Hiroaki Takeuchi

Publication List Details

Period

1999 - 2009

Number

47

Co-Authors

Oxygen electrode as a new tool to evaluate hydroxyl radical-scavenging ability (2008)

Komagoe, Keiko, Takeuchi, Hiroaki, Katsu, Takashi

An oxygen electrode was applied to determine hydroxyl radical ((OH)-O-center dot) levels for the first time. The method is based on the determination of (OH)-O-center dot generated by the Fenton...

Analysis of the contribution of cellular and viral RNA to the packaging of APOBEC3G into HIV-1 virions (2007)

Khan, Mohammad A, Goila-Gaur, Ritu, Opi, Sandrine, Miyagi, Eri, Takeuchi, Hiroaki, Kao, Sandra, ...

Abstract Background Efficient incorporation of the cellular cytidine deaminase APOBEC3G (APO3G) into HIV-1 virions is necessary for its antiviral activity. Even though cellular RNAs are known to be...

A Test Structure for Two-Dimensional Analysis of MOSFETs by Hot-Carrier-Induced Photoemission (2005)

MATSUDA, Toshihiro, TAKEUCHI, Hiroaki, MURAMATSU, Akira, IWATA, Hideyuki, OHZONE, Takashi, YAMASHITA, Kyoji, ...

A test structure and method for two-dimensional analysis of fabrication process variation of MOSFET using a photoemission microscope are presented. Arrays of 20 × 10 (=200) MOSFETs were...

Production of infectious human immunodeficiency virus type 1 does not require depletion of APOBEC3G from virus-producing cells (2004)

Kao, Sandra, Miyagi, Eri, Khan, Mohammad A, Takeuchi, Hiroaki, Opi, Sandrine, Goila-Gaur, Ritu, ...

Abstract Background The human immunodeficiency virus Vif protein overcomes the inhibitory activity of the APOBEC3G cytidine deaminase by prohibiting its packaging into virions. Inhibition of APOBEC3G...

Species-Specific Feeding Marks of Stink Bugs on Rice Grain in Leptocorisa chinensis Dallas (Hemiptera: Alydidae), Lagynotomus elongatus (Dallas) (Hemiptera: Pentatomidae) and Cletus punctiger (Dallas) (Hemiptera: Coreidae) (2004)

Hiroaki Takeuchi, Tomonari Watanabe, Yoshito Suzuki

The rice stink bugs, Leptocorisa chinensis, Lagynotomus elongatus and Cletus punctiger, are important cosmetic pests that cause pecky rice. The first step towards the establishment of effective and...

Inhibition of human immunodeficiency virus 1 replication in vitro by a self-stabilized oligonucleotide with 2'-O-methyl-guanosine-uridine quadruplex motifs (2003)

Kuwasaki, Tomoyuki, Hatta, Masasi, Takeuchi, Hiroaki, Takaku, Hiroshi

Objectives: Given that the guanosine-quadruplex may have a role in blocking the interaction between gp120 and CD4, we describe here the design of a highly nuclease-resistant dimeric hairpin...

Inhibition of human immunodeficiency virus 1 replication in vitro by a self-stabilized oligonucleotide with 2'-O-methyl-guanosine-uridine quadruplex motifs (2003)

Kuwasaki, Tomoyuki, Hatta, Masasi, Takeuchi, Hiroaki, Takaku, Hiroshi

Objectives: Given that the guanosine-quadruplex may have a role in blocking the interaction between gp120 and CD4, we describe here the design of a highly nuclease-resistant dimeric hairpin...

Inhibition of human immunodeficiency virus 1 replication in vitro by a self-stabilized oligonucleotide with 2'-O-methyl-guanosine-uridine quadruplex motifs (2003)

Kuwasaki, Tomoyuki, Hatta, Masasi, Takeuchi, Hiroaki, Takaku, Hiroshi

Objectives: Given that the guanosine-quadruplex may have a role in blocking the interaction between gp120 and CD4, we describe here the design of a highly nuclease-resistant dimeric hairpin...

Development of HIV-1 dependent gene expression vector with the Cre/IoxP (ON) system (2002)

Nagawa, Takashi, Habu, Yuichiro, Matsumoto, Norihiko, Takeuchi, Hiroaki, Kurosaki, Naoko, Takaku, Hiroshi

We used the HIV-1 5′LTR and the Cre/IoxP system to develop an anti-gene expression system. The LTR promoter of HIV-1 has a specific activity that includes the intermediary region of gag, as...

