Syntheses and Chemotactic Activities of 2,3-Methanophenylalanine3Chemotactic Peptides, (9999)
Kodama, Hiroaki, Miyazaki, Masaya, Kondo, Michio, Sakaguchi, Kazuyasu, Stammer, Charles H.
A family of N-formyl Met peptides is known to have chemotactic activity for neutrophils and macrophages, and neutrophil activating potency. The SAR of these peptides have been well-documented....
Studies of Dimeric fMLF with High Chemotactic Activities, (9999)
Kondo, Michio, Miyazaki, Masaya, Fan, Jiangin, Watanabe, Teruo, Kodama, Hiroaki
A number of peptides and proteins such as C5a, fMLF (also known as fMLP) and Interleukin 8 exhibit biological activity as chemoattractants in inflammatory sites. In addition to the directed migration...
Hayashi, Ryo, Osada, Satoshi, Yoshiki, Masahiro, Sugiyama, Daisuke, Fujita, Ichiro, Hamasaki, Yuhei, ...
Formyl peptide receptor (FPR) mediates a number of important host defense functions. Although studies have been performed on the ligand binding site of FPR, FPR dynamic behavior such as receptor...
新規な分子機構に基づく高等植物ジーンサイレンシングの解析 (2001)
児玉, 浩明, コダマ, ヒロアキ, Kodama, Hiroaki
研究概要:リノレン酸合成を触媒するタバコ小胞体局在型w-3脂肪酸不飽和化酵素遺伝子(NtFAD3)を導入した形質転換タバコでは、ほとんどの場合、野生...
新規な分子機構に基づく高等植物ジーンサイレンシングの解析 (2001)
児玉, 浩明, コダマ, ヒロアキ, Kodama, Hiroaki
研究概要:リノレン酸合成を触媒するタバコ小胞体局在型w-3脂肪酸不飽和化酵素遺伝子(NtFAD3)を導入した形質転換タバコでは、ほとんどの場合、野生...
Side Chain Effect on Ion Channel Characters of Aib Rich Peptides (2001)
Hara, Toshiaki, Kodama, Hiroaki, Higashimoto, Yuichiro, Yamaguchi, Hiroshi, Jelokhani-Niaraki, Masood, Ehara, Tsuguhisa, ...
As models of ion channel proteins and naturally occurring pore-forming peptides, we designed a series of Aib rich peptides [Ac-(Aib-Xxx-Aib-Ala)5 NH2 (Xxx = Lys, Glu, Ser, and Gly: BXBA-20)]...
Kodama, Hiroaki, Sumi, Jun-Ichi
The chiral phase structure of the Nambu-Jona-Lasinio/Gross-Neveu model at finite temperature T and finite chemical potential \mu is investigated using (Wilsonian) Non-Perturbative Renormalization...
Higashimoto, Yuichiro, Kodama, Hiroaki, Jelokhani-Niaraki, Masood, Kato, Fumio, Kondo, Michio
Peptaibols comprise a family of peptide antibiotics with high contents of 2-aminoiso-butyric acid (Aib) residues and C-terminal amino alcohols. These peptides form α-helical structures leading to...
Horiguchi, Gorou, Kawakami, Naoto, Kusumi, Kensuke, Kodama, Hiroaki, Iba, Koh
ω3 fatty acid desaturase is responsible for the production of α-linolenic acid, which is a major fatty acid constituent of membrane lipids in higher plants. In this study, the developmental...
Jelokhani-Niaraki, Masood, Nakashima, Kenichi, Kodama, Hiroaki, Kondo, Michio
The interaction and orientation of a membrane protein ion channel model, an α-aminoiso-butyric acid analogue of gramicidin B (GBA), in egg yolk phosphatidylcholine vesicles was studied by means of...
Inter-meson Potentials in Dual Ginzburg-Landau Theory (1997)
Kodama, Hiroaki, Matsubara, Yoshimi, Ohno, Shigeyoshi, Suzuki, Tsuneo
We calculate inter-meson potentials numerically by solving classical equations of motion derived from Dual Ginzburg-Landau (DGL) Theory. Inter-meson potentials in DGL theory are shown to be similar...
Hamada, Tatsurou, Nishiuchi, Takumi, Kodama, Hiroaki, Nishimura, Mitsuo, Iba, Koh
A cDNA encoding the plastid ω-3 fatty acid desaturase was isolated from a tobacco (Nicotiana tabacum cv. SR1) leaf cDNA library. The amino terminal extension of the deduced amino acid sequence of...
