Demonstration of enzymatic activity converting azathioprine to 6-mercaptopurine (2007)
Watanabe, Akiharu, Hobara, Norio, Nagashima, Hideo
The enzymatic conversion of azathioprine to 6-mercaptopurine was detected at pH 6.5 with rat liver supernatants, although the non-enzymatic reaction predominated at pH 7.0 and 7.5. Glutathione...
Tsuji, Takao, Naito, Kunihiko, Araki, Kiyonori, Onoue, Kimiaki, Nozaki, Hajime, Nagashima, Hideo
Tissue localization of a subcomponent of the first component of complement (CLq) was examined in one postmortem case of HBs antigen (HBs Ag) positive hepatocellular carcinoma and in six cases of...
Watanabe, Akiharu, Higashi, Toshihiro, Nagashima, Hideo
A mixture with essential and nonessential amino acids high in branched chain amino acids and low in aromatic amino acids (Fischer solution), and another synthetic mixture of branched chain amino...
An animal model of fulminant hepatic failure in the rat. (2007)
Watanabe, Akiharu, Higashi, Toshihiro, Nagashima, Hideo
A reproducible animal model of fulminant hepatic failure was developed by intraperitoneal administration of D-galactosamine hydrochloride to Sprague-Dawley rats. Biochemical and morphological hepatic...
Effect of nicomol on HDL cholesterol level. (2007)
Watanabe, Makoto, Taketa, Kazuhisa, Nagashima, Hideo, Yamamoto, Yoshio
In cardiovascular diseases with potential atherosclerosis, the serum concentration of HDL cholesterol as determined by a precipitation method with dextran sulfate and Mg++ was lower while that of...
Tsuji, Takao, Araki, Kiyonori, Inoue, Junichi, Onoue, Kimiaki, Tsuchiya, Masao, Shinohara, Toru, ...
Immune complexes in liver specimens from 10 patients with chronic liver diseases [2 with chronic persistent hepatitis (CPH), 3 with chronic aggressive hepatitis (CAH) of moderate activity, 3 with CAH...
Watanabe, Akiharu, Higashi, Toshihiro, Endo, Hiroshi, Nagashima, Hideo
Three patients at various stages of remission from leukemia died following the development of massive liver necrosis within only 4-6 days. All had either hepatitis B surface antigen or antibody in...
Ymadada, Gotaro, Sakamoto, Yuji, Mizuno, Motowo, Kobayashi, Toshinari, Nagashima, Hideo
In electron microscopic observation of a liver biopsy obtained from a hepatitis B surface antigen-positive patient, noncoated core particles were occasionally seen budding into the hepatocytic...
Yamada, Gotaro, Takahashi, Takashi, Mizuno, Motowo, Sakamoto, Yuji, Kaga, Kazumi, Kobayashi, Toshinari, ...
A recently modified method using peroxidase labeled antibodies for light and electron microscopic demonstration of hepatitis B virus (HBV) was applied to the evaluation of hepatitis B surface antigen...
Mizuno, Motowo, Yamada, Gotaro, Sakamoto, Yuzi, Yumoto, Yasuhiro, Nagashima, Hideo
Antibody to hepatitis B core antigen (anti-HBc) was measured by radioimmunoassay using CORAB (Abbott Laboratories) in 10 cases of chronic persistent hepatitis (CPH), 46 cases of chronic aggressive...
Hepatitis B virus associated particles in the bile canaliculus. (2007)
Yamada, Gotaro, Sakamoto, Yuji, Mizuno, Motowo, Kobayashi, Toshinari, Nagashima, Hideo
The liver biopsy specimen from a patient with hepatitis B surface antigen was pbserved by electron microscopy. Dane particles, uncoated core particles and tubular forms were demonstrated in...
Araki, Kiyonori, Tsuji, Takao, Onoue, Kimiaki, Tuchiya, Masao, Shinohara, Toru, Inoue, Junichi, ...
For the detection and characterization of circulating immune complexes (CIC) in various liver diseases, a Clq binding test was used. Though the CIC level was almost normal in HB surface antigen...
Tsuji, Takao, Naito, Kunihiko, Inoue, Junichi, Tsuchiya, Masao, Araki, Kiyonori, Shinohara, Toru, ...
