, Sumiyo, Kitamura, Hidetomo, Nakajima, Hideaki, Shibata, Fumi, Morikawa, Yoshihiro, ...

Dorsoventral patterning depends on the local concentrations of the morphogens. Twisted gastrulation (TSG) regulates the extracellular availability of a mesoderm inducer, bone morphogenetic protein 4...

Dimerization of MLL fusion proteins and FLT3 activation synergize to induce multiple-lineage leukemogenesis

Ono, Ryoichi, Nakajima, Hideaki, Ozaki, Katsutoshi, Kumagai, Hidetoshi, Kawashima, Toshiyuki, Taki, Tomohiko, ...

The mechanisms by which mixed-lineage leukemia (MLL) fusion products resulting from in utero translocations in 11q23 contribute to leukemogenesis and infant acute leukemia remain elusive. It is still...

Infertility with Defective Spermiogenesis in Mice Lacking AF5q31, the Target of Chromosomal Translocation in Human Infant Leukemia

Urano, Atsushi, Endoh, Masaki, Wada, Tadashi, Morikawa, Yoshihiro, Itoh, Miyuki, Kataoka, Yuki, ...

AF5q31 (also called MCEF) was identified by its involvement in chromosomal translocation with the gene MLL (mixed lineage leukemia), which is associated with infant acute lymphoblastic leukemia....

Disruption of Sept6, a Fusion Partner Gene of MLL, Does Not Affect Ontogeny, Leukemogenesis Induced by MLL-SEPT6, or Phenotype Induced by the Loss of Sept4

Ono, Ryoichi, Ihara, Masafumi, Nakajima, Hideaki, Ozaki, Katsutoshi, Kataoka-Fujiwara, Yuki, Taki, Tomohiko, ...

Septins are evolutionarily conserved GTP-binding proteins that can heteropolymerize into filaments. Recent studies have revealed that septins are involved in not only diverse normal cellular...

Endosymbiotic Bacteroidales Bacteria of the Flagellated Protist Pseudotrichonympha grassii in the Gut of the Termite Coptotermes formosanus

Noda, Satoko, Iida, Toshiya, Kitade, Osamu, Nakajima, Hideaki, Kudo, Toshiaki, Ohkuma, Moriya

A unique lineage of bacteria belonging to the order Bacteroidales was identified as an intracellular endosymbiont of the protist Pseudotrichonympha grassii (Parabasalia, Hypermastigea) in the gut of...

The centrosomal protein TACC3 is essential for hematopoietic stem cell function and genetically interfaces with p53-regulated apoptosis

Piekorz, Roland P., Hoffmeyer, Angelika, Duntsch, Christopher D., McKay, Catriona, Nakajima, Hideaki, Sexl, Veronika, ...

TACC3 is a centrosomal/mitotic spindle-associated protein that is highly expressed in a cell cycle-dependent manner in hematopoietic lineage cells. During embryonic development, TACC3 is expressed in...

Functional interaction of STAT5 and nuclear receptor co-repressor SMRT: implications in negative regulation of STAT5-dependent transcription

Nakajima, Hideaki, Brindle, Paul K., Handa, Makoto, Ihle, James N.

Signal transducers and activators of transcription (STATs) play a central role in cytokine signaling. Activating and repressing gene transcription is a dynamic process involving chromatin remodeling...

Identification, cDNA Cloning, and Targeted Deletion of p70, a Novel, Ubiquitously Expressed SH3 Domain-Containing Protein

Carpino, Nick, Kobayashi, Ryuji, Zang, Heesuk, Takahashi, Yutaka, Jou, Shiann-Tarrng, Feng, Jian, ...

In a screen for proteins that interact with Jak2, we identified a previously uncharacterized 70-kDa protein and cloned the corresponding cDNA. The predicated sequence indicates that p70 contains an...