Yasunaga, Teruo, Motoyama, Shihoko, Nose, Takeru, Kodama, Hiroaki, Kondo, Michio, Shimohigashi, Yasuyuki
The 3-nitro-2-pyridinesulfenyl (Npys) group bound to a mercapto group is a highly activated electrophilic reagent, which only reacts with a free mercapto group to form a disulfide bond via the...
Miyazaki, Masaya, Kodama, Hiroaki, Fujita, Ichiro, Hamasaki, Yuhei, Miyazaki, Sumio, Rondo, Michio
A series of dimeric fMLPs were synthesized by cross-linking with hydrophilic linkers, mono-, di-, tri-, and tetraethylene glycols. All of the dimers showed higher activities than monomeric fMLP in...
Study on Coacervation of the Repeat Pentapeptide Model of Tropoelastin: Effect of Cations (1987)
KONDO, Michio, NAKASHIMA, Yukio, KODAMA, Hiroaki, OKAMOTO, Kouji
The effects of various cations on coacervation of the polypentapeptide (Val-Pro-Gly-Val-Gly)n a sequential model of tropoelastin, were studied by following the turbidity at 300 nm and the...
Esashi, Esashi, Saitoh, Hisato, Saijoh, Yukio, Ishida, Satoko, Kodama, Hiroaki
In negatively photoblastic, lower seeds of cocklebur (Xanthium pennsylvanicum Wallr.), the respective germination-inhibiting effects of red (R) and far-red (FR) lights were found in the proximal and...
ESASHI, YOHJI, OOTA, HIROSHI, SAITOH, HISATO, KODAMA, HIROAKI
Esashi, Y., Oota, H., Saitoh, H. and Kodama, H. 1985. Light actions in the germination of cocklebur seeds. III. Effects of pre-treatment temperature on germination responses to far-red light and on...
CHIKUMA, Toshiyuki, ISHII, Yoko, KATO, Takeshi, KODAMA, Hiroaki, HAKEDA, Yoshiyuki, KUMEGAWA, Masayoshi
The effects of prostaglandin E2(PGE2) on the degradation of collagen and non-collagenous peptides in clonal osteoblastic MC3T3-E1 cells were investigated by using highly sensitive assay methods for...
ESASHI, YOHJI, ISHIHARA, NOBUYORI, KURAISHI, RITSU, KODAMA, HIROAKI
Germination responses to light were studied in the upper and lower seeds of cocklebur (Xanthium pennsylvanicum Wallr.). The lower seed was dark-germinating and negatively photoblastic; the upper one...
HIRAMATSU, Masahiko, IKEDA, Eiko, KASHIMATA, Masanori, MINAMI, Naomi, KODAMA, Hiroaki, SUDO, Hiroko, ...
The effects of dibutyryl cyclic AMP (DBcAMP) and related compounds on collagen synthesis in a clonal osteoblast-like cell line, MC3T3-E1, were investigated. The addition of DBcAMP to cultures...
兒玉, 浩明, コダマ, ヒロアキ, Kodama, Hiroaki, 児玉 浩明
研究種目:科学研究費補助金基盤研究(C)/報告年度:2003年度/研究課題番号:14540588/研究概要:タバコ小胞体局在型リノレン酸合成酵素遺伝子(NtFAD3)を導入...
児玉, 浩明, コダマ, ヒロアキ, Kodama, Hiroaki
研究種目:科学研究費補助金基盤研究(C)/報告年度:2001年度/研究課題番号:12640628/研究概要:リノレン酸合成を触媒するタバコ小胞体局在型w-3脂肪酸不飽...
児玉, 浩明, コダマ, ヒロアキ, Kodama, Hiroaki
研究種目:科学研究費補助金基盤研究(C)/報告年度:2003年度/研究課題番号:14540588/研究概要:タバコ小胞体局在型リノレン酸合成酵素遺伝子(NtFAD3)を導入...
Characterization of Transgenic Tobacco with an Increased α-Linolenic Acid Level1
Hamada, Tatsurou, Kodama, Hiroaki, Takeshita, Keizo, Utsumi, Hideo, Iba, Koh
Microsomal ω-3 fatty acid desaturase catalyzes the conversion of 18:2 (linoleic acid) to 18:3 (α-linolenic acid) in phospholipids, which are the main constituents of extrachloroplast membranes....
Nishiuchi, Takumi, Kodama, Hiroaki, Yanagisawa, Shuichi, Iba, Koh
The FAD7 gene is expressed preferentially in the chlorophyllous tissues of unwounded plants. Wounding activates the expression of the FAD7 gene not only in chlorophyllous tissues, but also in...
Cardiomyocytes can be generated from marrow stromal cells in vitro
Makino, Shinji, Fukuda, Keiichi, Miyoshi, Shunichirou, Konishi, Fusako, Kodama, Hiroaki, Pan, Jing, ...