A study of 52 liver biopsies (47 hepatitis type B and 5 asymptomatic carriers) was performed to clarify the roles of HBe antigen (HBeAg), HB surface antigen (HBsAg) and HB core antigen (HBcAg). In...
Tsuji, Takao, Araki, Kiyonori, Naito, Kunihiko, Inoue, Junichi, Nagashima, Hideo
Sera from 84 patients with chronic liver disease [CLD] (74 chronic active) and from 53 blood donors were tested immunochemically for anti-liver cell membrane antibody (LMAb). LMAb to rat liver tested...
Tsuji, Takao, Inoue, Junichi, Shinohara, Toru, Tsuchiya, Masao, Onoue, Kimiaki, Araki, Kiyonori, ...
Fragmented sheep red blood cell (SRBC) membrane was used for detection of T-cells in liver biopsy specimens from patients with chronic active hepatitis. SRBC was separated with Lymphoprep, sonicated,...
Biochemical and morphological study on hepatotoxicity of azathioprine in rat. (2007)
Watanabe, Akiharu, Hobara, Norio, Tobe, Kazuo, Endo, Hiroshi, Nagashima, Hideo
Sprague-Dawley rats given azathioprine in the diet for 3 to 4 weeks developed severe liver damage. Elevations of serum alkaline phosphatase and gamma-glutamyl transpeptidase activities were...
Effects of insulin and glucagon on serum amino acid concentrations in liver disease. (2007)
Watanabe, Akiharu, Higashi, Toshihiro, Hayashi, Shosaku, Obata, Takahiro, Sakata, Tatsuro, Takei, Nobuyuki, ...
The effects of insulin and glucagon administration on serum amino acid levels were investigated in patients with severe liver disease, since simultaneous injection of pancreatic hormones has been...
Increased excretion of urinary cyclic GMP in primary hepatoma and preneoplastic liver. (2007)
Shimamura, Junnosuke, Taketa, Kazuhisa, Ito, Toshio, Shimada, Yoshihiro, Nagashima, Hideo
Urinary excretion of cyclic GMP (cGMP) and the plasma level of cyclic AMP (cAMP) were determined in patients with liver diseases. The urinary excretion of cGMP, expressed on the basis of creatinine...
Hyperbilirubinemia and enhanced mitosis of hepatocytes in phalloidin-treated female rats. (2007)
Obata, Takahiro, Watanabe, Akiharu, Hayashi, Shosuku, Takei, Nobuyuki, Sakata, Tatsuro, Shiota, Tetsuya, ...
Cholestasis with htperbilirubinemia was induced in female, but not male, Sprague-Dawley rats by daily treatment with phalloidin for 7 days. Increases in serum direct bilirubin level and alkaline...
Hyperbilirubinemia and enhanced mitosis of hepatocytes in phalloidin-treated female rats. (2007)
Obata, Takahiro, Watanabe, Akiharu, Hayashi, Shosaku, Takei, Nobuyuki, Sakata, Tatsuro, Shiota, Tetsuya, ...
Cholestasis with hyperbilirubinemia was induced in female, but not male, Sprague-Dawley rats by daily treatment with phalloidin for 7 days. Increases in serum direct bilirubin level and alkaline...
Sakata, Tatsuo, Watanabe, Akiharu, Takei, Nobuyuki, Obata, Takahiro, Hayashi, Shosaku, Shiota, Tetsuya, ...
Hepatic ornithine decarboxylase and aniline hydroxylase activities increased as early as 6h after a single dosing of azathioprine tomale rats and reached maximum levels at the 12th h after the...
Watanabe, Akiharu, Obata, Takahiro, Nagashima, Hideo
Serum alpha-fetoprotein (AFP) concentrations were serially determined during the period following cessation of alcohol on thirty-five medical and psychiatric patients with histories of long-term...
Berberine therapy of hypertyraminemia in patients with liver cirrhosis. (2007)
Watanabe, Akiharu, Obata, Takahiro, Nagashima, Hideo
plasma tyramine concentrations ewre abnormally high in cirrhotic patients with hepatic encephalopathy. Oral administration of berberine hydrochloride corrected hyperyraminemia in cirrhotics and also...