RNA cleavage by a mammalian tRNA 3'processing endoribonuclease (3'tRNase) reduces HIV-1 expression (2002)

Yukita, Masakazu, Kitano, Michiko, Miyano-Kurosaki, Naoko, Takeuchi, Hiroaki, Nashimoto, Masayuki, Takaku, Hiroshi

We examined the suppression of HIV-1 expression by cleavage of the HIV-1 RNA gene, using a mammalian tRNA 3′processing endoribonuclease (3′tRNase) as an External Guide Sequence oligozyme (EGS) in...

Effective suppression of HIV-1 gene expression by a mammalian tRNA 3' processing endoribonuclease and external guide sequence oligozymes (2000)

Kitano, Michiko, Miyano-Kurosaki, Naoko, Endo, Yumihiko, Yukita, Masakazu, Takeuchi, Hiroaki, Tamura, Yutaka, ...

We examined the suppression of virus expression by cleaveage of the HIV-1 RNA gene using a mammalian tRNA 3′ processing endoribonuclease and an External Guide Sequence Oligozyme(EGS)in vivo. We...

Phosphorothioate G3T4G3 motifs inhibits the early stage of HIV-1 infection (1999)

Suzuki, Jun-ichiro, Miyano-Kurosaki, Naoko, Takeuchi, Hiroaki, Tamura, Yutaka, Kawai, Gota, Takai, Kazuyuki, ...

It is well known that G-rich phosphorothioate oligonucleotides (G-rich PS) bind to the V3 loop of HIV-1 gpl20 and inhibit HIV-1 infection. In this study, we investigated the inhibitory mechanism of a...

Development of an HIV-1-dependent expression vector with the Cre / IoxP system (1999)

Habu, Yuichiro, Takeuchi, Hiroaki, Tamura, Yutaka, Miyano-Kurosaki, Naoko, Takai, Kazuyuki, Takaku, Hiroshi

Previously, we used the human methionine tRNA promoter as an expression cassette for hammerhead ribozymes. The tRNA promoter driven ribozyme was targeted against the LTR portion of the HIV-1 NL4-3...

Nucleotide Sequence and Characterization of cdrA, a Cell Division-Related Gene of Helicobacter pylori

Takeuchi, Hiroaki, Shirai, Mutsunori, Akada, Junko K., Tsuda, Masataka, Nakazawa, Teruko

We identified cell division-related gene cdrA in Helicobacter pylori HPK5. The putative gene product, CdrA, is a 367-amino-acid polypeptide that exhibited a high level of homology to conserved...

Urease Plays an Important Role in the Chemotactic Motility of Helicobacter pylori in a Viscous Environment

Nakamura, Hiroki, Yoshiyama, Hironori, Takeuchi, Hiroaki, Mizote, Tomoko, Okita, Kiwamu, Nakazawa, Teruko

Helicobacter pylori exhibits chemotactic responses to urea, flurofamide, acetohydroxamic acid, and sodium bicarbonate. In buffer, the chemotactic activities of a urease-positive strain were higher...

Inhibition of Human Immunodeficiency Virus Type 1 Activity In Vitro by a New Self-Stabilized Oligonucleotide with Guanosine-Thymidine Quadruplex Motifs

Suzuki, Jun-ichiro, Miyano-Kurosaki, Naoko, Kuwasaki, Tomoyuki, Takeuchi, Hiroaki, Kawai, Gota, Takaku, Hiroshi

An oligonucleotide with a dimeric hairpin guanosine quadruplex (basket type structure) (dG3T4G3-s), containing phosphorothioate groups, was able to inhibit human immunodeficiency virus type 1...

A Case of Epstein-Barr Virus (EBV)-Associated Thymic Carcinoid and Investigation of Existence of EBV-Infected Cells in Thymus and Thymic Tumors

Takeuchi, Hiroaki, Fujita, Hiroshi, Iwasaki, Fumio, Takeuchi, Takako, Imadome, Ken-Ichi, Okumiya, Toshika, ...

We describe the first case of Epstein-Barr virus (EBV)-associated thymic carcinoid tumor found by in situ hybridization (ISH) on paraffin-embedded sections. ISH revealed that both tumor cells and...

Viral RNA Is Required for the Association of APOBEC3G with Human Immunodeficiency Virus Type 1 Nucleoprotein Complexes

Khan, Mohammad A., Kao, Sandra, Miyagi, Eri, Takeuchi, Hiroaki, Goila-Gaur, Ritu, Opi, Sandrine, ...

