Miyagawa, Tomoaki, Tsutsumi, Masakazu, Matsumura, Takeshi, Kawazoe, Natsui, Ishikawa, Satoru, Shimokama, Tatsuro, ...
Objective Elastography is a technique for detecting the stiffness of tissues. We applied elastography for the diagnosis of prostate cancer and evaluated the usefulness of elastography for prostate...
Shintaku, Ichiro, Satoh, Makoto, Okajima, Eijiro, Fujimoto, Hiroyuki, Kamoto, Toshiyuki, Ogawa, Osamu, ...
Background As a risk classification system of metastatic germ cell tumors, the International Germ Cell Consensus (IGCC) classification was proposed in 1997 and has received broad approval. Since the...
Hinotsu, Shiro, Akaza, Hideyuki, Usami, Michiyuki, Ogawa, Osamu, Kagawa, Susumu, Kitamura, Tadaichi, ...
Background Based on the data of current status of endocrine therapy for prostate cancer registered in the Japan Study Group of Prostate Cancer (J-CaP), we conducted an analysis of primary androgen...
Akaza, Hideyuki, Tsukamoto, Taiji, Murai, Masaru, Nakajima, Keiko, Naito, Seiji
Objective Sorafenib (Nexavar®) is an oral multi-kinase inhibitor that targets tumor growth and angiogenesis. This phase II study investigated efficacy, safety, and pharmacokinetics of sorafenib in...
Nrf2 and p53 cooperatively protect against BBN-induced urinary bladder carcinogenesis (2007)
Iida, Katsuyuki, Itoh, Ken, Maher, Jonathan M., Kumagai, Yoshito, Oyasu, Ryoichi, Mori, Yukio, ...
Nuclear factor-erythroid 2 (NF-E2)-related factor 2 (Nrf2), a transcription factor that regulates inducible expression of detoxifying enzymes, is critical in preventing...
Shimazui, Toru, Kawai, Koji, Miyanaga, Naoto, Kojima, Takahiro, Sekido, Noritoshi, Hinotsu, Shiro, ...
Background We previously reported that weekly treatment with docetaxel alone is useful for and well tolerated by patients with hormone-refractory prostate cancer (HRPC). Here, we compare it with the...
Miyanaga, Naoto, Akaza, Hideyuki, Hinotsu, Shiro, Joraku, Akira, Oikawa, Takehiro, Sekido, Noritoshi, ...
Objective The present study was undertaken to identify the patients suitable for bladder preservation by analysis of our data. Methods The subjects of this study were all 72 patients with T2–3N0M0...
Miyagawa, Tomoaki, Shimazui, Toru, Hinotsu, Shiro, Oikawa, Takehiro, Sekido, Noritoshi, Miyanaga, Naoto, ...
Background We retrospectively evaluated the effects of tumor size and microvascular tumor invasion on the clinical outcomes of patients who had undergone radical nephrectomy for renal cell carcinoma...
Kawai, Koji, Hinotsu, Shiro, Oikawa, Takehiro, Sekido, Noritoshi, Hattori, Kazunori, Miyanaga, Naoto, ...
Background Incidence of testicular cancer is low in Japan. Recent investigations showed that the outcome of metastatic testicular cancer is associated with the experience of the treatment...
Kawai, Koji, Ando, Satoshi, Hinotsu, Shiro, Oikawa, Takehiro, Sekido, Noritoshi, Miyanaga, Naoto, ...
Background: Combination of bleomycin, etoposide and cisplatin (BEP) remains the standard chemotherapy for testicular cancer. Since the development of BEP in the 1980s, there has been a considerable...
Takaoka, Ei-Ichiro, Kawai, Koji, Ando, Satoshi, Shimazui, Toru, Akaza, Hideyuki
A 54-year-old man received combination chemotherapy with nedaplatin and irinotecan as salvage chemotherapy for refractory non-seminomatous testicular cancer. The patient developed abdominal pain and...
Takaoka, Ei-Ichiro, Kawai, Koji, Ando, Satoshi, Shimazui, Toru, Akaza, Hideyuki
A 54-year-old man received combination chemotherapy with nedaplatin and irinotecan as salvage chemotherapy for refractory non-seminomatous testicular cancer. The patient developed abdominal pain and...
Kawai, Koji, Ando, Satoshi, Hinotsu, Shiro, Oikawa, Takehiro, Sekido, Noritoshi, Miyanaga, Naoto, ...
Background: Combination of bleomycin, etoposide and cisplatin (BEP) remains the standard chemotherapy for testicular cancer. Since the development of BEP in the 1980s, there has been a considerable...
Kawai, Koji, Takaoka, Ei-Ichiro, Naoi, Makito, Mori, Kensaku, Minami, Manabu, Shimazui, Toru, ...
A 26-year-old man was referred to our hospital for treatment of metastatic testicular cancer. The pathological diagnosis was choriocarcinoma with seminoma. Sequential computerized tomography...
Kawai, Koji, Hinotsu, Shiro, Oikawa, Takehiro, Sekido, Noritoshi, Hattori, Kazunori, Miyanaga, Naoto, ...
Background: Incidence of testicular cancer is low in Japan. Recent investigations showed that the outcome of metastatic testicular cancer is associated with the experience of the treatment...
Akaza, Hideyuki, Yamaguchi, Akito, Matsuda, Tadashi, Igawa, Mikio, Kumon, Hiromi, Soeda, Asaki, ...
Objectives: To evaluate bicalutamide (Casodex) 80 mg as a component of maximum androgen blockade (MAB) in Japanese patients with previously untreated advanced prostate cancer. Methods: 205 patients...