Complete in vitro replication of SV40 DNA and chromatin in saponin-treated permeable cells. (2007)
Ikeda, Satoru, Nagashima, Hideo, Taketa, Kazuhisa, Watanabe, Makoto
Effect of nicomol on high density lipoprotein (HDL) subfractions, HDL2e and HDL3e, separated by electrophoresis.
Mizuno, Motowo, Yamada, Gotaro, Sakamoto, Yuzi, Nishihara, Takashi, Yumoto, Yasuhiro, Moritsugu, Yasuo, ...
Serum specimens from 12 patients with type A hepatitis were analyzed for immunoglobulin M-type antibody to hepatitis A virus (IgM anti-HA). A recently developed solid-phase radioimmunoassay kit for...
Saito, Daiji, Yasuhara, Koichiro, Takeda, Hikaru, Hyodo, Tatuo, Yamada, Nobuyuki, Uchida, Toshiaki, ...
Changes in the stenotic resistance of a coronary artery following brief coronary occlusion were studied in the anesthetized open-chest dog. A critical coronary stenosis was constructed by tying a...
Insulin binding to erythrocytes in diabetes mellitus. (2007)
Okada, Yoshio, Arima, Terukatsu, Okazaki, Satoru, Nakata, Ken-ichi, Yamabuki, Takahiro, Nagashima, Hideo
Insulin binding to erythrocytes was studied in diabetic patients. Insulin binding was lower in untreated diabetics and diabetic patients treated with diet or insulin than in normal subjects. Binding...
Ito, Toshio, Itoshima, Tatsuya, Kiyotoshi, Shuzo, Kawaguchi, Kenji, Ogawa, Hiromichi, Kitadai, Masahiro, ...
Percutaneous transhepatic portal catheterization was performed in 68 cases of liver diseases in the 2 year period from 1978 to 1980. The Chiba University method was modified. Portal vein...
Effect of continued drinking on prognosis of alcoholic liver cirrhosis. (2007)
Kobayashi, Michio, Watanabe, Akiharu, Nakatsukasa, Harushige, Fujiwara, Masachika, Shiota, Tetsuya, Takei, Nobuyuki, ...
The prognoses of patients with alcoholic liver cirrhosis were compared between those who continued to drink and those who stopped. Clinical criteria were strictly set so as to control other variables...
Computed tomographic arteriography in the diagnosis of hepatocellular carcinoma. (2007)
Ito, Toshio, Yamamoto, Hiroshi, Itoshima, Tatsuya, Ukida, Minoru, Ogawa, Hiromichi, Kitadai, Masahiro, ...
Computed tomographic arteriography (CTA) was performed in 30 patients with hepatocellular carcinoma (HCC). Detection of HCC by CTA was compared with that of conventional celiac or hepatic...
Watanabe, Akiharu, Nagashima, Hideo
Increased activities of liver glucose-6-phosphate dehydrogenase (G6PD, EC 1.1.1.49) and 6-phosphogluconate dehydrogenase (6PGD, EC 1.1.1.44) in the pentose phosphate cycle were accompanied with a...
Watanabe, Akiharu, Hayashi, Syosaku, Shiota, Tetsuya, Nagashima, Hideo
The blood levels of amino acids, ammonia and pancreatic hormones following the intragastric and intravenous administration of a branched-chain amino acid (BCAA)-enriched solution were comparatively...
Saito, Daiji, Abe, Yukihiro, Takeda, Koh, Hyodo, Tazuo, Tani, Hideki, Ohnishi, Shigeru, ...
Stress-induced changes in the resistance due to coronary arterial stenosis of a fixed diameter and in the myocardial blood flow distal to the stenosis were investigated in the open-chest dog....
Watanabe, Akiharu, Ohashi, Yoshito, Nagashima, Hideo
Direct drain of the cystic duct and drain of the biliary tract through an internal fistula into the duodenum in a 81-year-old man were endoscopically diagnosed without an operation.
Watanabe, Akiharu, Takei, Nobuyuki, Hayashi, Syosaku, Nagashima, Hideo
Serum neutral amino acid levels in cirrhotic patients with abnormal oral glucose tolerance test patterns were not different from those of subjects without impaired carbohydrate metabolism. However,...
