Hiroaki Onda

Literature Triage and Indexing in the Mouse Genome Informatics (MGI) Group (2009)

Randal P. Babiuk, Dale A. Begley, Susan M. Bello, Dirck W. Bradt, Donna L. Burkart, Howard Dene, ...

The Mouse Genome Informatics (MGI; "http://www.informatics.jax.org":http://www.informatics.jax.org) group is comprised of several collaborating projects including the Mouse Genome Database...

Focused Microarray Analysis of Peripheral Mononuclear Blood Cells from Churg-Strauss Syndrome Patients (2008)

Tougan, Takahiro, Onda, Hiroaki, Okuzaki, Daisuke, Kobayashi, Shigeto, Hashimoto, Hiroshi, Nojima, Hiroshi

DNA diagnostics are useful but are hampered by difficult ethical issues. Moreover, it cannot provide enough information on the environmental factors that are important for pathogenesis of certain...

Expression Profiling of PBMC-based Diagnostic Gene Markers Isolated from Vasculitis Patients (2008)

Kobayashi, Shigeto, Ito, Akihiko, Okuzaki, Daisuke, Onda, Hiroaki, Yabuta, Norikazu, Nagamori, Ippei, ...

Vasculitis (angiitis) is a systemic autoimmune disease that often causes fatal symptoms. We aimed to isolate cDNA markers that would be useful for diagnosing not only vasculitis but also other...

Isolation and characterization of the TIGA genes, whose transcripts are induced by growth arrest (2006)

Yabuta, Norikazu, Onda, Hiroaki, Watanabe, Masafumi, Yoshioka, Naohisa, Nagamori, Ippei, Funatsu, Tomoyuki, ...

We report here the isolation of 44 genes that are upregulated after serum starvation and/or contact inhibition. These genes have been termed TIGA, after Transcript Induced by Growth Arrest. We found...

Isolation and Expression Profiling of Genes Upregulated in Bone Marrow-Derived Mononuclear Cells of Rheumatoid Arthritis Patients (2006)

Nakamura, Nobuo, Shimaoka, Yasunori, Tougan, Takahiro, Onda, Hiroaki, Okuzaki, Daisuke, Zhao, Hanjun, ...

We have comprehensively identified the genes whose expressions are augmented in bone marrow-derived mononuclear cells (BMMC) from patients with Rheumatoid Arthritis (RA) as compared with BMMCs from...

Isolation and characterization of the TIGA genes, whose transcripts are induced by growth arrest (2006)

Yabuta, Norikazu, Onda, Hiroaki, Watanabe, Masafumi, Yoshioka, Naohisa, Nagamori, Ippei, Funatsu, Tomoyuki, ...

We report here the isolation of 44 genes that are upregulated after serum starvation and/or contact inhibition. These genes have been termed TIGA, after Transcript Induced by Growth Arrest. We found...

Isolation and characterization of the TIGA genes, whose transcripts are induced by growth arrest (2006)

Yabuta, Norikazu, Onda, Hiroaki, Watanabe, Masafumi, Yoshioka, Naohisa, Nagamori, Ippei, Funatsu, Tomoyuki, ...

We report here the isolation of 44 genes that are upregulated after serum starvation and/or contact inhibition. These genes have been termed TIGA, after Transcript Induced by Growth Arrest. We found...

Isolation and characterization of the TIGA genes, whose transcripts are induced by growth arrest (2006)

Yabuta, Norikazu, Onda, Hiroaki, Watanabe, Masafumi, Yoshioka, Naohisa, Nagamori, Ippei, Funatsu, Tomoyuki, ...

We report here the isolation of 44 genes that are upregulated after serum starvation and/or contact inhibition. These genes have been termed TIGA, after Transcript Induced by Growth Arrest. We found...

Isolation and Expression Profiling of Genes Upregulated in the Peripheral Blood Cells of Systemic Lupus Erythematosus Patients (2006)

Ishii, Taeko, Onda, Hiroaki, Tanigawa, Akie, Ohshima, Shiro, Fujiwara, Hiroshi, Mima, Toru, ...

We have identified the genes whose expressions are augmented in the blood cells of the patients with systemic lupus erythematosus (SLE) using the ‘stepwise subtraction’ technique along with...

Isolation and characterization of the TIGA genes, whose transcripts are induced by growth arrest (2006)

Yabuta, Norikazu, Onda, Hiroaki, Watanabe, Masafumi, Yoshioka, Naohisa, Nagamori, Ippei, Funatsu, Tomoyuki, ...

We report here the isolation of 44 genes that are upregulated after serum starvation and/or contact inhibition. These genes have been termed TIGA, after Transcript Induced by Growth Arrest. We found...

Isolation and characterization of the TIGA genes, whose transcripts are induced by growth arrest (2006)

Yabuta, Norikazu, Onda, Hiroaki, Watanabe, Masafumi, Yoshioka, Naohisa, Nagamori, Ippei, Funatsu, Tomoyuki, ...

We report here the isolation of 44 genes that are upregulated after serum starvation and/or contact inhibition. These genes have been termed TIGA, after Transcript Induced by Growth Arrest. We found...

Isolation and characterization of the TIGA genes, whose transcripts are induced by growth arrest (2006)

Yabuta, Norikazu, Onda, Hiroaki, Watanabe, Masafumi, Yoshioka, Naohisa, Nagamori, Ippei, Funatsu, Tomoyuki, ...