We have isolated a cardiomyogenic cell line (CMG) from murine bone marrow stromal cells. Stromal cells were immortalized, treated with 5-azacytidine, and spontaneously beating cells were repeatedly...
Kodama, Hiroaki, Kawakami, Naoto, Watanabe, Akira, Komamine, Atsushi
This study shows an overall analysis of gene expression during the cell cycle in synchronous suspension cultures of Catharanthus roseus cells. First, the cellular cytoplasmic proteins were...
Kodama, Hiroaki, Ito, Masaki, Hattori, Tsukaho, Nakamura, Kenzo, Komamine, Atsushi
A cDNA library was screened for genes that may be involved in the progression of the cell cycle of cells of higher plants. The Catharanthus roseus L. (G) Don. cells were synchronized by the double...
Polyamines and the Cell Cycle of Catharanthus roseus Cells in Culture 1
Maki, Hisae, Ando, Satoshi, Kodama, Hiroaki, Komamine, Atsushi
Investigation was made on the effect of partial depletion of polyamines (PAs), induced by treatment with inhibitors of the biosynthesis of PAs, on the distribution of cells at each phase of the cell...
Characterization of Transgenic Tobacco with an Increased α-Linolenic Acid Level1
Hamada, Tatsurou, Kodama, Hiroaki, Takeshita, Keizo, Utsumi, Hideo, Iba, Koh
Microsomal ω-3 fatty acid desaturase catalyzes the conversion of 18:2 (linoleic acid) to 18:3 (α-linolenic acid) in phospholipids, which are the main constituents of extrachloroplast membranes....
Nishiuchi, Takumi, Kodama, Hiroaki, Yanagisawa, Shuichi, Iba, Koh
The FAD7 gene is expressed preferentially in the chlorophyllous tissues of unwounded plants. Wounding activates the expression of the FAD7 gene not only in chlorophyllous tissues, but also in...
Cardiomyocytes can be generated from marrow stromal cells in vitro
Makino, Shinji, Fukuda, Keiichi, Miyoshi, Shunichirou, Konishi, Fusako, Kodama, Hiroaki, Pan, Jing, ...
We have isolated a cardiomyogenic cell line (CMG) from murine bone marrow stromal cells. Stromal cells were immortalized, treated with 5-azacytidine, and spontaneously beating cells were repeatedly...
Kodama, Hiroaki, Kawakami, Naoto, Watanabe, Akira, Komamine, Atsushi
This study shows an overall analysis of gene expression during the cell cycle in synchronous suspension cultures of Catharanthus roseus cells. First, the cellular cytoplasmic proteins were...
Kodama, Hiroaki, Ito, Masaki, Hattori, Tsukaho, Nakamura, Kenzo, Komamine, Atsushi
A cDNA library was screened for genes that may be involved in the progression of the cell cycle of cells of higher plants. The Catharanthus roseus L. (G) Don. cells were synchronized by the double...
Polyamines and the Cell Cycle of Catharanthus roseus Cells in Culture 1
Maki, Hisae, Ando, Satoshi, Kodama, Hiroaki, Komamine, Atsushi
Investigation was made on the effect of partial depletion of polyamines (PAs), induced by treatment with inhibitors of the biosynthesis of PAs, on the distribution of cells at each phase of the cell...
Cardiomyogenic Differentiation in Cardiac Myxoma Expressing Lineage-Specific Transcription Factors
Kodama, Hiroaki, Hirotani, Takashi, Suzuki, Yusuke, Ogawa, Satoshi, Yamazaki, Kazuto
We investigated five cases of cardiac myxoma and one case of cardiac undifferentiated sarcoma by light and electron microscopy, in situ hybridization, immunohistochemical staining, and reverse...
Niida, Shumpei, Kaku, Masato, Amano, Hitoshi, Yoshida, Hisahiro, Kataoka, Hiroshi, Nishikawa, Satomi, ...
We demonstrated previously that a single injection of recombinant human macrophage colony-stimulating factor (rhM-CSF) is sufficient for osteoclast recruitment and survival in osteopetrotic (op/op)...
Takakura, Nobuyuki, Kodama, Hiroaki, Nishikawa, Satomi, Nishikawa, Shin-Ichi
The establishment of culture conditions that selectively support hematopoietic stem cells is an important goal of hematology. In this study, we investigated the possibility of using for this purpose...
Shimizu, Natsumi, Noda, Shinichi, Katayama, Kazufumi, Ichikawa, Hitoshi, Kodama, Hiroaki, Miyoshi, Hiroyuki
Although coculture of hematopoietic stem cells (HSCs) with stromal cells is a useful system to study hematopoiesis in the niche, little is known regarding the precise cellular and molecular...