Akaza, Hideyuki, Usami, Michiyuki, Hinotsu, Shiro, Ogawa, Osamu, Kagawa, Susumu, Kitamura, Tadaichi, ...
Objective: Hormone therapy for prostate cancer has empirically prevailed in Japan. We planned to evaluate the trends and outcome of hormone therapy for establishing an adequate guideline. Methods:...
Kojima, Takahiro, Shimazui, Toru, Onozawa, Mizuki, Tsukamoto, Sadamu, Hinotsu, Shiro, Miyanaga, Naoto, ...
Objective: Although treatment of hormone-refractory prostate cancer (HRPC) is difficult, a single-agent weekly dose of docetaxel has been reported as a promising regimen for patients with HRPC. The...
Akaza, Hideyuki, Miyanaga, Naoto, Takashima, Naomi, Naito, Seiji, Hirao, Yoshihiko, Tsukamoto, Taiji, ...
Background: Our previous case-control study revealed that the Japanese residents in Japan could be divided into those who are able to degrade daidzein, a soybean isoflavone, to equol and those...
Akaza, Hideyuki, Koiso, Kenkichi, Ozono, Seiichiro, Kuroda, Masao, Kameyama, Shuji, Okajima, Eigoro, ...
Background: Intravesical Bacillus Calmette–Guérin (BCG) is now a standard treatment for Ta, T1 carcinoma and carcinoma in situ (CIS) of the urinary bladder. In Japan, however, only BCG Tokyo 172...
Miyazaki, Jun, Kawai, Koji, Hayashi, Hitoshi, Onozawa, Mizuki, Tsukamoto, Sadamu, Miyanaga, Naoto, ...
Background: Combination chemotherapy of methotrexate, actinomycin D and cisplatin (MAP) is reported to be effective against gestational choriocarcinoma. Methods: Eight patients with metastatic...
Kawai, Koji, Miyazaki, Jun, Tsukamoto, Sadamu, Hinotsu, Shiro, Hattori, Kazunori, Shimazui, Toru, ...
Background: Paclitaxel, ifosfamide and cisplatin (TIP) has been tested with successful results on metastatic testicular cancer in Western countries. Because paclitaxel, the key drug of this regimen,...
Akaza, Hideyuki, Miyanaga, Naoto, Takashima, Naomi, Naito, Seiji, Hirao, Yoshihiko, Tsukamoto, Taiji, ...
Background: It has been postulated that soybean isoflavones act as inhibitory factors in prostate cancer. However, to date there have been no case-controlled clinical studies carried out to compare...
Niimi, Miyuki, Yamamoto, Seiichiro, Fukuda, Haruhiko, Ishizuka, Naoki, Akaza, Hideyuki
Background: Progression-free survival (PFS) is a common endpoint in cancer clinical trials. This study was undertaken to assess the impact of data errors and data handling on the statistical...
Treated Natural History of Superficial Bladder Cancer (2001)
Ozono, Seiichiro, Hinotsu, Shiro, Tabata, Shoichi, Takashima, Kenji, Fujimoto, Kiyohide, Okajima, Eigoro, ...
Background: The present study was conducted to examine the natural history of superficial bladder cancer. Methods: One hundred and forty-four patients with superficial bladder cancer who had been...
Akaza, Hideyuki, Homma, Yukio, Okada, Kiyoki, Yokoyama, Masao, Moriyama, Nobuo, Usami, Michiyuki, ...
Background: The majority of patients with localized and some cases of locally advanced prostate cancer undergo radical prostatectomy. However, radical prostatectomy cannot always be selected for...
Ota, Tomonori, Asamoto, Makoto, Toriyama-Baba, Hiroyasu, Yamamoto, Fumi, Matsuoka, Yoichiro, Ochiya, Takahiro, ...
We have established a transgenic rat line carrying three copies of the human c-Ha-ras proto-oncogene with its own original promoter region, Jcl/SD-TgN(HrasGen)128Ncc (Hras128) rat. c-Ha-ras protein...
Uchida, Katsunori, Takeshima, Hitoshi, Akaza, Hideyuki, Ono, Yukio
Background: The incidence of prostate cancer in Japan is not very high but it is the most increasing malignant tumor form. To decrease the mortality from cancer, detection of early cancer and early...
Chemoprevention of Rat Prostate Carcinogenesis by Use of Finasteride or Casodex (1995)
Tsukamoto, Sadamu, Akaza, Hideyuki, Imada, Seiki, Koiso, Kenkichi, Shirai, Tomoyuki, Ideyama, Yukitaka, ...
Akaza, Hideyuki, Isurugi, Koichiro, Oishi, Yukihiko, Kitajima, Kiyoaki, Sawamura, Yoshikatsu, Baba, Shiro, ...
The present study was designed to investigate the efficacy of various combinations of chemotherapeutic agents in the treatment of prostatic cancer in a group refractory to antiandrogenic therapy...
Hashimoto, Makoto, Akaza, Hideyuki, Shibamoto, Kenshu, Kishi, Hiroichi, Umeda, Takashi, Isurugi, Koichiro, ...
A survivor of the Hiroshima atomic bomb experienced triple cancer of the urogenital organs after a long history of heavy smoking. The cancers comprised a clear cell carcinoma of the right kidney,...
Prophylactic Intravesical Chemotherapy: Its Unexpected Course (1982)
AKAZA, HIDEYUKI, KOISO, KENKICHI, NIIJIMA, TADAO, OSHI, MASAYA, NAKAMURA, SHOHEI, ASANO, MICHIO
Generally, prophylactic intravesical chemotherapy is effective in decreasing the rate of recurrence of bladder cancer. However, we have experienced four cases presenting invasive development of...