Watanabe, Akiharu, Shiota, Tetsuya, Okita, Misako, Nagashima, Hideo
A new nutritional product (SF-1008C) containing a high proportion of branched chain amino acids (BCAA) and low proportion of aromatic amino acids (AAA) and methionine was tested to see its effect on...
A simple and rapid method for determining blood ammonia levels. (2007)
Shiota, Tetsuya, Watanabe, Akiharu, Takei, Nobuyuki, Hayashi, Shosaku, Obata, Takahiro, Sakata, Tatsuro, ...
Blood ammonia levels in patients with various liver diseases were determined quantitatively by a simple and rapid method using the Amitest Meter System. The results were compared to those obtained by...
Ogawa, Hiromichi, Itoshima, Tatsuya, Ito, Toshio, Kiyotoshi, Syozo, Kawaguchi, Kenji, Kitadai, Masahiro, ...
Absence of Kupffer cells in rat liver hyperplastic nodules induced by a chemical carcinogen was demonstrated by intravenous injection of indian ink. Hyperplastic nodules appeared 4 weeks after...
Long-term survival in a case of hepatocellular carcinoma. (2007)
Shiota, Tetsuya, Watanabe, Akiharu, Mitani, Ken, Ito, Toshio, Tobe, Kazuo, Nagashima, Hideo
A patient with an unresectable hepatocellular carcinoma (HCC) who survived without active treatment 3 years and 8 months after histological diagnosis is described. The size of the liver, which was...
Peritoneoscopy of the liver after abdominal surgery. (2007)
Kawaguchi, Kenji, Itoshima, Tatsuya, Ukida, Minoru, Ito, Toshio, Kiyotoshi, Shozo, Ogawa, Hiromichi, ...
The incidence of intraperitoneal adhesion after abdominal surgery was studied. Peritoneoscopy was performed in 933 patients with liver diseases over the 6 year 5 month period from March 1974 to July...
Saito, Daiji, Yasuhara, Koichiro, Takeda, Kou, Hyodo, Tatsuo, Fujii, Akinobu, Uchida, Toshiaki, ...
The effects of intravenous infusion of isoproterenol on stenosis resistance were studied in the anesthetized open-chest dog. The circumflex coronary artery (LCx) was isolated near its origin and an...
Shiota, Tetsuya, Watanabe, Akiharu, Itoshima, Tatsuya, Yamamoto, Hiroshi, Takahashi, Kenji, Nagashima, Hideo
Two cases of chronic unconjugated hyperbilirubinemia and marked retention of indocyanine green (ICG) are described. Since bilirubin uridine diphosphate (UDP)-glucuronyl transferase activities were...
Ultrasonographic characteristics of small hepatocellular carcinoma. (2007)
Higashi, Toshihiro, Tobe, Kazuo, Asano, Ken-ichiro, Ikeda, Hiroshi, Ohsawa, Toshiya, Iwasaki, Yoshiaki, ...
The ultrasonographic characteristics of hepatocellular carcinomas (HCC) were investigated. Four typical features of HCCs, "mosaic internal echo pattern", "halo", "lateral shadow" and "posterior echo...
Watanabe, Jun-ichi, Arima, Terukatsu, Nagashima, Hideo
The analysis of bile acids in human bile was tried by high-performance liquid chromatography (HPLC). Bile acids in human bile were first prefractionated into free, glycine- and taurine-conjugated...
Injurious effects of ethanol on rat Kupffer cells. (2007)
Kitadai, Masahiro, Itoshima, Tatsuya, Nagashima, Hideo
The effects of ethanol on rat Kupffer cells were studied functionally and morphologically. Eight g ethanol per kg body weight per day was intragastrically administered to rats for 7 days. An...
Koide, Norio, Ukida, Minoru, Kondo, Hideaki, Jitoku, Michihiro, Ono, Ryosaku, Tanabe, Takayoshi, ...
The amino-terminal peptides of type III procollagen (PIIIP) in the urine of 40 patients with various liver diseases were determined with a commercial radioimmunoassay kit. The level of urinary PIIIP...
Tubular structures in the hepatic nuclei of a patient with delta agent. (2007)
Yamada, Gotaro, Manabe, Koji, Nagashima, Hideo
Liver biopsy specimens obtained from a 31-year-old female with delta-positive hepatitis were studied by routine electron microscopy. In several nuclei of hepatocytes, there were filamentous or...