We report here the isolation of 44 genes that are upregulated after serum starvation and/or contact inhibition. These genes have been termed TIGA, after Transcript Induced by Growth Arrest. We found...

Isolation and Expression Profiling of Genes Upregulated in the Peripheral Blood Cells of Systemic Lupus Erythematosus Patients (2005)

Ishii, Taeko, Onda, Hiroaki, Tanigawa, Akie, Ohshima, Shiro, Fujiwara, Hiroshi, Mima, Toru, ...

We have identified the genes whose expressions are augmented in the blood cells of the patients with systemic lupus erythematosus (SLE) using the ‘stepwise subtraction’ technique along with...

A mouse model of TSC1 reveals sex-dependent lethality from liver hemangiomas, and up-regulation of p70S6 kinase activity in Tsc1 null cells (2002)

Kwiatkowski, David J., Zhang, Hongbing, Bandura, Jennifer L., Heiberger, Kristina M., Glogauer, Michael, El-Hashemite, Nisreen, ...

Tuberous sclerosis (TSC) is a autosomal dominant genetic disorder caused by mutations in either TSC1 or TSC2, and characterized by benign hamartoma growth. We developed a murine model of Tsc1 disease...

Loss of Tsc1/Tsc2 activates mTOR and disrupts PI3K-Akt signaling through downregulation of PDGFR

Zhang, Hongbing, Cicchetti, Gregor, Onda, Hiroaki, Koon, Henry B., Asrican, Kirsten, Bajraszewski, Natalia, ...

Tuberous sclerosis (TSC) is a familial tumor syndrome due to mutations in TSC1 or TSC2, in which progression to malignancy is rare. Primary Tsc2–/– murine embryo fibroblast cultures display early...

Tsc2+/– mice develop tumors in multiple sites that express gelsolin and are influenced by genetic background

Onda, Hiroaki, Lueck, Andreas, Marks, Peter W., Warren, Henry B., Kwiatkowski, David J.

Tuberous sclerosis (TSC) is an autosomal dominant genetic disorder in which benign hamartomas develop in multiple organs, caused by mutations in either TSC1 or TSC2. We developed a murine model of...

Isolation and characterization of the TIGA genes, whose transcripts are induced by growth arrest

Yabuta, Norikazu, Onda, Hiroaki, Watanabe, Masafumi, Yoshioka, Naohisa, Nagamori, Ippei, Funatsu, Tomoyuki, ...

We report here the isolation of 44 genes that are upregulated after serum starvation and/or contact inhibition. These genes have been termed TIGA, after Transcript Induced by Growth Arrest. We found...

Loss of Tsc1/Tsc2 activates mTOR and disrupts PI3K-Akt signaling through downregulation of PDGFR

Zhang, Hongbing, Cicchetti, Gregor, Onda, Hiroaki, Koon, Henry B., Asrican, Kirsten, Bajraszewski, Natalia, ...

Tuberous sclerosis (TSC) is a familial tumor syndrome due to mutations in TSC1 or TSC2, in which progression to malignancy is rare. Primary Tsc2–/– murine embryo fibroblast cultures display early...

Tsc2+/– mice develop tumors in multiple sites that express gelsolin and are influenced by genetic background

Onda, Hiroaki, Lueck, Andreas, Marks, Peter W., Warren, Henry B., Kwiatkowski, David J.

Tuberous sclerosis (TSC) is an autosomal dominant genetic disorder in which benign hamartomas develop in multiple organs, caused by mutations in either TSC1 or TSC2. We developed a murine model of...

Isolation and characterization of the TIGA genes, whose transcripts are induced by growth arrest

Yabuta, Norikazu, Onda, Hiroaki, Watanabe, Masafumi, Yoshioka, Naohisa, Nagamori, Ippei, Funatsu, Tomoyuki, ...

We report here the isolation of 44 genes that are upregulated after serum starvation and/or contact inhibition. These genes have been termed TIGA, after Transcript Induced by Growth Arrest. We found...

Functional Tyrosine Kinase Inhibitor Profiling : A Generally Applicable Method Points to a Novel Role of Platelet-Derived Growth Factor Receptor-β in Tuberous Sclerosis

Arbiser, Jack L., Govindarajan, Baskaran, Bai, Xianhe, Onda, Hiroaki, Kazlauskas, Andrius, Lim, So Dug, ...

Tumors often exhibit activation of specific tyrosine kinases, which may allow targeting of therapy through inhibition of tyrosine kinase signaling. This strategy has been used successfully in the...

Expression Profiling of PBMC-based Diagnostic Gene Markers Isolated from Vasculitis Patients

Kobayashi, Shigeto, Ito, Akihiko, Okuzaki, Daisuke, Onda, Hiroaki, Yabuta, Norikazu, Nagamori, Ippei, ...

Vasculitis (angiitis) is a systemic autoimmune disease that often causes fatal symptoms. We aimed to isolate cDNA markers that would be useful for diagnosing not only vasculitis but also other...

Focused Microarray Analysis of Peripheral Mononuclear Blood Cells from Churg–Strauss Syndrome Patients

Tougan, Takahiro, Onda, Hiroaki, Okuzaki, Daisuke, Kobayashi, Shigeto, Hashimoto, Hiroshi, Nojima, Hiroshi

DNA diagnostics are useful but are hampered by difficult ethical issues. Moreover, it cannot provide enough information on the environmental factors that are important for pathogenesis of certain...