Toyama, Tatsuya, Yamashita, Hiroko, Kondo, Naoto, Okuda, Katsuhiro, Takahashi, Satoru, Sasaki, Hidefumi, ...
Abstract Background Triple-negative breast cancer (estrogen receptor-, progesterone receptor-, and HER2-negative) (TNBC) is a high risk breast cancer that lacks specific therapy targeting these...
Characterizing the cancer genome in lung adenocarcinoma (2007)
Weir, Barbara A., Woo, Michele S., Getz, Gad, Perner, Sven, Ding, Li, Beroukhim, Rameen, ...
Somatic alterations in cellular DNA underlie almost all human cancers(1). The prospect of targeted therapies(2) and the development of high-resolution, genome-wide approaches(3-8) are now spurring...
Corrigendum: High-throughput oncogene mutation profiling in human cancer. (2007)
Thomas, Roman K, Baker, Alissa C, Debiasi, Ralph M, Winckler, Wendy, Laframboise, Thomas, Lin, William M, ...
Systematic efforts are underway to decipher the genetic changes associated with tumor initiation and progression1, 2. However, widespread clinical application of this information is hampered by an...
High-throughput oncogene mutation profiling in human cancer (2007)
Thomas, Roman K., Baker, Alissa C., Debiasi, Ralph M., Winckler, Wendy, Laframboise, Thomas, Lin, William M., ...
Characterizing the cancer genome in lung adenocarcinoma (2007)
Weir, Barbara A., Woo, Michele S., Getz, Gad, Perner, Sven, Ding, Li, Beroukhim, Rameen, ...
Thomas, Roman K., Nickerson, Elizabeth, Simons, Jan F., Jänne, Pasi A., Tengs, Torstein, Yuza, Yuki, ...
Suzuki, Eriko, Sasaki, Hidefumi, Kawano, Osamu, Endo, Katsuhiko, Haneda, Hiroshi, Yukiue, Haruhiro, ...
Background: Epidermal growth factor receptor (EGFR) gene mutations have been reported to correlate with the sensitivity to the tyrosine kinase inhibitor treatment for advanced lung cancers. Since...
Haneda, Hiroshi, Sasaki, Hidefumi, Lindeman, Neal, Kawano, Osamu, Endo, Katsuhiko, Suzuki, Eriko, ...
Background: The presence of epidermal growth factor receptor (EGFR) mutations in gefitinib-naive lung cancer patients has been reported to be higher in females, in non-smokers, in Japanese, and in...
Haneda, Hiroshi, Sasaki, Hidefumi, Lindeman, Neal, Kawano, Osamu, Endo, Katsuhiko, Suzuki, Eriko, ...
Background: The presence of epidermal growth factor receptor (EGFR) mutations in gefitinib-naive lung cancer patients has been reported to be higher in females, in non-smokers, in Japanese, and in...
Suzuki, Eriko, Sasaki, Hidefumi, Kawano, Osamu, Endo, Katsuhiko, Haneda, Hiroshi, Yukiue, Haruhiro, ...
Background: Epidermal growth factor receptor (EGFR) gene mutations have been reported to correlate with the sensitivity to the tyrosine kinase inhibitor treatment for advanced lung cancers. Since...
Paez, J. Guillermo, Lin, Ming, Beroukhim, Rameen, Lee, Jeffrey C., Zhao, Xiaojun, Richter, Daniel J., ...
Major efforts are underway to systematically define the somatic and germline genetic variations causally associated with disease. Genome‐wide genetic analysis of actual clinical samples is,...
{beta}IGH3, a TGF-{beta} Inducible Gene, is Overexpressed in Lung Cancer (2002)
Sasaki, Hidefumi, Kobayashi, Yoshihiro, Nakashima, Yoshiaki, Moriyama, Satoru, Yukiue, Haruhiro, Kaji, Masahiro, ...
Background: Transforming growth factor-&bgr; (TGF-&bgr;) is capable of affecting the proliferation of many cell types. &bgr;IGH3, TGF-&bgr; inducible gene, was originally isolated from lung...
Terashita, Yukio, Sasaki, Hidefumi, Haruki, Nobuhiro, Nishiwaki, Tadashi, Ishiguro, Hideyuki, Shibata, Yasuyuki, ...
Background: Peroxisome proliferator-activated receptor gamma (PPAR&ggr;) induces apoptosis by ligand stimulation in various tumor cell lines. In esophageal cancer cell lines, PPAR&ggr; activation...
Expression of the cdc25B mRNA Correlated with that of N-myc in Neuroblastoma (2001)
Sato, Yoko, Sasaki, Hidefumi, Kondo, Satoshi, Fukai, Ichiro, Kiriyama, Masanobu, Yamakawa, Yosuke, ...
Background: Neuroblastoma is one of the most common solid tumors in early childhood. Overexpression of the proto-oncogene N-myc has been reported to be correlated with more malignant course of the...
Sasaki, Hidefumi, Yukiue, Haruhiro, Moriyama, Satoru, Kobayashi, Yoshihiro, Nakashima, Yoshiaki, Kaji, Masahiro, ...
Background: In a tumor, increased deubiquitination of cyclins by a protein gene product gene, PGP9.5, could contribute to the uncontrolled growth of somatic cells that is a hallmark of cancer. We...
Paez, J. Guillermo, Lin, Ming, Beroukhim, Rameen, Lee, Jeffrey C., Zhao, Xiaojun, Richter, Daniel J., ...
Major efforts are underway to systematically define the somatic and germline genetic variations causally associated with disease. Genome-wide genetic analysis of actual clinical samples is, however,...
Ji, Hongbin, Zhao, Xiaojun, Yuza, Yuki, Shimamura, Takeshi, Li, Danan, Protopopov, Alexei, ...
The tyrosine kinase inhibitors gefitinib (Iressa) and erlotinib (Tarceva) have shown anti-tumor activity in the treatment of non-small cell lung cancer (NSCLC). Dramatic and durable responses have...
Paez, J. Guillermo, Lin, Ming, Beroukhim, Rameen, Lee, Jeffrey C., Zhao, Xiaojun, Richter, Daniel J., ...
Major efforts are underway to systematically define the somatic and germline genetic variations causally associated with disease. Genome-wide genetic analysis of actual clinical samples is, however,...
Ji, Hongbin, Zhao, Xiaojun, Yuza, Yuki, Shimamura, Takeshi, Li, Danan, Protopopov, Alexei, ...
The tyrosine kinase inhibitors gefitinib (Iressa) and erlotinib (Tarceva) have shown anti-tumor activity in the treatment of non-small cell lung cancer (NSCLC). Dramatic and durable responses have...