Jitoku, Michihiro, Koide, Norio, Nagashima, Hideo
We applied a modified enzyme-linked immunosorbent assay (ELISA) for the measurement of human plasma fibronectin and determined the level of plasma fibronectin in 90 patients with various liver...
Detection of type V collagen-degrading enzyme activity in human liver. (2007)
Kobayashi, Michio, Nakatsukasa, Harushige, Watanabe, Akiharu, Yamauchi, Yasuhiko, Fujiwara, Masachika, Hashimoto, Makoto, ...
Type V collagen-degrading enzyme activity was detected as a metalloprotease acting at neutral pH in the human liver. Type V collagen extracted from human placenta and labeled with [1-14C] acetic...
Ono, Ryosaku, Koide, Norio, Nagashima, Hideo
The structure of hepatitis B virus surface antigen (HBs) recognized by anti-HBs antibody was analyzed by western blotting using anti-HBs sera obtained from normal subjects, from rabbits immunized...
Fujiwara, Ryoji, Tobe, Kazuo, Nagashima, Hideo
Cellular immunity against human bile proteins was investigated by the leukocyte migration inhibition test (LMIT) with 13 primary biliary cirrhosis (PBC) patients, 10 chronic aggressive hepatitis...
Usui, Hiroko, Ukida, Minoru, Nagashima, Hideo
Fulminant hepatic failure (FHF) was produced in rats with intraperitoneal injection of D-galactosamine. Control rats received only physiological saline. 15N-leucine (200 mg/kg of body weight) was...
Shimamura, Junnosuke, Taketa, Kazuhisa, Ide, Takero, Nakata, Kenichi, Nagashima, Hideo
Levels of plasma cyclic AMP, serum immunoreactive insulin (IRI), serum c-peptide immunoreactivity (CPR) and blood sugar (BS) were determined 0, 15, 30, 45 and 60 min after a glucagon injection (0.01...
Yuasa, Shiro, Itoshima, Tatsuya, Ono, Ryosaku, Nagashima, Hideo
Problems with infusion therapy for correcting fluid and sodium imbalance in decompensated liver cirrhosis (DLC) were investigated by establishing the safety zone of Talbot et al. for parenteral fluid...
Comparison of estimation methods of liver maximum removal rate of indocyanine green. (2007)
Tanaka, Ryoji, Itoshima, Tatsuya, Ukida, Minoru, Ito, Toshio, Kitadai, Masahiro, Hattori, Shuzo, ...
Three linear plots by which the liver's maximum removal rate (Rmax) of indocyanine green (ICG) and the Michaelis constant (Km) can be calculated were compared in a microcomputer simulation study. The...
Peritoneoscopy of alcoholic liver cirrhosis in comparison with non-alcoholic liver cirrhosis. (2007)
Kitadai, Masahiro, Hattori, Shuzo, Itoshima, Tatsuya, Ukida, Minoru, Ito, Toshio, Ogawa, Hiromichi, ...
Peritoneoscopic findings of 39 patients with alcoholic liver cirrhosis (ALC) were compared with those of 95 patients with non-alcoholic liver cirrhosis (NALC). They were selected from 245 patients...
Cerebral edema associated with acute hepatic failure. (2007)
Fujiwara, Masachika, Watanabe, Akiharu, Yamauchi, Yasuhiko, Hashimoto, Makoto, Nakatsukasa, Harushige, Kobayashi, Michio, ...
The clinicopathological findings of cerebral edema were investigated in patients with acute hepatic failure autopsied at Okayama University Hospital between 1970 and 1980 retrospectively. Nine (64%)...
Plasma branched chain amino acid abnormalities in sake-treated rats. (2007)
Watanabe, Akiharu, Nakatsukasa, Harushige, Kobayashi, Michio, Nagashima, Hideo
Plasma amino acid abnormalities in rats treated with large doses of sake and whisky for 3 days were investigated under adequate nutritional conditions. A significant decrease in plasma branched-chain...
A vegetable protein-rich diet for the treatment of liver cirrhosis (2007)
Okita, Misako, Watanabe, Akiharu, Nagashima, Hideo
Twelve patients were administered a vegetable protein-rich diet, which was low in methionine and high in the branched-chain amino acid (BCAA) to aromatic amino acid (AAA) molar ratio, and an animal...