APOBEC3G (APO3G) is a host cytidine deaminase that is incorporated into human immunodeficiency virus type 1 (HIV-1) particles. We report here that viral RNA promotes stable association of APO3G with...

Monomeric APOBEC3G Is Catalytically Active and Has Antiviral Activity

Opi, Sandrine, Takeuchi, Hiroaki, Kao, Sandra, Khan, Mohammad A., Miyagi, Eri, Goila-Gaur, Ritu, ...

APOBEC3G (APO3G) is a cytidine deaminase that restricts replication of vif-defective human immunodeficiency virus type 1 (HIV-1). Like other members of the cellular deaminase family, APO3G has the...

Anti-V3 Humanized Antibody KD-247 Effectively Suppresses Ex Vivo Generation of Human Immunodeficiency Virus Type 1 and Affords Sterile Protection of Monkeys against a Heterologous Simian/Human Immunodeficiency Virus Infection

Eda, Yasuyuki, Murakami, Toshio, Ami, Yasushi, Nakasone, Tadashi, Takizawa, Mari, Someya, Kenji, ...

In an accompanying report (Y. Eda, M. Takizawa, T. Murakami, H. Maeda, K. Kimachi, H. Yonemura, S. Koyanagi, K. Shiosaki, H. Higuchi, K. Makizumi, T. Nakashima, K. Osatomi, S. Tokiyoshi, S....

Biochemical Activities of Highly Purified, Catalytically Active Human APOBEC3G: Correlation with Antiviral Effect

Iwatani, Yasumasa, Takeuchi, Hiroaki, Strebel, Klaus, Levin, Judith G.

APOBEC3G (APO3G), a cytidine deaminase with two zinc finger domains, inhibits human immunodeficiency virus type 1 replication in the absence of Vif. Here, we provide a comprehensive molecular...

Nucleotide Sequence and Characterization of cdrA, a Cell Division-Related Gene of Helicobacter pylori

Takeuchi, Hiroaki, Shirai, Mutsunori, Akada, Junko K., Tsuda, Masataka, Nakazawa, Teruko

We identified cell division-related gene cdrA in Helicobacter pylori HPK5. The putative gene product, CdrA, is a 367-amino-acid polypeptide that exhibited a high level of homology to conserved...

Urease Plays an Important Role in the Chemotactic Motility of Helicobacter pylori in a Viscous Environment

Nakamura, Hiroki, Yoshiyama, Hironori, Takeuchi, Hiroaki, Mizote, Tomoko, Okita, Kiwamu, Nakazawa, Teruko

Helicobacter pylori exhibits chemotactic responses to urea, flurofamide, acetohydroxamic acid, and sodium bicarbonate. In buffer, the chemotactic activities of a urease-positive strain were higher...

Inhibition of Human Immunodeficiency Virus Type 1 Activity In Vitro by a New Self-Stabilized Oligonucleotide with Guanosine-Thymidine Quadruplex Motifs

Suzuki, Jun-ichiro, Miyano-Kurosaki, Naoko, Kuwasaki, Tomoyuki, Takeuchi, Hiroaki, Kawai, Gota, Takaku, Hiroshi

An oligonucleotide with a dimeric hairpin guanosine quadruplex (basket type structure) (dG3T4G3-s), containing phosphorothioate groups, was able to inhibit human immunodeficiency virus type 1...

A Case of Epstein-Barr Virus (EBV)-Associated Thymic Carcinoid and Investigation of Existence of EBV-Infected Cells in Thymus and Thymic Tumors

Takeuchi, Hiroaki, Fujita, Hiroshi, Iwasaki, Fumio, Takeuchi, Takako, Imadome, Ken-Ichi, Okumiya, Toshika, ...

We describe the first case of Epstein-Barr virus (EBV)-associated thymic carcinoid tumor found by in situ hybridization (ISH) on paraffin-embedded sections. ISH revealed that both tumor cells and...

Viral RNA Is Required for the Association of APOBEC3G with Human Immunodeficiency Virus Type 1 Nucleoprotein Complexes

Khan, Mohammad A., Kao, Sandra, Miyagi, Eri, Takeuchi, Hiroaki, Goila-Gaur, Ritu, Opi, Sandrine, ...

APOBEC3G (APO3G) is a host cytidine deaminase that is incorporated into human immunodeficiency virus type 1 (HIV-1) particles. We report here that viral RNA promotes stable association of APO3G with...

Monomeric APOBEC3G Is Catalytically Active and Has Antiviral Activity

Opi, Sandrine, Takeuchi, Hiroaki, Kao, Sandra, Khan, Mohammad A., Miyagi, Eri, Goila-Gaur, Ritu, ...

