Hidenobu Senpuku

Identification of an Antigenic Epitope in Helicobacter pylori Urease That Induces Neutralizing Antibody Production

Hirota, Kaoru, Nagata, Kumiko, Norose, Yoshihiko, Futagami, Seiji, Nakagawa, Yohko, Senpuku, Hidenobu, ...

We previously reported a mouse monoclonal antibody (MAb), termed L2, specific for Helicobacter pylori urease strongly inhibited its enzymatic activity. Here, to gain insight into how this antibody...

Maintenance of Serum Immunoglobulin G Antibodies to Epstein-Barr Virus (EBV) Nuclear Antigen 2 in Healthy Individuals from Different Age Groups in a Japanese Population with a High Childhood Incidence of Asymptomatic Primary EBV Infection

Harada, Shizuko, Kamata, Yoshio, Ishii, Yasuyuki, Eda, Hiroyuki, Kitamura, Ryo, Obayashi, Maya, ...

Immunoglobulin G (IgG) antibodies to Epstein-Barr virus (EBV) nuclear antigens 2 and 1 (EBNA-2 and EBNA-1, respectively) were studied using sera from healthy individuals of a population with a high...

Establishment of an Animal Model Using Recombinant NOD.B10.D2 Mice To Study Initial Adhesion of Oral Streptococci

Salam, Mohammad Abdus, Matsumoto, Naoko, Matin, Khairul, Tsuha, Yuzo, Nakao, Ryoma, Hanada, Nobuhiro, ...

An oral biofilm is a community of surface-attached microorganisms that coats the oral cavity, including the teeth, and provides a protective reservoir for oral microbial pathogens, which are the...

Molecular Interactions of Surface Protein Peptides of Streptococcus gordonii with Human Salivary Components

Hamada, Tomoyuki, Kawashima, Masatsugu, Watanabe, Haruo, Tagami, Junji, Senpuku, Hidenobu

Oral streptococci play a large role in dental biofilm formation, and several types interact as early colonizers with the enamel salivary pellicle to form the primary biofilm, as well as to...

Identification of an Antigenic Epitope in Helicobacter pylori Urease That Induces Neutralizing Antibody Production

Hirota, Kaoru, Nagata, Kumiko, Norose, Yoshihiko, Futagami, Seiji, Nakagawa, Yohko, Senpuku, Hidenobu, ...

We previously reported a mouse monoclonal antibody (MAb), termed L2, specific for Helicobacter pylori urease strongly inhibited its enzymatic activity. Here, to gain insight into how this antibody...

Maintenance of Serum Immunoglobulin G Antibodies to Epstein-Barr Virus (EBV) Nuclear Antigen 2 in Healthy Individuals from Different Age Groups in a Japanese Population with a High Childhood Incidence of Asymptomatic Primary EBV Infection

Harada, Shizuko, Kamata, Yoshio, Ishii, Yasuyuki, Eda, Hiroyuki, Kitamura, Ryo, Obayashi, Maya, ...

Immunoglobulin G (IgG) antibodies to Epstein-Barr virus (EBV) nuclear antigens 2 and 1 (EBNA-2 and EBNA-1, respectively) were studied using sera from healthy individuals of a population with a high...

Establishment of an Animal Model Using Recombinant NOD.B10.D2 Mice To Study Initial Adhesion of Oral Streptococci

Salam, Mohammad Abdus, Matsumoto, Naoko, Matin, Khairul, Tsuha, Yuzo, Nakao, Ryoma, Hanada, Nobuhiro, ...

An oral biofilm is a community of surface-attached microorganisms that coats the oral cavity, including the teeth, and provides a protective reservoir for oral microbial pathogens, which are the...

Molecular Interactions of Surface Protein Peptides of Streptococcus gordonii with Human Salivary Components

Hamada, Tomoyuki, Kawashima, Masatsugu, Watanabe, Haruo, Tagami, Junji, Senpuku, Hidenobu

Oral streptococci play a large role in dental biofilm formation, and several types interact as early colonizers with the enamel salivary pellicle to form the primary biofilm, as well as to...

Assessment of Genes Associated with Streptococcus mutans Biofilm Morphology

Motegi, Mizuho, Takagi, Yuzo, Yonezawa, Hideo, Hanada, Nobuhiro, Terajima, Jun, Watanabe, Haruo, ...

Streptococcus mutans, the major pathogen responsible for dental caries in humans, is a biofilm-forming bacterium. In the present study, 17 different pulsed-field gel electrophoresis patterns of...

Effects of human interleukin-18 and interleukin-12 treatment on human lymphocyte engraftment in NOD-scid mouse

Senpuku, Hidenobu, Asano, Toshihiko, Matin, Khairul, Salam, M Abdus, Tsuha, Yuzo, Horibata, Shigeo, ...

NOD/LtSz-prkdcscid/prkdcscid (non-obese diabetic-severe combine immunodeficiency; NOD-scid) mice grafted with human peripheral blood lymphoid cells have been used as an in vivo humanized mouse model...

Role of stromal-cell derived factor-1 in the development of autoimmune diseases in non-obese diabetic mice

Matin, Khairul, Salam, M Abdus, Akhter, Joynab, Hanada, Nobuhiro, Senpuku, Hidenobu

The chemokine stromal-cell derived factor-1 (SDF-1) controls maturation, trafficking, and homing of certain subsets, lymphoid cells including immunogenic B and T cells, as a ligand of the CXCR4...

Assessment of oral transmission using cell-free human immunodeficiency virus-1 in mice reconstituted with human peripheral blood leucocyte

Nakao, Ryoma, Hanada, Nobuhiro, Asano, Toshihiko, Hara, Takashi, Abdus Salam, MD, Matin, Khairul, ...

Oral–genital contact is one of the risk factors for the transmission of human immunodeficiency virus (HIV) in adults. In recent reports, oral exposure to simian immunodeficiency virus (SIV) was...

Porphyromonas gingivalis galE Is Involved in Lipopolysaccharide O-Antigen Synthesis and Biofilm Formation▿

Nakao, Ryoma, Senpuku, Hidenobu, Watanabe, Haruo

Porphyromonas gingivalis is a crucial component of complex plaque biofilms that form in the oral cavity, resulting in the progression of periodontal disease. To elucidate the mechanism of periodontal...

Opr86 Is Essential for Viability and Is a Potential Candidate for a Protective Antigen against Biofilm Formation by Pseudomonas aeruginosa▿

Tashiro, Yosuke, Nomura, Nobuhiko, Nakao, Ryoma, Senpuku, Hidenobu, Kariyama, Reiko, Kumon, Hiromi, ...

Pseudomonas aeruginosa is an opportunistic bacterial pathogen that is one of the most refractory to therapy when it forms biofilms in the airways of cystic fibrosis patients. To date, studies...