Comparative diagnosis of alcoholic liver diseases by multivariate and histological analysis. (2007)
Kitadai, Masahiro, Itoshima, Tatsuya, Hattori, Shuzo, Ukida, Minoru, Ito, Toshio, Ogawa, Hiromichi, ...
Sixty-seven cases of alcoholic liver disease were histologically classified into 4 groups: alcoholic liver cirrhosis (ALC), alcoholic hepatitis (AH), alcoholic liver fibrosis (ALF) and alcoholic...
Watanabe, Akiharu, Obata, Takahiro, Nagashima, Hideo, Sakagami, Kenichi, Orita, Kunzo
A 26-year-old male with renal allograft, who received immunosuppressive treatment with azathioprine, presented marked elevations of serum biliary tract enzymes, such as gamma-glutamyl transpeptidase...
Effects of sake and bourbon on liver histopathology and function in rats. (2007)
Kitadai, Masahiro, Hattori, Shuzo, Itoshima, Tatsuya, Ukida, Minoru, Ito, Toshio, Ogawa, Hiromichi, ...
Sake or bourbon (8g ethanol/kg body weight) was intragastrically administered to rats for 12 days. An equal dose of ethanol in water or an isocaloric glucose solution was administered to control...
Shiota, Tetsuya, Watanabe, Akiharu, Higashi, Toshihiro, Nagashima, Hideo
The prevention of hepatic encephalopathy by the intravenous infusion of a branched chain amino acid (BCAA)-enriched solution was investigated in methionine and ammonium acetate-treated rats whose...
Potentiation of carbon tetrachloride hepatotoxicity by beta-phenethyl alcohol. (2007)
Watanabe, Akiharu, Nakatsukasa, Harushige, Kobayashi, Michio, Nagashima, Hideo
Carbon tetrachloride (CCl4)-induced hepatotoxicity was potentiated by pretreatment with beta-phenethyl alcohol, abundantly present in sake. The injury was determined by serum GPT levels and...
Clinical and histological features of sporadic non-A, non-B hepatitis. (2007)
Hyodo, Ichinosuke, Yamada, Gotaro, Nishihara, Takashi, Okushin, Hiroaki, Kinoyama, Shingo, Sakamoto, Yuji, ...
The incidence of hepatitis A (HA), hepatitis B (HB), and non-A, non-B hepatitis (NANBH) was 27%, 30% and 43% among 73 patients with sporadic hepatitis. Epidemiological data (geographical...
Clinical studies of hepatocellular carcinoma with liver cirrhosis and ascites. (2007)
Yuasa, Shiro, Itoshima, Tatsuya, Nagashima, Hideo
A comparison was made of the clinical findings of 59 patients with liver cirrhosis (LC) accompanied with hepatocellular carcinoma (HCC) (of which 35 had ascites and 24 did not at the time of...
Clinical studies of resistant ascites in liver cirrhosis. (2007)
Yuasa, Shiro, Itoshima, Tatsuya, Nagashima, Hideo
Resistant ascites was studied in 34 patients with liver cirrhosis and ascites. The patients were initially divided into 3 groups on the basis of the weekly cumulative ascites retention curve:...
Watanabe, Akiharu, Hattori, Shyuzo, Sato, Yasumasa, Nagashima, Hideo, Kitajima, Koichi
A 31-year-old female with chronic myelogenous leukemia, who developed myeloblastic involvement of the central nervous system during acute myeloblastic transformation of the disease, was treated with...
Tsuji, Takao, Takahashi, Kenji, Naito, Kunihiko, Nagashima, Hideo
An enzyme-linked immunosorbent assay (ELISA) for the detection of serum blocking factors (BF), or antibodies to the albumin receptor on HBsAg particles, was developed, and its clinical usefulness was...
Yamada, Gotaro, Mizuno, Motowo, Kinoyama, Shingo, Nishihara, Takashi, Okushin, Hiroaki, Hyodo, Ichinosuke, ...
In 144 cases of hepatocellular carcinoma (HCC), 166 cases of cirrhosis without HCC and 142 cases of chronic hepatitis, we examined HBsAg, anti-HBs and anti-HBc in sera and compared the following...