APOBEC3G (APO3G) is a cytidine deaminase that restricts replication of vif-defective human immunodeficiency virus type 1 (HIV-1). Like other members of the cellular deaminase family, APO3G has the...

Anti-V3 Humanized Antibody KD-247 Effectively Suppresses Ex Vivo Generation of Human Immunodeficiency Virus Type 1 and Affords Sterile Protection of Monkeys against a Heterologous Simian/Human Immunodeficiency Virus Infection

Eda, Yasuyuki, Murakami, Toshio, Ami, Yasushi, Nakasone, Tadashi, Takizawa, Mari, Someya, Kenji, ...

In an accompanying report (Y. Eda, M. Takizawa, T. Murakami, H. Maeda, K. Kimachi, H. Yonemura, S. Koyanagi, K. Shiosaki, H. Higuchi, K. Makizumi, T. Nakashima, K. Osatomi, S. Tokiyoshi, S....

Biochemical Activities of Highly Purified, Catalytically Active Human APOBEC3G: Correlation with Antiviral Effect

Iwatani, Yasumasa, Takeuchi, Hiroaki, Strebel, Klaus, Levin, Judith G.

APOBEC3G (APO3G), a cytidine deaminase with two zinc finger domains, inhibits human immunodeficiency virus type 1 replication in the absence of Vif. Here, we provide a comprehensive molecular...

Exocytosis of Neutrophil Formyl Peptide Receptor-Like 1 (fPRL1) Results in Downregulation of Cytoplasmic fPRL1 in Patients with Purulent Dermatitis▿

Ohara, Eiji, Kumon, Yoshitaka, Kobayashi, Toshihiro, Takeuchi, Hiroaki, Sugiura, Tetsuro

N-Formyl peptide receptor-like 1 (fPRL1) is a member of the chemoattractant subfamily of G protein-coupled receptors and plays a key role in inflammation via chemotaxis and the regulation of mediator...

Human Immunodeficiency Virus Type 1 Vif Inhibits Packaging and Antiviral Activity of a Degradation-Resistant APOBEC3G Variant▿

Opi, Sandrine, Kao, Sandra, Goila-Gaur, Ritu, Khan, Mohammad A., Miyagi, Eri, Takeuchi, Hiroaki, ...

Human immunodeficiency virus type 1 (HIV-1) Vif counteracts the antiviral activity of the human cytidine deaminase APOBEC3G (APO3G) by inhibiting its incorporation into virions. This has been...

Vif Counteracts a Cyclophilin A-Imposed Inhibition of Simian Immunodeficiency Viruses in Human Cells▿

Takeuchi, Hiroaki, Buckler-White, Alicia, Goila-Gaur, Ritu, Miyagi, Eri, Khan, Mohammad A., Opi, Sandrine, ...

Vif is a primate lentiviral accessory protein that is crucial for viral infectivity. Vif counteracts the antiviral activity of host deaminases such as APOBEC3G and APOBEC3F. We now report a novel...

Enzymatically Active APOBEC3G Is Required for Efficient Inhibition of Human Immunodeficiency Virus Type 1▿

Miyagi, Eri, Opi, Sandrine, Takeuchi, Hiroaki, Khan, Mohammad, Goila-Gaur, Ritu, Kao, Sandra, ...

APOBEC3G (APO3G) is a cellular cytidine deaminase with potent antiviral activity. Initial studies of the function of APO3G demonstrated extensive mutation of the viral genome, suggesting a model in...

Role of bacterial and genetic factors in gastric cancer in Costa Rica

Con, Sergio A, Takeuchi, Hiroaki, Con-Chin, Gil R, Con-Chin, Vicky G, Yasuda, Nobufumi, Con-Wong, Reinaldo

AIM: To evaluate several risk factors for gastric cancer (GC) in Costa Rican regions with contrasting GC incidence rate (GCIR).

Gag-Specific Cytotoxic T-Lymphocyte-Based Control of Primary Simian Immunodeficiency Virus Replication in a Vaccine Trial ▿

Kawada, Miki, Tsukamoto, Tetsuo, Yamamoto, Hiroyuki, Iwamoto, Nami, Kurihara, Kyoko, Takeda, Akiko, ...

Gag-specific cytotoxic T lymphocytes (CTLs) exert strong suppressive pressure on human immunodeficiency virus (HIV) and simian immunodeficiency virus (SIV) replication. However, it has remained...