The distal region and receptor tyrosines of the Epo receptor are non-essential for in vivo erythropoiesis

Zang, Heesuk, Sato, Ken, Nakajima, Hideaki, McKay, Catriona, Ney, Paul A., Ihle, James N.

The erythropoietin receptor (EpoR) is required for the proliferation and survival of committed erythroid lineage cells. Previous studies have utilized receptor mutations to show the requirement for...

Mammalian Twisted Gastrulation Is Essential for Skeleto-Lymphogenesis

Nosaka, Tetsuya, Morita, Sumiyo, Kitamura, Hidetomo, Nakajima, Hideaki, Shibata, Fumi, Morikawa, Yoshihiro, ...

Dorsoventral patterning depends on the local concentrations of the morphogens. Twisted gastrulation (TSG) regulates the extracellular availability of a mesoderm inducer, bone morphogenetic protein 4...

Dimerization of MLL fusion proteins and FLT3 activation synergize to induce multiple-lineage leukemogenesis

Ono, Ryoichi, Nakajima, Hideaki, Ozaki, Katsutoshi, Kumagai, Hidetoshi, Kawashima, Toshiyuki, Taki, Tomohiko, ...

The mechanisms by which mixed-lineage leukemia (MLL) fusion products resulting from in utero translocations in 11q23 contribute to leukemogenesis and infant acute leukemia remain elusive. It is still...

Infertility with Defective Spermiogenesis in Mice Lacking AF5q31, the Target of Chromosomal Translocation in Human Infant Leukemia

Urano, Atsushi, Endoh, Masaki, Wada, Tadashi, Morikawa, Yoshihiro, Itoh, Miyuki, Kataoka, Yuki, ...

AF5q31 (also called MCEF) was identified by its involvement in chromosomal translocation with the gene MLL (mixed lineage leukemia), which is associated with infant acute lymphoblastic leukemia....

Disruption of Sept6, a Fusion Partner Gene of MLL, Does Not Affect Ontogeny, Leukemogenesis Induced by MLL-SEPT6, or Phenotype Induced by the Loss of Sept4

Ono, Ryoichi, Ihara, Masafumi, Nakajima, Hideaki, Ozaki, Katsutoshi, Kataoka-Fujiwara, Yuki, Taki, Tomohiko, ...

Septins are evolutionarily conserved GTP-binding proteins that can heteropolymerize into filaments. Recent studies have revealed that septins are involved in not only diverse normal cellular...

Endosymbiotic Bacteroidales Bacteria of the Flagellated Protist Pseudotrichonympha grassii in the Gut of the Termite Coptotermes formosanus

Noda, Satoko, Iida, Toshiya, Kitade, Osamu, Nakajima, Hideaki, Kudo, Toshiaki, Ohkuma, Moriya

A unique lineage of bacteria belonging to the order Bacteroidales was identified as an intracellular endosymbiont of the protist Pseudotrichonympha grassii (Parabasalia, Hypermastigea) in the gut of...

Comprehensive analysis of myeloid lineage conversion using mice expressing an inducible form of C/EBPα

Fukuchi, Yumi, Shibata, Fumi, Ito, Miyuki, Goto-Koshino, Yuko, Sotomaru, Yusuke, Ito, Mamoru, ...

CCAAT/enhancer-binding protein (C/EBP) α is a critical regulator for early myeloid differentiation. Although C/EBPα has been shown to convert B cells into myeloid lineage, precise roles of C/EBPα...

Rac1 and a GTPase-activating protein, MgcRacGAP, are required for nuclear translocation of STAT transcription factors

Kawashima, Toshiyuki, Bao, Ying Chun, Nomura, Yasushi, Moon, Yuseok, Tonozuka, Yukio, Minoshima, Yukinori, ...

STAT transcription factors are tyrosine phosphorylated upon cytokine stimulation and enter the nucleus to activate target genes. We show that Rac1 and a GTPase-activating protein, MgcRacGAP, bind...