Hideki Yamaguchi

Orexins, orexigenic hypothalamic peptides, interact with autonomic, neuroendocrine and neuroregulatory systems

Date, Yukari, Ueta, Yoichi, Yamashita, Hiroshi, Yamaguchi, Hideki, Matsukura, Shigeru, Kangawa, Kenji, ...

We determined the immunohistochemical distributions of orexin-A and orexin-B, hypothalamic peptides that function in the regulation of feeding behavior and energy homeostasis. Orexin-A and -B neurons...

Two tandem verprolin homology domains are necessary for a strong activation of Arp2/3 complex-induced actin polymerization and induction of microspike formation by N-WASP

Yamaguchi, Hideki, Miki, Hiroaki, Suetsugu, Shiro, Ma, Le, Kirschner, Marc W., Takenawa, Tadaomi

All WASP family proteins share a common C terminus that consists of the verprolin homology domain (V), cofilin homology domain (C), and acidic region (A), through which they activate Arp2/3...

Orexins, orexigenic hypothalamic peptides, interact with autonomic, neuroendocrine and neuroregulatory systems

Date, Yukari, Ueta, Yoichi, Yamashita, Hiroshi, Yamaguchi, Hideki, Matsukura, Shigeru, Kangawa, Kenji, ...

We determined the immunohistochemical distributions of orexin-A and orexin-B, hypothalamic peptides that function in the regulation of feeding behavior and energy homeostasis. Orexin-A and -B neurons...

Two tandem verprolin homology domains are necessary for a strong activation of Arp2/3 complex-induced actin polymerization and induction of microspike formation by N-WASP

Yamaguchi, Hideki, Miki, Hiroaki, Suetsugu, Shiro, Ma, Le, Kirschner, Marc W., Takenawa, Tadaomi

All WASP family proteins share a common C terminus that consists of the verprolin homology domain (V), cofilin homology domain (C), and acidic region (A), through which they activate Arp2/3...

Molecular mechanisms of invadopodium formation: the role of the N-WASP–Arp2/3 complex pathway and cofilin

Yamaguchi, Hideki, Lorenz, Mike, Kempiak, Stephan, Sarmiento, Corina, Coniglio, Salvatore, Symons, Marc, ...

Invadopodia are actin-rich membrane protrusions with a matrix degradation activity formed by invasive cancer cells. We have studied the molecular mechanisms of invadopodium formation in metastatic...

WASP family members and formin proteins coordinate regulation of cell protrusions in carcinoma cells

Sarmiento, Corina, Wang, Weigang, Dovas, Athanassios, Yamaguchi, Hideki, Sidani, Mazen, El-Sibai, Mirvat, ...

We examined the role of the actin nucleation promoters neural Wiskott-Aldrich syndrome protein (N-WASP) and WAVE2 in cell protrusion in response to epidermal growth factor (EGF), a key regulator in...