Itoshima, Tatsuya, Kawaguchi, Kenji, Ukida, Minoru, Ito, Toshio, Hattori, Shuzo, Kitadai, Masahiro, ...
Sex, age and 21 routine liver function assays were analyzed by stepwise selection and the best-of-all-possible-combinations method to identify a small group of assays valuable in establishing which...
Lack of uptake of indocyanine green and trypan blue by hepatocellular carcinoma. (2007)
Itoshima, Tatsuya, Ito, Toshio, Ukida, Minoru, Ogawa, Hiromichi, Kitadai, Masahiro, Hattori, Shunzo, ...
Experimental hepatocellular carcinoma (HCC) in rats did not take up intravenously administered indocyanine green (ICG) and trypan blue, while surrounding tissue did. The lack of ICG uptake was also...
Clinical significance of eosinophilia in the diagnosis of halothane-induced liver injury. (2007)
Fujiwara, Masachika, Watanabe, Akiharu, Sato, Yasumasa, Shiota, Tetsuya, Nakatsukasa, Harushige, Yamada, Gotaro, ...
Three patients with severe halothane-induced liver injury are described. All patients received halothane anesthesia twice within a short period. High fever and jaundice were noticed soon after the...
Tsuchiya, Kazuhiro, Nagashima, Hideo, 永島, 英夫, ツチヤ, カズヒロ, ナガシマ, ヒデオ
The insertion of two sterically different isocyanides into a Pd-Me bond was investigated by spectroscopy and crystallography; this contribute to better understanding of ethylene polymerization...
Matsubara, Kouki, Iura, Takafumi, Maki, Tomoyuki, Terasawa, Jun-ichi, Nagashima, Hideo, 松原, 公紀, ...
Pre-activation of (μ_2,η^2:η^3:η^5-acenaphthylene)Ru_3(CO)_7 (1) by hydrosilanes in a small amount of dioxane provides novel convenient and useful procedures for hydrosilylation of carbonyl...
Hayashida, Taizo, Nagashima, Hideo, 林田, 大造, 永島, 英夫, ハヤシダ, タイゾウ, ナガシマ, ヒデオ
The first organoruthenium amidinates bearing a Ru-C σ bond were prepared, and their structures were elucidated by spectroscopy and crystallography. A halogenoruthenium amidinate precursor,...
Iura, Takafumi, Matsubara, Kouki, Nagashima, Hideo, 井浦, 貴史, 松原, 公紀, 永島, 英夫, ...
Treatment of H[(CH_2)_4O]_nSiR_3, which were prepared by the silane induced polymerization of THF with acyl halides catalyzed by (μ_3:η^2:η^3:η^5-acenaphthylene)Ru_3(CO)_7, provides a novel...
Oe, Katsunori, Sperlágh, Beáta, Sántha, Ernô, Matkó, Ida, Nagashima, Hideo, Foldes, Francis F, ...
Objective: The aim of this study was to show, whether ATP sensitive K+ channels (KATP channels), are involved in the modulation of norepinephrine (NE) release from the sympathetic nerves innervating...
永島, 英夫, 鈴木, 昭洋, Nagashima, Hideo, Suzuki, Akihiro, ナガシマ, ヒデオ, スズキ, アキヒロ
Thermal or photochemical isomerization of dinuclear carbonyl species bound to conjugate π-systems is presented Typically, irradiation of a diiron carbonyl complex,...
Watanabe, Akiharu, Yamauchi, Yasuhiko, Kobayashi, Michio, Nagashima, Hideo
The potentiating effect of pre-existing cirrhosis on the fonnation of hyperplastic liver nodules and/or foci was investigated by feeding a low dose (0.008%) of 2-N-fluor-enylacetamide (FAA) in a...
ANAESTHETIC MANAGEMENT OF "PRUNE BELLY" SYNDROME: Case Report (1974)
KARAMANIAN, AGOP, KRAVATH, RICHARD, NAGASHIMA, HIDEO, GENTSCH, HANS-HEINRICH
A 14-month-old boy suffering from the “prune belly” syndrome was anaesthetized for surgery of the urogenital tract. Postoperative respiratory insufficiency was treated with oxygen therapy and...