Regulation of Actin Dynamics by WASP Family Proteins (2003)
Miki, Hiroaki, Takenawa, Tadaomi
Rapid reorganization of the actin cytoskeleton underlies morphological changes and motility of cells. WASP family proteins have received a great deal of attention as the signal-regulated molecular...
Yamaguchi, Hideki, Miki, Hiroaki, Suetsugu, Shiro, Ma, Le, Kirschner, Marc W., Takenawa, Tadaomi
All WASP family proteins share a common C terminus that consists of the verprolin homology domain (V), cofilin homology domain (C), and acidic region (A), through which they activate Arp2/3...
The pre-mRNA-splicing factor SF3a66 functions as a microtubule-binding and -bundling protein
Takenaka, Kei, Nakagawa, Hiroyuki, Miyamoto, Shigeaki, Miki, Hiroaki
SF3a (splicing factor 3a) complex is an essential component of U2 snRNPs (small nuclear ribonucleoprotein particles), which are involved in pre-mRNA splicing. This complex consists of three subunits:...
Yamaguchi, Hideki, Miki, Hiroaki, Suetsugu, Shiro, Ma, Le, Kirschner, Marc W., Takenawa, Tadaomi
All WASP family proteins share a common C terminus that consists of the verprolin homology domain (V), cofilin homology domain (C), and acidic region (A), through which they activate Arp2/3...
The pre-mRNA-splicing factor SF3a66 functions as a microtubule-binding and -bundling protein
Takenaka, Kei, Nakagawa, Hiroyuki, Miyamoto, Shigeaki, Miki, Hiroaki
SF3a (splicing factor 3a) complex is an essential component of U2 snRNPs (small nuclear ribonucleoprotein particles), which are involved in pre-mRNA splicing. This complex consists of three subunits:...
Yamaguchi, Hideki, Lorenz, Mike, Kempiak, Stephan, Sarmiento, Corina, Coniglio, Salvatore, Symons, Marc, ...
Invadopodia are actin-rich membrane protrusions with a matrix degradation activity formed by invasive cancer cells. We have studied the molecular mechanisms of invadopodium formation in metastatic...
Rho Family Gtpase Cdc42 Is Essential for the Actin-Based Motility of Shigella in Mammalian Cells
Suzuki, Toshihiko, Mimuro, Hitomi, Miki, Hiroaki, Takenawa, Tadaomi, Sasaki, Takuya, Nakanishi, Hiroyuki, ...
Shigella, the causative agent of bacillary dysentery, is capable of directing its movement within host cells by exploiting actin dynamics. The VirG protein expressed at one pole of the bacterium can...
Profilin Enhances Cdc42-Induced Nucleation of Actin Polymerization
Yang, Changsong, Huang, Minzhou, DeBiasio, John, Pring, Martin, Joyce, Michael, Miki, Hiroaki, ...
We find that profilin contributes in several ways to Cdc42-induced nucleation of actin filaments in high speed supernatant of lysed neutrophils. Depletion of profilin inhibited Cdc42-induced...
Fukuoka, Maiko, Suetsugu, Shiro, Miki, Hiroaki, Fukami, Kiyoko, Endo, Takeshi, Takenawa, Tadaomi
We identified a novel adaptor protein that contains a Src homology (SH)3 domain, SH3 binding proline-rich sequences, and a leucine zipper-like motif and termed this protein WASP interacting SH3...